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Scientific Articles

Open Access | Synergistic and Additive Effects of Epigallocatechin Gallate and Digitonin on Plasmodium Sporozoite Survival and Motility

January 14, 2010 - 11:57 -- Ingeborg van Schayk
Author(s): 
Janina K. Hellmann, Sylvia Münter, Michael Wink, Friedrich Frischknecht
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PLoS ONE 5(1): e8682

Most medicinal plants contain a mixture of bioactive compounds, including chemicals that interact with intracellular targets and others that can act as adjuvants to facilitate absorption of polar agents across cellular membranes.

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Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum

January 14, 2010 - 11:49 -- Ingeborg van Schayk
Author(s): 
Nurhidanatasha Abu Bakar, Nectarios Klonis, Eric Hanssen, Cherrine Chan, and Leann Tilley
Reference: 
JCS ePress online publication date 12 Jan 2010

The digestive vacuole of the malaria parasite Plasmodium falciparum is the site of haemoglobin digestion and haem detoxification, and is the target of chloroquine and other antimalarials.

Open Access | Acquisition of antibody isotypes against Plasmodium falciparum blood stage antigens in a birth cohort

January 14, 2010 - 11:31 -- Ingeborg van Schayk
Author(s): 
N. Duah, D. Miles, H. Whittle, D. Conway
Reference: 
Parasite Immunology, Volume 32 Issue 2, Pages 125 - 13

Information on the period during which infants lose their maternally derived antibodies to malaria and begin to acquire naturally their own immune responses against parasite antigens is crucial for understanding when malaria vaccines may be best administered.

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Evidence for Pleistocene Population Divergence and Expansion of Anopheles albimanus in Southern Central America

January 14, 2010 - 11:20 -- Ingeborg van Schayk
Author(s): 
Jose R. Loaiza, Marilyn E. Scott, Eldredge Bermingham, Jose Rovira, AND Jan E. Conn
Reference: 
Am J Trop Med Hyg 2010;82 156-164

The micro-geographic structure of Anopheles albimanus was studied in southern Central America using partial sequences of the mtDNA cytochrome oxidase subunit I gene (COI).

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Quality Assurance of Rapid Diagnostic Tests for Malaria in Routine Patient Care in Rural Tanzania

January 14, 2010 - 11:09 -- Ingeborg van Schayk
Author(s): 
Meredith L. McMorrow, M. Irene Masanja, Elizeus Kahigwa, Salim M. K. Abdulla, AND S. Patrick Kachur
Reference: 
Am J Trop Med Hyg 2010;82 151-155

We evaluated sensitivity and specificity of RDTs during routine use for malaria case management in peripheral health facilities.

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Brief report: HIV Protease Inhibitors, Indinavir or Nelfinavir, Augment Antimalarial Action of Artemisinin in vitro

January 14, 2010 - 11:06 -- Ingeborg van Schayk
Author(s): 
Lokesh C. Mishra, Amit Bhattacharya, Manish Sharma, AND Virendra K. Bhasin
Reference: 
Am J Trop Med Hyg 2010;82 148-150

Most malaria endemic regions are co-infested with HIV infection. 

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Brief report: Utility of a Point-of-Care Malaria Rapid Diagnostic Test for Excluding Malaria as the Cause of Fever among HIV-Positive Adults in Rural Rakai, Uganda

January 14, 2010 - 11:01 -- Ingeborg van Schayk
Author(s): 
Lisa A. Mills, Joseph Kagaayi, Gertrude Nakigozi, Ronald M. Galiwango, Joseph Ouma, Joseph P. Shott, Victor Ssempijja, Ronald H. Gray, Maria J. Wawer, David Serwadda, Thomas C. Quinn, AND Steven J. Reynolds
Reference: 
Am J Trop Med Hyg 2010;82 145-147

We compared results of a malaria rapid diagnostic test (Binax Now® Malaria, Binax-M, Inverness Medical Innovations, Inc., Waltham, MA) performed at rural mobile clinics in Uganda by clinicians evaluating febrile adult HIV patients to thick smear evaluated at a central laboratory by trained microscopists.

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A Randomized Trial of Artesunate Mefloquine versus Artemether Lumefantrine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Senegalese Children

January 14, 2010 - 10:55 -- Ingeborg van Schayk
Author(s): 
Babacar Faye, Jean Louis Ndiaye, Roger Tine, Khadim Sylla, Ali Gueye, Aminata Colle Lô, AND Oumar Gaye
Reference: 
Am J Trop Med Hyg 2010;82 140-144

An open randomized clinical trial study was carried out to compare efficacy and tolerability of artesunate mefloquine 25 mg/kg body weight (Artequin paediatric) versus artemether lumefantrine (Coartem) in the treatment of uncomplicated Plasmodium falciparum malaria in children.

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Brief report: Elevated Levels of Vascular Endothelial Growth Factor (VEGF) and Soluble Vascular Endothelial Growth Factor Receptor (VEGFR)-2 in Human Malaria

January 14, 2010 - 10:48 -- Ingeborg van Schayk
Author(s): 
Takahisa Furuta, Mikio Kimura, AND Naohiro Watanabe
Reference: 
Am J Trop Med Hyg 2010;82 136-139

This is the first report to suggest that the interaction of VEGF and sVEGFR-2 is involved in the host immune response to malarial infection and that malarial parasites induce VEGF secretion from human mast cells.

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The Effect of Malaria and Intestinal Helminth Coinfection on Birth Outcomes in Kumasi, Ghana

January 14, 2010 - 10:31 -- Ingeborg van Schayk
Author(s): 
Nelly J. Yatich, Pauline E. Jolly, Ellen Funkhouser, Tsiri Agbenyega, Julian C. Rayner, John E. Ehiri, Archer Turpin, Jonathan K. Stiles, William O. Ellis, Yi Jiang, AND Jonathan H. Williams
Reference: 
Am J Trop Med Hyg 2010;82 28-34

This study was conducted to investigate the effect of Plasmodium falciparum and intestinal helminth coinfection on maternal anemia and birth outcomes. 

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