To facilitate the characterization of DPAP1, we have developed a method for the production of purified recombinant DPAP1 with properties closely resembling those of the native enzyme.
In this study, the sequence of RAP-3 was finely mapped using synthetic peptides in order to identify which are the specific binding regions involved in RAP3–RBC interactions.
The concept of a malaria vaccine has sparked great interest for decades; however, the challenge is proving to be a difficult one.
The over-replicating wMelPop strain of the endosymbiont Wolbachia pipientis has recently been shown to be capable of inducing immune upregulation and inhibition of pathogen transmission in Aedes aegypti mosquitoes.
The molecular mechanisms underlying transcriptional regulation in apicomplexan parasites remain poorly understood.
None of the plant extracts investigated exhibited residual repellencies >60% after three hours.
The annual number of imported malaria shows a continuing declining trend, even with an increasing number of travellers visiting malaria endemic countries.
Several factors potentially have contributed to recent health improvement in African countries, but there is substantial evidence that achieving high malaria control intervention coverage, especially with ITNs and targeted IRS, has been the leading contributor to reduced child mortality.
The SMS for Life pilot provided visibility of anti-malarial stock levels to support more efficient stock management using simple and widely available SMS technology, via a public-private partnership model that worked highly effectively.
CareStart appeared to be the most appropriate option for use at health posts in Ethiopia, considering the combination of quantitative performance, ease of use and heat stability.