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Scientific Articles

Review: Evolutionary forces on Anopheles: what makes a malaria vector?

February 25, 2010 - 22:12 -- Kabogo Ndegwa
Author(s): 
Anna Cohuet, Caroline Harris, Vincent Robert, Didier Fontenille
Reference: 
Trends in Parasitology, Volume 26, Issue 3, March 2010, Pages 130-136

Here, we review key factors of vectorial capacity and competence in Anopheles, with a particular focus on the most important malaria vector Anopheles gambiae. 

Acquired immune response to defined Plasmodium vivax antigens in individuals residing in northern India

February 25, 2010 - 21:59 -- Kabogo Ndegwa
Author(s): 
Ratanesh K. Seth, Ajaz A. Bhat, Donthamsetty N. Rao, Sukla Biswas
Reference: 
Microbes and Infection, Volume 12, Issue 3, March 2010, Pages 199-206

In this investigation, we evaluated the naturally acquired immune response to Plasmodium vivax stage-specific antigens in individuals of different age groups belonging to malaria endemic areas of northern India.

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New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

February 25, 2010 - 21:46 -- Kabogo Ndegwa
Author(s): 
Satoru Tamura, Bruno Kilunga Kubata, Syamsurizal, Sawako Itagaki, Toshihiro Horii, Muzele Kalulu Taba, Nobutoshi Murakami
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 5, 1 March 2010, Pages 1520-1523

A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation.

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Antimalarial Asexual Stage-Specific and Gametocytocidal Activities of HIV Protease Inhibitors

February 25, 2010 - 21:41 -- Kabogo Ndegwa
Author(s): 
Christopher L. Peatey, Katherine T. Andrews, Nina Eickel, Timothy MacDonald, Alice S. Butterworth, Katharine R. Trenholme, Donald L. Gardiner, James S. McCarthy, and Tina S. Skinner-Adams
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 1334-1337, Volume. 54, No. 3

The stage-specific antimalarial activities of a panel of antiretroviral protease inhibitors (PIs), including two nonpeptidic PIs (tipranavir and darunavir), were tested in vitro against Plasmodium falciparum.

Probing the Antimalarial Mechanism of Artemisinin and OZ277 (Arterolane) with Nonperoxidic Isosteres and Nitroxyl Radicals

February 25, 2010 - 21:35 -- Kabogo Ndegwa
Author(s): 
Matthias A. Fügi, Sergio Wittlin, Yuxiang Dong, and Jonathan L. Vennerstrom
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 1042-1046, Volume 54, No. 3

Using combination experiments with cultured Plasmodium falciparum cells, we investigated the interactions of the nitroxide radical spin trap, 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), and four of its analogs with artemisinin and the ozonide drug development candidate OZ277.

Mechanisms of Resistance: Evidence of Selective Sweeps in Genes Conferring Resistance to Chloroquine and Pyrimethamine in Plasmodium falciparum Isolates in India

February 25, 2010 - 21:28 -- Kabogo Ndegwa
Author(s): 
Tonya Mixson-Hayden, Vidhan Jain, Neeru Singh et al.
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 997-1006, Volume 54, No. 3

We tested whether chloroquine- and antifolate drug-resistant genotypes would be more commonly associated with cases of cerebral malaria than with cases of mild malaria in the province of Jabalpur, India, by genotyping the dhps, dhfr, pfmdr-1, and pfcrt genes using pyrosequencing, direct sequencing, and real-time PCR.

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Pharmacology: Pharmacokinetics of Chloroquine and Monodesethylchloroquine in Pregnancy

February 25, 2010 - 20:54 -- Kabogo Ndegwa
Author(s): 
Harin A. Karunajeewa, Sam Salman, Ivo Mueller, Francisca Baiwog, Servina Gomorrai, Irwin Law,1 Madhu Page-Sharp, Stephen Rogerson, Peter Siba, Kenneth F. Ilett, and Timothy M. E. Davis
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 1186-1192, Volume 54, No. 3

Reduced plasma concentrations of both CQ and DECQ could compromise both curative efficacy and posttreatment prophylactic properties in pregnant patients. Higher IPTp CQ doses may be desirable but could increase the risk of adverse hemodynamic effects.

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In Vitro Sensitivities of Plasmodium falciparum to Different Antimalarial Drugs in Uganda

February 25, 2010 - 13:51 -- Kabogo Ndegwa
Author(s): 
Samuel L. Nsobya, Moses Kiggundu, Sarah Nanyunja, Moses Joloba, Bryan Greenhouse, and Philip J. Rosenthal
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 1200-1206, Volume 54, No. 3

The control of malaria is challenged by resistance of Plasmodium falciparum to multiple drugs. New combination regimens are now advocated for the treatment of uncomplicated falciparum malaria, but the extent of resistance to newer agents is incompletely understood.

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Open Access | Clinical Therapeutics: Amodiaquine Dosage and Tolerability for Intermittent Preventive Treatment To Prevent Malaria in Children

February 25, 2010 - 13:49 -- Kabogo Ndegwa
Author(s): 
M. Cairns, B. Cisse, C. Sokhna, C. Cames, K. Simondon, E. H. Ba, J.-F. Trape, O. Gaye, B. M. Greenwood, and P. J. M. Milligan
Reference: 
Antimicrobial Agents and Chemotherapy, March 2010, Pages 1265-1274, Volume 54, No. 3

We determined the association between amodiaquine dosage by body weight and mild adverse events (AEs) and investigated whether alternative age-based regimens could improve dosing accuracy and tolerability, using data from two trials of IPTc in Senegal, one in which AQ dose was determined by age and the other in which it was determined by weight category.

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Brief report: Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings

February 25, 2010 - 13:39 -- Kabogo Ndegwa
Author(s): 
Daniel J. Bridges, James Bunn, Jan A. van Mourik, Georges Grau, Roger J.S. Preston, Malcolm Molyneux, Valery Combes, James S. O'Donnell, Bas de Laat, and Alister Craig
Reference: 
Blood, 18 February 2010, Pages 1472-1474 Volume. 115. No. 7

During Plasmodium falciparum malaria infections, von Willebrand factor (VWF) levels are elevated, postmortem studies show platelets colocalized with sequestered infected erythrocytes (IEs) at brain microvascular sites, whereas in vitro studies have demonstrated platelet-mediated IE adhesion to tumor necrosis factor-activated brain endothelium via a bridging mechanism.

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