The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 9990 malaria professionals are enjoying the free benefits of MalariaWorld today

Scientific Articles

Case report: Histopathology of Fatal Respiratory Distress Caused by Plasmodium vivax Malaria

November 10, 2009 - 21:20 -- Ingeborg van Schayk
Tags: 
Author(s): 
Neena Valecha, Rock G. W. Pinto, Gareth D. H. Turner, Ashwani Kumar, Savio Rodrigues, Nagesh G. Dubhashi, Edmond Rodrigues, Sidhartha S. Banaulikar, Ruchi Singh, Aditya P. Dash, AND J. Kevin Baird
Reference: 
Am J Trop Med Hyg 2009;81 758-762

An otherwise healthy 20-year-old woman in Goa, India, received antibiotics after a diagnosis of upper respiratory tract infection. In this patient, vivax malaria caused a rapidly fatal respiratory distress.

 

Country: 
City: 

Short report: Malaria Diagnosis by a Polymerase Chain Reaction–Based Assay Using a Pooling Strategy

November 10, 2009 - 21:04 -- Ingeborg van Schayk
Tags: 
Author(s): 
Ajay R. Bharti, Scott L. Letendre, Kailash P. Patra, Joseph M. Vinetz, AND Davey M. Smith
Reference: 
Am J Trop Med Hyg 2009;81 754-757

Pooling clinical specimens reduces the number of assays needed when screening for infectious diseases. Polymerase chain reaction (PCR)-based assays are the most sensitive tests to diagnose malaria, but its high cost limits its use.

 

Medical Treatment: 

Sex Affects the Steady-State Pharmacokinetics of Primaquine but Not Doxycycline in Healthy Subjects

November 10, 2009 - 20:57 -- Ingeborg van Schayk
Author(s): 
Vu Quoc Binh, Nguyen Trong Chinh, Nguyen Xuan Thanh, Bui Tri Cuong, Nguyen Ngoc Quang, Bui Dai, Thomas Travers, AND Michael D. Edstein
Reference: 
Am J Trop Med Hyg 2009;81 747-753

The primaquine pharmacokinetic data suggest that women have increased exposure to primaquine, which may put them at increased risk for toxicity when administered the same maintenance dose as men. The similar pharmacokinetics of doxycycline between the two sexes justifies the same maintenance dose.

 

Technology: 
Person: 
Medical Treatment: 

Case report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors

November 10, 2009 - 20:48 -- Ingeborg van Schayk
Author(s): 
Sócrates Herrera, Olga Fernández, María R. Manzano, Bermans Murrain, Juana Vergara, Pedro Blanco, Ricardo Palacios, Juan D. Vélez, Judith E. Epstein, Mario Chen-Mok, Zarifah H. Reed, AND Myriam Arévalo-Herrera
Reference: 
Am J Trop Med Hyg 2009;81 740-746

In conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2–10 An. albimanus mosquitoes carrying P. vivax sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.

 

Technology: 
Person: 
Medical Condition: 

Multiple functions of human T cells generated by experimental malaria challenge

November 10, 2009 - 20:40 -- Ingeborg van Schayk
Author(s): 
Stephen M. Todryk, Michael Walther, Philip Bejon, Claire Hutchings, Fiona M. Thompson, Britta C. Urban, David W. Porter, Adrian V. S. Hill
Reference: 
European Journal of Immunology, Volume 39 Issue 11, Pages 3042 – 3051

In this study, cellular immune responses were investigated in individuals receiving Plasmodium falciparum sporozoite challenge by the natural (mosquito bite) route as part of a malaria vaccine efficacy trial. 

 

Technology: 
Medical Condition: 
Medical Treatment: 

Comparative Transcriptional and Genomic Analysis of Plasmodium falciparum Field Isolates

November 10, 2009 - 20:32 -- Ingeborg van Schayk
Tags: 
Author(s): 
Mackinnon MJ, Li J, Mok S, Kortok MM, Marsh K, et al.
Reference: 
PLoS Pathog 5(10): e1000644

Mechanisms for differential regulation of gene expression may underlie much of the phenotypic variation and adaptability of malaria parasites. Here we describe transcriptional variation among culture-adapted field isolates of Plasmodium falciparum, the species responsible for most malarial disease.

 

Opinion: Malaria Vaccines: Where Next?

November 10, 2009 - 20:26 -- Ingeborg van Schayk
Tags: 
Author(s): 
Holder AA
Reference: 
PLoS Pathog 5(10): e1000638

A malaria vaccine for mass immunization, which could be delivered cheaply and widely and provide long lasting protection, would have a massive effect on global public health. However, such a vaccine does not currently exist.

 

Medical Treatment: 

A Distinct Peripheral Blood Monocyte Phenotype Is Associated with Parasite Inhibitory Activity in Acute Uncomplicated Plasmodium falciparum Malaria

November 10, 2009 - 20:12 -- Ingeborg van Schayk
Tags: 
Author(s): 
Chimma P, Roussilhon C, Sratongno P, Ruangveerayuth R, Pattanapanyasat K, et al.
Reference: 
PLoS Pathog 5(10): e1000631

Monocyte (MO) subpopulations display distinct phenotypes and functions which can drastically change during inflammatory states. We hypothesized that discrete MO subpopulations are induced during malaria infection and associated with anti-parasitic activity.

 

The Quantity and Quality of African Children's IgG Responses to Merozoite Surface Antigens Reflect Protection against Plasmodium falciparum Malaria

November 10, 2009 - 14:02 -- Ingeborg van Schayk
Tags: 
Author(s): 
Courtin D, Oesterholt M, Huismans H, Kusi K, Milet J, et al.
Reference: 
PLoS ONE 4(10): e7590

Our data are consistent with the idea that protection against P. falciparum malaria in children depends on acquisition of a constellation of appropriate, functionally active IgG subclass responses directed to multiple asexual stage antigens.

 

Person: 
Medical Condition: 
Medical Treatment: 

The Synthetic Plasmodium falciparum Circumsporozoite Peptide PfCS102 as a Malaria Vaccine Candidate: A Randomized Controlled Phase I Trial

November 10, 2009 - 13:53 -- Ingeborg van Schayk
Tags: 
Author(s): 
Audran R, Lurati-Ruiz F, Genton B, Blythman HE, Ofori-Anyinam O, et al.
Reference: 
PLoS ONE 4(10): e7304

PfCS102 peptide was safe and highly immunogenic, allowing the design of more advanced trials to test its potential for protection. Two or three immunizations with a dose of 30 µg formulated with AS02A appeared the most appropriate choice for such studies.

Technology: 
Medical Condition: 

Pages

Subscribe to Scientific Articles