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Scientific Articles

Centers for Disease Control Light Traps for Monitoring Anopheles arabiensis Human Biting Rates in an Area with Low Vector Density and High Insecticide-Treated Bed Net Use

October 5, 2010 - 09:20 -- Patrick Sampao
Author(s): 
Christen M. Fornadel, Laura C. Norris, AND Douglas E. Norris
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 838 - 842.

Our results suggest that in regions where use of vector control interventions is high and vector densities are low, CDC light traps can be used to monitor An. arabiensis HBRs.

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Analysis of Anopheles arabiensis Blood Feeding Behavior in Southern Zambia during the Two Years after Introduction of Insecticide-Treated Bed Nets

October 5, 2010 - 09:07 -- Patrick Sampao
Author(s): 
Christen M. Fornadel, Laura C. Norris, Gregory E. Glass, AND Douglas E. Norris
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 848 - 853.

Because insecticide-treated bed nets (ITNs) have the potential to alter host feeding behavior, the extent of the zoophilic and exophagic tendencies of the vector was evaluated during the two rainy seasons after ITN introduction.

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Brief report: Large Variation in Detection of Histidine-Rich Protein 2 in Plasmodium falciparum Isolates from Colombia

October 5, 2010 - 09:01 -- Patrick Sampao
Author(s): 
Zuleima Pava, Diego F. Echeverry, Gustavo Díaz, AND Claribel Murillo
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 834 - 837.

To determine possible geographic differences and their effects on the performance of RDTs, 22 blood samples from patients with P. falciparum malaria from Tumaco and Buenaventura, Colombia were assessed by measurement of HRP2 concentration by an HRP2 enzyme-linked immunosorbent assay, RDTs, and thick blood smear.

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Predicting the Unmet Need for Biologically Targeted Coverage of Insecticide-Treated Nets in Kenya

October 5, 2010 - 08:52 -- Patrick Sampao
Author(s): 
Abdisalan M. Noor, Victor A. Alegana, Anand P. Patil, AND Robert W. Snow
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 854 - 860.

Spatially defined data on coverage of treated nets from recent national household surveys in Kenya were used within a Bayesian geostatistical framework to predict treated net coverage nationally.

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Open Access | Long- and Short-Term Selective Forces on Malaria Parasite Genomes

October 4, 2010 - 13:02 -- Kabogo Ndegwa
Author(s): 
Sanne Nygaard, Alexander Braunstein, Daniel C. Jeffares, et al.
Reference: 
PLoS Genet 6(9): e1001099

Plasmodium parasites, the causal agents of malaria, result in more than 1 million deaths annually. Plasmodium are unicellular eukaryotes with small ~23 Mb genomes encoding ~5200 protein-coding genes.

Brief Report: Increased Risk of Early Vomiting among Infants and Young Children Treated with Dihydroartemisinin-Piperaquine Compared with Artemether-Lumefantrine for Uncomplicated Malaria

October 4, 2010 - 12:25 -- Patrick Sampao
Author(s): 
Darren Creek, Victor Bigira, Emmanuel Arinaitwe, Humphrey Wanzira, Abel Kakuru, Jordan Tappero, Moses R. Kamya, Grant Dorsey, AND Taylor G. Sandison
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 873 - 875.

We used data from a randomized control trial in rural Uganda to compare the risk of early vomiting (within one hour of dosing) for children 6–24 months of age randomized to receive DP (n = 240) or AL (n = 228) for treatment of uncomplicated malaria.

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Comparing the Understanding of Subjects Receiving a Candidate Malaria Vaccine in the United States and Mali

October 4, 2010 - 12:15 -- Patrick Sampao
Author(s): 
Ruth D., Issaka S., et al.
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 868 - 872.

Initial responses to questionnaires used to assess participants' understanding of informed consent for malaria vaccine trials conducted in the United States and Mali were tallied.

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Open Access | Plasmodium falciparum Erythrocyte Membrane Protein 1 Diversity in Seven Genomes – Divide and Conquer

October 4, 2010 - 12:06 -- Kabogo Ndegwa
Author(s): 
Thomas S. Rask, Daniel A. Hansen, Thor G. Theander, Anders Gorm Pedersen, Thomas Lavstsen
Reference: 
PLoS Comput Biol 6(9): e1000933

The var gene encoded hyper-variable Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediates cytoadhesion of infected erythrocytes to human endothelium. Antibodies blocking cytoadhesion are important mediators of malaria immunity acquired by endemic populations.

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Open Access | Forcing Versus Feedback: Epidemic Malaria and Monsoon Rains in Northwest India

October 4, 2010 - 11:57 -- Kabogo Ndegwa
Author(s): 
Karina Laneri, Anindya Bhadra, Edward L. Ionides, Menno Bouma, Ramesh C. Dhiman, Rajpal S. Yadav, Mercedes Pascual
Reference: 
PLoS Comput Biol 6(9): e1000898

Malaria epidemics in regions with seasonal windows of transmission can vary greatly in size from year to year. A central question has been whether these interannual cycles are driven by climate, are instead generated by the intrinsic dynamics of the disease, or result from the resonance of these two mechanisms.

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Minimal Association of Common Red Blood Cell Polymorphisms with Plasmodium falciparum Infection and Uncomplicated Malaria in Papua New Guinean School Children

October 4, 2010 - 11:57 -- Patrick Sampao
Author(s): 
Enmoore L., Livingstone T., et al.
Reference: 
Am J Trop Med Hyg, Oct 2010; 83: 828 - 833.

In a cohort of children 5–14 years of age the effect of +-thalassemia, SAO (SLC4A127), CR1 polymorphisms, and Gerbich negativity (GYPCex3) on risk of P. falciparum infections and uncomplicated illness were evaluated.

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