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Scientific Articles

Nitric oxide is an essential component of the hemocyte-mediated mosquito immune response against bacteria

December 3, 2009 - 09:22 -- Patrick Sampao
Author(s): 
Julián F. Hillyer, Tania Y. Estévez-Lao
Reference: 
Developmental & Comparative Immunology, Volume 34, Issue 2, February 2010, Pages 141-149, doi:10.1016/j.dci.2009.08.014

Here, we characterized the temporal and spatial expression of the Anopheles gambiae nitric oxide synthase gene and explored the role nitric oxide plays in the antibacterial response in the mosquito hemocoel.

Lessons learned: Difficulties in organizing first indoor spray programme against malaria in Angola under the President’s Malaria Initiative

December 2, 2009 - 09:39 -- Ingeborg van Schayk
Author(s): 
Martinho Somandjinga a, Manuel Lluberas b & William R Jobin c
Reference: 
Bulletin of the World Health Organization 2009;87:871-874. doi: 10.2471/BLT.08.052514

The first PMI programme to control malaria in Africa failed to have an impact in southern Angola because of hurried and inadequate preparation, based primarily on administrative reports of malaria prevalence.

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Parasite threshold associated with clinical malaria in areas of different transmission intensities in north eastern Tanzania

November 30, 2009 - 15:03 -- Ingeborg van Schayk
Author(s): 
Bruno P Mmbando, John P Lusingu, Lasse S Vestergaard, Martha M Lemnge, Thor G Theander and Thomas H Scheike
Reference: 
BMC Medical Research Methodology 2009, 9:75 doi:10.1186/1471-2288-9-75

This paper describes step function and dose response model with threshold parameter as a tool for estimation of parasite threshold for onset of malaria fever in highlands (low transmission) and lowlands (high transmission intensity) strata.

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Analysis of the phylogenetic relationship of Anopheles species, subgenus Cellia (Diptera: Culicidae) and using it to define the relationship of morphologically similar species

November 29, 2009 - 07:00 -- Patrick Sampao
Author(s): 
Amitav Mohanty, Sunita Swain, Santanu K. Kar, Rupenangshu K. Hazra.
Reference: 
Infection, Genetics and Evolution, Volume 9, Issue 6, December 2009, Pages 1204-1224, doi:10.1016/j.meegid.2009.06.021

Studies on the relationship of various vectors and non-vectors of malaria from the evolutionary point of view are important. Use of molecular methods to define phylogeny helps to understand the interrelationship among the members of the anophelines and elucidate the ambiguity that has arisen from improper classification. It could also help to design molecular markers for species differentiation, particularly in those which pose difficulty when classified, based on morphological features.

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Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial

November 27, 2009 - 14:30 -- Ingeborg van Schayk
Author(s): 
Roly Gosling , Samwel Gesase, Jacklin Mosha, Ilona Carneiro, Ramadhan Hashim, Martha Lemnge, Frank Mosha , Brian Greenwood, Daniel Chandramohan
Reference: 
The Lancet, Volume 374, Issue 9700, Pages 1521 - 1532, 31 October 2009, doi:10.1016/S0140-6736(09)60997-1

Administration of sulfadoxine-pyrimethamine at times of vaccination—intermittent preventive treatment in infants (IPTi)—is a promising strategy to prevent malaria. However, rising resistance to this combination is a concern. We investigated a shortacting and longacting antimalarial drug as alternative regimens for IPTi.

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A Role for Immune Responses against Non-CS Components in the Cross-Species Protection Induced by Immunization with Irradiated Malaria Sporozoites

November 26, 2009 - 14:54 -- Ingeborg van Schayk
Author(s): 
Marjorie Mauduit, Anne Charlotte Grüner, Rita Tewari, Nadya Depinay, Michèle Kayibanda, Jean-Marc Chavatte, Jean-François Franetich, Andrea Crisanti, Dominique Mazier, Georges Snounou, Laurent Rénia
Reference: 
PLoS ONE 4(11): e7717. doi:10.1371/journal.pone.0007717

In order to investigate the involvement of CS in the cross-species protection recently observed between the two rodent parasites P. berghei and P. yoelii, we adopted our gene replacement approach for the P. yoelii CS and exploited the ability to conduct reciprocal challenges.

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Environmental factors associated with the malaria vectors Anopheles gambiae and Anopheles funestus in Kenya

November 26, 2009 - 13:12 -- Ingeborg van Schayk
Author(s): 
Louise A Kelly-Hope, Janet Hemingway, F Ellis McKenzie
Reference: 
Malaria Journal 2009, 8:268 (26 November 2009)

In a retrospective study, the authors show that the abundance, distribution and malaria transmission of different malaria vectors are driven by different environmental factors.

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Inter-rater reliability of malaria parasite counts and comparison of methods

November 26, 2009 - 13:00 -- Ingeborg van Schayk
Author(s): 
Katherine M Bowers, David Bell, Peter L Chiodini, John Barnwell, Sandra Incardona, Seiha Yen, Jennifer Luchavez, Hilary Watt
Reference: 
Malaria Journal 2009, 8:267 (25 November 2009)

The paper compares the accuracy and reproducibility of different methods commonly used to measure parasite densities from malaria blood smears and thin films. The study was designed to provide regulatory authorities in endemic countries with standardized and simple protocols to test RDT performances with calibrated parasitized blood samples to implement locally appropriate quality control procedures.

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Access to malaria treatment in young children of rural Burkina Faso

November 26, 2009 - 12:55 -- Ingeborg van Schayk
Author(s): 
Maike Tipke, Valerie R Louis, Maurice Ye, Manuela De Allegri, Claudia Beiersmann, Ali Sie, Olaf Mueller, Albrecht Jahn
Reference: 
Malaria Journal 2009, 8:266 (24 November 2009)

This deals with a subject of great relevance for malaria control in Africa, the need to increase access to anti-malarial treatment through community health works and home-treatment.

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Cost-effectiveness analysis of rapid diagnostic test, microscopy and syndromic approach in the diagnosis of malaria in Nigeria: implications for scaling-up deployment of ACT

November 26, 2009 - 12:49 -- Ingeborg van Schayk
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Author(s): 
Benjamin SC Uzochukwu, Eric N Obikeze, Obinna E Onwujekwe, Chima A Onoka, Ulla K Griffiths
Reference: 
Malaria Journal 2009, 8:265 (23 November 2009)

Paper comparing different diagnostic methods used in Nigeria, from a cost-effectiveness view point .

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