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Scientific Articles

Health Seeking Behavior after Fever Onset in a Malaria-Endemic Area of Malawi

December 18, 2009 - 10:33 -- Ingeborg van Schayk
Author(s): 
Ruben E. Mujica Mota, Antonieta Medina Lara, Esthery D. Kunkwenzu, AND David G. Lalloo
Reference: 
Am J Trop Med Hyg 2009;81 935-943

Informal sources of care may lead to ineffective use of antimalarial drugs. A survey conducted in Malawi estimated the frequency of use of informal and formal services, medications, and household costs.

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Perspective: Rapid Malaria Tests: Where Do We Go After 20 Years?

December 18, 2009 - 10:27 -- Ingeborg van Schayk
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Author(s): 
Michael T. Makler AND Robert C. Piper
Reference: 
Am J Trop Med Hyg 2009;81 921-926

We propose that the study and implementation of such RDTs should be aggressively advanced and propose a series of questions that can guide efforts.

Open Access | Pharmaceutical and Medicinal Chemistry: Falcipain-2 inhibitors

December 17, 2009 - 13:34 -- Kabogo Ndegwa
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Author(s): 
Roberta Ettari, Floriana Bova, Maria Zappalà, Silvana Grasso, Nicola Micale
Reference: 
Medicinal Research Reviews, Volume 30 Issue 1, Pages 136 – 167

This review is focused on inhibitors of falcipain-2, a cysteine protease from P. falciparum, which represents one of the most promising targets for antimalarial drug design.

Phylogeny of Asian primate malaria parasites inferred from apicoplast genome-encoded genes with special emphasis on the positions of Plasmodium vivax and P. fragile

December 17, 2009 - 13:33 -- Patrick Sampao
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Author(s): 
Hideya Mitsui, Nobuko Arisue, Naoko Sakihama, Yuji Inagaki, Toshihiro Horii, Masami Hasegawa, Kazuyuki Tanabe, Tetsuo Hashimoto
Reference: 
Gene, Volume 450, Issues 1-2, 15 January 2010, Pages 32-38

The present analyses place P. fragile in a position that is incongruent with the early branching status of P. fragile amongst P-vivax-related primate Plasmodium species propose by Escalante et al. (Proc Natl Acad Sci USA 2005 102: 1980).

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Review: Low Complexity Regions behave as tRNA sponges to help co-translational folding of plasmodial proteins

December 17, 2009 - 13:29 -- Patrick Sampao
Author(s): 
Magali Frugier, Tania Bour, Maya Ayach, Manuel A.S. Santos, Joëlle Rudinger-Thirion, Anne Théobald-Dietrich, Elizabetta Pizzi
Reference: 
FEBS Letters, Volume 584, Issue 2, 21 January 2010, Pages 448-454

In our model, the abundant Low Complexity Regions present in Plasmodium proteins replace the codon preferences, which influence the assembly of protein secondary structures.

Review: Diversity and similarity in the tRNA world: Overall view and case study on malaria-related tRNAs

December 17, 2009 - 13:24 -- Patrick Sampao
Author(s): 
Joern Pütza, Richard Giegéa and Catherine Florentz
Reference: 
FEBS Letters, Volume 584, Issue 2, 21 January 2010, Pages 350-358

Transfer RNAs (tRNAs) are ancient macromolecules that have evolved under various environmental pressures as adaptors in translation in all forms of life but also towards alternative structures and functions. The present knowledge on both “canonical” and “deviating” signature motifs retrieved from vertical and horizontal sequence comparisons is briefly reviewed.

Open Access | Clinical Microbiology : The impact of a small-scale irrigation scheme on malaria transmission in Ziway area, Central Ethiopia

December 17, 2009 - 13:23 -- Kabogo Ndegwa
Author(s): 
Solomon Kibret, Yihenew Alemu, Eline Boelee, Habte Tekie, Dawit Alemu, Beyene Petros
Reference: 
Tropical Medicine & International Health, Volume 15, Issue 1, Date: January 2010, Pages: 41-50

To assess the impact of a small-scale irrigation scheme in Ziway area, a semi-arid area in the Central Ethiopian Rift Valley, on malaria transmission.

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Open Access : Clinical Microbiology : Evaluation of the pyrrole insecticide chlorfenapyr against pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae)

December 17, 2009 - 13:21 -- Kabogo Ndegwa
Author(s): 
S. V. Oliver, M. L. Kaiser, O. R. Wood, M. Coetzee, M. Rowland, B. D. Brooke
Reference: 
Tropical Medicine & International Health,Volume 15, Issue 1, Date: January 2010, Pages: 127-131

Objective : To evaluate the pyrrole insecticide chlorfenapyr, which has a novel non-neurotoxic mode of action and is a promising alternative to conventional adulticides, against Anopheles funestus. Method : The toxicity of a range of concentrations of chlorfenapyr against pyrethroid resistant and susceptible laboratory reared southern African An. funestus was assessed using standard WHO protocols and analysed using probit analysis.

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Open Access | Clinical Microbiloby:Low-high season variation in Plasmodium falciparum erythrocyte binding antigen 175 (eba-175) allelic forms in malaria endemic area of Burkina Faso

December 17, 2009 - 13:19 -- Kabogo Ndegwa
Author(s): 
Issiaka Soulama, Edith C. Bougouma, Amidou Diarra, Issa Nebie, Sodiomon B. Sirima
Reference: 
Tropical Medicine & International Healt,Volume 15, Issue 1, Date: January 2010, Pages: 51-59

To assess the impact of seasonal variation on the distribution of the eba-175 allelic forms in the area where malaria transmission is markedly seasonal.

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