Here, we characterized the temporal and spatial expression of the Anopheles gambiae nitric oxide synthase gene and explored the role nitric oxide plays in the antibacterial response in the mosquito hemocoel.
The first PMI programme to control malaria in Africa failed to have an impact in southern Angola because of hurried and inadequate preparation, based primarily on administrative reports of malaria prevalence.
This paper describes step function and dose response model with threshold parameter as a tool for estimation of parasite threshold for onset of malaria fever in highlands (low transmission) and lowlands (high transmission intensity) strata.
Studies on the relationship of various vectors and non-vectors of malaria from the evolutionary point of view are important. Use of molecular methods to define phylogeny helps to understand the interrelationship among the members of the anophelines and elucidate the ambiguity that has arisen from improper classification. It could also help to design molecular markers for species differentiation, particularly in those which pose difficulty when classified, based on morphological features.
Administration of sulfadoxine-pyrimethamine at times of vaccination—intermittent preventive treatment in infants (IPTi)—is a promising strategy to prevent malaria. However, rising resistance to this combination is a concern. We investigated a shortacting and longacting antimalarial drug as alternative regimens for IPTi.
In order to investigate the involvement of CS in the cross-species protection recently observed between the two rodent parasites P. berghei and P. yoelii, we adopted our gene replacement approach for the P. yoelii CS and exploited the ability to conduct reciprocal challenges.
In a retrospective study, the authors show that the abundance, distribution and malaria transmission of different malaria vectors are driven by different environmental factors.
The paper compares the accuracy and reproducibility of different methods commonly used to measure parasite densities from malaria blood smears and thin films. The study was designed to provide regulatory authorities in endemic countries with standardized and simple protocols to test RDT performances with calibrated parasitized blood samples to implement locally appropriate quality control procedures.
This deals with a subject of great relevance for malaria control in Africa, the need to increase access to anti-malarial treatment through community health works and home-treatment.