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Scientific Articles

Open Access | A comparative study of a flow-cytometry-based assessment of in vitro Plasmodium falciparum drug sensitivity

December 23, 2009 - 11:03 -- Ingeborg van Schayk
Author(s): 
Stephan Karl, Rina PM Wong, Tim G St. Pierre, Timothy ME Davis
Reference: 
Malaria Journal 2009, 8:294 (14 December 2009)

Although flow cytometric equipment is expensive, the necessary reagents are inexpensive, the procedure is simple and rapid, and the cell volume required is minimal. This should allow field studies using fingerprick sample volumes.

Open Access | Evaluation of the Palutop+4 malaria rapid diagnostic test in a non-endemic setting

December 23, 2009 - 10:46 -- Ingeborg van Schayk
Author(s): 
David PJ van Dijk, Philippe Gillet, Erika Vlieghe, Lieselotte Cnops, Marjan Van Esbroeck, Jan Jacobs
Reference: 
Malaria Journal 2009, 8:293 (12 December 2009)

Palutop+4 performed moderately for the detection of P. falciparum and P. vivax, but sensitivities were lower than those of three-band malaria RDTs.

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Open Access | Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control

December 23, 2009 - 10:41 -- Ingeborg van Schayk
Author(s): 
Collins K Ahorlu, Kwadwo A Koram, Atsu K Seakey, Mitchell G Weiss
Reference: 
Malaria Journal 2009, 8:292 (11 December 2009)

This study explored the potential of a strategy of intermittent preventive treatment for children (IPTC) and timely treatment of malaria-related febrile illness in the home in reducing the parasite prevalence and malaria morbidity in young children in a coastal village in Ghana.

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Open Access | Temporal and spatial stability of Anopheles gambiae larval habitat distribution in western Kenya highlands

December 23, 2009 - 09:33 -- Ingeborg van Schayk
Author(s): 
Li L, Bian L, Yakob L, Zhou G, Yan G
Reference: 
International Journal of Health Geographics 2009, 8:70 (18 December 2009)

Results from this study suggest that larval habitat management activities need to consider the dynamic nature of malaria vector habitats.

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Open Access | Malaria control in Timor-Leste during a period of political instability: what lessons can be learned?

December 23, 2009 - 09:28 -- Ingeborg van Schayk
Author(s): 
Martins JS, Zwi AB, Martins N, Kelly PM
Reference: 
Conflict and Health 2009, 3:11 (16 December 2009)

To examine the impact of political upheaval and population displacement in Timor-Leste (2006) on malaria in the country.

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Open Access | Functional Memory B Cells and Long-Lived Plasma Cells Are Generated after a Single Plasmodium chabaudi Infection in Mice

December 23, 2009 - 09:21 -- Ingeborg van Schayk
Author(s): 
Ndungu FM, Cadman ET, Coulcher J, Nduati E, Couper E, et al.
Reference: 
PLoS Pathog 5(12): e1000690

The cellular mechanisms underlying B cell and antibody responses are difficult to study in human infections; therefore, we have investigated the kinetics, duration and characteristics of the Plasmodium-specific memory B cell response in an infection of P. chabaudi in mice.

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The comparative antimalarial properties of weak base and neutral synthetic ozonides

December 22, 2009 - 13:35 -- Patrick Sampao
Author(s): 
Yuanqing Tang, Sergio Wittlin, Susan A. Charman, Jacques Chollet, Francis C.K. Chiu, Julia Morizzi, Lisa M. Johnson, Josefina Santo Tomas, Christian Scheurer, Chistopher Snyder, Lin Zhou, Yuxiang Dong, William N. Charman, Hugues Matile, Heinrich Urwyler, Arnulf Dorn, Jonathan L. Vennerstrom
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 2, 15 January 2010, Pages 563-566

Thirty-three N-acyl 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. For these ozonides, weak base functional groups were not required for high antimalarial potency against Plasmodium falciparum in vitro, but were necessary for high antimalarial efficacy in Plasmodium berghei-infected mice. A wide range of Log P/DpH 7.4 values were tolerated, although more lipophilic ozonides tended to be less metabolically stable.

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Spurious Amplification of a Plasmodium vivax Small-Subunit RNA Gene by Use of Primers Currently Used To Detect P. knowlesi

December 22, 2009 - 13:32 -- Kabogo Ndegwa
Author(s): 
Mallika Imwong, Naowarat Tanomsing, Sasithon Pukrittayakamee, Nicholas P. J. Day, Nicholas J. White and Georges Snounou
Reference: 
Journal of Clinical Microbiology, December 2009, p. 4173-4175, Vol. 47, No. 12

The PCR primers commonly used to detect Plasmodium knowlesi infections in humans were found to cross-react stochastically with P. vivax genomic DNA. A nested primer set that targets one of the P. knowlesi small-subunit rRNA genes was validated for specificity and for sensitivity of detection of <10 parasite genomes.

Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines

December 22, 2009 - 13:19 -- Patrick Sampao
Author(s): 
Pierre Verhaeghe, Nadine Azas, Monique Gasquet, Sébastien Hutter, Christophe Ducros, Michèle Laget, Sylvain Rault, Pascal Rathelot, Patrice Vanelle
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 1, 1 January 2008, Pages 396-401

A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach.

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Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline–triazine conjugates

December 22, 2009 - 12:59 -- Patrick Sampao
Author(s): 
Sunny Manohar, Shabana I. Khan, Diwan S. Rawat
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 1, 1 January 2010, Pages 322-325

A series of 4-aminoquinoline–triazine conjugates with different substitution pattern have been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive and resistant strains of Plasmodium falciparum.

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