In the course of a medium throughput screen of 640 plant extracts for antimalarial activity an ethyl acetate extract of Pistacia atlantica DC. (Anacardiaceae) was found to be active.
Looking to the future, and hoping that current downward trends in malaria are sustained, we need to evaluate the newly introduced antimalarials (piperaquine and pyronaridine look promising12) as well as mefloquine to assess whether and when is the best time to give IPT.
Intermittent preventive treatment (IPT) is a promising strategy for previous termmalarianext term control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.
Here, we describe a series of readily obtainable benzophenone derivatives with antimalarial and antitrypanosomal activity.
No abstract available.
Recent advances in genome-based technologies and in in vitro screening of whole parasites have broadened the range of therapeutic targets and are accelerating the development of a new generation of treatments for both malaria control and eradication.
We conducted a 5-year prospective surveillance study for malaria parasitemia, clinical malaria and severe malarial anemia (SMA) in Dar-es-Salaam, Tanzania between 2004 and 2009.
We propose that this new mechanism contributes to sequestration both independently of and in concert with current adhesion mechanisms.
Because the brain endothelium is at the interface of these processes, we investigated the global gene responses of human brain endothelium after the interaction with Plasmodium falciparum–infected erythrocytes with either high- or low-binding phenotypes.
Increasing use of AQ in Africa poses the threat of a selective sweep of highly AQ-resistant, CQ-resistant parasites with pfcrt and pfmdr1 mutations that are as advantaged and persistent as in South America.