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Scientific Articles

On the use of satellite-based estimates of rainfall temporal distribution to simulate the potential for malaria transmission in rural Africa

March 9, 2011 - 08:37 -- Kabogo Ndegwa
Author(s): 
Teresa K. Yamana, Elfatih A. B. Eltahir
Reference: 
Water Resources Research, Vol. 47, W02540, 12 PP., 2011

The results demonstrate that adjusted rainfall estimates from satellites can be used with a mechanistic model to accurately simulate the dynamics of mosquito populations.

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Reactions of Antimalarial Peroxides with Each of Leucomethylene Blue and Dihydroflavins: Flavin Reductase and the Cofactor Model Exemplified

March 9, 2011 - 08:30 -- Kabogo Ndegwa
Author(s): 
Haynes, R. K., Cheu, K.-W., Tang, M. M.-K., Chen, M.-J., Guo, Z.-F., Guo, Z.-H., Coghi, P. and Monti, D
Reference: 
ChemMedChem, Special Issue: Rare & Neglected Diseases, Volume 6, Issue 2, pages 279–291, February 7, 2011

Flavin adenine dinucleotide (FAD) is reduced by NADPH–E. coli flavin reductase (Fre) to FADH2 in aqueous buffer at pH 7.4 under argon.

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Open Access | Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure

March 9, 2011 - 08:26 -- Kabogo Ndegwa
Author(s): 
Codd A, Teuscher F, Kyle DE, Cheng Q, Gatton ML
Reference: 
Malaria Journal 2011, 10:56 (8 March 2011)

Although further studies are required to confirm dormancy in vivo, this theoretical study adds support for the hypothesis, highlighting the potential role of this parasite sub-population in treatment failure following monotherapy and reinforcing the importance of using ART in combination with other anti-malarials.

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Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)

March 9, 2011 - 08:22 -- Patrick Sampao
Author(s): 
Vinay Bulusu, Suman S. Thakur, Roopa Venkatachala, Hemalatha Balaram
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 1, May 2011, Pages 1-11

As AICAR and ZMP are metabolites in the human serum and erythrocytes, our studies reported here throw light on their possible role in disease susceptibility, and also suggests the possibility of AICAR being a potential prophylactic or chemotherapeutic anti-malarial compound.

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2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites

March 9, 2011 - 08:21 -- Kabogo Ndegwa
Author(s): 
Swetlana, Heinrich Mirko, Altenkämper Benjamin, Bechem Johann, Perruchon Regina, Ortmann Hans-Martin, Dahse Yulin, Wang Michael, Lanzer Martin, Schlitzer
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 4, April 2011, Pages 1331-1342

Through the replacement of the 5-acylamino moiety by simple chlorine and further modifications of the 2-acylamino residue we could obtain inhibitors with improved selectivity towards malaria parasites combined with an acceptable reduction of antimalarial activity.

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Open Access | Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study

March 9, 2011 - 08:17 -- Kabogo Ndegwa
Author(s): 
Muema DK, Ndungu FM, Kinyanjui SM, Berkley JA
Reference: 
Malaria Journal 2011, 10:55 (5 March 2011)

In children with severe malaria, HIV infection is associated with a lower magnitude and narrower breadth of IgG responses to merozoite antigens and stunting of age-related acquisition of the IgG antibody response to schizont extract.

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Short Communication: Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes

March 9, 2011 - 08:14 -- Patrick Sampao
Author(s): 
Gordon A. Awandare, Carmenza Spadafora, J. Kathleen Moch, Sheetij Dutta, J. David Haynes, José A. Stoute
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 1, May 2011, Pages 57-60

To determine the role of CR1 in erythrocyte invasion among P. falciparum field isolates, we tested eight isolates obtained from children in Kenya.

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Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids

March 9, 2011 - 08:13 -- Kabogo Ndegwa
Author(s): 
Marli C. Lombard, David D. N’Da, Jaco C. Breytenbach, Peter J. Smith, Carmen A. Lategan
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 6, 15 March 2011, Pages 1683-1686c

Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids 9–14, which were then treated with oxalic acid to form oxalate salts (9a–14a).

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection

March 9, 2011 - 08:08 -- Patrick Sampao
Author(s): 
Suresh M. Ganesan., Joanne M. Morrisey.,Akhil B. Vaidya., et al.
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 1, May 2011, Pages 29-34

As a proof of concept, we have successfully disrupted the type II vacuolar proton-pumping pyrophosphatase gene (PfVP2) in P. falciparum by double crossover recombination, showing that this gene is not essential for the survival of blood stage parasites.

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Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance

March 9, 2011 - 08:01 -- Patrick Sampao
Author(s): 
Louise M. Hughes, Charlotte A. Lanteri, Michael T. O’Neil, Jacob D. Johnson, Gordon W. Gribble, Bernard L. Trumpower
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 1, May 2011, Pages 12-19

In order to determine the optimal parameters required for inhibition of respiration in parasites and pathogenic fungi and overcome drug resistance, we have synthesized and tested the inhibitory activity of novel hydroxy-naphthoquinones against blood stage P. falciparum and liver stage P. berghei and against cytochrome bc1 complexes isolated from yeast strains bearing mutations in cytochrome b associated with resistance in Plasmodium, Pneumocystis, and Toxoplasma.

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