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Scientific Articles

Prevalence of malaria from peripheral blood smears examination: A 1-year retrospective study from the Serbo Health Center, Kersa Woreda, Ethiopia

November 26, 2009 - 07:25 -- Patrick Sampao
Author(s): 
Kaliyaperumal Karunamoorthi, Mammo Bekele
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Journal of Infection and Public Health, Volume 2, Issue 4, 2009, Pages 171-176, doi:10.1016/j.jiph.2009.08.005

Malaria is a major public health problem in Ethiopia. Over the past years, the disease has been consistently reported as the first leading cause of outpatient visits, hospitalization and death in health facilities across the country. Thus, a retrospective study was conducted to determine the prevalence of malaria from peripheral blood smear examination from the Serbo Health Center of Ethiopia. The case notes of all malaria cases treated between July 2007 and June 2008 were carefully reviewed and analyzed.

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Accuracy of a multispecies rapid diagnostic test kit for detection of malarial parasite at the point of care in a low endemicity region

November 26, 2009 - 07:24 -- Kabogo Ndegwa
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Author(s): 
M. Meena, D. Joshi, R. Joshi, S. Sridhar, S. Waghdhare, N. Gangane, S.P. Kalantri
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1237-1244, doi:10.1016/j.trstmh.2009.04.011

Although highly accurate rapid diagnostic tests (RDT) for Plasmodium falciparum [based on identification of histidine-rich protein-2 (PfHRP2)] have been developed, the accuracy of non-falciparum tests is relatively poor. Recently, a Plasmodium vivax-specific RDT [based on identification of species-specific lactate dehydrogenase (PvLDH)] became available, which along with PfHRP2 may improve malaria diagnosis by identifying the species correctly.

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Traditional antimalarial phytotherapy remedies in herbal markets in southern Ghana

November 26, 2009 - 07:20 -- Patrick Sampao
Author(s): 
Alex Asase, Gloria Oppong-Mensah.
Reference: 
Journal of Ethnopharmacology, Volume 126, Issue 3, 10 December 2009, Pages 492-499, doi:10.1016/j.jep.2009.09.008

Ethnopharmacological relevance. Although traditional antimalarial plant remedies in herbal markets are a very important component of the health care system in Ghana this has not been previously studied to allow for the formulation of effective strategy for malaria control in Ghana. Aim of study The main objective of the present study was to collect and analyse data on the antimalarial plant remedies in herbal markets in southern Ghana.

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Short communication: El Niño and variations in the prevalence of Plasmodium vivax and P. falciparum in Vanuatu

November 26, 2009 - 07:20 -- Kabogo Ndegwa
Author(s): 
M. Gilbert, R. Brindle
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1285-1287, doi:10.1016/j.trstmh.2008.10.048

As P. vivax is more prevalent in seasonal climates and P. falciparum in areas of more consistent rainfall, it is postulated that there will be a correlation between the ratio of vivax:falciparum and the El Niño Southern Oscillation (ENSO), which affects sea surface temperatures and rainfall.

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Fabrication of drug nanoparticles by evaporative precipitation of nanosuspension

November 26, 2009 - 07:15 -- Patrick Sampao
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Author(s): 
M. Kakran, N.G. Sahoo, L. Li, Z. Judeh, Y. Wang, K. Chong, L. Loh.
Reference: 
International Journal of Pharmaceutics, Volume 383, Issues 1-2, 4 January 2010, Pages 285-292, doi:10.1016/j.ijpharm.2009.09.030

Evaporative precipitation of nanosuspension (EPN) was used to fabricate nanoparticles of a poorly water-soluble antimalarial drug, artemisinin (ART), with the aim of enhancing its dissolution rate. We investigated the nanoparticle fabrication of ART via a full factorial experimental design considering the effects of drug concentration and solvent to antisolvent ratio on the physical, morphological and dissolution properties of ART.

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Sleeping arrangements under long-lasting impregnated mosquito nets: differences during low and high malaria transmission seasons

November 26, 2009 - 07:01 -- Kabogo Ndegwa
Author(s): 
S.D. Fernando, R.R. Abeyasinghe, G.N.L. Galappaththy, N. Gunawardena, A.C.R. Ranasinghe, L.C. Rajapaksa
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Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1204-1210, doi:10.1016/j.trstmh.2008.10.018

Sleeping arrangements under long-lasting impregnated nets (LLIN) were recorded in 2467 households during the low malaria transmission season (May–June 2007) and the same families were followed up during the high malaria transmission season (December 2007–January 2008) in two malaria-endemic areas of Sri Lanka. Approximately 800 households each from the three main ethnic groups were studied. The number of families lost to follow-up was 68.

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Intermittent preventive treatment of malaria in pregnancy (IPTp): participation of community-directed distributors of ivermectin for onchocerciasis improves IPTp access in Ugandan rural communities

November 26, 2009 - 06:58 -- Kabogo Ndegwa
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Author(s): 
Richard Ndyomugyenyi, Ephraim Tukesiga, James Katamanywa
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1221-1228, doi:10.1016/j.trstmh.2009.03.006

Access and compliance to sulfadoxine–pyrimethamine (SP) for intermittent preventive treatment of malaria in pregnancy (IPTp) when delivered by community-directed drug distributors (CDDs) of ivermectin for onchocerciasis control (intervention arm) and through delivery of SP–IPTp during antenatal care visit (control arm) was investigated in western Uganda.

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Nucleotide sequence polymorphism at the apical membrane antigen-1 locus reveals population history of Plasmodium vivax in Thailand

November 26, 2009 - 06:55 -- Patrick Sampao
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Author(s): 
Chaturong Putaporntip, Somchai Jongwutiwes, Priscila Grynberg, Liwang Cui, Austin L. Hughes.
Reference: 
Infection, Genetics and Evolution, Volume 9, Issue 6, December 2009, Pages 1295-1300, doi:10.1016/j.meegid.2009.07.005.

Apical membrane antigen-1 is a candidate for inclusion in a vaccine for the human malaria parasite Plasmodium vivax.

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Recurrence rate of vivax malaria in the Republic of Korea

November 26, 2009 - 06:53 -- Kabogo Ndegwa
Author(s): 
Ki Tae Moon, Young Keun Kim, Dong Hoon Ko, Inho Park, Dong Chun Shin, Changsoo Kim.
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1245-1249, doi:10.1016/j.trstmh.2008.10.023

In the Republic of Korea (ROK), military antimalarial chemoprophylaxis was initiated in 1997. Although chemoprophylaxis reduces malaria cases, long-term chemoprophylaxis could increase resistance. In this study, the recurrence rate of vivax malaria was investigated.

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Short communication: Absence of an impact of resistance to chloroquine on consultations for malaria in Niakhar, Senegal (1992–2004)

November 26, 2009 - 06:50 -- Kabogo Ndegwa
Author(s): 
A. Munier, A. Diallo, J.P. Chippaux
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1288-1290, doi:10.1016/j.trstmh.2009.03.017

We retrospectively assessed the impact of chloroquine (CQ) resistance in the rural region of Niakhar, Senegal, where resistance to CQ emerged in 1992, from increases in consultations and returns of patients to the health centre following antimalarial treatment.

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