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Scientific Articles

Open Access | Forcing Versus Feedback: Epidemic Malaria and Monsoon Rains in Northwest India

October 4, 2010 - 11:57 -- Kabogo Ndegwa
Author(s): 
Karina Laneri, Anindya Bhadra, Edward L. Ionides, Menno Bouma, Ramesh C. Dhiman, Rajpal S. Yadav, Mercedes Pascual
Reference: 
PLoS Comput Biol 6(9): e1000898

Malaria epidemics in regions with seasonal windows of transmission can vary greatly in size from year to year. A central question has been whether these interannual cycles are driven by climate, are instead generated by the intrinsic dynamics of the disease, or result from the resonance of these two mechanisms.

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Minimal Association of Common Red Blood Cell Polymorphisms with Plasmodium falciparum Infection and Uncomplicated Malaria in Papua New Guinean School Children

October 4, 2010 - 11:57 -- Patrick Sampao
Author(s): 
Enmoore L., Livingstone T., et al.
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 828 - 833.

In a cohort of children 5–14 years of age the effect of +-thalassemia, SAO (SLC4A127), CR1 polymorphisms, and Gerbich negativity (GYPCex3) on risk of P. falciparum infections and uncomplicated illness were evaluated.

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A Comparison of Iron and Folate with Folate Alone in Hematologic Recovery of Children Treated for Acute Malaria

October 4, 2010 - 11:44 -- Patrick Sampao
Author(s): 
Samuel N. Gara, Aboi J. K. Madaki, AND Tom D. Thacher
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 843 - 847.

We compared the effect of iron and folate with folate alone on hematologic recovery in children treated for acute malaria.

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Open Access | Quantitative Analysis of Immune Response and Erythropoiesis during Rodent Malarial Infection

October 4, 2010 - 11:41 -- Kabogo Ndegwa
Author(s): 
Martin R. Miller, Lars Råberg, Andrew F. Read, Nicholas J. Savill
Reference: 
PLoS Comput Biol 6(9): e1000946

Malarial infection is associated with complex immune and erythropoietic responses in the host.

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Mapping Malaria Risk in Bangladesh Using Bayesian Geostatistical Models

October 4, 2010 - 11:32 -- Patrick Sampao
Author(s): 
Heidi Reid, Ubydul Haque, Archie C. A. Clements, Andrew J. Tatem, Andrew Vallely, Syed Masud Ahmed, Akramul Islam, AND Rashidul Haque
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 861 - 867.

Here, we construct Plasmodium falciparum risk maps for Bangladesh for 2007 at a scale enabling the malaria-control bodies to more accurately define the needs of the program.

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Open Access | The Armadillo Repeat Protein PF16 Is Essential for Flagellar Structure and Function in Plasmodium Male Gametes

October 4, 2010 - 09:19 -- Kabogo Ndegwa
Author(s): 
Ursula Straschil, Arthur M. Talman, David J. P. Ferguson, Karen A. Bunting, Zhengyao Xu, Elizabeth Bailes, Robert E. Sinden, Anthony A. Holder, Elizabeth F. Smith, Juliet C. Coates, Rita Tewari
Reference: 
PLoS ONE 5(9): e12901

Malaria, caused by the apicomplexan parasite Plasmodium, threatens 40% of the world's population. Transmission between vertebrate and insect hosts depends on the sexual stages of the life-cycle.

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Detection of Plasmodium falciparum, P. vivax, P. ovale, and P. malariae Merozoite Surface Protein 1-p19 Antibodies in Human Malaria Patients and Experimentally Infected Nonhuman Primates

October 4, 2010 - 09:07 -- Kabogo Ndegwa
Author(s): 
A. Scott Muerhoff, Larry G. Birkenmeyer, Ruthie Coffey, Bruce J. Dille, John W. Barnwell, William E. Collins, Joann S. Sullivan, George J. Dawson, and Suresh M. Desai
Reference: 
Clin. Vaccine Immunol. 2010;17 1631-1638

Approximately 3.2 billion people live in areas where malaria is endemic, and WHO estimates that 350 to 500 million malaria cases occur each year worldwide. This high prevalence, and the high frequency of international travel, creates significant risk for the exportation of malaria to countries where malaria is not endemic and for the introduction of malaria organisms into the blood supply.

Plasma Concentration of Malaria Parasite-Derived Macrophage Migration Inhibitory Factor in Uncomplicated Malaria Patients Correlates with Parasitemia and Disease Severity

October 4, 2010 - 08:29 -- Kabogo Ndegwa
Author(s): 
Cong Han, Yahui Lin, Guangliang Shan, Zaixing Zhang, Xiaodong Sun, Zhensheng Wang, Chunyan Wei, Yan Deng, Lianhui Zhang, Lingyi Bu, Dingding Shao, and Heng Wang
Reference: 
Clin. Vaccine Immunol. 2010;17 1524-1532

Host macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of malaria infections. Several Plasmodium parasite-derived MIFs were identified to have the potential to regulate host immune response.

Safety and Immunogenicity of a Recombinant Nonglycosylated Erythrocyte Binding Antigen 175 Region II Malaria Vaccine in Healthy Adults Living in an Area Where Malaria Is Not Endemic

October 4, 2010 - 08:24 -- Kabogo Ndegwa
Author(s): 
H. M. El Sahly, S. M. Patel, R. L. Atmar, T. A. Lanford, T. Dube, D. Thompson, B. K. L. Sim, C. Long, and W. A. Keitel
Reference: 
Clin. Vaccine Immunol. 2010;17 1552-1559

Erythrocyte binding antigen region II (EBA-175) is a conserved antigen of Plasmodium falciparum that is involved in binding of the parasite to the host's erythrocytes.

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Open Access | Potential threat of malaria epidemics in a low transmission area, as exemplified by Sao Tome and Principe

October 1, 2010 - 13:46 -- Kabogo Ndegwa
Author(s): 
Lee P, Liu C, do Rosario VE, de Sousa B, Rampao H, Shaio M
Reference: 
Malaria Journal 2010, 9:264 (29 September 2010)

At the initial stage of the integrated malaria control programme, IRS contributed to the visible effect on the rapid reduction of malaria morbidity and mortality, while this programme highlights an urgent demand for the improvement of other measures, particularly promotion of LLINs usage, with close monitoring of asymptomatic carriers and with ACT treatment in malaria transmission hotspots.

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