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Scientific Articles

In a Randomized Controlled Trial of Iron Fortification, Anthelmintic Treatment and Intermittent Preventive Treatment of Malaria for Anemia Control in Ivorian Children, only Anthelmintic Treatment Shows Modest Benefit

February 2, 2010 - 20:29 -- Ingeborg van Schayk
Author(s): 
Fabian Rohner, Michael B. Zimmermann, Renaude J. Amon, Penelope Vounatsou, Andreas B. Tschannen, Eliézer K. N'Goran, Charlemagne Nindjin, Marie-Chantal Cacou, Marguerite D. Té-Bonlé, Hortense Aka, Daniel E. Sess, Jürg Utzinger, and Richard F. Hurrell
Reference: 
J. Nutr. published 28 January 2010

In this study, we aimed to assess the effect of iron fortification, intermittent preventive treatment (IPT) of malaria, and anthelmintic treatment on hemoglobin concentration and anemia prevalence among school children.

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Murine Cerebral Malaria Is Associated with a Vasospasm-Like Microcirculatory Dysfunction, and Survival upon Rescue Treatment Is Markedly Increased by Nimodipine

February 2, 2010 - 20:22 -- Ingeborg van Schayk
Author(s): 
Pedro Cabrales, Graziela M. Zanini, Diana Meays, John A. Frangos, and Leonardo J.M. Carvalho
Reference: 
Am. J. Pathol. published 28 January 2010

We conclude that vasoconstriction and vascular collapse play a role in murine CM pathogenesis and nimodipine holds potential as adjunctive therapy for CM.

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Open Access | Conflict-affected displaced persons need to benefit more from HIV and malaria national strategic plans and Global Fund grants

February 1, 2010 - 11:24 -- Ingeborg van Schayk
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Author(s): 
Spiegel PB, Hering H, Paik E, Schilperoord M
Reference: 
Conflict and Health 2010, 4:2 (29 January 2010)

Access to HIV and malaria control programmes for refugees and internally displaced persons (IDPs) is not only a human rights issue but a public health priority for affected populations and host populations.

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Open Access | Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter

February 1, 2010 - 11:06 -- Ingeborg van Schayk
Author(s): 
Neils B Quashie, Lisa C Ranford-Cartwright, Harry P De Koning
Reference: 
Malaria Journal 2010, 9:36 (29 January 2010)

Paper that provides conclusive novel information on purine transport in Plasmodium-infected RBC. The information is important as the purine salvage pathway is a target for new chemotherapy.

Open Access | A cell-based high-throughput screen validates the plasmodial surface anion channel as an antimalarial target

February 1, 2010 - 10:48 -- Ingeborg van Schayk
Author(s): 
Ajay D. Pillai, Margaret Pain, Tsione Solomon, Abdullah A.B. Bokhari, and Sanjay A Desai
Reference: 
Mol. Pharmacol. published 25 January 2010

A statistically significant correlation between channel inhibition and in vitro parasite killing by a family of compounds provided chemical validation of PSAC as a drug target. 

Open Access | A global view of the nonprotein-coding transcriptome in Plasmodium falciparum

February 1, 2010 - 10:36 -- Ingeborg van Schayk
Author(s): 
Carsten A. Raabe, Cecilia P. Sanchez, Timofey S. Rozhdestvensky et al.
Reference: 
Nucleic Acids Res. 2010; 38:608-617

Our findings have important implications for a better understanding of gene regulatory mechanisms in P. falciparum, revealing an extended and sophisticated npcRNA network that may control the expression of housekeeping genes and virulence factors.

Assessment of DDT levels in selected environmental media and biological samples from Mexico and Central America

February 1, 2010 - 10:28 -- Ingeborg van Schayk
Author(s): 
ván N. Pérez-Maldonado, Antonio Trejo, Fernando Díaz-Barriga et al.
Reference: 
Chemosphere Article in Press, Corrected Proof

Taking into account the environmental persistence and the toxicity of DDT, the Pan American Health Organization (PAHO) organized a surveillance program in Mesoamerica which included the detection of residual DDT in environmental (soil) and biological samples (fish tissue and children’s blood).

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Characterization of Two Linear Cationic Antimalarial Peptides in the Scorpion Mesobuthus eupeus

February 1, 2010 - 10:17 -- Ingeborg van Schayk
Author(s): 
Bin Gao, Jia Xu, Maria del Carmen Rodriguez, Humberto Lanz-Mendoza, Rosaura Hernández-Rivas, Weihong Du and Shunyi Zhu
Reference: 
Biochimie, Article in Press, Uncorrected Proof

In this work, we report two cDNA clones from the scorpion Mesobuthus eupeus venom gland, which encode peptides inhibiting the development of Plasmodium berghei, killing intraerythrocytic P. falciparum, and toxic to the Drosophila S2 cell at micromolar concentrations.

African great apes are natural hosts of multiple related malaria species, including Plasmodium falciparum

February 1, 2010 - 09:56 -- Ingeborg van Schayk
Author(s): 
Franck Prugnolle, Patrick Durand, François Renaud et al.
Reference: 
PNAS, Published online before print January 19, 2010

The continuously increasing contacts between humans and primate populations raise concerns about further reciprocal host transfers of these pathogens.

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Open Access | A novel method for standardized application of fungal spore coatings for mosquito exposure bioassays

January 31, 2010 - 17:30 -- Ingeborg van Schayk
Author(s): 
Marit Farenhorst, Bart G J Knols
Reference: 
Malaria Journal 2010, 9:27 (20 January 2010)

Two novel fungus application methods using equipment developed in the paint industry are presented and compared.

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