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Scientific Articles

Open Access | Comment: Malignant malaria and microangiopathies: merging mechanisms

February 25, 2010 - 13:12 -- Kabogo Ndegwa
Author(s): 
José A. López
Reference: 
Blood, 18 February 2010, Pages 1317-1318, Volume. 115, No. 7

In this issue of Blood, Bridges and colleagues report that Plasmodium falciparum–infected erythrocytes are able to attach to the endothelial surface by binding platelet-decorated VWF strands in a CD36-dependent fashion, revealing a new mechanism for erythrocyte cytoadherence in malaria

Systematic review: Cochrane Review highlights the need for more targeted research on the tolerability of malaria chemoprophylaxis in travellers

February 25, 2010 - 12:46 -- Ingeborg van Schayk
Author(s): 
Patricia Schlagenhauf
Reference: 
Evid Based Med 2010;15:25-26

Commentary on:

Jacquerioz FA, Croft AM . Drugs for preventing malaria in travellers. Cochrane Database Syst Rev 2009:CD006491.

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Anopheles hervyi in Niger: no evidence for a role in Plasmodium falciparum transmission

February 24, 2010 - 10:50 -- Ingeborg van Schayk
Author(s): 
R. Labbo, C. Czeher, A. Djibrila, I. Arzika, I. Jeanne, J.B. Duchemin
Reference: 
Medical and Veterinary Entomology, Volume 24 Issue 1, Pages 62 - 65

In the present study, the use of CDC light traps showed it to be much more abundant than previously found but there was no evidence to suggest it was a malaria vector in this region.

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Modeling Erythropoiesis Subject to Malaria Infection

February 24, 2010 - 10:01 -- Ingeborg van Schayk
Author(s): 
Jeremy J. Thibodeaux
Reference: 
Mathematical Biosciences, In Press, Accepted Manuscript, Available online 12 February 2010

A mathematical model of erythropoiesis subject to malaria infection is developed by combining ideas from previous models that addressed only one of the two phenomena.

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Open Access | Universal Features of Post-Transcriptional Gene Regulation Are Critical for Plasmodium Zygote Development

February 24, 2010 - 09:46 -- Ingeborg van Schayk
Author(s): 
Gunnar R. Mair, Edwin Lasonder, Lindsey S. Garver, Blandine M. D. Franke-Fayard, Céline K. Carret, Joop C. A. G. Wiegant, Roeland W. Dirks, George Dimopoulos, Chris J. Janse, Andrew P. Waters
Reference: 
PLoS Pathog 6(2): e1000767

Using affinity purification coupled with mass-spectrometric analysis we identify a messenger ribonucleoprotein (mRNP) from Plasmodium berghei gametocytes defined by DOZI and the Sm-like factor CITH (homolog of worm CAR-I and fly Trailer Hitch).

Open Access | On the Diversity of Malaria Parasites in African Apes and the Origin of Plasmodium falciparum from Bonobos

February 23, 2010 - 12:13 -- Ingeborg van Schayk
Author(s): 
Krief S, Escalante AA, Pacheco MA, Mugisha L, André C, et al.
Reference: 
PLoS Pathog 6(2): e1000765

Finally, our data and that of others indicated that chimpanzees and bonobos maintain malaria parasites, to which humans are susceptible, a factor of some relevance to the renewed efforts to eradicate malaria.

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Open Access | Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine

February 23, 2010 - 12:02 -- Ingeborg van Schayk
Author(s): 
Jianping Song, Duong Socheat, Bo Tan, Prak Dara, Changsheng Deng, Sreng Sokunthea, Suon Seila, Fengzhen Ou, Huaxiang Jian, Guoqiao Li
Reference: 
Malaria Journal 2010, 9:57 (23 February 2010)

This is an important paper which demonstrates the utility of a mass drug treatment approach to malaria control in areas of relatively high transmission in south-western Cambodia.

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Open Access | Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon

February 19, 2010 - 15:53 -- Ingeborg van Schayk
Author(s): 
Solange Whegang Youdom, Rachida Tahar, Vincent Foumane Ngane, Georges Soula, Henri Gwet, Jean-Christophe Thalabard, Leonardo K Basco
Reference: 
Malaria Journal 2010, 9:56 (19 February 2010)

The relative effectiveness of various drug combinations was compared by a multi-treatment Bayesian random-effect meta-analysis.

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Plasmodium falciparum: In vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin

February 19, 2010 - 12:36 -- Kabogo Ndegwa
Author(s): 
Kirti Mishra, Dipjyoti Chakraborty, Amita Pal, Nrisingha Dey
Reference: 
Experimental Parasitology, Volume 124, Issue 4, April 2010, Pages 421-427

Quassia amara L. (Family Simaroubaceae) is known to have several medicinal properties including the activity against malaria. An HPLC method was employed for purification of the biologically active quassinoids; quassin (Q) and neo-quassin (NQ), further characterized by MALDI-TOF analyses.

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