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Scientific Articles

Open Access | Accuracy of an Immunochromatographic Diagnostic Test (ICT Malaria Combo Cassette Test) Compared to Microscopy among under Five-Year-Old Children when Diagnosing Malaria in Equatorial Guinea

August 25, 2010 - 14:49 -- Patrick Sampao
Author(s): 
José-Luis P., Maria R., et al.
Reference: 
Malaria Research and Treatment, Volume 2010 (2010)

The general results showed little concordance between the ICT test and microscopy (kappa = 0.28, se: 0.04). In Equatorial Guinea, the ICT Malaria Combo Cassette Test has proven to be an acceptable test to detect high P. falciparum parasitemias.

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Open Access | Additive In Vitro Antiplasmodial Effect of N-Alkyl and N-Benzyl-1,10-Phenanthroline Derivatives and Cysteine Protease Inhibitor E64

August 25, 2010 - 14:11 -- Patrick Sampao
Author(s): 
Mahardika Agus Wijayanti, Eti Nurwening Sholikhah, Ruslin Hadanu, Jumina Jumina, Supargiyono Supargiyono and Mustofa Mustofa
Reference: 
Malaria Research and Treatment, Volume 2010 (2010)

As the interaction of chloroquine and E64 was additive, the results indicated that these new compounds had a mechanism of action by inhibiting Plasmodium proteases.

Open Access | Glutathione Reductase-null Malaria Parasites Have Normal Blood Stage Growth but Arrest during Development in the Mosquito

August 25, 2010 - 08:48 -- Kabogo Ndegwa
Author(s): 
Rebecca Pastrana-Mena, Rhoel R. Dinglasan, Adelfa E. Serrano, et al
Reference: 
The Journal of Biological Chemistry, August 27, 2010, 285 27045-27056

Malaria parasites contain a complete glutathione (GSH) redox system, and several enzymes of this system are considered potential targets for antimalarial drugs.

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Open Access | Geographic medicine: Oviposition deterrence induced by Ocimum kilimandscharicum and Ocimum suave extracts to gravid Anopheles gambiae s.s (Diptera: Culicidae) in laboratory

August 24, 2010 - 15:25 -- Patrick Sampao
Author(s): 
Eliningaya J Kweka, Ester E Lyatuu, Michael A Mboya, Beda J Mwang'onde, Aneth M Mahande
Reference: 
Journal of Global Infectious Diseases, Volume 2 : 3 Page : 242-245, 2010

Further research needs to be done on the effect of secondary metabolites of these plant extracts as they decompose in the breeding sites. In the event of favorable results, the potential of these plant extracts can be harnessed on a larger scale.

Geographic medicine: Effect of different hosts on feeding patterns and mortality of mosquitoes (Diptera: Culicidae) and their implications on parasite transmission

August 24, 2010 - 14:35 -- Patrick Sampao
Author(s): 
Eliningaya J Kweka, Beda J Mwang'onde, Lucile Lyaruu, Filemoni Tenu, Aneth M Mahande
Reference: 
Journal of Global Infectious Diseases, Volume 2 : 2 Page : 121-123, 2010

We investigated the feeding and mortality rates of three mosquito species, namely Culex quinquefasciatus, Aedes aegypti and Anopheles arabiensis against three different hosts.

Open Access | Geographic medicine: Field evaluation of the bio-efficacy of three pyrethroid based coils against wild populations of anthropophilic mosquitoes in Northern Tanzania

August 24, 2010 - 14:16 -- Patrick Sampao
Author(s): 
Shandala Msangi, Beda J Mwang'onde, Aneth M Mahande, Eliningaya J Kweka
Reference: 
Journal of Global Infectious Diseases , Volume 2 : 2 Page : 116-120, 2010

This study aims to assess the feeding inhibition and repellency effect of three brands of mosquito coils in experimental huts (East African design).

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Priority Paper Evaluation: How do malaria parasites activate dendritic cells?

August 24, 2010 - 12:15 -- Kabogo Ndegwa
Author(s): 
Tracey J Lamb, Michael P Schenk, Stephen M Todryk
Reference: 
Future Microbiology August 2010, Vol. 5, No. 8, Pages 1167-1171

The authors suggest that parasite DNA complexed with protein is the main trigger for activation of DCs in malaria-infected red blood cells.

Open Access | Malaria: what can apes teach humans?

August 24, 2010 - 11:38 -- Kabogo Ndegwa
Author(s): 
J Cox-Singh
Reference: 
Future Microbiology August 2010, Vol. 5, No. 8, Pages 1157-1160

Human malaria is caused by four human-host restricted or adapted species of the genus Plasmodium, listed here in their order of risk for causing severe disease Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malariae – or so we thought.

Open Access | Short Report: Malaria among antenatal clients attending primary health care facilities in Kano state, Nigeria

August 24, 2010 - 10:08 -- Kabogo Ndegwa
Author(s): 
AU Gajida, Z Iliyasu, AI Zoakah
Reference: 
Annals of African Medicine, Volume : 9 Issue : 3 2010 Page : 188-193

Intermittent Preventive Treatment (IPT) should be provided especially among primigravid, secondigravid and younger mothers at PHC centres.

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