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Scientific Articles

Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites

October 29, 2009 - 13:28 -- Ingeborg van Schayk
Author(s): 
Brolin KJ, Ribacke U, Nilsson S, Ankarklev J, Moll K, Wahlgren M, Chen Q
Reference: 
Genome Biology 2009, 10:R117 (22 October 2009)

Allelic discrimination assays have traditionally been applied to study zygosity in diploid genomes. The assays presented here are instead successfully applied to the identification and evaluation of transcriptional activity of duplicated genes in the haploid genome of the P. falciparum parasite.

The malaria candidate vaccine liver stage antigen-3 is highly conserved in Plasmodium falciparum isolates from diverse geographical areas

October 29, 2009 - 12:53 -- Ingeborg van Schayk
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Author(s): 
Eric Prieur, Pierre Druilhe
Reference: 
Malaria Journal 2009, 8:247 (29 October 2009)

The paper compares the sequences of LSA-3 from four geographical areas and found LSA-3 to be a highly conserved antigen. This finding further supports the usefulness of LSA-3 as a pre-erythrocytic stage vaccine candidate.

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Malaria treatment perceptions, practices and influences on provider behaviour: comparing hospitals and non-hospitals in south-east Nigeria

October 29, 2009 - 12:50 -- Ingeborg van Schayk
Author(s): 
Obinna Onwujekwe, Benjamin Uzochukwu, Nkem Dike, Nkoli Uguru, Emmanuel Nwobi, Elvis Shu
Reference: 
Malaria Journal 2009, 8:246 (28 October 2009)

The behaviour of providers is often influenced by their knowledge, financial incentives, competition, or to follow patient demands and expectations. This study used a pre-tested structured questionnaire to collect data from 225 providers from hospitals and non-hospitals about their malaria treatment practices.

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Assessing the burden of pregnancy-associated malaria under changing transmission settings

October 29, 2009 - 12:47 -- Ingeborg van Schayk
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Author(s): 
Mario Recker, Menno J Bouma, Paul Bamford, Sunetra Gupta, Andy P Dobson
Reference: 
Malaria Journal 2009, 8:245 (28 October 2009)

The clinical presentation of pregnancy-associated malaria depends crucially on the particular epidemiological settings. By re-examining historical data, and the use of a simple mathematical model, it is demonstrated how excess female mortality can be used to evaluate the burden of pregnancy-associated malaria.

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Comparison of different methods for delayed post-mortem diagnosis of falciparum malaria

October 29, 2009 - 12:43 -- Ingeborg van Schayk
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Author(s): 
Nicole Berens-Riha, Inga Sinicina, Erna Fleischmann, Thomas Loscher
Reference: 
Malaria Journal 2009, 8:244 (28 October 2009)

An interesting paper which addresses the issue of delayed post-mortem diagnosis of P. falciparum with ICT tests.

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Review: Reviewing the literature on access to prompt and effective malaria treatment in Kenya: implications for meeting the Abuja targets

October 29, 2009 - 12:40 -- Ingeborg van Schayk
Author(s): 
Jane Chuma, Timothy Abuya, Dorothy Memusi, Elizabeth Juma, Willis Akhwale, Janet Ntwiga, Andrew Nyandigisi, Gladys Tetteh, Rima Shretta, Abdinasir Amin
Reference: 
Malaria Journal 2009, 8:243 (28 October 2009)

This review on access to malaria treatment in Kenya is particularly interesting in the light of the wealth of studies that have been carried out on related topics in Kenya.

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What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity

October 29, 2009 - 12:37 -- Ingeborg van Schayk
Author(s): 
Samson M Kinyanjui, Philip Bejon, Faith H Osier, Peter C Bull, Kevin Marsh
Reference: 
Malaria Journal 2009, 8:242 (28 October 2009)

Failure to distinguish between individuals who do not get a clinical episode during follow-up because they were unexposed and those who are genuinely immune undermines our ability to assign a protective role to immune responses against malaria. The brevity of antibodies responses makes it difficult to assign the true serological status of an individual at any given time, i.e. those positive at a survey may be negative by the time they encounter the next infection.

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Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

October 29, 2009 - 12:34 -- Ingeborg van Schayk
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Author(s): 
Elizabeth A Ashley, Malek Touabi, Margareta Ahrer, Robert Hutagalung, Khayae Htun, Jennifer Luchavez, Christine Dureza, Stephane Proux, Mara Leimanis, Myo Min Lwin, Alena Koscalova, Eric Comte, Prudence Hamade, Anne-Laure Page, Francois Nosten, Philippe J Guerin
Reference: 
Malaria Journal 2009, 8:241 (27 October 2009)

In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH). In Dawei, southern Myanmar, three pLDH based RDTs (CareStartTM Malaria pLDH (Pan), CareStartTM Malaria pLDH (Pan, Pf) and OptiMAL-IT(R)) were evaluated in patients presenting with clinically suspected malaria.

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Two treatments, one disease: childhood malaria management in Tanga, Tanzania

October 29, 2009 - 12:30 -- Ingeborg van Schayk
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Author(s): 
Deshka Foster, Stacie Vilendrer
Reference: 
Malaria Journal 2009, 8:240 (27 October 2009)

In the Tanga District of coastal Tanzania, malaria is one of the primary causes of mortality for children under the age of five. While some children are treated with malaria medications in biomedical facilities, as the World Health Organization recommends, others receive home-care or treatment from traditional healers. 

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Seasonal distribution of Anopheles funestus chromosomal forms from Burkina Faso

October 29, 2009 - 12:26 -- Ingeborg van Schayk
Author(s): 
Wamdaogo M Guelbeogo, N'Fale Sagnon, Olga Grushko, Malgaouende A Yameogo, Daniela Boccolini, Nora J Besansky, Carlo Costantini
Reference: 
Malaria Journal 2009, 8:239 (26 October 2009)

Previous studies of Anopheles funestus chromosomal inversion polymorphisms in Burkina Faso showed large departures from Hardy-Weinberg equilibrium and linkage disequilibrium among inversions located on different chromosomes, implying the existence of two taxonomic units ("chromosomal forms") with limited genetic flow. One chromosomal form, named Folonzo, is highly polymorphic for alternative rearrangements of 3Ra, 3Rb, 2Ra, and 3La; the other, Kiribina, is predominantly characterized by the standard arrangement of these inversions. To investigate the temporal distribution of these chromosomal forms, further collections were carried out in two villages near Ouagadougou where they are found in sympatry.

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