A series of novel chalcones bearing acridine moiety attached to the amino group in their ring A have been synthesized through noncatalyzed nucleophilic aromatic substitution reaction between various 3′-aminochalcone or 4′-aminochalcones and 9-chloroacridine.
A series of 1,3,5-trisubstituted pyrazolines were synthesized and evaluated for in vitro antimalarial efficacy against chloroquine sensitive (MRC-02) as well as chloroquine resistant (RKL9) strains of Plasmodium falciparum.
The multistep synthesis of new quinazoline-derived molecules and their in vitro antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is described herein. These molecules have also been studied concerning their in vitro cytotoxicity toward two human cell lines (K652 and HepG2) in order to calculate their respective selectivity indexes (S.I.).
Structural studies of proteins by hydrogen/deuterium exchange coupled to mass spectrometry (DXMS) require the use of proteases working at acidic pH and low temperatures.
In this study Macaca fascicularis was used as a model to understand the host response to P. knowlesi using parasitological and haematological parameters.
Defining the trend in genotypes related to drug resistance is essential for the control of malaria in Vietnam.
A study which documents the association of placental malaria with restricted postnatal growth independent of low birthweight, a well-known cause of neonatal and infant mortality.
The manuscript contains valuable data on Anopheline species prevalence and their infection status in malaria epidemic-prone area in Bangladesh.
The need to identify biologically relevant and protective peptide sequences from Plasmodium falciparum proteins remains a very important area in malaria vaccine studies.
A useful contribution on severe vivax malaria in one municipality of the state of Rondonia in the Brazilian Amazon. This paper is a reminder that there is currently no WHO definition of severe vivax malaria, a disease substantially different from falciparum malaria.