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Scientific Articles

Persistence of full-length caspase-12 and its relation to malaria in West and Central African populations.

January 31, 2011 - 10:43 -- Patrick Sampao
Author(s): 
McCall MB., Ferwerda B., Netea MG., et al.
Reference: 
Eur Cytokine Netw. 2010 Jun;21(2):77-83. Epub 2010 Apr 27.

We investigated associations between caspase-12 genotype and malarial parameters in three West-African populations, in studies encompassing immunological, clinical and obstetric data.

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Population Pharmacokinetics of Sulfadoxine and Pyrimethamine in Malawian Children With Malaria

January 31, 2011 - 10:29 -- Patrick Sampao
Author(s): 
D J Bell, S K Nyirongo, M Mukaka, M E Molyneux, P A Winstanley and S A Ward
Reference: 
Clinical Pharmacology & Therapeutics 89, 268-275 (February 2011)

Our findings suggest that PK factors contributed to the observed high rate of treatment failure, and we therefore recommend a higher SP dose for children under the age of 5 years.

Communication: Design, Synthesis, and Study of a Mycobactin−Artemisinin Conjugate That Has Selective and Potent Activity against Tuberculosis and Malaria

January 31, 2011 - 10:24 -- Patrick Sampao
Author(s): 
Marvin J. Miller., Andrew J. Walz., Helena I. Boshoff., et al.
Reference: 
Journal of the American Chemical Society

The result is that one appropriate conjugate has potent and selective activity against two of the most deadly diseases in the world.

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Open Access | The role of proboscis of the malaria vector mosquito Anopheles stephensi in host-seeking behavior

January 31, 2011 - 09:57 -- Patrick Sampao
Author(s): 
Maekawa E, Aonuma H, Nelson B, Yoshimura A, Tokunaga F, Fukumoto S, Kanuka H
Reference: 
Parasites & Vectors 2011, 4:10 (27 January 2011)

Our findings support an emerging view with a possible role of proboscis as important equipment during host-seeking, and give us an insight into how these appendages likely evolved from a common origin in order to function as antenna organs.

Post-malaria neurological syndrome complicating a relapse of Plasmodium falciparum malaria after atovaquone-proguanil treatment

January 28, 2011 - 09:20 -- Patrick Sampao
Author(s): 
E. Forestier, A. Labe, D. Raffenot, C. Lecomte, O. Rogeaux
Reference: 
Médecine et Maladies Infectieuses, Volume 41, Issue 1, January 2011, Pages 41-43

No abstract available.

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Infection of Anopheles gambiae mosquitoes with entomopathogenic fungi: effect of host age and blood-feeding status

January 28, 2011 - 08:47 -- Kabogo Ndegwa
Author(s): 
Ladslaus L. Mnyone, Matthew J. Kirby, Monica W. Mpingwa, Dickson W. Lwetoijera, Bart G. J. Knols, Willem Takken, Constantianus J. M. Koenraadt & Tanya L. Russell
Reference: 
Parasitology Research, Volume 108, Number 2, 317-322

Physiological characteristics of insects can influence their susceptibility to fungal infection of which age and nutritional status are among the most important.

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Comparative genomic analysis of simple sequence repeats in three Plasmodium species

January 28, 2011 - 08:16 -- Kabogo Ndegwa
Author(s): 
Suchi Tyagi, Meenu Sharma & Aparup Das
Reference: 
Parasitology Research, Volume 108, Number 2, 451-458

Simple sequence repeats (SSRs) are known to be responsible for genetic complexities and play major roles in gene and genome evolution.

Paul de Kruif, American science writer on malaria: a case study

January 27, 2011 - 21:27 -- Ingeborg van Schayk
Tags: 
Author(s): 
Jan Peter Verhave
Reference: 
MWJ 2011, 2, 1

This article focuses on the life of American science writer and microbiologist Paul de Kruif, and his dealing with various malaria topics. A case is made for the role of science journalists in driving the application of newly generated knowledge in the real world of malaria control.

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Open Access | A Research Agenda for Malaria Eradication: Cross-Cutting Issues for Eradication

January 27, 2011 - 10:09 -- Kabogo Ndegwa
Author(s): 
The malERA Consultative Group on Integration Strategies
Reference: 
PLoS Med 8(1): e1000404

Discipline-specific Malaria Eradication Research Agenda (malERA) Consultative Groups have recognized several cross-cutting issues that must be addressed to prevent repetition of some of the mistakes of past malaria elimination campaigns in future programs.

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