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Scientific Articles

A retrospective evaluation of the role of T cells in the development of malaria vaccine

September 10, 2010 - 13:13 -- Kabogo Ndegwa
Author(s): 
Moriya Tsuji
Reference: 
Experimental Parasitology, Volume 126, Issue 3, November 2010, Pages 421-425

Due to the fact that the life cycle of malaria parasites is complex, undergoing both an extracellular and intracellular phases in its host, the human immune system has to mobilize both the humoral and cellular arms of immune responses to fight against this parasitic infection.

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Open Access | Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network

September 9, 2010 - 12:55 -- Patrick Sampao
Author(s): 
Germán Plata, Tzu-Lin Hsiao, Kellen L Olszewski, Manuel Llinás & Dennis Vitkup
Reference: 
Molecular Systems Biology 6 Article number: 408

To demonstrate that the model can be used to make clinically relevant predictions, we experimentally tested one of the identified drug targets, nicotinate mononucleotide adenylyltransferase, using a recently discovered small-molecule inhibitor.

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Open Access | A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting

September 9, 2010 - 12:43 -- Patrick Sampao
Author(s): 
Harris I, Sharrock WW, Bain LM, Gray K, Bobogare A, Boaz L, Lilley K, Krause D, Vallely A, Johnson M, Gatton ML, Shanks GD, Cheng Q
Reference: 
Malaria Journal 2010, 9:254 (7 September 2010)

During the survey, 9,491 blood samples were collected and examined by microscopy for Plasmodium species and density, with a subset also examined by polymerase chain reaction (PCR) and rapid diagnostic tests (RDTs).

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Open Access | Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1

September 9, 2010 - 12:07 -- Patrick Sampao
Author(s): 
Louise J., Dominique C., et al.
Reference: 
PLoS Pathogens Volume 6 Issue 9 September 02, 2010

These new results on PfEMP1 antigen expression indicate that a re-evaluation of the molecular mechanisms involved in P. falciparum adhesion and of the accepted paradigm of absolutely mutually exclusive var gene transcription is required.

Microbiology: Is the Tide Turning for New Malaria Medicines?

September 8, 2010 - 09:21 -- Kabogo Ndegwa
Author(s): 
Timothy N. C. Wells
Reference: 
Science 3 September 2010, Vol. 329. no. 5996, pp. 1153 - 1154

Every so often, the tide turns in a field of science. In malaria research, for a while an approach called "rational design" held sway, with great optimism that new drugs would emerge from understanding the biology of the malaria parasite at the molecular level.

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Spiroindolones, a Potent Compound Class for the Treatment of Malaria

September 8, 2010 - 09:10 -- Kabogo Ndegwa
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Author(s): 
M Rottmann, C McNamara, TT Diagana, et al
Reference: 
Science 3 September 2010, Vol. 329. no. 5996, pp. 1175 – 1180

Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments.

Minireview: Regulation of immunity to Plasmodium: Implications from mouse models for blood stage malaria vaccine design

September 8, 2010 - 08:46 -- Kabogo Ndegwa
Author(s): 
Andrew W. Taylor-Robinson
Reference: 
Experimental Parasitology, Volume 126, Issue 3, November 2010, Pages 406-414

Malaria, a disease caused by the protozoan parasite Plasmodium, remains a serious healthcare problem in developing countries worldwide.

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TNF family members and malaria: Old observations, new insights and future directions Original

September 8, 2010 - 08:38 -- Kabogo Ndegwa
Author(s): 
Louise M. Randall, Christian R. Engwerda
Reference: 
Experimental Parasitology, Volume 126, Issue 3, November 2010, Pages 326-331

Tumor necrosis factor (TNF) has long been recognized to promote malaria parasite killing, but also to contribute to the development of severe malaria disease. The precise molecular mechanisms that influence these different outcomes in malaria patients are not well understood, but the virulence and drug-resistance phenotype of malaria parasites and the genetic background and age of patients are likely to be important determinants.

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Open Access | Early clinical development of artemether-lumefantrine dispersible tablet: palatability of three flavours and bioavailability in healthy subjects

September 7, 2010 - 14:22 -- Kabogo Ndegwa
Author(s): 
Abdulla S, Amuri B, Kabanywanyi AM, Ubben D, Reynolds C, Pascoe S, Fitoussi S, Yeh C, Nuortti M, Sechaud R, Kaiser G, Lefevre G
Reference: 
Malaria Journal 2010, 9:253 (3 September 2010)

Considering that cherry was the preferred flavour, and that the novel A-L dispersible tablet demonstrated similar pharmacokinetic performances to the tablet administered crushed, a cherry-flavoured A-L dispersible tablet formulation was selected for further development and testing in a large efficacy and safety study in African children with malaria.

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Open Access | Spatial heterogeneity and temporal evolution of malaria transmission risk in Dakar, Senegal, according to remotely sensed environmental data

September 7, 2010 - 14:15 -- Kabogo Ndegwa
Author(s): 
Machault V, Vignolles C, Pages F, Gadiaga L, Gaye A, Sokhna C, Trape J, Lacaux J, Rogier C
Reference: 
Malaria Journal 2010, 9:252 (3 September 2010)

Environmental data retrieved from high spatial resolution SPOT satellite images were associated with An. arabiensis densities in Dakar urban setting, which allowed to generate malaria transmission risk maps.

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