The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10148 malaria professionals are enjoying the free benefits of MalariaWorld today

Scientific Articles

Synthesis of new chalcone derivatives containing acridinyl moiety with potential antimalarial activity

January 14, 2010 - 18:23 -- Kabogo Ndegwa
V. Tomar, G. Bhattacharjee, Kamaluddin, S. Rajakumar, Kumkum Srivastava, S.K. Puri
European Journal of Medicinal Chemistry, Volume 45, Issue 2, February 2010, Pages 745-751

A series of novel chalcones bearing acridine moiety attached to the amino group in their ring A have been synthesized through noncatalyzed nucleophilic aromatic substitution reaction between various 3′-aminochalcone or 4′-aminochalcones and 9-chloroacridine.


Synthesis and antimalarial evaluation of 1, 3, 5-trisubstituted pyrazolines

January 14, 2010 - 18:19 -- Kabogo Ndegwa
Badri Narayan Acharyaa, Deepika Saraswata, Mugdha Tiwaria, Asish Kumar Shrivastavaa, Ramarao Ghorpadea, Saroj Bapnab and Mahabir Parshad Kaushika
European Journal of Medicinal Chemistry Volume 45, Issue 2, February 2010, Pages 430-438

A series of 1,3,5-trisubstituted pyrazolines were synthesized and evaluated for in vitro antimalarial efficacy against chloroquine sensitive (MRC-02) as well as chloroquine resistant (RKL9) strains of Plasmodium falciparum.

Medical Treatment: 

Original quinazoline derivatives displaying antiplasmodial properties

January 14, 2010 - 18:13 -- Kabogo Ndegwa
Youssef Kabria, Nadine Azasb, Aurélien Dumètreb, Sébastien Hutterb, Michèle Lagetb, Pierre Verhaeghea, Armand Gellisa and Patrice Vanellea
European Journal of Medicinal Chemistry Volume 45, Issue 2, February 2010, Pages 616-622

The multistep synthesis of new quinazoline-derived molecules and their in vitro antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is described herein. These molecules have also been studied concerning their in vitro cytotoxicity toward two human cell lines (K652 and HepG2) in order to calculate their respective selectivity indexes (S.I.).

Investigating Alternative Acidic Proteases for H/D Exchange Coupled to Mass Spectrometry: Plasmepsin 2 but not Plasmepsin 4 Is Active Under Quenching Conditions

January 14, 2010 - 18:12 -- Kabogo Ndegwa
Julien Marcouxa, b, Eric Thierrya, Corinne Vivèsb, Luca Signora, Franck Fieschib and Eric Foresta
Journal of the American Society for Mass Spectrometry, Volume 21, Issue 1, January 2010, Pages 76-79

Structural studies of proteins by hydrogen/deuterium exchange coupled to mass spectrometry (DXMS) require the use of proteases working at acidic pH and low temperatures.

Medical Condition: 

In vivo study of human Plasmodium knowlesi in Macaca fascicularis

January 14, 2010 - 18:04 -- Kabogo Ndegwa
F. Anderios, A. NoorRain, I. Vythilingam
Experimental Parasitology, Volume 124, Issue 2, February 2010, Pages 181-189

In this study Macaca fascicularis was used as a model to understand the host response to P. knowlesi using parasitological and haematological parameters.

Medical Condition: 

Longitudinal Survey of Plasmodium falciparum Infection in Vietnam: Characteristics of Antimalarial Resistance and Their Associated Factors

January 14, 2010 - 17:54 -- Kabogo Ndegwa
Rie Isozumi, Haruki Uemura, Le Duc Dao, Truong Van Hanh, Nguyen Duc Giang, Ha Viet Vien, Bui Quang Phuc, Nguyen Van Tuan, and Shusuke Nakazawa
Journal of Clinical Microbiology, January 2010, p. 70-77, Vol. 48, No. 1

Defining the trend in genotypes related to drug resistance is essential for the control of malaria in Vietnam.


Open Access | Placental malaria is associated with reduced early life weight development of affected children independent of low birth weight

January 14, 2010 - 12:25 -- Ingeborg van Schayk
Brigitte Walther, David JC Miles, Sarah Crozier, Pauline Waight, Melba S Palmero, Olubukola Ojuola, Ebrima Touray, Marianne van der Sande, Hilton Whittle, Sarah Rowland-Jones, Katie L Flanagan
Malaria Journal 2010, 9:16 (14 January 2010)

 A study which documents the association of placental malaria with restricted postnatal growth independent of low birthweight, a well-known cause of neonatal and infant mortality.


Open Access | Prevalence of anopheline species and their Plasmodium infection status in epidemic-prone border areas of Bangladesh

January 14, 2010 - 12:20 -- Ingeborg van Schayk
Mohammad Shafiul Alam, Md. Gulam Musawwir Khan, Nurunnabi Chaudhury, Sharmina Deloer, Forida Nazib, A Mannan Bangali, Rashidul Haque
Malaria Journal 2010, 9:15 (14 January 2010)

The manuscript contains valuable data on Anopheline species prevalence and their infection status in malaria epidemic-prone area in Bangladesh.

Medical Condition: 

Open Access | Shift in epitope dominance of IgM and IgG responses to Plasmodium falciparum MSP1 block 4

January 14, 2010 - 12:13 -- Ingeborg van Schayk
Sandra P Chang, Alexander KK Kayatani, Zilka I Terrientes, Socrates Herrera, Rose GF Leke, Diane W Taylor
Malaria Journal 2010, 9:14 (13 January 2010)

The need to identify biologically relevant and protective peptide sequences from Plasmodium falciparum proteins remains a very important area in malaria vaccine studies.

Open Access | Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance

January 14, 2010 - 12:06 -- Ingeborg van Schayk
Bruno B Andrade, Antonio Reis-Filho, Sebastiao M Souza-Neto, Jorge Clarencio, Luis MA Camargo, Aldina Barral, Manoel Barral-Netto
Malaria Journal 2010, 9:13 (13 January 2010)

A useful contribution on severe vivax malaria in one municipality of the state of Rondonia in the Brazilian Amazon. This paper is a reminder that there is currently no WHO definition of severe vivax malaria, a disease substantially different from falciparum malaria.


Subscribe to Scientific Articles