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Scientific Articles

Open Access | Discovery of Plasmodium modulators by genome-wide analysis of circulating hemocytes in Anopheles gambiae

December 24, 2009 - 13:25 -- Ingeborg van Schayk
Author(s): 
Sofia B. Pinto, Fabrizio Lombardo, Anastasios C. Koutsos, Robert M. Waterhouse, Krista McKay, Chunju An, Chandra Ramakrishnan, Fotis C. Kafatos, and Kristin Michel
Reference: 
PNAS December 15, 2009 vol. 106 no. 50 21270-21275

We assess, via an RNAi screen, the roles in development of Plasmodium berghei of 63 genes expressed in hemocytes and provide a molecular comparison of the transcriptome of these cells during malaria infection.

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Open Access | Substantial Contribution of Submicroscopical Plasmodium falciparum Gametocyte Carriage to the Infectious Reservoir in an Area of Seasonal Transmission

December 24, 2009 - 13:05 -- Ingeborg van Schayk
Author(s): 
Ouédraogo AL, Bousema T, Schneider P, de Vlas SJ, Ilboudo-Sanogo E, et al.
Reference: 
PLoS ONE 4(12): e8410

Submicroscopical gametocyte carriage is common in an area of seasonal transmission in Burkina Faso and contributes substantially to the human infectious reservoir.

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Is the Scale Up of Malaria Intervention Coverage Also Achieving Equity?

December 24, 2009 - 12:59 -- Ingeborg van Schayk
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Author(s): 
Richard W. Steketee, Thomas P. Eisele
Reference: 
PLoS ONE 4(12): e8409

Reports were reviewed from nationally representative surveys in African malaria-endemic countries from 2006 through 2008 to understand how reported intervention coverage rates reflect access by the most at-risk populations.

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Open Access | Quantitative PCR Evaluation of Cellular Immune Responses in Kenyan Children Vaccinated with a Candidate Malaria Vaccine

December 24, 2009 - 12:55 -- Ingeborg van Schayk
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Author(s): 
Jedidah Mwacharo, Susanna J. Dunachie, Oscar Kai, Adrian V. S. Hill, Philip Bejon, Helen A. Fletcher
Reference: 
PLoS ONE 4(12): e8434

Quantitative PCR is a useful method for evaluating vaccine induced cell mediated immune responses in frozen PBMC from children in a malaria endemic country.

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Open Access | Interactions between Age and ITN Use Determine the Risk of Febrile Malaria in Children

December 24, 2009 - 12:50 -- Ingeborg van Schayk
Author(s): 
Philip Bejon, Edna Ogada, Norbert Peshu, Kevin Marsh
Reference: 
PLoS ONE 4(12): e8321

These data on age interactions with ITN use suggest that larger scale studies on the long term individual outcomes should be undertaken if the policy of targeted ITN use for vulnerable groups is to continue.

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Open Access | Transglutaminase-Mediated Semen Coagulation Controls Sperm Storage in the Malaria Mosquito

December 24, 2009 - 12:44 -- Ingeborg van Schayk
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Author(s): 
Rogers DW, Baldini F, Battaglia F, Panico M, Dell A, et al.
Reference: 
PLoS Biol 7(12): e1000272

Our data show that the mating plug is an important feature of An. gambiae reproduction, and reinforce the notion that a deeper understanding of mosquito reproductive biology can aid efforts to eradicate these disease vectors.

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Open Access | Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects

December 23, 2009 - 21:47 -- Ingeborg van Schayk
Author(s): 
Beesan Tan, Himanshu Naik, In-Jin Jang, Kyung-Sang Yu, Lee E Kirsch, Chang-Sik Shin, J Carl Craft, Lawrence Fleckenstein
Reference: 
Malaria Journal 2009, 8:304 (18 December 2009)

The population pharmacokinetics of artesunate (AS) and its active metabolite dihydroartemisinin (DHA) were studied in healthy subjects receiving single- or multiple-dosing of AS orally either in combination with pyronaridine (PYR) or as a monotherapy with or without food.

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Open Access | Chloroquine reduces arylsulphatase B activity and increases chondroitin 4-sulphate: implications for mechanisms of action and resistance

December 23, 2009 - 21:42 -- Ingeborg van Schayk
Author(s): 
Sumit Bhattacharyya, Kemal Solakyildirim, Zhenqing Zhang, Robert J Linhardt, Joanne K Tobacman
Reference: 
Malaria Journal 2009, 8:303 (17 December 2009)

If chloroquine reduced ASB activity, leading to increased chondroitin-4-sulphation, it was hypothesized that the anti-malarial mechanism of chloroquine might derive, at least in part, from suppression of ASB.

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Open Access | Cultured skin microbiota attracts malaria mosquitoes

December 23, 2009 - 21:35 -- Ingeborg van Schayk
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Author(s): 
Niels O Verhulst, Hans Beijleveld, Bart GJ Knols, Willem Takken, Gosse Schraa, Harro J Bouwmeester, Renate C Smallegange
Reference: 
Malaria Journal 2009, 8:302 (17 December 2009)

A study is presented in which the production and constituency of volatile organic compounds (VOCs) by human skin microbiota is examined and the behavioural responses of An. gambiae to VOCs from skin microbiota are investigated.

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