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Scientific Articles

Argemone Mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: policy and public-health implications.

December 3, 2009 - 12:07 -- Patrick Sampao
Author(s): 
Bertrand Graz, Merlin L. Willcox, Chiaka Diakite, Jacques Falquet, Florent Dackuo, Oumar Sidibe, Sergio Giani, Drissa Diallo
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 1, January 2010, Pages 33-41, doi:10.1016/j.trstmh.2009.07.005

A classic way of delaying drug resistance is to use an alternative when possible. We tested the malaria treatment Argemone mexicana decoction (AM), a validated self-prepared traditional medicine made with one widely available plant and safe across wide dose variations. In an attempt to reflect the real situation in the home-based management of malaria in a remote Malian village, 301 patients with presumed uncomplicated malaria (median age 5 years) were randomly assigned to receive AM or artesunate-amodiaquine [artemisinin combination therapy (ACT)] as first-line treatment.

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Priorities in research and development of vaccines against Plasmodium vivax malaria

December 3, 2009 - 12:05 -- Kabogo Ndegwa
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Author(s): 
Graham V. Brown, Vasee S. Moorthy, Zarifah Reed, Kamini Mendis, Myriam Arévalo-Herrera, Pedro Alonso.
Reference: 
Vaccine, Volume 27, Issue 52, 9 December 2009, Pages 7228-7235, doi:10.1016/j.vaccine.2009.08.112

The WHO Initiative for Vaccine Research (IVR) Malaria Vaccine Advisory Committee (MALVAC) provides advice to WHO on priorities in malaria vaccine research and development (R&D). 

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Open Access | Interaction of Artemisinins with Oxyhemoglobin Hb-FeII, Hb-FeII, CarboxyHb-FeII, Heme-FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

December 3, 2009 - 12:01 -- Patrick Sampao
Author(s): 
Paolo Coghi, Nicoletta Basilico, Donatella Taramelli, Wing-Chi Chan, Richard K. Haynes, Diego Monti
Reference: 
ChemMedChem Volume 4, Issue 12, Date: December 7, 2009, Pages: 2045-2053

The findings not only indicate that artemisinins do not require Hb-FeII or heme-FeII for promotion of antimalarial activity, but are also important in relation to the therapy of severe/complicated or cerebral malaria.

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Shape- and Chemical Feature-Based 3D-Pharmacophore Model Generation and Virtual Screening: Identification of Potential Leads for P. falciparum DHFR Enzyme Inhibition

December 3, 2009 - 11:57 -- Patrick Sampao
Author(s): 
Legesse Adane, Dhilon. S. Patel, Prasad V. Bharatam.
Reference: 
Chemical Biology & Drug Design ,Volume 75, Issue 1, Date: January 2010, Pages: 115-126

Plasmodium falciparum dihydrofolate reductase (Pf DHFR) enzyme is one of the validated targets in the treatment of malaria using typical antifolates such as cycloguanil and pyrimethamine. 

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Case Report: A case series of splenic infarction during acute malaria in northwest Rajasthan, India

December 3, 2009 - 11:51 -- Patrick Sampao
Author(s): 
B.K. Gupta, Kapil Sharma, K.C. Nayak, T.D. Agrawal, Anand Binani, V.P. Purohit, D.K. Kochar
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 1, January 2010, Pages 81-83, doi:10.1016/j.trstmh.2009.05.015

Here we report a series of four acute malaria patients with splenic infarction, two with P. vivax infection, one with P. falciparum and one with a mixed infection (P. vivax and P. falciparum). 

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Open Access | Case report: Plasmodium malariae in Bangladesh

December 3, 2009 - 11:47 -- Patrick Sampao
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Author(s): 
W. Rahman, K. Chotivanich, K. Silamut, N. Tanomsing, A. Hossain, M.A. Faiz, A.M. Dondorp, R.J. Maude
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 1, January 2010, Pages 78-80, doi:10.1016/j.trstmh.2009.06.014

We describe a 32-year-old Bangladeshi male presenting with severe malaria caused by a mono-infection with Plasmodium malariae. 

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An imported case of P. falciparum malaria presenting as black water fever with acute renal failure

December 3, 2009 - 09:51 -- Patrick Sampao
Author(s): 
Fahmi Yousef Khan, Dalia Al-Haddada
Reference: 
Travel Medicine and Infectious Disease, Volume 7, Issue 6, November 2009, Pages 378-380, doi:10.1016/j.tmaid.2009.11.002

This is a report of a case of blackwater fever in a 28-year-old Nigerian man who was admitted to hospital with fever, jaundice and passing dark urine. Abdominal examination revealed splenomegaly and an examination of the peripheral smear of the patient showed the ring form of the trophozoites of Plasmodium falciparum (P. falciparum). Serum creatinine was 200 μmol/L. Treatment with quinine and doxycycline was started and intravenous fluids were administered with close monitoring of the urine output and serum electrolytes.

Evaluation of simian adenoviral vector AdCh63 expressing MSP-1 as a candidate blood-stage malaria vaccine

December 3, 2009 - 09:34 -- Patrick Sampao
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Author(s): 
Anna Goodman, Sarah Gilbert, Stefano Colloca, Matthew Dicks, Adrian Hill, Simon Draper
Reference: 
Journal of Infection, Volume 59, Issue 6, December 2009, Pages S427-S428, doi:10.1016/j.jinf.2009.10.008

No abstract available.

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Spurious Amplification of a Plasmodium vivax Small-Subunit RNA Gene by Use of Primers Currently Used To Detect P. knowlesi

December 3, 2009 - 09:28 -- Patrick Sampao
Author(s): 
Mallika Imwong, Naowarat Tanomsing, Sasithon Pukrittayakamee, Nicholas P. J. Day, Nicholas J. White, and Georges Snounou
Reference: 
Journal of Clinical Microbiology, December 2009, p. 4173-4175, Vol. 47, No. 12, doi:10.1128/JCM.00811-09

A nested primer set that targets one of the P. knowlesi small-subunit rRNA genes was validated for specificity and for sensitivity of detection of <10 parasite genomes.

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