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Scientific Articles

HPLC-profiling for antiplasmodial compounds—3-Methoxycarpachromene from Pistacia atlantica

November 13, 2009 - 10:49 -- Ingeborg van Schayk
Author(s): 
Michael Adams, Inken Plitzko, Marcel Kaiser, Reto Brun and Matthias Hamburger
Reference: 
Phytochemistry Letters Volume 2, Issue 4, 19 November 2009, Pages 159-162

In the course of a medium throughput screen of 640 plant extracts for antimalarial activity an ethyl acetate extract of Pistacia atlantica DC. (Anacardiaceae) was found to be active.

Comment: Intermittent preventive treatment of malaria in infancy

November 13, 2009 - 10:40 -- Ingeborg van Schayk
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Author(s): 
Rose McGready
Reference: 
The Lancet, Volume 374, Issue 9700, 31 October 2009-6 November 2009, Pages 1478-1480

Looking to the future, and hoping that current downward trends in malaria are sustained, we need to evaluate the newly introduced antimalarials (piperaquine and pyronaridine look promising12) as well as mefloquine to assess whether and when is the best time to give IPT.

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Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials

November 13, 2009 - 10:24 -- Ingeborg van Schayk
Author(s): 
John J Aponte et al.
Reference: 
The Lancet, Volume 374, Issue 9700, 31 October 2009-6 November 2009, Pages 1533-1542

Intermittent preventive treatment (IPT) is a promising strategy for previous termmalarianext term control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa.

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Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone

November 13, 2009 - 10:11 -- Ingeborg van Schayk
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Author(s): 
Mirko Altenkämper et al.
Reference: 
Bioorganic & Medicinal Chemistry Volume 17, Issue 22, 15 November 2009, Pages 7690-7697

Here, we describe a series of readily obtainable benzophenone derivatives with antimalarial and antitrypanosomal activity.

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Review: New medicines to improve control and contribute to the eradication of malaria

November 13, 2009 - 09:38 -- Ingeborg van Schayk
Author(s): 
Timothy N. C. Wells, Pedro L. Alonso & Winston E. Gutteridge
Reference: 
Nature Reviews Drug Discovery 8, 879-891 (November 2009)

Recent advances in genome-based technologies and in in vitro screening of whole parasites have broadened the range of therapeutic targets and are accelerating the development of a new generation of treatments for both malaria control and eradication.

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Malaria in patients with sickle cell anemia: burden, risk factors and outcome at outpatient clinic and during hospitalization

November 13, 2009 - 09:30 -- Ingeborg van Schayk
Author(s): 
J K Makani, A N Komba, S E Cox, J Oruo, K Mwamtemi, J Kitundu, P Magesa, S Rwezaula, E Meda, J Mgaya, K Pallangyo, E Okiro, D Muturi, C R Newton, G Fegan, K Marsh and T N Williams
Reference: 
Blood, November 9, 2009; DOI 10.1182/blood-2009-07-233528

We conducted a 5-year prospective surveillance study for malaria parasitemia, clinical malaria and severe malarial anemia (SMA) in Dar-es-Salaam, Tanzania between 2004 and 2009.

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Rapid activation of endothelial cells enables P. falciparum adhesion to platelet decorated von Willebrand factor strings

November 13, 2009 - 09:09 -- Ingeborg van Schayk
Author(s): 
Daniel J. Bridges, James Bunn, Jan A. van Mourik, Georges Grau, Roger J.S. Preston, Malcolm Molyneux, Valery Combes, James S. O'Donnell, Bas de Laat and Alister Craig
Reference: 
Blood, November 6, 2009; DOI 10.1182/blood-2009-07-235150

We propose that this new mechanism contributes to sequestration both independently of and in concert with current adhesion mechanisms.

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Plasmodium falciparum–infected erythrocytes induce NF-{kappa}B regulated inflammatory pathways in human cerebral endothelium

November 13, 2009 - 08:51 -- Ingeborg van Schayk
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Author(s): 
Abhai K. Tripathi, Wei Sha, Vladimir Shulaev, Monique F. Stins, and David J. Sullivan, Jr
Reference: 
Blood, 5 November 2009, Vol. 114, No. 19, pp. 4243-4252, DOI 10.1182/blood-2009-06-226415

Because the brain endothelium is at the interface of these processes, we investigated the global gene responses of human brain endothelium after the interaction with Plasmodium falciparum–infected erythrocytes with either high- or low-binding phenotypes.

Inaugural Article: Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine

November 11, 2009 - 10:16 -- Ingeborg van Schayk
Author(s): 
Juliana Martha Sá, Olivia Twu, Karen Hayton, Sahily Reyes, Michael P. Fay, Pascal Ringwald, and Thomas E. Wellems
Reference: 
PNAS November 10, 2009 vol. 106 no. 45 18883-18889

Increasing use of AQ in Africa poses the threat of a selective sweep of highly AQ-resistant, CQ-resistant parasites with pfcrt and pfmdr1 mutations that are as advantaged and persistent as in South America.

 

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