The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10054 malaria professionals are enjoying the free benefits of MalariaWorld today

Scientific Articles

Mosquito abundance and behavior in the influence area of the hydroelectric complex on the Madeira River, Western Amazon, Brazil

October 25, 2009 - 17:51 -- Bart G.J. Knols
Author(s): 
Rafael Mesquita Bastos Cruz, Luiz Herman Soares Gil, Alexandre de Almeida e Silva, Maisa da Silva Araújo, Tony Hiroshi Katsuragawa
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1174-1176, doi:10.1016/j.trstmh.2008.09.007

Malaria is currently highly prevalent and restricted to the north of Brazil, and its dynamics are severely affected by human environmental changes, such as the large dam construction recently approved by the Brazilian Government in Rondônia. We studied the mosquito fauna and behavior before hydroelectric construction. Mosquitoes were captured by human landing catches on the riversides of the Madeira River in Porto Velho, Rondônia. 

Technology: 
Continent: 
Country: 
Province Or State: 
Medical Condition: 

The development and evaluation of a single step multiplex PCR for simultaneous detection of Anopheles annularis group mosquitoes, human host preference and Plasmodium falciparum sporozoite presence

October 25, 2009 - 17:45 -- Bart G.J. Knols
Tags: 
Author(s): 
Sunita Swain, Amitav Mohanty, Namita Mahapatra, S.K. Parida, N.S. Marai, H.K. Tripathy, Santanu K. Kar, Rupenangshu K. Hazra
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1146-1152, doi:10.1016/j.trstmh.2009.03.022

The Anopheles annularis group mosquitoes, subgenus Cellia Theobald (Diptera: Culicidae), includes five recognized species: An. annularis Van der Wulp, An. nivipes Theobald, An. pallidus Theobald, An. philippinensis Ludlow and An. schueffneri Stanton. From these five, the three most common species found in Orissa were considered for this study because of their remarkable vectorial and behavioral variation and the important role they play in malaria transmission. To identify and understand their role in malaria transmission we developed a single multiplex PCR-based assay.  This one-step PCR-based method constitutes a very powerful tool in large surveys of anopheline populations.

Medical Condition: 

Evidence of multiple pyrethroid resistance mechanisms in the malaria vector Anopheles gambiae sensu stricto from Nigeria

October 25, 2009 - 17:39 -- Bart G.J. Knols
Tags: 
Author(s): 
T.S. Awolola, O.A. Oduola, C. Strode, L.L. Koekemoer, B. Brooke, H. Ranson
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1139-1145, doi:10.1016/j.trstmh.2008.08.021

 Pyrethroid insecticide resistance in Anopheles gambiae sensu stricto is a major concern to malaria vector control programmes. Resistance is mainly due to target-site insensitivity arising from a single point mutation, often referred to as knockdown resistance (kdr). Metabolic-based resistance mechanisms have also been implicated in pyrethroid resistance in East Africa and are currently being investigated in West Africa. Here we report the co-occurrence of both resistance mechanisms in a population of An. gambiae s.s. from Nigeria.

Continent: 
Country: 

The distribution of insecticide resistance in Anopheles gambiae s.l. populations from Cameroon: an update

October 25, 2009 - 17:32 -- Bart G.J. Knols
Author(s): 
Hamadou N.M. et al.
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1127-1138, doi:10.1016/j.trstmh.2008.11.018

Insecticides are a key component of vector-based malaria control programmes in Cameroon. As part of ongoing resistance surveillance efforts, Anopheles gambiae s.l. female mosquitoes were exposed to organochlorine (DDT), a carbamate (bendiocarb), an organophosphate (malathion), and three pyrethroids (deltamethrin, lambda-cyhalothrin and permethrin) in WHO bioassay test kits.

Carbamate and organophosphorous compounds could thus be used as alternatives in locations in Cameroon where pyrethroid-resistant populations are found.

Continent: 
Country: 
Medical Condition: 

Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda

October 25, 2009 - 17:27 -- Bart G.J. Knols
Author(s): 
Urvashi Ramphul, Thomas Boase, Chris Bass, Loyce M. Okedi, Martin J. Donnelly, Pie Müller
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1121-1126, doi:10.1016/j.trstmh.2009.02.014

Insecticide resistance in Anopheles gambiae threatens the success of malaria vector control programmes in sub-Saharan Africa. In order to manage insecticide resistance successfully, it is essential to assess continuously the target mosquito population. Here, we collected baseline information on the distribution and prevalence of insecticide resistance and its association with target-site mutations in eastern Uganda.

Continent: 
Country: 
Medical Condition: 

Distribution of pyrethroid and DDT resistance and the L1014F kdr mutation in Anopheles gambiae s.l. from Burkina Faso (West Africa)

October 25, 2009 - 17:23 -- Bart G.J. Knols
Author(s): 
K.R. Dabiré, A. Diabaté, M. Namountougou, K.H. Toé, A. Ouari, P. Kengne, C. Bass, T. Baldet
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1113-1120, doi:10.1016/j.trstmh.2009.01.008

This study reports on the distribution of pyrethroid and DDT resistance and the L1014F knockdown resistance (kdr) mutation in Anopheles gambiae s.l. populations from 21 localities in three different climatic zones of Burkina Faso from August to October 2006. These results have practical significance for malaria vector control programs.

Continent: 
Country: 

Agent-based modelling of mosquito foraging behaviour for malaria control

October 25, 2009 - 17:15 -- Bart G.J. Knols
Author(s): 
Weidong Gu, Robert J. Novak
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1105-1112, doi:10.1016/j.trstmh.2009.01.006

Traditional environmental management programmes require extensive coverage of larval habitats to reduce drastically the emergence of adult mosquitoes. Recent studies have highlighted the impact of reduced availability of aquatic habitats on mosquito foraging for hosts and oviposition sites. In this study, we developed an agent-based model to track the status and movement of mosquitoes individually.

Preliminary examination of integrated vector management in a tropical rainforest area of Cameroon

October 25, 2009 - 17:09 -- Bart G.J. Knols
Author(s): 
G.A. Matthews, H.M. Dobson, P.B. Nkot, T.L. Wiles, M. Birchmore
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1098-1104, doi:10.1016/j.trstmh.2009.03.003

In a malaria-endemic area, a pilot study examined different mosquito control interventions applied to entire villages to assess their impact on vectors, malaria incidence and the quality of life of the communities. Malaria incidence several months after treatments was not significantly different from pre-treatment levels. Blackfly adult populations were reduced for several weeks following larvicide application but recovered when treatment was halted.

Country: 
Medical Condition: 

Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria: Implications for Vaccine Development

October 25, 2009 - 17:04 -- Bart G.J. Knols
Author(s): 
Shannon L. Takala et al.
Reference: 
Science Translational Medicine. 2009; 1:2ra5

Vaccines directed against the blood stages of Plasmodium falciparum malaria are intended to prevent the parasite from invading and replicating within host cells. No blood-stage malaria vaccine has shown clinical efficacy in humans. Most malaria vaccine antigens are parasite surface proteins that have evolved extensive genetic diversity, and this diversity could allow malaria parasites to escape vaccine-induced immunity. We examined the extent and within-host dynamics of genetic diversity in the blood-stage malaria vaccine antigen apical membrane antigen–1 in a longitudinal study in Mali. 

Technology: 
Country: 
Medical Condition: 
Medical Treatment: 

Distillery: Therapeutic: Plasmepsin (Plasmodium falciparum)

October 25, 2009 - 17:01 -- Bart G.J. Knols
Author(s): 
-
Reference: 
Science-Business eXchange 2, (15 October 2009) doi:10.1038/scibx.2009.1508

In vitro studies identified a plasmepsin inhibitor that could aid in the development of new treatments for malaria. Further details on the research, next steps and licensing status are discussed in the article.

 

Pages

Subscribe to Scientific Articles