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Scientific Articles

Biochemical characterization of Plasmodium falciparum dipeptidyl aminopeptidase

November 2, 2010 - 14:47 -- Patrick Sampao
Author(s): 
Flora Wang, Priscilla Krai, Edgar Deu, Brittney Bibb, Conni Lauritzen, John Pedersen, Matthew Bogyo, Michael Klemba
Reference: 
Molecular and Biochemical Parasitology, Volume 175, Issue 1, January 2011, Pages 10-20

To facilitate the characterization of DPAP1, we have developed a method for the production of purified recombinant DPAP1 with properties closely resembling those of the native enzyme.

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Conserved regions of the Plasmodium falciparum rhoptry-associated protein 3 mediate specific host-pathogen interactions during invasion of red blood cells

November 2, 2010 - 14:38 -- Patrick Sampao
Author(s): 
Jeison García, Hernando Curtidor, Magnolia Vanegas, Gabriela Arévalo-Pinzon, Manuel A. Patarroyo, Manuel E. Patarroyo
Reference: 
Peptides, Volume 31, Issue 12, December 2010, Pages 2165-2172

In this study, the sequence of RAP-3 was finely mapped using synthetic peptides in order to identify which are the specific binding regions involved in RAP3–RBC interactions.

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Malaria Vaccine Design: Immunological Considerations

November 2, 2010 - 08:36 -- Kabogo Ndegwa
Author(s): 
Michael F. Good, Denise L. Doolan
Reference: 
Immunity, Volume 33, Issue 4, 29 October 2010, Pages 555-566

The concept of a malaria vaccine has sparked great interest for decades; however, the challenge is proving to be a difficult one.

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Open Access | Wolbachia Stimulates Immune Gene Expression and Inhibits Plasmodium Development in Anopheles gambiae

November 2, 2010 - 08:11 -- Kabogo Ndegwa
Author(s): 
Zakaria Kambris, Andrew M. Blagborough, Sofia B. Pinto, Marcus S. C. Blagrove, H. Charles J. Godfray, Robert E. Sinden, Steven P. Sinkins
Reference: 
Pathog 6(10): e1001143

The over-replicating wMelPop strain of the endosymbiont Wolbachia pipientis has recently been shown to be capable of inducing immune upregulation and inhibition of pathogen transmission in Aedes aegypti mosquitoes.

Open Access | Identification and Genome-Wide Prediction of DNA Binding Specificities for the ApiAP2 Family of Regulators from the Malaria Parasite

November 2, 2010 - 08:00 -- Kabogo Ndegwa
Author(s): 
Tracey L. Campbell, Erandi K. De Silva, Kellen L. Olszewski, Olivier Elemento, Manuel Llinás
Reference: 
PLoS Pathog 6(10): e1001165

The molecular mechanisms underlying transcriptional regulation in apicomplexan parasites remain poorly understood.

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Open Access | Evaluation of selected South African ethnomedicinal plants as mosquito repellents against the Anopheles arabiensis mosquito in a rodent model

November 2, 2010 - 07:54 -- Kabogo Ndegwa
Author(s): 
Maharaj R, Maharaj V, Newmarch M, Crouch NR, Bhagwandin N, Folb PI, Pillay P, Gayaram R
Reference: 
Malaria Journal 2010, 9:301 (28 October 2010)

None of the plant extracts investigated exhibited residual repellencies >60% after three hours.

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Open Access | Declining incidence of imported malaria in the Netherlands, 2000-2007

November 2, 2010 - 07:35 -- Kabogo Ndegwa
Author(s): 
van Rijckevorsel GG, Sonder GJ, Geskus RB, Wetsteyn JC, Ligthelm RJ, Visser LG, Keuter M, van Genderen PJ, van den Hoek A
Reference: 
Malaria Journal 2010, 9:300 (28 October 2010)

The annual number of imported malaria shows a continuing declining trend, even with an increasing number of travellers visiting malaria endemic countries.

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Open Access | Impact of national malaria control scale-up programmes in Africa: magnitude and attribution of effects

November 2, 2010 - 07:09 -- Kabogo Ndegwa
Author(s): 
Steketee RW, Campbell CC
Reference: 
Malaria Journal 2010, 9:299 (27 October 2010)

Several factors potentially have contributed to recent health improvement in African countries, but there is substantial evidence that achieving high malaria control intervention coverage, especially with ITNs and targeted IRS, has been the leading contributor to reduced child mortality.

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Open Access | SMS for Life: a pilot project to improve anti-malarial drug supply management in rural Tanzania using standard technology

November 2, 2010 - 06:32 -- Kabogo Ndegwa
Author(s): 
Barrington J, Wereko-Brobby O, Ward P, Mwafongo W, Kungulwe S
Reference: 
Malaria Journal 2010, 9:298 (27 October 2010)

The SMS for Life pilot provided visibility of anti-malarial stock levels to support more efficient stock management using simple and widely available SMS technology, via a public-private partnership model that worked highly effectively.

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Open Access | Performance of three multi-species rapid diagnostic tests for diagnosis of Plasmodium falciparum and Plasmodium vivax malaria in Oromia Regional State, Ethiopia

November 2, 2010 - 06:29 -- Kabogo Ndegwa
Author(s): 
Ashton RA, Kefyalew T, Tesfaye G, Counihan H, Yadeta D, Cundill B, Reithinger R, Kolaczinski JH
Reference: 
Malaria Journal 2010, 9:297 (27 October 2010)

CareStart appeared to be the most appropriate option for use at health posts in Ethiopia, considering the combination of quantitative performance, ease of use and heat stability.

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