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Scientific Articles

Review: Diversity and similarity in the tRNA world: Overall view and case study on malaria-related tRNAs

December 17, 2009 - 13:24 -- Patrick Sampao
Author(s): 
Joern Pütza, Richard Giegéa and Catherine Florentz
Reference: 
FEBS Letters, Volume 584, Issue 2, 21 January 2010, Pages 350-358

Transfer RNAs (tRNAs) are ancient macromolecules that have evolved under various environmental pressures as adaptors in translation in all forms of life but also towards alternative structures and functions. The present knowledge on both “canonical” and “deviating” signature motifs retrieved from vertical and horizontal sequence comparisons is briefly reviewed.

Open Access | Clinical Microbiology : The impact of a small-scale irrigation scheme on malaria transmission in Ziway area, Central Ethiopia

December 17, 2009 - 13:23 -- Kabogo Ndegwa
Author(s): 
Solomon Kibret, Yihenew Alemu, Eline Boelee, Habte Tekie, Dawit Alemu, Beyene Petros
Reference: 
Tropical Medicine & International Health, Volume 15, Issue 1, Date: January 2010, Pages: 41-50

To assess the impact of a small-scale irrigation scheme in Ziway area, a semi-arid area in the Central Ethiopian Rift Valley, on malaria transmission.

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Open Access : Clinical Microbiology : Evaluation of the pyrrole insecticide chlorfenapyr against pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae)

December 17, 2009 - 13:21 -- Kabogo Ndegwa
Author(s): 
S. V. Oliver, M. L. Kaiser, O. R. Wood, M. Coetzee, M. Rowland, B. D. Brooke
Reference: 
Tropical Medicine & International Health,Volume 15, Issue 1, Date: January 2010, Pages: 127-131

Objective : To evaluate the pyrrole insecticide chlorfenapyr, which has a novel non-neurotoxic mode of action and is a promising alternative to conventional adulticides, against Anopheles funestus. Method : The toxicity of a range of concentrations of chlorfenapyr against pyrethroid resistant and susceptible laboratory reared southern African An. funestus was assessed using standard WHO protocols and analysed using probit analysis.

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Open Access | Clinical Microbiloby:Low-high season variation in Plasmodium falciparum erythrocyte binding antigen 175 (eba-175) allelic forms in malaria endemic area of Burkina Faso

December 17, 2009 - 13:19 -- Kabogo Ndegwa
Author(s): 
Issiaka Soulama, Edith C. Bougouma, Amidou Diarra, Issa Nebie, Sodiomon B. Sirima
Reference: 
Tropical Medicine & International Healt,Volume 15, Issue 1, Date: January 2010, Pages: 51-59

To assess the impact of seasonal variation on the distribution of the eba-175 allelic forms in the area where malaria transmission is markedly seasonal.

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Open Access | Clinical Microbiology : Therapeutic efficacy of chloroquine and sequence variation in pfcrt gene among patients with falciparum malaria in central India

December 17, 2009 - 13:17 -- Kabogo Ndegwa
Author(s): 
Praveen Kumar Bharti, Mohammad Tauqeer Alam, Robert Boxer, Man Mohan Shukla, Sant P. Gautam, Yagya D. Sharma, Neeru Singh
Reference: 
Tropical Medicine & International Health,Volume 15, Issue 1, Date: January 2010, Pages: 33-40

To assess the therapeutic efficacy of chloroquine (CQ) treatment against uncomplicated Plasmodium falciparum infections in a tribal population of central India (Madhya Pradesh) and to investigate the prevalence of mutant P. falciparum chloroquine-resistant transporter (pfcrt) gene in the parasite population.

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Open Access | Viewpoint: Health systems strengthening through insurance subsidies: the GFATM experience in Rwanda

December 17, 2009 - 13:10 -- Kabogo Ndegwa
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Author(s): 
Andreas Kalk , Natalie Groos , Jean-Claude Karasi and Elisabeth Girrbach
Reference: 
Tropical Medicine & International Health Volume 15 Issue 1, Pages 94 – 97

This project intends to enhance financial access to health care by subsidising health insurance for the poor in order to combat the three diseases successfully.

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Open Access | Cell and Molecular Biology: Shape- and Chemical Feature-Based 3D-Pharmacophore Model Generation and Virtual Screening: Identification of Potential Leads for P. falciparum DHFR Enzyme Inhibition

December 17, 2009 - 13:08 -- Patrick Sampao
Author(s): 
Legesse Adane, Dhilon. S. Patel and Prasad V. Bharatam
Reference: 
Chemical Biology & Drug Design, Volume 75 Issue 1, Pages 115 - 126

The hits reported in this article showed good potential to be inhibitors of the above Pf DHFRs based on their (i) best-fit values (ii) binding scores (iii) binding modes and (iv) interactions with the key amino acid residues (Asp54, Ileu/Leu164, Asn/Ser108 and Ile14).

Open Access | Clinical Microbiology: Are malaria treatment expenditures catastrophic to different socio-economic and geographic groups and how do they cope with payment? A study in southeast Nigeria

December 17, 2009 - 13:05 -- Kabogo Ndegwa
Author(s): 
Obinna Onwujekwe , Kara Hanson, Benjamin Uzochukwu , Hyacinth Ichoku , Edith Ike and Benjamin Onwughalu
Reference: 
Tropical Medicine & International Health, Volume 15 Issue 1, Pages 18 – 25

To determine the inequities in the household income depletion resulting from malaria treatment expenditures, the sacrifice of basic household needs (catastrophe) and the differences in payment strategies among different socio-economic and geographic groups in southeast Nigeria.

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Short communication: Investigation of memory responses following Plasmodium chabaudi AS infection in mice distinct in susceptibility to clinical malaria

December 16, 2009 - 10:44 -- Ingeborg van Schayk
Author(s): 
Jiraprapa Wipasa, Panida Hemsokana, Tunlaya Ruankham & Surat Hongsibsong
Reference: 
Parasitology Research, Volume 106, Number 1 / December, 2009 : 283-287

This study aimed to investigate the development of memory responses in susceptible A/J and resistant C57BL/6 mice which differ in the degree of susceptibility to clinical malaria following P. chabaudi AS infection.

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Amaranthus oleracea and Euphorbia hirta: natural potential larvicidal agents against the urban Indian malaria vector, Anopheles stephensi Liston (Diptera: Culicidae)

December 16, 2009 - 10:34 -- Ingeborg van Schayk
Author(s): 
Preeti Sharma, Lalit Mohan & C. N. Srivastava
Reference: 
Parasitology Research, Volume 106, Number 1 / December, 2009 : 171-176

The present work highlights the larvicidal property of extracts of Amaranthus oleracea and Euphorbia hirta against the third instar larvae of Anopheles stephensi, the urban malaria vector.

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