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Scientific Articles

Short communication: Absence of an impact of resistance to chloroquine on consultations for malaria in Niakhar, Senegal (1992–2004)

November 26, 2009 - 06:50 -- Kabogo Ndegwa
Author(s): 
A. Munier, A. Diallo, J.P. Chippaux
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Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1288-1290, doi:10.1016/j.trstmh.2009.03.017

We retrospectively assessed the impact of chloroquine (CQ) resistance in the rural region of Niakhar, Senegal, where resistance to CQ emerged in 1992, from increases in consultations and returns of patients to the health centre following antimalarial treatment.

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Short communication: IFNGR1 polymorphisms in Thai malaria patients

November 26, 2009 - 06:50 -- Patrick Sampao
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Author(s): 
Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Katsushi Tokunaga, Naoyuki Tsuchiya, Jun Ohashi
Reference: 
Infection, Genetics and Evolution, Volume 9, Issue 6, December 2009, Pages 1406-1409, doi:10.1016/j.meegid.2009.08.004

Interferon-γ (IFN-γ) has been suggested to play an important role in the pathogenesis of malaria.

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Mini review: A new global malaria eradication strategy: implications for malaria research from an Indian perspective

November 26, 2009 - 06:48 -- Kabogo Ndegwa
Author(s): 
Neeru Singh
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1202-1203, doi:10.1016/j.trstmh.2009.04.023

The Roll Back Malaria Partnership has developed the Global Malaria Action Plan for a substantial reduction in the burden of malaria and its eradication in the long term.

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The action of falciparum malaria on the human and chimpanzee genomes compared: Absence of evidence for a genomic signature of malaria at HBB and G6PD in three subspecies of chimpanzee

November 26, 2009 - 06:45 -- Patrick Sampao
Author(s): 
T.S. MacFie, E. Nerrienet, R.E. Bontrop, N.I. Mundy
Reference: 
Infection, Genetics and Evolution, Volume 9, Issue 6, December 2009, Pages 1248-1252, doi:10.1016/j.meegid.2009.06.025

Here we investigate whether the genomic signatures of plasmodial infection found in humans are also present in chimpanzees.

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Microfinance against malaria: impact of Freedom from Hunger's malaria education when delivered by rural banks in Ghana

November 26, 2009 - 06:45 -- Kabogo Ndegwa
Author(s): 
Natalie De La Cruz, Benjamin Crookston, Bobbi Gray, Steve Alder, Kirk Dearden
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1229-1236, doi:10.1016/j.trstmh.2009.03.018

Results indicate that, although significant barriers to malaria control remain, a malaria education program provided by microfinance institutions can effectively contribute to community and national malaria initiatives.

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Individual, household and environmental risk factors for malaria infection in Amhara, Oromia and SNNP regions of Ethiopia

November 26, 2009 - 06:43 -- Kabogo Ndegwa
Author(s): 
Patricia M. Graves, Frank O. Richards, Jeremiah Ngondi, Paul M. Emerson, Estifanos Biru Shargie, Tekola Endeshaw, Pietro Ceccato, Yeshewamebrat Ejigsemahu, Aryc W. Mosher, Afework Hailemariam, Mulat Zerihun, Tesfaye Teferi, Berhan Ayele, Ayenew Mesele, Gideon Yohannes, Abate Tilahun, Teshome Gebre
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Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 12, December 2009, Pages 1211-1220, doi:10.1016/j.trstmh.2008.11.016

We assessed malaria infection in relation to age, altitude, rainfall, socio-economic factors and coverage of control measures in a representative sample of 11 437 people in Amhara, Oromia and SNNP regions of Ethiopia in December 2006–January 2007.

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A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity

November 26, 2009 - 06:41 -- Patrick Sampao
Author(s): 
Stefano Guglielmo, Massimo Bertinaria, Barbara Rolando, Marco Crosetti, Roberta Fruttero, Vanessa Yardley, Simon L. Croft, Alberto Gasco
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European Journal of Medicinal Chemistry, Volume 44, Issue 12, December 2009, Pages 5071-5079, doi:10.1016/j.ejmech.2009.09.012

The synthesis and the study of new amodiaquine derivatives bearing modified lateral basic chains as new agents with both antimalarial and antileishmanial activities are reported.

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Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance

November 25, 2009 - 16:38 -- Ingeborg van Schayk
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Author(s): 
Nicholas J White, Wirichada Pongtavornpinyo, Richard J Maude, Sompob Saralamba, Ricardo Aguas, Kasia Stepniewska, Sue J Lee, Arjen M Dondorp, Lisa J White, Nicholas PJ Day
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Malaria Journal 2009, 8:253 (11 November 2009)

The probability of de-novo resistant malaria parasites surviving and transmitting depends on the relationship between their degree of resistance and the blood concentration profiles of the anti-malarial drug to which they are exposed. The conditions required for the in-vivo selection of de-novo emergent resistant malaria parasites were examined and relative probabilities assessed.

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Spatial risk profiling of Plasmodium falciparum parasitaemia in a high endemicity area in Cote d'Ivoire

November 25, 2009 - 15:54 -- Ingeborg van Schayk
Author(s): 
Giovanna Raso, Kigbafori D Silue, Penelope Vounatsou, Burton H Singer, Ahoua Yapi, Marcel Tanner, Juerg Utzinger, Eliezer K N'Goran
Reference: 
Malaria Journal 2009, 8:252 (11 November 2009)

The objective of this study was to identify demographic, environmental and socioeconomic risk factors and spatial patterns of Plasmodium falciparum parasitaemia in a high endemicity area of Africa, and to specify how this information can facilitate improved malaria control at the district level.

Synthesis of 9-anilinoacridine triazines as new class of hybrid antimalarial agents.

November 18, 2009 - 13:00 -- Patrick Sampao
Author(s): 
Ashok Kumar, Kumkum Srivastava, S. Raja Kumar, S.K. Puri, Prem M.S. Chauhan
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 19, Issue 24, 15 December 2009, Pages 6996-6999, doi:10.1016/j.bmcl.2009.10.010

There is challenge and urgency to synthesize cost-effective chemotherapeutic agents for treatment of malarianext term after the widespread development of resistance to CQ. In the present study, we synthesized a new series of hybrid 9-anilinoacridine triazines using the cheap chemicals 6,9-dichloro-2-methoxy acridine and cyanuric chloride.

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