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Scientific Articles

Combining Fungal Biopesticides and Insecticide-Treated Bednets to Enhance Malaria Control

November 10, 2009 - 13:15 -- Ingeborg van Schayk
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Author(s): 
Hancock PA
Reference: 
PLoS Comput Biol 5(10): e1000525

In developing strategies to control malaria vectors, there is increased interest in biological methods that do not cause instant vector mortality, but have sublethal and lethal effects at different ages and stages in the mosquito life cycle. By incorporating biological mechanisms relevant to vectorial capacity, continuous-time vector population models can increase their applicability to integrated vector management.

 

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Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells

November 10, 2009 - 12:58 -- Ingeborg van Schayk
Author(s): 
Nadine Fievet, Stefania Varani, Samad Ibitokou, Valerie Briand, Stephanie Louis, Rene-Xavier Perrin, Achille Massougbodji, Anne Hosmalin, Marita Troye-Blomberg, Philippe Deloron
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Malaria Journal 2009, 8:251 (5 November 2009)

The findings support the view that placental parasitization is significantly associated with partial maturation of different dendritic cell subsets and also to slightly increased responses to TLR9 ligand in cord blood.

Comparison of Plasmodium falciparum allelic frequency distribution in different endemic settings by high-resolution genotyping

November 10, 2009 - 12:40 -- Ingeborg van Schayk
Author(s): 
Sonja Schoepflin, Francesca Valsangiacomo, Enmoore Lin, Benson Kiniboro, Ivo Mueller, Ingrid Felger
Reference: 
Malaria Journal 2009, 8:250 (30 October 2009)

A description of allele frequencies of two polymorphic P. falciparum surface antigens from two sites of varying transmission intensity, Papua New Guinea and Tanzania. It confirms previous reports of a higher mean multiplicity of infection and increased genetic diversity in areas of higher endemicity.

Human Plasmodium knowlesi infections in young children in central Vietnam

November 10, 2009 - 10:49 -- Ingeborg van Schayk
Author(s): 
Peter Van den Eede, Hong Nguyen Van, Chantal Van Overmeir, Indra Vythilingam, Thang Ngo Duc, Le Xuan Hung, Hung Nguyen Manh, Jozef Anné, Umberto D'Alessandro, Annette Erhart
Reference: 
Malaria Journal 2009, 8:249 (30 October 2009)

Three of 95 samples from Vietnamese people believed to be infected with P. malariae were also positive for P. knowlesi by PCR. These findings extend the number of countries in Southeast Asia with reports of human P. knowlesi infections.

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Impact of insecticide-treated nets on wild pyrethroid resistant Anopheles epiroticus population from southern Vietnam tested in experimental huts

November 10, 2009 - 10:37 -- Ingeborg van Schayk
Author(s): 
Wim Van Bortel, Vu Duc Chinh, Dirk Berkvens, Niko Speybroeck, Ho Dinh Trung, Marc Coosemans
Reference: 
Malaria Journal 2009, 8:248 (29 October 2009)

This paper describes the results of experimental hut trials to investigate the efficacy of a variety of insecticide-treated nets. The local vector population is partially resistant to multiple pyrethroid insecticides and so the rational behind the study was to determine whether the nets were still effective against resistant mosquitoes.

Antimicrobial Agents: Global resistance surveillance: ensuring antimalarial efficacy in the future

October 31, 2009 - 10:39 -- Ingeborg van Schayk
Author(s): 
Guerin, Philippe J; Bates, Sarah J; Sibley, Carol H
Reference: 
Current Opinion in Infectious Diseases. 22(6):593-600, December 2009

This review summarizes the current status and the challenges to effective surveillance, and suggests approaches for improvement.

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Antimicrobial Agents: Progress in the development of piperaquine combinations for the treatment of malaria

October 31, 2009 - 10:33 -- Ingeborg van Schayk
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Author(s): 
D'Alessandro, Umberto
Reference: 
Current Opinion in Infectious Diseases. 22(6):588-592, December 2009

The dosage recommended for children may need to be reviewed and the usefulness of the coadministration with food should be determined. Establishing safety and efficacy of this treatment in pregnancy remains a priority.

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Molecular organization of heterochromatin in malaria mosquitoes of the Anopheles maculipennis subgroup

October 31, 2009 - 10:25 -- Ingeborg van Schayk
Author(s): 
Olga G. Grushko, Maria V. Sharakhova, Vladimir N. Stegnii, Igor V. Sharakhov
Reference: 
Gene, Volume 448, Issue 2, 15 December 2009, Pages 192-197

This study reports an initial survey of the molecular organization of the pericentric heterochromatin in nonmodel species from the A. maculipennis subgroup.

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Kinetic benefits and thermal stability of orotate phosphoribosyltransferase and orotidine 5′-monophosphate decarboxylase enzyme complex in human malaria parasite Plasmodium falciparum

October 31, 2009 - 10:17 -- Ingeborg van Schayk
Author(s): 
Panan Kanchanaphum, Jerapan Krungkrai
Reference: 
Biochemical and Biophysical Research Communications, Volume 390, Issue 2, 11 December 2009, Pages 337-341

The result suggests that the OPRT–OMPDC enzyme complex might have kinetic benefits and thermal stability significantly different from the monofunctional enzyme.

Short Communication: Species B of Anopheles culicifacies (Diptera: Culicidae) is reproductively less fit than species A and C of the complex

October 31, 2009 - 10:00 -- Ingeborg van Schayk
Author(s): 
Anil Sharma, Hardev Parasher, O.P. Singh, Tridibes Adak
Reference: 
Acta Tropica, Volume 112, Issue 3, December 2009, Pages 316-319

The present attempt is made to study and compare the fecundity of the differentially susceptible members of the An. culicifacies complex.

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