By definition, eradication of human malaria parasites globally requires that intervention options are available that can eliminate transmission anywhere in the world.
After the 2007 Bill & Melinda Gates Foundation meeting at which malaria eradication was declared back on the table , the charity was joined in its call by the World Health Organization (WHO) director general, the United States National Institutes of Health, and the Clinton Foundation, among others.
The results of this study suggest that washing and drying regimen influence the insecticidal activity of LLINs.
Increasing prevalence of the dhfr triple mutant and dhps double mutant genotypes in Africa are consistent with the loss of efficacy of SP for treatment of clinical malaria in most parts of this continent.
Our assay provides a number of technical improvements that facilitate the high-throughput screening of patient samples to identify SP-resistant malaria.
Both fungal isolates reduced mosquito survival on immediate exposure and up to 28 d after application. Conidia were more effective when applied on mud panels and cotton cloth compared with polyester netting.
IPTi-SP appears to have no impact on the multiplicity of infection during infancy and thereafter. This suggests that tolerance of multiple infections, a component of protective immunity in highly endemic areas, is not affected by this intervention.
Because these results suggest that infected mosquitoes may incur fitness costs under natural-like conditions, they are particularly relevant to vector control strategies aiming at boosting naturally occurring refractoriness or spreading natural or foreign genes for refractoriness using genetic drive systems in vector populations.
Information on significant malaria vectors associated with specific topography is useful for planning the mosquito control aspect of malaria management.
In the present work, QSAR and molecular docking studies have been performed on triazolopyrimidine-based dihydroorotate dehydrogenase (DHODH) inhibitors as antimalarial agents.