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Scientific Articles

Microbial Immunity and Vaccines: Elevated Levels of the Plasmodium yoelii Homologue of Macrophage Migration Inhibitory Factor Attenuate Blood-Stage Malaria

November 16, 2010 - 10:02 -- Patrick Sampao
Author(s): 
Swati Thorat, Thomas M. Daly, Lawrence W. Bergman, and James M. Burns, Jr.
Reference: 
Infect. Immun., Dec 2010; 78: 5151 - 5162.

Combined, the data indicate that parasite-derived MIF does not contribute significantly to immunopathology but, through its chemotactic ability toward macrophages, may attenuate disease and prolong infection of highly virulent parasite isolates.

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Comparative responses of ovipositing Anopheles gambiae and Culex quinquefasciatus females to the presence of Culex egg rafts and larvae

November 16, 2010 - 09:18 -- Kabogo Ndegwa
Author(s): 
S. W. Wachira, M. Ndunb’u, P. G. N. Njagi, A. Hassanali
Reference: 
Medical and Veterinary Entomology, Volume 24, Issue 4, pages 369–374, December 2010

Field observations have demonstrated that gravid Anopheles gambiae Giles s.s. (Diptera: Culicidae) are selective in their choice of oviposition sites. For example, immature stages of An. gambiae s.s. are rarely found in water that contains Culex quinquefasciatus Say immatures.

An experimental hut evaluation of PermaNet® 3.0, a deltamethrin–piperonyl butoxide combination net, against pyrethroid-resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes in southern Benin

November 15, 2010 - 14:22 -- Patrick Sampao
Author(s): 
Raphael N’Guessan, Alex Asidi, Pelagie Boko, Abibatou Odjo, Martin Akogbeto, Olivier Pigeon, Mark Rowland
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 12, December 2010, Pages 758-765

An experimental hut trial comparing unwashed and 20 times washed PermaNet 3.0 and PermaNet 2.0, Olyset Net and a conventional deltamethrin-treated net washed three times was conducted in southern Benin.

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Towards eradication: three years after the tsunami of 2004, has malaria transmission been eliminated from the island of Simeulue?

November 15, 2010 - 14:07 -- Patrick Sampao
Author(s): 
Mohammad Sudomo, Yusniar Arianti, Isra Wahid, Din Safruddin, Erling M. Pedersen, J. Derek Charlwood
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 12, December 2010, Pages 777-781

The results indicate that despite the continuing presence of potential vectors in some places the anti-malaria measures introduced following the tsunami have controlled, and may be close to eliminating, malaria from the island.

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Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy (pages 495–503)

November 15, 2010 - 14:01 -- Patrick Sampao
Author(s): 
Quirijn De Mast., Philip G. De Groot., Andre J. Van Der Ven., et al.
Reference: 
British Journal of Haematology, Volume 151, Issue 5, pages 495–503, December 2010

We studied the aetiology of malaria-associated thrombocytopenia in volunteers experimentally infected with Plasmodium falciparum malaria, in Indonesian malaria patients and in ex vivo studies.

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Fast Track: Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

November 15, 2010 - 13:43 -- Patrick Sampao
Author(s): 
Arjen M Dondorp, Caterina I Fanello, Juliet Mwanga-Amumpaire et al.
Reference: 
The Lancet, Volume 376, Issue 9753, 13 November 2010-19 November 2010, Pages 1647-1657

These data, together with a meta-analysis of all trials comparing artesunate and quinine, strongly suggest that parenteral artesunate should replace quinine as the treatment of choice for severe falciparum malaria worldwide.

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Antimalarial drugs: Speeding to a new lead

November 15, 2010 - 11:36 -- Patrick Sampao
Author(s): 
Man Tsuey Tse
Reference: 
Nature Reviews Drug Discovery 9, 842 (November 2010)

A public–private partnership has identified a promising new antimalarial compound that is potently effective against a range of Plasmodium species — including some that are resistant to currently used agents — and possesses the pharmacokinetic properties needed to become a viable drug.

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