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Scientific Articles

Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities

December 22, 2009 - 12:32 -- Patrick Sampao
Author(s): 
Johanna Faist, Werner Seebacher, Marcel Kaiser, Reto Brun, Robert Saf, Robert Weis
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 1, January 2010, Pages 179-185

N-Alkyl and N-(2-dialkylaminoethyl) derivatives of 5-amino-2-azabicyclo-nonanes were prepared and tested in vitro for their activities against the multidrug-resistant K1 strain of Plasmodium falciparum and Trypanosoma brucei rhodesiense (STIB 900).

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Plasmodium Sporozoite Motility Is Modulated by the Turnover of Discrete Adhesion Sites

December 22, 2009 - 12:21 -- Patrick Sampao
Author(s): 
Sylvia Münter, Benedikt Sabass, Christine Selhuber-Unkel, Mikhail Kudryashev, Stephan Hegge, Ulrike Engel, Joachim P. Spatz, Kai Matuschewski, Ulrich S. Schwarz, Friedrich Frischknecht
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Cell Host & Microbe, Volume 6, Issue 6, 17 December 2009, Pages 551-562

Here, we show that sporozoite motility is characterized by a continuous sequence of stick-and-slip phases.

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Open Access| Residual Antimalarials in Malaria Patients from Tanzania – Implications on Drug Efficacy Assessment and Spread of Parasite Resistance

December 22, 2009 - 12:06 -- Ingeborg van Schayk
Author(s): 
Hodel EM, Kabanywanyi AM, Malila A, Zanolari B, Mercier T, et al.
Reference: 
PLoS ONE 4(12): e8184

We report the findings from baseline plasma sampling of malaria patients prior to inclusion into an in vivo study in Tanzania and discuss the implications of residual concentrations of antimalarials in this setting.

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Open Access | IgG Autoantibody to Brain Beta Tubulin III Associated with Cytokine Cluster-II Discriminate Cerebral Malaria in Central India

December 22, 2009 - 11:54 -- Ingeborg van Schayk
Author(s): 
Bansal D, Herbert F, Lim P, Deshpande P, Bécavin C, et al.
Reference: 
PLoS ONE 4(12): e8245

We extended our analysis to an Indian population with genetic backgrounds and endemic and environmental status different from Africa to determine if these autoantibodies could be either a biomarker or a risk factor of developing CM.

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Open Access | High Antibody Titer against Apical Membrane Antigen-1 Is Required to Protect against Malaria in the Aotus Model

December 22, 2009 - 11:48 -- Ingeborg van Schayk
Author(s): 
Dutta S, Sullivan JS, Grady KK, Haynes JD, Komisar J, et al.
Reference: 
PLoS ONE 4(12): e8138

A Plasmodium falciparum 3D7 strain Apical Membrane Antigen-1 (AMA1) vaccine, formulated with AS02A adjuvant, slowed parasite growth in a recent Phase 1/2a trial, however sterile protection was not observed. We tested this AS02A, and a Montanide ISA720 (ISA) formulation of 3D7 AMA1 in Aotus monkeys.

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Open Access | Optimizing Odor-Baited Trap Methods for Collecting Mosquitoes during the Malaria Season in The Gambia

December 22, 2009 - 11:43 -- Ingeborg van Schayk
Author(s): 
Musa Jawara, Renate C. Smallegange, David Jeffries, Davis C. Nwakanma, Taiwo Samson Awolola, Bart G. J. Knols, Willem Takken, David J. Conway
Reference: 
PLoS ONE 4(12): e8167

To optimize the use of counter-flow traps baited with human odor (nylon socks that had been worn for a single day) to capture wild mosquitoes in the Gambia, investigations were conducted at a field experimental site.

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Novel Putative Glycosylphosphatidylinositol-Anchored Micronemal Antigen of Plasmodium falciparum That Binds to Erythrocytes

December 22, 2009 - 11:35 -- Ingeborg van Schayk
Author(s): 
Louise Hinds, Judith L. Green, Ellen Knuepfer, Munira Grainger, and Anthony A. Holder
Reference: 
Eukaryotic Cell 2009;8 1869-1879

We have identified a new Plasmodium falciparum erythrocyte binding protein that appears to be located in the micronemes of the merozoite stage of the parasite and membrane linked through a glycosylphosphatidylinositol (GPI) anchor.

Coagulation Status and Platelet Functions in Children with Severe Falciparum Malaria and their Correlation of Outcome

December 21, 2009 - 12:08 -- Ingeborg van Schayk
Tags: 
Author(s): 
Rajniti Prasad, B. K. Das, Rahul Pengoria, Om P. Mishra, Jyoti Shukla, and Tej B. Singh
Reference: 
J Trop Pediatr 2009 55: 374-378; doi:10.1093/tropej/fmp028

This study was undertaken to observe the changes in coagulation and platelet profile, and findings were correlated with their outcome.

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Land Use and Land Cover Changes and Spatiotemporal Dynamics of Anopheline Larval Habitats during a Four-Year Period in a Highland Community of Africa

December 18, 2009 - 16:45 -- Ingeborg van Schayk
Author(s): 
Stephen Munga, Laith Yakob, Emmanuel Mushinzimana, Guofa Zhou, Tom Ouna, Noboru Minakawa, Andrew Githeko, AND Guiyun Yan
Reference: 
Am J Trop Med Hyg 2009;81 1079-1084

Land-use changes in the study area are favorable to An. gambiae larval development, thereby risking a more widespread distribution of malaria vector habitats and potentially increasing malaria transmission in western Kenya highlands.

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