The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10034 malaria professionals are enjoying the free benefits of MalariaWorld today

Scientific Articles

Shape- and Chemical Feature-Based 3D-Pharmacophore Model Generation and Virtual Screening: Identification of Potential Leads for P. falciparum DHFR Enzyme Inhibition

December 3, 2009 - 11:57 -- Patrick Sampao
Author(s): 
Legesse Adane, Dhilon. S. Patel, Prasad V. Bharatam.
Reference: 
Chemical Biology & Drug Design ,Volume 75, Issue 1, Date: January 2010, Pages: 115-126

Plasmodium falciparum dihydrofolate reductase (Pf DHFR) enzyme is one of the validated targets in the treatment of malaria using typical antifolates such as cycloguanil and pyrimethamine. 

Medical Condition: 
Medical Treatment: 

Case Report: A case series of splenic infarction during acute malaria in northwest Rajasthan, India

December 3, 2009 - 11:51 -- Patrick Sampao
Author(s): 
B.K. Gupta, Kapil Sharma, K.C. Nayak, T.D. Agrawal, Anand Binani, V.P. Purohit, D.K. Kochar
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 1, January 2010, Pages 81-83, doi:10.1016/j.trstmh.2009.05.015

Here we report a series of four acute malaria patients with splenic infarction, two with P. vivax infection, one with P. falciparum and one with a mixed infection (P. vivax and P. falciparum). 

Country: 
Medical Condition: 

Open Access | Case report: Plasmodium malariae in Bangladesh

December 3, 2009 - 11:47 -- Patrick Sampao
Tags: 
Author(s): 
W. Rahman, K. Chotivanich, K. Silamut, N. Tanomsing, A. Hossain, M.A. Faiz, A.M. Dondorp, R.J. Maude
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 1, January 2010, Pages 78-80, doi:10.1016/j.trstmh.2009.06.014

We describe a 32-year-old Bangladeshi male presenting with severe malaria caused by a mono-infection with Plasmodium malariae. 

Technology: 
Country: 
Medical Condition: 

An imported case of P. falciparum malaria presenting as black water fever with acute renal failure

December 3, 2009 - 09:51 -- Patrick Sampao
Author(s): 
Fahmi Yousef Khan, Dalia Al-Haddada
Reference: 
Travel Medicine and Infectious Disease, Volume 7, Issue 6, November 2009, Pages 378-380, doi:10.1016/j.tmaid.2009.11.002

This is a report of a case of blackwater fever in a 28-year-old Nigerian man who was admitted to hospital with fever, jaundice and passing dark urine. Abdominal examination revealed splenomegaly and an examination of the peripheral smear of the patient showed the ring form of the trophozoites of Plasmodium falciparum (P. falciparum). Serum creatinine was 200 μmol/L. Treatment with quinine and doxycycline was started and intravenous fluids were administered with close monitoring of the urine output and serum electrolytes.

Evaluation of simian adenoviral vector AdCh63 expressing MSP-1 as a candidate blood-stage malaria vaccine

December 3, 2009 - 09:34 -- Patrick Sampao
Tags: 
Author(s): 
Anna Goodman, Sarah Gilbert, Stefano Colloca, Matthew Dicks, Adrian Hill, Simon Draper
Reference: 
Journal of Infection, Volume 59, Issue 6, December 2009, Pages S427-S428, doi:10.1016/j.jinf.2009.10.008

No abstract available.

Medical Condition: 
Medical Treatment: 

Spurious Amplification of a Plasmodium vivax Small-Subunit RNA Gene by Use of Primers Currently Used To Detect P. knowlesi

December 3, 2009 - 09:28 -- Patrick Sampao
Author(s): 
Mallika Imwong, Naowarat Tanomsing, Sasithon Pukrittayakamee, Nicholas P. J. Day, Nicholas J. White, and Georges Snounou
Reference: 
Journal of Clinical Microbiology, December 2009, p. 4173-4175, Vol. 47, No. 12, doi:10.1128/JCM.00811-09

A nested primer set that targets one of the P. knowlesi small-subunit rRNA genes was validated for specificity and for sensitivity of detection of <10 parasite genomes.

Nitric oxide is an essential component of the hemocyte-mediated mosquito immune response against bacteria

December 3, 2009 - 09:22 -- Patrick Sampao
Author(s): 
Julián F. Hillyer, Tania Y. Estévez-Lao
Reference: 
Developmental & Comparative Immunology, Volume 34, Issue 2, February 2010, Pages 141-149, doi:10.1016/j.dci.2009.08.014

Here, we characterized the temporal and spatial expression of the Anopheles gambiae nitric oxide synthase gene and explored the role nitric oxide plays in the antibacterial response in the mosquito hemocoel.

Lessons learned: Difficulties in organizing first indoor spray programme against malaria in Angola under the President’s Malaria Initiative

December 2, 2009 - 09:39 -- Ingeborg van Schayk
Author(s): 
Martinho Somandjinga a, Manuel Lluberas b & William R Jobin c
Reference: 
Bulletin of the World Health Organization 2009;87:871-874. doi: 10.2471/BLT.08.052514

The first PMI programme to control malaria in Africa failed to have an impact in southern Angola because of hurried and inadequate preparation, based primarily on administrative reports of malaria prevalence.

Technology: 
Organization: 
Country: 
Medical Condition: 

Parasite threshold associated with clinical malaria in areas of different transmission intensities in north eastern Tanzania

November 30, 2009 - 15:03 -- Ingeborg van Schayk
Author(s): 
Bruno P Mmbando, John P Lusingu, Lasse S Vestergaard, Martha M Lemnge, Thor G Theander and Thomas H Scheike
Reference: 
BMC Medical Research Methodology 2009, 9:75 doi:10.1186/1471-2288-9-75

This paper describes step function and dose response model with threshold parameter as a tool for estimation of parasite threshold for onset of malaria fever in highlands (low transmission) and lowlands (high transmission intensity) strata.

Country: 
Medical Condition: 

Pages

Subscribe to Scientific Articles