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Scientific Articles

Cell and Molecular Biology: Trafficking of the Phosphoprotein PfCRT to the Digestive Vacuolar Membrane in Plasmodium falciparum

January 6, 2010 - 12:50 -- Patrick Sampao
Author(s): 
Yvonne Kuhn, Cecilia P. Sanchez, Daniel Ayoub, Theodora Saridaki, Alain van Dorsselaer, Michael Lanzer
Reference: 
Traffic : Volume 11, Issue 2, Date: February 2010, Pages: 236-249

The digestive vacuole plays an important role in the pathophysiology of the human malaria parasite Plasmodium falciparum.

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Plasmodium falciparum acyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growth

January 6, 2010 - 12:42 -- Patrick Sampao
Author(s): 
John R. Gallagher, Sean T. Prigge
Reference: 
Proteins: Structure, Function, and Bioinformatics, Volume 78, Issue 3, Date: 15 February 2010, Pages: 575-588

Together, these results suggest that the apicoplast is a reducing compartment, as suggested by models of P. falciparum metabolism, and that PfACP is maintained in a reduced state during blood stage growth.

Structural and functional comparison of MIF ortholog from Plasmodium yoelii with MIF from its rodent host

January 6, 2010 - 12:36 -- Patrick Sampao
Author(s): 
Dingding Shao, Xiang Zhong, Yan-Feng Zhou, Zhifu Han, Yahui Lin, Zhensheng Wang, Lingyi Bu, Lianhui Zhang, Xiao-Dong Su, Heng Wang
Reference: 
Molecular Immunology, Volume 47, Issue 4, January 2010, Pages 726-737

These data suggest that PyMIF modulates host immune responses together with host MIF and has potential to prolong parasitemia or the chronicity of malaria infection.

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Open Access | Habitat suitability and ecological niche profile of major malaria vectors in Cameroon

January 5, 2010 - 21:00 -- Ingeborg van Schayk
Author(s): 
Diego Ayala, Carlo Costantini, Kenji Ose, Guy C Kamdem, Christophe Antonio-Nkondjio, Jean-Pierre Agbor, Parfait Awono-Ambene, Didier Fontenille, Frederic Simard
Reference: 
Malaria Journal 2009, 8:307 (23 December 2009)

The distribution of major malaria vectors in Cameroon is strongly affected by the impact of humans on the environment, with variables related to proximity to human settings being among the best predictors of habitat suitability.

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Open Access | Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to Plasmodium falciparum malaria

January 5, 2010 - 20:55 -- Ingeborg van Schayk
Author(s): 
Hayder A Giha, Amre Nasr, Nnaemeka C Iriemenam, David Arnot, Marita Troye-Blomberg, Thor G Theander, Klavs Berzins, Gehad ElGhazali, Janardan P Pandey
Reference: 
Malaria Journal 2009, 8:306 (22 December 2009)

The GM allotypes have significant influence on susceptibility to uncomplicated P. falciparum malaria and antigen-dependent influence on total IgG and IgG subclasses.

Open Access | Commentary: Drug procurement, the Global Fund and misguided competition policies

January 5, 2010 - 20:50 -- Ingeborg van Schayk
Author(s): 
Richard Tren, Kimberly Hess, Roger Bate
Reference: 
Malaria Journal 2009, 8:305 (22 December 2009)

In an effort to increase competition and decrease price, the Global Fund to Fight AIDS, Tuberculosis and Malaria recently began asking some grant recipients to use international competitive bidding processes for certain drug purchases.

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Plasmepsin 4-Deficient Plasmodium berghei Are Virulence Attenuated and Induce Protective Immunity against Experimental Malaria

December 30, 2009 - 08:13 -- Patrick Sampao
Author(s): 
Roberta Spaccapelo, Chris J. Janse, Sara Caterbi, Blandine Franke-Fayard{dagger, J. Alfredo Bonilla, Luke M. Syphard, Manlio Di Cristina, Tania Dottorini, Andrea Savarino, Antonio Cassone, Francesco Bistoni, Andrew P. Waters, John B. Dame and Andrea Crisanti
Reference: 
American Journal of Pathology. 2010; 176:205-217

Parasite blood-stage attenuation should help identify protective immune responses against malaria, unravel parasite-derived factors involved in malarial pathologies, such as cerebral malaria, and potentially pave the way for blood-stage whole organism vaccines.

Review: Vitamin B metabolism in Plasmodium falciparum as a source of drug targets

December 29, 2009 - 14:27 -- Patrick Sampao
Author(s): 
Ingrid B, John E. Hyde and Carsten Wrenger
Reference: 
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 35-43

This review summarizes and updates the current knowledge of vitamin B de novo synthesis and salvage in P. falciparum and focuses on their potential as targets for drug intervention.

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Update: Focusing on complement in the antiparasitic defense of mosquitoes

December 29, 2009 - 14:23 -- Patrick Sampao
Author(s): 
Gloria Volohonskya, Stefanie Steinerta and Elena A. Levashina
Reference: 
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 1-3

Identification of the components of the mosquito complement system now provides new focus for studies on the activation and control of this pathway, whose manipulation is expected to block malaria transmission at the vector level.

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Review: Heroes or villains? T regulatory cells in malaria infection

December 29, 2009 - 14:19 -- Patrick Sampao
Author(s): 
Anja Scholzen, Gabriela Minigo and Magdalena Plebanski
Reference: 
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 16-25

This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection.

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