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Scientific Articles

Minireview: Plasmodial heat shock proteins: targets for chemotherapy

January 10, 2010 - 16:46 -- Ingeborg van Schayk
Author(s): 
Addmore Shonhai
Reference: 
FEMS Immunology & Medical Microbiology, Early View (Articles online in advance of print)

Heat shock protein 90 (Hsp90), Hsp70/Hsp40 partnerships and small heat shock proteins are major malaria drug targets. This review examines the structural and functional features of these proteins that render them ideal drug targets and the challenges of targeting these proteins towards malaria drug design.

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Open Access | Are there geographic and socio-economic differences in incidence, burden and prevention of malaria? A study in southeast Nigeria

January 10, 2010 - 16:42 -- Ingeborg van Schayk
Author(s): 
Obinna Onwujekwe , Benjamin Uzochukwu , Nkem Dike , Chijioke Okoli , Soludo Eze and Ogoamaka Chukwuogo
Reference: 
International Journal for Equity in Health 2009, 8:45

This study explored the socioeconomic and geographic differences in incidence and burden of malaria as well as ownership of mosquito nets.

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Open Access | A Multifactorial Mechanism in the Superior Antimalarial Activity of α-C-GalCer

January 10, 2010 - 16:39 -- Ingeborg van Schayk
Author(s): 
John Schmieg, Guangli Yang, Richard W. Franck, and Moriya Tsuji
Reference: 
Journal of Biomedicine and Biotechnology, Volume 2010 (2010), Article ID 283612

In this study, we demonstrate that NK cells, as well as IL-12, are a key contributor for the superior activity displayed by α-C-GalCer.

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Open Access | Review: The Coming-Out of Malaria Gametocytes

January 10, 2010 - 16:34 -- Ingeborg van Schayk
Author(s): 
Andrea Kuehn and Gabriele Pradel
Reference: 
Journal of Biomedicine and Biotechnology, Volume 2010 (2010), Article ID 976827

This review summarizes recent findings on the role of gametocytes during transmission to the mosquito and particularly focuses on the molecular mechanisms underlying gametocyte activation and emergence from the host erythrocyte during gametogenesis.

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Chronic malaria infections increase family inequalities and reduce parental fitness: experimental evidence from a wild bird population

January 10, 2010 - 16:31 -- Ingeborg van Schayk
Author(s): 
S. C. L. Knowles, V. Palinauskas & B. C. Sheldon
Reference: 
Journal of Evolutionary Biology, Early View (Articles online in advance of print)

Overall, these results demonstrate that chronic avian malaria infections, far from being benign, can have significant effects on host fitness and may thus constitute an important selection pressure in wild bird populations.

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Changes in cell migration-related molecules expressed by thymic microenvironment during experimental Plasmodium berghei infection: consequences on thymocyte development

January 10, 2010 - 16:25 -- Ingeborg van Schayk
Author(s): 
Jacy Gameiro, Patrícia R. A. Nagib, Carolina F. Andrade, Déa M. S. Villa-Verde, Suse D. Silva-Barbosa, Wilson Savino, Fábio T. M. Costa, Liana Verinaud
Reference: 
Immunology, Volume 129 Issue 2, Pages 248 - 256

Overall, we show that the thymic atrophy observed in P. berghei-infected mice is accompanied by thymic microenvironmental changes that comprise altered expression of thymocyte migration-related molecules of the ECM and chemokine protein families, which in turn can alter the thymocyte migration pattern.

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Field, genetic and modelling approaches show strong positive selection acting upon an insecticide resistance mutation in Anopheles gambiae s.s.

January 10, 2010 - 15:28 -- Ingeborg van Schayk
Author(s): 
Amy Lynd, David Weetman, Susana Barbosa, Alexander Egyir-Yawson, Sara Mitchell, Joao Pinto, Ian Hastings, and Martin J Donnelly
Reference: 
Mol. Biol. Evol. published 7 January 2010

Our data show that strong, recent positive selective events, such as those caused by insecticide resistance, can be identified in wild insect populations.

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Nucleosome landscape and control of transcription in the human malaria parasite

January 10, 2010 - 15:26 -- Ingeborg van Schayk
Author(s): 
Nadia Ponts, Elena Y. Harris, Jacques Prudhomme, Ivan Wick, Colleen Eckhardt-Ludka, Glenn R. Hicks, Gary Hardiman, Stefano Lonardi, and Karine G. Le Roch
Reference: 
Genome Res. published 6 January 2010

Our results demonstrate that the processes driving gene expression in Plasmodium challenge the classical eukaryotic model of transcriptional regulation occurring mostly at the transcription initiation level.

Open Access | The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

January 10, 2010 - 15:20 -- Ingeborg van Schayk
Author(s): 
Helen M. Taylor, Louisa McRobert, Munira Grainger, Audrey Sicard, Anton R. Dluzewski, Christine S. Hopp, Anthony A. Holder, and David A. Baker
Reference: 
Eukaryotic Cell 2010;9 37-45

In the present study we examined the role of PfPKG in the asexual blood-stage of the parasite life cycle, the stage that causes malaria pathology.

Open Access | Difficulties in organizing first indoor spray programme against malaria in Angola under the President's Malaria Initiative

January 10, 2010 - 15:18 -- Ingeborg van Schayk
Author(s): 
Martinho Somandjinga; Manuel Lluberas; William R Jobin
Reference: 
Bull World Health Organ vol.87 no.11 Genebra Nov. 2009

Unfortunately malaria transmission in Africa is often assessed using routine administrative reports from local health units, which are plagued by sporadic reporting failures. It is unfortunate that WHO is also trying to plan and evaluate its malaria control efforts based on these same kinds of inadequate administrative reports.

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