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Scientific Articles

Open Access | Functional Memory B Cells and Long-Lived Plasma Cells Are Generated after a Single Plasmodium chabaudi Infection in Mice

December 23, 2009 - 09:21 -- Ingeborg van Schayk
Author(s): 
Ndungu FM, Cadman ET, Coulcher J, Nduati E, Couper E, et al.
Reference: 
PLoS Pathog 5(12): e1000690

The cellular mechanisms underlying B cell and antibody responses are difficult to study in human infections; therefore, we have investigated the kinetics, duration and characteristics of the Plasmodium-specific memory B cell response in an infection of P. chabaudi in mice.

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The comparative antimalarial properties of weak base and neutral synthetic ozonides

December 22, 2009 - 13:35 -- Patrick Sampao
Author(s): 
Yuanqing Tang, Sergio Wittlin, Susan A. Charman, Jacques Chollet, Francis C.K. Chiu, Julia Morizzi, Lisa M. Johnson, Josefina Santo Tomas, Christian Scheurer, Chistopher Snyder, Lin Zhou, Yuxiang Dong, William N. Charman, Hugues Matile, Heinrich Urwyler, Arnulf Dorn, Jonathan L. Vennerstrom
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 2, 15 January 2010, Pages 563-566

Thirty-three N-acyl 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. For these ozonides, weak base functional groups were not required for high antimalarial potency against Plasmodium falciparum in vitro, but were necessary for high antimalarial efficacy in Plasmodium berghei-infected mice. A wide range of Log P/DpH 7.4 values were tolerated, although more lipophilic ozonides tended to be less metabolically stable.

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Spurious Amplification of a Plasmodium vivax Small-Subunit RNA Gene by Use of Primers Currently Used To Detect P. knowlesi

December 22, 2009 - 13:32 -- Kabogo Ndegwa
Author(s): 
Mallika Imwong, Naowarat Tanomsing, Sasithon Pukrittayakamee, Nicholas P. J. Day, Nicholas J. White and Georges Snounou
Reference: 
Journal of Clinical Microbiology, December 2009, p. 4173-4175, Vol. 47, No. 12

The PCR primers commonly used to detect Plasmodium knowlesi infections in humans were found to cross-react stochastically with P. vivax genomic DNA. A nested primer set that targets one of the P. knowlesi small-subunit rRNA genes was validated for specificity and for sensitivity of detection of <10 parasite genomes.

Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines

December 22, 2009 - 13:19 -- Patrick Sampao
Author(s): 
Pierre Verhaeghe, Nadine Azas, Monique Gasquet, Sébastien Hutter, Christophe Ducros, Michèle Laget, Sylvain Rault, Pascal Rathelot, Patrice Vanelle
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 1, 1 January 2008, Pages 396-401

A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach.

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Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline–triazine conjugates

December 22, 2009 - 12:59 -- Patrick Sampao
Author(s): 
Sunny Manohar, Shabana I. Khan, Diwan S. Rawat
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 1, 1 January 2010, Pages 322-325

A series of 4-aminoquinoline–triazine conjugates with different substitution pattern have been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive and resistant strains of Plasmodium falciparum.

Antiplasmodial activity of piperazine sulfonamides

December 22, 2009 - 12:50 -- Patrick Sampao
Author(s): 
Derek C. Martyn, Joseph F. Cortese, Erin Tyndall, Justin Dick, Ralph Mazitschek, Benito Munoz, Jon Clardy
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 1, 1 January 2010, Pages 218-221

A high-throughput screening program identified two piperazine sulfonamides with activity against Plasmodium falciparum.

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Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines

December 22, 2009 - 12:41 -- Patrick Sampao
Author(s): 
Derek C. Martyn, Amarjit Nijjar, Cassandra A. Celatka, Ralph Mazitschek, Joseph F. Cortese, Erin Tyndall, Hanlan Liu, Maria M. Fitzgerald, Thomas J. O’Shea, Sanjay Danthi, Jon Clardy
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 1, 1 January 2010, Pages 228-231

Two sets of diaminopyrimidines, totalling 45 compounds, were synthesized and assayed against Plasmodium falciparum.

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Antimalarial activity of azadipeptide nitriles

December 22, 2009 - 12:36 -- Patrick Sampao
Author(s): 
Reik Löser, Jiri Gut, Philip J. Rosenthal, Maxim Frizler, Michael Gütschow, Katherine T. Andrews
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 1, 1 January 2010, Pages 252-255

These first generation azadipeptide nitriles represent a promising new class of compounds for antimalarial drug development.

Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities

December 22, 2009 - 12:32 -- Patrick Sampao
Author(s): 
Johanna Faist, Werner Seebacher, Marcel Kaiser, Reto Brun, Robert Saf, Robert Weis
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 1, January 2010, Pages 179-185

N-Alkyl and N-(2-dialkylaminoethyl) derivatives of 5-amino-2-azabicyclo-nonanes were prepared and tested in vitro for their activities against the multidrug-resistant K1 strain of Plasmodium falciparum and Trypanosoma brucei rhodesiense (STIB 900).

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Plasmodium Sporozoite Motility Is Modulated by the Turnover of Discrete Adhesion Sites

December 22, 2009 - 12:21 -- Patrick Sampao
Author(s): 
Sylvia Münter, Benedikt Sabass, Christine Selhuber-Unkel, Mikhail Kudryashev, Stephan Hegge, Ulrike Engel, Joachim P. Spatz, Kai Matuschewski, Ulrich S. Schwarz, Friedrich Frischknecht
Reference: 
Cell Host & Microbe, Volume 6, Issue 6, 17 December 2009, Pages 551-562

Here, we show that sporozoite motility is characterized by a continuous sequence of stick-and-slip phases.

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