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Scientific Articles

Open Access | Development of temporal modelling for forecasting and prediction of malaria infections using time-series and ARIMAX analyses: A case study in endemic districts of Bhutan

September 7, 2010 - 14:06 -- Kabogo Ndegwa
Author(s): 
Wangdi K, Singhasivanon P, Silawan T, Lawpoolsri S, White NJ, Kaewkungwal J
Reference: 
Malaria Journal 2010, 9:251 (3 September 2010)

The ARIMA models of time-series analysis were useful in forecasting the number of cases in the endemic areas of Bhutan.

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Open Access | An Economic Evaluation of Home Management of Malaria in Uganda: An Interactive Markov Model

September 7, 2010 - 11:59 -- Patrick Sampao
Author(s): 
Yoel Lubell, Anne J. Mills, Christopher J. M. Whitty, Sarah G. Staedke
Reference: 
PLoS ONE August 2010 Volume 5 Issue 8

Model output is stratified by level of malaria transmission and the probability that a child would receive appropriate care from a health facility, to indicate the circumstances in which HMM is likely to be cost-effective.

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Open Access | Mosquito nets in a rural area of Western Kenya: ownership, use and quality

September 7, 2010 - 08:52 -- Patrick Sampao
Author(s): 
Githinji S, Herbst S, Kistemann T, Noor AM
Reference: 
Malaria Journal 2010, 9:250 (2 September 2010)

This study analyses the use and quality of nets owned by households in an area of high net coverage.

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Malaria parasite sequences from chimpanzee support the co-speciation hypothesis for the origin of virulent human malaria (Plasmodium falciparum)

September 6, 2010 - 14:30 -- Patrick Sampao
Author(s): 
Austin L. Hughes, Federica Verra
Reference: 
Molecular Phylogenetics and Evolution, Volume 57, Issue 1, October 2010, Pages 135-143

The available data are thus most consistent with the hypothesis that P. reichenowi (in the strict sense) and P. falciparum co-speciated with their hosts about 5–7 million years ago.

Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines

September 6, 2010 - 09:29 -- Patrick Sampao
Author(s): 
Manolo Casagrande, Nicoletta Basilico, Chiara Rusconi, Donatella Taramelli, Anna Sparatore
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 18, 15 September 2010, Pages 6625-6633

The antimalarial activity of this new class of compounds seems to be related to the inhibition of heme detoxification process of parasites, as in the case of chloroquine.

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Structure–activity relationships of mononuclear metal–thiosemicarbazone complexes endowed with potent antiplasmodial and antiamoebic activities

September 6, 2010 - 09:22 -- Patrick Sampao
Author(s): 
Deepa B., Fareeda A., et al.
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 18, 15 September 2010, Pages 6857-6864

Four functionalized furyl-thiosemicarbazones (NT1–4) treated with divalent metals (Cu, Co, Pt, and Pd) to form the mononuclear metallic complexes of formula [M(L)2Cl2] or [M(L)Cl2] were examined.

Dialkylaminoalkyl derivatives of bicyclic compounds with antiplasmodial activity

September 6, 2010 - 09:14 -- Patrick Sampao
Author(s): 
Johanna Faist, Werner Seebacher, Marcel Kaiser, Reto Brun, Robert Saf, Robert Weis
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 18, 15 September 2010, Pages 6796-6804

Dialkylaminoalkyl derivatives of 2-azabicyclo[3.2.2]nonanes and of bicyclo[2.2.2]octanes were prepared and their activities determined in vitro against the multiresistant K1 strain of Plasmodium falciparum.

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Immune-Mediated Mechanisms of Parasite Tissue Sequestration during Experimental Cerebral Malaria

September 6, 2010 - 08:32 -- Patrick Sampao
Author(s): 
Fiona H. Amante, Ashraful Haque
Reference: 
The Journal of Immunology, 2010, 185, 3632 -3642

We show that a rapid increase in parasite biomass is strongly associated with the induction of ECM, mediated by IFN-{gamma} and lymphotoxin {alpha}, whereas TNF and IL-10 limit this process.

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Open Access | Aestivation of the African Malaria Mosquito, Anopheles gambiae in the Sahel

September 3, 2010 - 08:22 -- Patrick Sampao
Author(s): 
Tovi L., Adama D., et al.
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 601-606

These results provide evidence that An. gambiae persists throughout the dry season by aestivation and open new questions for mosquito and parasite research.

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Open Access | An Exposure-Free Tool for Monitoring Adult Malaria Mosquito Populations

September 3, 2010 - 08:14 -- Patrick Sampao
Author(s): 
Nicodem J. Govella, Jason D. Moore, and Gerry F. Killeen
Reference: 
Am. J. Trop. Med. Hyg., 83(3), 2010, pp. 596-600

An improved C model (ITT-C) was developed and evaluated by comparing with ITT-B in semi-field and full-field conditions in southern Tanzania.

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