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Scientific Articles

Multiple functions of human T cells generated by experimental malaria challenge

November 10, 2009 - 20:40 -- Ingeborg van Schayk
Author(s): 
Stephen M. Todryk, Michael Walther, Philip Bejon, Claire Hutchings, Fiona M. Thompson, Britta C. Urban, David W. Porter, Adrian V. S. Hill
Reference: 
European Journal of Immunology, Volume 39 Issue 11, Pages 3042 – 3051

In this study, cellular immune responses were investigated in individuals receiving Plasmodium falciparum sporozoite challenge by the natural (mosquito bite) route as part of a malaria vaccine efficacy trial. 

 

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Comparative Transcriptional and Genomic Analysis of Plasmodium falciparum Field Isolates

November 10, 2009 - 20:32 -- Ingeborg van Schayk
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Author(s): 
Mackinnon MJ, Li J, Mok S, Kortok MM, Marsh K, et al.
Reference: 
PLoS Pathog 5(10): e1000644

Mechanisms for differential regulation of gene expression may underlie much of the phenotypic variation and adaptability of malaria parasites. Here we describe transcriptional variation among culture-adapted field isolates of Plasmodium falciparum, the species responsible for most malarial disease.

 

Opinion: Malaria Vaccines: Where Next?

November 10, 2009 - 20:26 -- Ingeborg van Schayk
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Author(s): 
Holder AA
Reference: 
PLoS Pathog 5(10): e1000638

A malaria vaccine for mass immunization, which could be delivered cheaply and widely and provide long lasting protection, would have a massive effect on global public health. However, such a vaccine does not currently exist.

 

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A Distinct Peripheral Blood Monocyte Phenotype Is Associated with Parasite Inhibitory Activity in Acute Uncomplicated Plasmodium falciparum Malaria

November 10, 2009 - 20:12 -- Ingeborg van Schayk
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Author(s): 
Chimma P, Roussilhon C, Sratongno P, Ruangveerayuth R, Pattanapanyasat K, et al.
Reference: 
PLoS Pathog 5(10): e1000631

Monocyte (MO) subpopulations display distinct phenotypes and functions which can drastically change during inflammatory states. We hypothesized that discrete MO subpopulations are induced during malaria infection and associated with anti-parasitic activity.

 

The Quantity and Quality of African Children's IgG Responses to Merozoite Surface Antigens Reflect Protection against Plasmodium falciparum Malaria

November 10, 2009 - 14:02 -- Ingeborg van Schayk
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Author(s): 
Courtin D, Oesterholt M, Huismans H, Kusi K, Milet J, et al.
Reference: 
PLoS ONE 4(10): e7590

Our data are consistent with the idea that protection against P. falciparum malaria in children depends on acquisition of a constellation of appropriate, functionally active IgG subclass responses directed to multiple asexual stage antigens.

 

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The Synthetic Plasmodium falciparum Circumsporozoite Peptide PfCS102 as a Malaria Vaccine Candidate: A Randomized Controlled Phase I Trial

November 10, 2009 - 13:53 -- Ingeborg van Schayk
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Author(s): 
Audran R, Lurati-Ruiz F, Genton B, Blythman HE, Ofori-Anyinam O, et al.
Reference: 
PLoS ONE 4(10): e7304

PfCS102 peptide was safe and highly immunogenic, allowing the design of more advanced trials to test its potential for protection. Two or three immunizations with a dose of 30 µg formulated with AS02A appeared the most appropriate choice for such studies.

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Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children

November 10, 2009 - 13:46 -- Ingeborg van Schayk
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Author(s): 
Owusu-Agyei S, Ansong D, Asante K, Kwarteng Owusu S, Owusu R, et al.
Reference: 
PLoS ONE 4(10): e7302

Both candidate malaria vaccines were well tolerated. Anti-circumsporozoite responses were greater with RTS,S/AS01E than RTS,S/AS02D and when 3 rather than 2 doses were given. This study supports the selection of RTS,S/AS01E and a 3 dose schedule for further development in children and infants.

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Long-Lasting Insecticidal Hammocks for Controlling Forest Malaria: A Community-Based Trial in a Rural Area of Central Vietnam

November 10, 2009 - 13:39 -- Ingeborg van Schayk
Author(s): 
Thang ND, Erhart A, Speybroeck N, Xa NX, Thanh NN, et al.
Reference: 
PLoS ONE 4(10): e7369

Long Lasting Insecticidal Hammocks (LLIH), a tailored and user-friendly tool for forest workers, may further contribute in reducing the malaria burden. Their effectiveness was tested in a large community-based intervention trial carried out in Ninh Thuan province in Central Vietnam.

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Safety and Immunogenicity of the Malaria Vaccine Candidate MSP3 Long Synthetic Peptide in 12–24 Months-Old Burkinabe Children

November 10, 2009 - 13:33 -- Ingeborg van Schayk
Author(s): 
Sirima SB, Tiono AB, Ouédraogo A, Diarra A, Ouédraogo AL, et al.
Reference: 
PLoS ONE 4(10): e7549

Our results support the promise of MSP3-LSP as a malaria vaccine candidate, both in terms of tolerability and of immunogenicity. Further assessment of the efficacy of this vaccine is recommended.

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A Randomized Trial Assessing the Safety and Immunogenicity of AS01 and AS02 Adjuvanted RTS,S Malaria Vaccine Candidates in Children in Gabon

November 10, 2009 - 13:26 -- Ingeborg van Schayk
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Author(s): 
Lell B, Agnandji S, von Glasenapp I, Haertle S, Oyakhiromen S, et al.
Reference: 
PLoS ONE 4(10): e7611

RTS,S/AS01E proved similarly as well tolerated and immunogenic as RTS,S/AS02D, completing an essential step in the age de-escalation process within the RTS,S clinical development plan.

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