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Scientific Articles

Genetic Structure of Anopheles (Nyssorhynchus) marajoara (Diptera: Culicidae) in Colombia

September 3, 2010 - 08:01 -- Patrick Sampao
Author(s): 
Helena Brochero, Cong Li, Richard Wilkerson, Jan E. Conn, AND Manuel Ruiz-García
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 585-595

The assignment analyses showed two incompletely isolated gene pools separated by the Eastern Andean cordillera. However, other possible geographical barriers (rivers and other mountains) did not play any role in the moderate genetic heterogeneity found among these populations (FST = 0.069).

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Rapid Detection of Lactate Dehydrogenase and Genotyping of Plasmodium falciparum in Saliva of Children with Acute Uncomplicated Malaria

September 3, 2010 - 07:42 -- Patrick Sampao
Author(s): 
Grace O. Gbotosho, Christian T. Happi, Onikepe Folarin, Ochuko Keyamo, Akintunde Sowunmi, and Ayoade M. J. Oduola
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 496-501

Rapid detection of Plasmodium falciparum lactate dehydrogenase (pLDH) in saliva samples from 130 of 144 children with microscopically confirmed P. falciparum infection was evaluated using Optimal-IT dipsticks.

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A Comparison of Methods to Detect and Quantify the Markers of Antimalarial Drug Resistance

September 2, 2010 - 15:04 -- Patrick Sampao
Author(s): 
Ian M. Hastings, Christian Nsanzabana, and Tom A. Smith
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 489-495

Simple counting dramatically reduced sample size and estimate precision, and we show that analysis of unambiguous samples is biased, leaving maximum likelihood or similar statistical inference as the only practical option.

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Open Access | Scaling Up Malaria Control in Zambia: Progress and Impact 2005–2008

September 2, 2010 - 14:26 -- Patrick Sampao
Author(s): 
Elizabeth C., John M., et al.
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 480-488

Zambia national survey, administrative, health facility, and special study data were used to assess progress and impact in national malaria control between 2000 and 2008.

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Mutations in the Antifolate-Resistance-Associated Genes Dihydrofolate Reductase and Dihydropteroate Synthase in Plasmodium vivax Isolates from Malaria-Endemic Countries

September 2, 2010 - 13:51 -- Patrick Sampao
Author(s): 
Feng L., Chae S., et al.
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 474-479

We sequenced the Plasmodium vivax dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps) genes to examine the prevalence and extent of point mutations in isolates from malaria-endemic countries.

Open Access | Malaria Incidence and Prevalence Among Children Living in a Peri-Urban Area on the Coast of Benin, West Africa: A Longitudinal Study

September 2, 2010 - 13:30 -- Patrick Sampao
Author(s): 
Alain N., Annette E., et al.
Reference: 
Am J Trop Med Hyg 2010 83: 465-473

Three cross-sectional surveys were also carried out. Malaria incidence showed a marked seasonal distribution with two peaks: the first corresponding to the long rainy season, and the second corresponding to the overflowing of Lake Nokoue.

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Evaluation of Recurrent Parasitemia after Artemether-Lumefantrine Treatment for Uncomplicated Malaria in Children in Western Kenya

September 2, 2010 - 13:16 -- Patrick Sampao
Author(s): 
Joseph V. Woodring, Bernhards Ogutu, David Schnabel, John N. Waitumbi, Cara H. Olsen, Douglas S. Walsh, D. Gray Heppner, Jr.,and Mark E. Polhemus
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 458-464

Although recrudescence in some cannot be ruled out, our cohort had a shorter median time to RP compared with other artemether-lumefantrine treatment studies.

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Open Access | Reducing Plasmodium falciparum Malaria Transmission in Africa: A Model-Based Evaluation of Intervention Strategies

September 2, 2010 - 12:37 -- Kabogo Ndegwa
Author(s): 
Jamie T. Griffin, T. Deirdre Hollingsworth, Azra C. Ghani, et al
Reference: 
PLoS Med 7(8): e1000324

Interventions using current tools can result in major reductions in P. falciparum malaria transmission and the associated disease burden in Africa. Reduction to the 1% parasite prevalence threshold is possible in low- to moderate-transmission settings when vectors are primarily endophilic (indoor-resting), provided a comprehensive and sustained intervention program is achieved through roll-out of interventions.

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Open Access | Safety of artemether-lumefantrine in pregnant women with malaria: results of a prospective cohort study in Zambia

September 2, 2010 - 12:01 -- Kabogo Ndegwa
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Author(s): 
Manyando C, Mkandawire R, Puma L, Sinkala M, Mpabalwani E, Njunju E, Gomes M, Ribeiro I, Walter V, Virtanen M, Schlienger R, Cousin M, Chipimo M, Sullivan FM
Reference: 
Malaria Journal 2010, 9:249 (1 September 2010)

These data suggest that exposure to AL in pregnancy, including first trimester, is not associated with particular safety risks in terms of perinatal mortality, malformations, or developmental impairment. However, more data are required on AL use during the first trimester.

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Molecular identification and phylogeny of Myzomyia and Neocellia series of Anopheles subgenus Cellia (Diptera: Culicidae)

September 1, 2010 - 13:55 -- Patrick Sampao
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Author(s): 
Sunita Swain, Amitav Mohanty, H.K. Tripathy, Namita Mahapatra, Santanu K. Kar, Rupenangshu K. Hazra
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 7, October 2010, Pages 931-939

This assay can be applied as an unbiased confirmatory method for the identification of morphological variants, imperfectly preserved specimens and life stages for which taxonomic keys do not allow a definitive species determination.

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