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Scientific Articles

Characterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34)

December 5, 2009 - 16:25 -- Kabogo Ndegwa
Author(s): 
Alvaro Mongui, Diana I. Angel, Gina Gallego, Claudia Reyes, Paola Martinez, Felipe Guhl, Manuel A. Patarroyo
Reference: 
Vaccine, Volume 28, Issue 2, 11 December 2009, Pages 415-421, doi:10.1016/j.vaccine.2009.10.034

This study describes the identification of the Plasmodium vivax rhoptry antigen Pv34 whose sequence was obtained based on homology comparison with the Plasmodium falciparum Pf34.

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Correspondence: Diagnostic importance of headache as a key symptom in suspecting malaria in adult returning travelers

December 5, 2009 - 16:21 -- Patrick Sampao
Author(s): 
Francisco M. Pherez, Burke A. Cunha
Reference: 
Travel Medicine and Infectious Disease, Volume 7, Issue 6, November 2009, Pages 383-384. doi:10.1016/j.tmaid.2009.09.004

No abstract available.

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Evaluation of the safety and immunogenicity of Plasmodium falciparum apical membrane antigen 1, merozoite surface protein 1 or RTS, S vaccines with adjuvant system AS02A administered alone or concurrently in rhesus monkeys

December 5, 2009 - 16:19 -- Kabogo Ndegwa
Author(s): 
S. Pichyangkul, P. Tongtawe, U. Kum-Arb, K. Yongvanitchit, M. Gettayacamin, M.R. Hollingdale, A. Limsalakpetch, V.A. Stewart, D.E. Lanar, S. Dutta, E. Angov, L.A Ware, E.S. Bergmann-Leitner, B. House, G. Voss, M.C. Dubois, J.D. Cohen, M.M. Fukuda, D.G. Heppner, R.S. Miller.
Reference: 
Vaccine, Volume 28, Issue 2, 11 December 2009, Pages 452-462, doi:10.1016/j.vaccine.2009.10.022

In an effort to broaden the immune response induced by the RTS,S/AS02A,vaccine, we have evaluated the immunogenicity of the RTS,S antigen when combined with MSP142 and with AMA1, antigens derived from the asexual blood stage.

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Effectiveness of malaria chemoprophylaxis against Plasmodium falciparum infection in UK travellers: Retrospective observational data

December 4, 2009 - 16:07 -- Patrick Sampao
Author(s): 
Jane N. Zuckerman, Anthony J. Batty, Michael E. Jones.
Reference: 
Travel Medicine and Infectious Disease, Volume 7, Issue 6, November 2009, Pages 329-336, doi:10.1016/j.tmaid.2009.10.002.

Further work is required to ascertain whether ease of use and compliance may be important factors in the outcomes associated with malariachemoprophylaxis.

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Anopheles mosquito transmission of brain tumor

December 4, 2009 - 16:00 -- Patrick Sampao
Author(s): 
Steven Lehrer
Reference: 
Medical Hypotheses, Volume 74, Issue 1, January 2010, Pages 167-168, doi:10.1016/j.mehy.2009.07.005 R

If a mosquito-transmitted brain tumor virus could be identified, development of a brain tumor vaccine might be possible.

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Comparing human T cell and NK cell responses in viral-based malaria vaccine trials

December 3, 2009 - 12:17 -- Patrick Sampao
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Author(s): 
Tamara K. Berthoud, Helen Fletcher, David Porter, Fiona Thompson, Adrian V.S. Hill, Stephen M. Todryk
Reference: 
Vaccine, Volume 28, Issue 1, 10 December 2009, Pages 21-27

In conclusion, measuring antigen-specific T cells is more meaningful than NK cells in these vaccination regimens.

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Household risk factors for clinical malaria in a semi-urban area of Burkina Faso: a case–control study

December 3, 2009 - 12:13 -- Patrick Sampao
Author(s): 
S. Yamamotoa, V.R. Louisa, A. Siéb and R. Sauerborna
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 1, January 2010, Pages 61-65, doi:10.1016/j.trstmh.2009.07.003.

This study examined the effect of different housing and household characteristics on malaria risk among 98 case and 185 control children in the semi-urban area of Nouna, Burkina Faso.

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Vaccination with recombinant Plasmodium vivax MSP-10 formulated in different adjuvants induces strong immunogenicity but no protection.

December 3, 2009 - 12:11 -- Kabogo Ndegwa
Author(s): 
Manuel A. Giraldo, Gabriela Arevalo-Pinzon, Jose Rojas-Caraballo, Alvaro Mongui, Raul Rodriguez, Manuel A. Patarroyo
Reference: 
Vaccine, Volume 28, Issue 1, 10 December 2009, Pages 7-13, doi:10.1016/j.vaccine.2009.09.046.

In this study, the P. vivax merozoite surface protein 10 (MSP-10) was expressed as a recombinant protein in Escherichia coli and purified by affinity chromatography. 

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Immunogenicity and antigenic properties of Pf332-C231, a fragment of a non-repeat region of the Plasmodium falciparum antigen Pf332.

December 3, 2009 - 12:08 -- Kabogo Ndegwa
Author(s): 
H.A. Balogun, N.-M. Vasconcelos, R. Lindberg, M. Haeggström, K. Moll, Q. Chen, M. Wahlgren, K. Berzins
Reference: 
Vaccine, Volume 28, Issue 1, 10 December 2009, Pages 90-97, doi:10.1016/j.vaccine.2009.09.110

Antigen Pf332, a megadalton protein has been shown to be associated with the membrane of infected erythrocytes. Detailed functional studies on the antigen have remained hampered by the cross-reactive nature of antibodies generated to Pf332. Pf332-C231, identified in the C-terminal region of Pf332 was cloned and antibodies against the C231 fragment were shown to react with intact Pf332 antigen by both immunofluorescence and immunoblotting analyses. Antibodies to C231 inhibited in vitro Plasmodium falciparum growth efficiently.

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