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Scientific Articles

Open Access | Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children

December 8, 2009 - 11:55 -- Ingeborg van Schayk
Author(s): 
Shereen Katrak, Anne Gasasira, Emmanuel Arinaitwe, Abel Kakuru, Humphrey Wanzira, Victor Bigira, Taylor G Sandison, Jaco Homsy, Jordan W Tappero, Moses R Kamya, Grant Dorsey
Reference: 
Malaria Journal 2009, 8:272 (30 November 2009)

Both AL and DP were safe and well tolerated for the treatment of uncomplicated malaria in young HIV-infected and uninfected children.

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Open access | Assessment of the prozone effect in malaria rapid diagnostic tests

December 8, 2009 - 11:49 -- Ingeborg van Schayk
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Author(s): 
Philippe Gillet, Marcella Mori, Marjan Van Esbroeck, Jef Van den Ende, Jan Jacobs
Reference: 
Malaria Journal 2009, 8:271 (30 November 2009)

This study confirms the prozone effect as a cause of false-negative HRP-2 RDTs in samples with hyperparasitaemia.

Open Access | Evolution of malaria mortality and morbidity after the emergence of chloroquine resistance in Niakhar, Senegal

December 8, 2009 - 11:39 -- Ingeborg van Schayk
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Author(s): 
Aline Munier, Aldiouma Diallo, Adama Marra, Michel Cot, Pascal Arduin, Ousmane Ndiaye, Balla Mbacké Mboup, Barnabé Gning, Jean-Philippe Chippaux
Reference: 
Malaria Journal 2009, 8:270 (27 November 2009)

The study aimed to assess the impact of chemoresistance on mortality attributable to malaria in a rural area of Senegal.

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Dihydroartemisinin-Piperaquine and Artemether-Lumefantrine for Treating Uncomplicated Malaria in African Children: A Randomised, Non-Inferiority Trial

December 7, 2009 - 13:33 -- Ingeborg van Schayk
Author(s): 
Bassat Q, Mulenga M, Tinto H, Piola P, Borrmann S, et al.
Reference: 
PLoS ONE 4(11): e7871

Dihydroartemisinin-piperaquine (DHA-PQP) is a promising fixed-dose ACT with limited information on its safety and efficacy in African children.

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Malaria vector composition and insecticide susceptibility status in Guinea Conakry, West Africa

December 7, 2009 - 12:16 -- Ingeborg van Schayk
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Author(s): 
S. B. VEZENEGHO, B. D. BROOKE, R. H. HUNT, M. COETZEE, L. L. KOEKEMOER
Reference: 
Medical and Veterinary Entomology Volume 23 Issue 4, Pages 326 - 334

This study provides data on malaria vector species composition and insecticide susceptibility status from three localities in Guinea Conakry.

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Behavioural and insecticidal effects of organophosphate-, carbamate- and pyrethroid-treated mosquito nets against African malaria vectors

December 7, 2009 - 12:11 -- Ingeborg van Schayk
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Author(s): 
R. C. MALIMA, R. M. OXBOROUGH, P. K. TUNGU, C. MAXWELL, I. LYIMO, V. MWINGIRA , F. W. MOSHA, J. MATOWO, S. M. MAGESA and M. W. ROWLAND
Reference: 
Medical and Veterinary Entomology Volume 23 Issue 4, Pages 317 - 325

Three insecticides – the pyrethroid deltamethrin, the carbamate carbosulfan and the organophosphate chlorpyrifos-methyl – were tested on mosquito nets in experimental huts to determine their potential for introduction as malaria control measures.

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In Vitro Activities of Piperaquine, Lumefantrine, and Dihydroartemisinin in Kenyan Plasmodium falciparum Isolates and Polymorphisms in pfcrt and pfmdr1

December 7, 2009 - 12:03 -- Ingeborg van Schayk
Author(s): 
Leah Mwai, Steven M. Kiara, Abdi Abdirahman, Lewa Pole, Anja Rippert, Abdi Diriye, Pete Bull, Kevin Marsh, Steffen Borrmann, and Alexis Nzila
Reference: 
Antimicrob. Agents Chemother. 2009;53 5069-5073

We have analyzed the in vitro chemosensitivity profiles of 115 Kenyan isolates for chloroquine (CQ), piperaquine, lumefantrine (LM), and dihydroartemisinin in association with polymorphisms in pfcrt at codon 76 and pfmdr1 at codon 86, as well as with variations of the copy number of pfmdr1.

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Characteristics of Genetic Hitchhiking around Dihydrofolate Reductase Gene Associated with Pyrimethamine Resistance in Plasmodium falciparum Isolates from India

December 7, 2009 - 11:58 -- Ingeborg van Schayk
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Author(s): 
Vanshika Lumb, Manoj K. Das, Neeru Singh, Vas Dev, Wajihullah, and Yagya D. Sharma
Reference: 
Antimicrob. Agents Chemother. 2009;53 5173-5180

To study the origin and evolution of pyrimethamine resistance on the Indian subcontinent, microsatellite markers flanking the pfdhfr gene were mapped.

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Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

December 7, 2009 - 11:51 -- Ingeborg van Schayk
Author(s): 
Pedro A. Moura, John B. Dame, and David A. Fidock
Reference: 
Antimicrob. Agents Chemother. 2009;53 4968-4978

Hemoglobin (Hb) degradation is essential for the growth of the intraerythrocytic stages of malarial parasites.

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Inhibition of Erythrocyte Invasion and Plasmodium falciparum Merozoite Surface Protein 1 Processing by Human Immunoglobulin G1 (IgG1) and IgG3 Antibodies

December 7, 2009 - 11:26 -- Ingeborg van Schayk
Author(s): 
Maria Lazarou, Jose A. Guevara Patino, Richard M. Jennings, Richard S. McIntosh, Jianguo Shi, Steven Howell, Eilish Cullen, Tarran Jones, Jaime R. Adame-Gallegos, Jonathan A. Chappel, Jana S. McBride, Michael J. Blackman, Anthony A. Holder, and Richard J. Pleass
Reference: 
Infect. Immun. 2009;77 5659-5667

Antigen-specific antibodies (Abs) to the 19-kDa carboxy-terminal region of Plasmodium falciparum merozoite surface protein 1 (MSP119) play an important role in protective immunity to malaria.

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