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Scientific Articles

Review: Reviewing the literature on access to prompt and effective malaria treatment in Kenya: implications for meeting the Abuja targets

October 29, 2009 - 12:40 -- Ingeborg van Schayk
Author(s): 
Jane Chuma, Timothy Abuya, Dorothy Memusi, Elizabeth Juma, Willis Akhwale, Janet Ntwiga, Andrew Nyandigisi, Gladys Tetteh, Rima Shretta, Abdinasir Amin
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Malaria Journal 2009, 8:243 (28 October 2009)

This review on access to malaria treatment in Kenya is particularly interesting in the light of the wealth of studies that have been carried out on related topics in Kenya.

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What you see is not what you get: implications of the brevity of antibody responses to malaria antigens and transmission heterogeneity in longitudinal studies of malaria immunity

October 29, 2009 - 12:37 -- Ingeborg van Schayk
Author(s): 
Samson M Kinyanjui, Philip Bejon, Faith H Osier, Peter C Bull, Kevin Marsh
Reference: 
Malaria Journal 2009, 8:242 (28 October 2009)

Failure to distinguish between individuals who do not get a clinical episode during follow-up because they were unexposed and those who are genuinely immune undermines our ability to assign a protective role to immune responses against malaria. The brevity of antibodies responses makes it difficult to assign the true serological status of an individual at any given time, i.e. those positive at a survey may be negative by the time they encounter the next infection.

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Evaluation of three parasite lactate dehydrogenase-based rapid diagnostic tests for the diagnosis of falciparum and vivax malaria

October 29, 2009 - 12:34 -- Ingeborg van Schayk
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Author(s): 
Elizabeth A Ashley, Malek Touabi, Margareta Ahrer, Robert Hutagalung, Khayae Htun, Jennifer Luchavez, Christine Dureza, Stephane Proux, Mara Leimanis, Myo Min Lwin, Alena Koscalova, Eric Comte, Prudence Hamade, Anne-Laure Page, Francois Nosten, Philippe J Guerin
Reference: 
Malaria Journal 2009, 8:241 (27 October 2009)

In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH). In Dawei, southern Myanmar, three pLDH based RDTs (CareStartTM Malaria pLDH (Pan), CareStartTM Malaria pLDH (Pan, Pf) and OptiMAL-IT(R)) were evaluated in patients presenting with clinically suspected malaria.

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Two treatments, one disease: childhood malaria management in Tanga, Tanzania

October 29, 2009 - 12:30 -- Ingeborg van Schayk
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Author(s): 
Deshka Foster, Stacie Vilendrer
Reference: 
Malaria Journal 2009, 8:240 (27 October 2009)

In the Tanga District of coastal Tanzania, malaria is one of the primary causes of mortality for children under the age of five. While some children are treated with malaria medications in biomedical facilities, as the World Health Organization recommends, others receive home-care or treatment from traditional healers. 

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Seasonal distribution of Anopheles funestus chromosomal forms from Burkina Faso

October 29, 2009 - 12:26 -- Ingeborg van Schayk
Author(s): 
Wamdaogo M Guelbeogo, N'Fale Sagnon, Olga Grushko, Malgaouende A Yameogo, Daniela Boccolini, Nora J Besansky, Carlo Costantini
Reference: 
Malaria Journal 2009, 8:239 (26 October 2009)

Previous studies of Anopheles funestus chromosomal inversion polymorphisms in Burkina Faso showed large departures from Hardy-Weinberg equilibrium and linkage disequilibrium among inversions located on different chromosomes, implying the existence of two taxonomic units ("chromosomal forms") with limited genetic flow. One chromosomal form, named Folonzo, is highly polymorphic for alternative rearrangements of 3Ra, 3Rb, 2Ra, and 3La; the other, Kiribina, is predominantly characterized by the standard arrangement of these inversions. To investigate the temporal distribution of these chromosomal forms, further collections were carried out in two villages near Ouagadougou where they are found in sympatry.

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Methodology: A simple cost-effective high performance liquid chromatographic assay of sulphadoxine in whole blood spotted on filter paper for field studies

October 29, 2009 - 12:22 -- Ingeborg van Schayk
Author(s): 
Grace O Gbotosho, Christian T Happi, Abayomi O Sijuade, Akin Sowunmi, Ayoade MJ Oduola
Reference: 
Malaria Journal 2009, 8:238 (24 October 2009)

Efforts in this study were thus devoted to development and evaluation of a simple, cost-effective and sensitive method for quantification of sulphadoxine in small capillary samples of whole blood dried on filter paper.

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Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial

October 29, 2009 - 12:18 -- Ingeborg van Schayk
Author(s): 
Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial Victoria Nakibuuka, Grace Ndeezi, Deborah Nakiboneka, Christopher M Ndugwa, James K Tumwine
Reference: 
Malaria Journal 2009, 8:237 (24 October 2009)

Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these children despite unacceptably high levels of resistance. Intermittent presumptive treatment with sulphadoxine-pyrimethamine (SP) has shown great potential for reducing prevalence of malaria and anaemia among pregnant women and infants.

Presumptive treatment with SP was more efficacious than weekly chloroquine in reducing prevalence of malaria in children with sickle cell anaemia. Continued use of chloroquine for malaria chemoprophylaxis in children with sickle cell anaemia in Uganda does not seem to be justified. ClinicalTrials.gov Identifier: NCTOO124267

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Use of short message service (SMS) to improve malaria chemoprophylaxis compliance after returning from a malaria endemic area

October 29, 2009 - 12:15 -- Ingeborg van Schayk
Author(s): 
Lenaick Ollivier, Olivier Romand, Catherine Marimoutou, Remy Michel, Corinne Pognant, Alain Todesco, Rene Migliani, Dominique Baudon, Jean-Paul Boutin
Reference: 
Malaria Journal 2009, 8:236 (23 October 2009)

Malaria chemoprophylaxis compliance is suboptimal among French soldiers despite the availability of free malaria chemoprophylaxis and repeated health education before, during and after deployments to malaria endemic areas.

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Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals

October 29, 2009 - 12:12 -- Ingeborg van Schayk
Author(s): 
Thanh V Nguyen, John B Sacci Jr, Patricia de la Vega, Chandy C John, Anthony A James, Angray S Kang
Reference: 
Malaria Journal 2009, 8:235 (23 October 2009)

MB2 protein is a sporozoite surface antigen on the human malaria parasite Plasmodium falciparum. A preliminary analysis of the human humoral response against MB2 indicates that it may be an additional highly conserved target for immune intervention at the pre-erythrocytic stage of P. falciparum life cycle.

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Habitat stability and occurrences of malaria vector larvae in western Kenya highlands

October 29, 2009 - 12:07 -- Ingeborg van Schayk
Author(s): 
Yousif E Himeidan, Guofa Zhou, Laith Yakob, Yaw Afrane, Stephen Munga, Harrysonne Atieli, El-Amin El-Rayah, Andrew K Githeko, Guiyun Yan
Reference: 
Malaria Journal 2009, 8:234 (21 October 2009)

Although the occurrence of malaria vector larvae in the valleys of western Kenya highlands is well documented, knowledge of larval habitats in the uphill sites is lacking. Given that most inhabitants of the highlands actually dwell in the uphill regions, it is important to develop understanding of mosquito breeding habitat stability in these sites in order to determine their potential for larval control.

The occurrence of malaria vector larvae in the hilltop area was uncommon as a result of the low availability and high instability of habitats. To optimize the cost-effectiveness of malaria interventions in the western Kenya highlands, larval control should be focused primarily along the streams, as these are likely the only productive habitats at high altitude.

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