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Scientific Articles

Open Access | Ecology: A Prerequisite for Malaria Elimination and Eradication

September 1, 2010 - 12:24 -- Kabogo Ndegwa
Author(s): 
Heather M. Ferguson, Anna Dornhaus, Arlyne Beeche, Christian Borgemeister, Michael Gottlieb, Mir S. Mulla, John E. Gimnig, Durland Fish, Gerry F. Killeen
Reference: 
PLoS Med 7(8): e1000303

By definition, eradication of human malaria parasites globally requires that intervention options are available that can eliminate transmission anywhere in the world.

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Open Access | Essay: Assessing Strategy and Equity in the Elimination of Malaria

September 1, 2010 - 12:10 -- Kabogo Ndegwa
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Author(s): 
Naman K. Shah
Reference: 
PLoS Med 7(8): e1000312

After the 2007 Bill & Melinda Gates Foundation meeting at which malaria eradication was declared back on the table [1], the charity was joined in its call by the World Health Organization (WHO) director general, the United States National Institutes of Health, and the Clinton Foundation, among others.

Open Access | Wash durability and optimal drying regimen of four brands of long-lasting insecticide-treated nets after repeated washing under tropical conditions

September 1, 2010 - 08:36 -- Kabogo Ndegwa
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Author(s): 
Atieli FK, Munga SO, Ofulla AV, Vulule JM
Reference: 
Malaria Journal 2010, 9:248 (30 August 2010)

The results of this study suggest that washing and drying regimen influence the insecticidal activity of LLINs.

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Open Access | Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations

September 1, 2010 - 08:07 -- Kabogo Ndegwa
Author(s): 
Sridaran S, McClintock SK, Syphard LM, Herman KM, Barnwell JW, Udhayakumar V
Reference: 
Malaria Journal 2010, 9:247 (30 August 2010)

Increasing prevalence of the dhfr triple mutant and dhps double mutant genotypes in Africa are consistent with the loss of efficacy of SP for treatment of clinical malaria in most parts of this continent.

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Parasitology: High-Throughput Genotyping of Single Nucleotide Polymorphisms in the Plasmodium falciparum dhfr Gene by Asymmetric PCR and Melt-Curve Analysis

August 31, 2010 - 14:34 -- Patrick Sampao
Author(s): 
Rochelle E. Cruz, Sandra E. Shokoples, Dammika P. Manage, and Stephanie K. Yanow
Reference: 
J. Clin. Microbiol., Sep 2010; 48: 3081 - 3087.

Our assay provides a number of technical improvements that facilitate the high-throughput screening of patient samples to identify SP-resistant malaria.

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Open Access | Tools for delivering entomopathogenic fungi to malaria mosquitoes: effects of delivery surfaces on fungal efficacy and persistence

August 31, 2010 - 13:43 -- Kabogo Ndegwa
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Author(s): 
Mnyone LL, Kirby MJ, Lwetoijera DW, Mpingwa MW, Simfukwe ET, Knols BG, Takken W, Russell TL
Reference: 
Malaria Journal 2010, 9:246 (27 August 2010)

Both fungal isolates reduced mosquito survival on immediate exposure and up to 28 d after application. Conidia were more effective when applied on mud panels and cotton cloth compared with polyester netting.

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Open Access | Multiplicity of Plasmodium falciparum infection following intermittent preventive treatment in infants

August 31, 2010 - 13:36 -- Kabogo Ndegwa
Author(s): 
Buchholz U, Kobbe R, Danquah I, Zanger P, Reither K, Abruquah HH, Grobusch MP, Ziniel P, May J, Mockenhaupt FP
Reference: 
Malaria Journal 2010, 9:244 (26 August 2010)

IPTi-SP appears to have no impact on the multiplicity of infection during infancy and thereafter. This suggests that tolerance of multiple infections, a component of protective immunity in highly endemic areas, is not affected by this intervention.

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Open Access | Hydric stress-dependent effects of Plasmodium falciparum infection on the survival of wild-caught Anopheles gambiae female mosquitoes

August 31, 2010 - 13:23 -- Kabogo Ndegwa
Author(s): 
Aboagye-Antwi F, Guindo A, Traore AS, Hurd H, Coulibaly M, Traore S, Tripet F
Reference: 
Malaria Journal 2010, 9:243 (26 August 2010)

Because these results suggest that infected mosquitoes may incur fitness costs under natural-like conditions, they are particularly relevant to vector control strategies aiming at boosting naturally occurring refractoriness or spreading natural or foreign genes for refractoriness using genetic drive systems in vector populations.

Open Access | Relationships between anopheline mosquitoes and topography in West Timor and Java, Indonesia

August 31, 2010 - 13:15 -- Kabogo Ndegwa
Author(s): 
Ndoen E, Wild C, Dale P, Sipe N, Dale M
Reference: 
Malaria Journal 2010, 9:242 (26 August 2010)

Information on significant malaria vectors associated with specific topography is useful for planning the mosquito control aspect of malaria management.

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Chemometric modeling, docking and in silico design of triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors as antimalarials

August 30, 2010 - 14:32 -- Kabogo Ndegwa
Author(s): 
Probir Kumar Ojha, Kunal Roy
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 10, October 2010, Pages 4645-4656

In the present work, QSAR and molecular docking studies have been performed on triazolopyrimidine-based dihydroorotate dehydrogenase (DHODH) inhibitors as antimalarial agents.

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