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Scientific Articles

Phenotypic and transcriptomic analyses of Plasmodium falciparum protein kinase A catalytic subunit inhibition

October 29, 2009 - 13:51 -- Ingeborg van Schayk
Author(s): 
Nathalie Wurtz, Jérôme Desplans & Daniel Parzy
Reference: 
Parasitology Research, Volume 105, Number 6 / November, 2009 : 1691-1699, DOI 10.1007/s00436-009-1615-6

In this study, gene silencing with double-stranded RNA (dsRNA) and microarray techniques were used to study the biological function of the cAMP-dependent protein kinase catalytic subunit (PfPKAc) in the parasite erythrocytic life cycle.

Oviposition-deterrent, ovicidal, and repellent activities of indigenous plant extracts against Anopheles subpictus Grassi (Diptera: Culicidae)

October 29, 2009 - 13:38 -- Ingeborg van Schayk
Author(s): 
G. Elango, A. Bagavan, C. Kamaraj, A. Abduz Zahir & A. Abdul Rahuman
Reference: 
Parasitology Research,Volume 105, Number 6 / November, 2009 : 1567-1576, DOI 10.1007/s00436-009-1593-8

Insecticides of botanical origin may serve as suitable alternative biocontrol techniques in the future. The leaf acetone, ethyl acetate, and methanol extracts of Aegle marmelos (Linn.) Correa ex Roxb, Andrographis lineata Wallich ex Nees, and Cocculus hirsutus (L.) Diels were tested for oviposition-deterrent, ovicidal, and repellent activities against Anopheles subpictus Grassi (Diptera: Culicidae).

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Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites

October 29, 2009 - 13:28 -- Ingeborg van Schayk
Author(s): 
Brolin KJ, Ribacke U, Nilsson S, Ankarklev J, Moll K, Wahlgren M, Chen Q
Reference: 
Genome Biology 2009, 10:R117 (22 October 2009)

Allelic discrimination assays have traditionally been applied to study zygosity in diploid genomes. The assays presented here are instead successfully applied to the identification and evaluation of transcriptional activity of duplicated genes in the haploid genome of the P. falciparum parasite.

The malaria candidate vaccine liver stage antigen-3 is highly conserved in Plasmodium falciparum isolates from diverse geographical areas

October 29, 2009 - 12:53 -- Ingeborg van Schayk
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Author(s): 
Eric Prieur, Pierre Druilhe
Reference: 
Malaria Journal 2009, 8:247 (29 October 2009)

The paper compares the sequences of LSA-3 from four geographical areas and found LSA-3 to be a highly conserved antigen. This finding further supports the usefulness of LSA-3 as a pre-erythrocytic stage vaccine candidate.

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Malaria treatment perceptions, practices and influences on provider behaviour: comparing hospitals and non-hospitals in south-east Nigeria

October 29, 2009 - 12:50 -- Ingeborg van Schayk
Author(s): 
Obinna Onwujekwe, Benjamin Uzochukwu, Nkem Dike, Nkoli Uguru, Emmanuel Nwobi, Elvis Shu
Reference: 
Malaria Journal 2009, 8:246 (28 October 2009)

The behaviour of providers is often influenced by their knowledge, financial incentives, competition, or to follow patient demands and expectations. This study used a pre-tested structured questionnaire to collect data from 225 providers from hospitals and non-hospitals about their malaria treatment practices.

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Assessing the burden of pregnancy-associated malaria under changing transmission settings

October 29, 2009 - 12:47 -- Ingeborg van Schayk
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Author(s): 
Mario Recker, Menno J Bouma, Paul Bamford, Sunetra Gupta, Andy P Dobson
Reference: 
Malaria Journal 2009, 8:245 (28 October 2009)

The clinical presentation of pregnancy-associated malaria depends crucially on the particular epidemiological settings. By re-examining historical data, and the use of a simple mathematical model, it is demonstrated how excess female mortality can be used to evaluate the burden of pregnancy-associated malaria.

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Comparison of different methods for delayed post-mortem diagnosis of falciparum malaria

October 29, 2009 - 12:43 -- Ingeborg van Schayk
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Author(s): 
Nicole Berens-Riha, Inga Sinicina, Erna Fleischmann, Thomas Loscher
Reference: 
Malaria Journal 2009, 8:244 (28 October 2009)

An interesting paper which addresses the issue of delayed post-mortem diagnosis of P. falciparum with ICT tests.

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Review: Reviewing the literature on access to prompt and effective malaria treatment in Kenya: implications for meeting the Abuja targets

October 29, 2009 - 12:40 -- Ingeborg van Schayk
Author(s): 
Jane Chuma, Timothy Abuya, Dorothy Memusi, Elizabeth Juma, Willis Akhwale, Janet Ntwiga, Andrew Nyandigisi, Gladys Tetteh, Rima Shretta, Abdinasir Amin
Reference: 
Malaria Journal 2009, 8:243 (28 October 2009)

This review on access to malaria treatment in Kenya is particularly interesting in the light of the wealth of studies that have been carried out on related topics in Kenya.

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What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity

October 29, 2009 - 12:37 -- Ingeborg van Schayk
Author(s): 
Samson M Kinyanjui, Philip Bejon, Faith H Osier, Peter C Bull, Kevin Marsh
Reference: 
Malaria Journal 2009, 8:242 (28 October 2009)

Failure to distinguish between individuals who do not get a clinical episode during follow-up because they were unexposed and those who are genuinely immune undermines our ability to assign a protective role to immune responses against malaria. The brevity of antibodies responses makes it difficult to assign the true serological status of an individual at any given time, i.e. those positive at a survey may be negative by the time they encounter the next infection.

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Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

October 29, 2009 - 12:34 -- Ingeborg van Schayk
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Author(s): 
Elizabeth A Ashley, Malek Touabi, Margareta Ahrer, Robert Hutagalung, Khayae Htun, Jennifer Luchavez, Christine Dureza, Stephane Proux, Mara Leimanis, Myo Min Lwin, Alena Koscalova, Eric Comte, Prudence Hamade, Anne-Laure Page, Francois Nosten, Philippe J Guerin
Reference: 
Malaria Journal 2009, 8:241 (27 October 2009)

In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH). In Dawei, southern Myanmar, three pLDH based RDTs (CareStartTM Malaria pLDH (Pan), CareStartTM Malaria pLDH (Pan, Pf) and OptiMAL-IT(R)) were evaluated in patients presenting with clinically suspected malaria.

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