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Scientific Articles

In Vitro Activities of Piperaquine, Lumefantrine, and Dihydroartemisinin in Kenyan Plasmodium falciparum Isolates and Polymorphisms in pfcrt and pfmdr1

December 7, 2009 - 12:03 -- Ingeborg van Schayk
Author(s): 
Leah Mwai, Steven M. Kiara, Abdi Abdirahman, Lewa Pole, Anja Rippert, Abdi Diriye, Pete Bull, Kevin Marsh, Steffen Borrmann, and Alexis Nzila
Reference: 
Antimicrob. Agents Chemother. 2009;53 5069-5073

We have analyzed the in vitro chemosensitivity profiles of 115 Kenyan isolates for chloroquine (CQ), piperaquine, lumefantrine (LM), and dihydroartemisinin in association with polymorphisms in pfcrt at codon 76 and pfmdr1 at codon 86, as well as with variations of the copy number of pfmdr1.

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Characteristics of Genetic Hitchhiking around Dihydrofolate Reductase Gene Associated with Pyrimethamine Resistance in Plasmodium falciparum Isolates from India

December 7, 2009 - 11:58 -- Ingeborg van Schayk
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Author(s): 
Vanshika Lumb, Manoj K. Das, Neeru Singh, Vas Dev, Wajihullah, and Yagya D. Sharma
Reference: 
Antimicrob. Agents Chemother. 2009;53 5173-5180

To study the origin and evolution of pyrimethamine resistance on the Indian subcontinent, microsatellite markers flanking the pfdhfr gene were mapped.

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Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

December 7, 2009 - 11:51 -- Ingeborg van Schayk
Author(s): 
Pedro A. Moura, John B. Dame, and David A. Fidock
Reference: 
Antimicrob. Agents Chemother. 2009;53 4968-4978

Hemoglobin (Hb) degradation is essential for the growth of the intraerythrocytic stages of malarial parasites.

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Inhibition of Erythrocyte Invasion and Plasmodium falciparum Merozoite Surface Protein 1 Processing by Human Immunoglobulin G1 (IgG1) and IgG3 Antibodies

December 7, 2009 - 11:26 -- Ingeborg van Schayk
Author(s): 
Maria Lazarou, Jose A. Guevara Patino, Richard M. Jennings, Richard S. McIntosh, Jianguo Shi, Steven Howell, Eilish Cullen, Tarran Jones, Jaime R. Adame-Gallegos, Jonathan A. Chappel, Jana S. McBride, Michael J. Blackman, Anthony A. Holder, and Richard J. Pleass
Reference: 
Infect. Immun. 2009;77 5659-5667

Antigen-specific antibodies (Abs) to the 19-kDa carboxy-terminal region of Plasmodium falciparum merozoite surface protein 1 (MSP119) play an important role in protective immunity to malaria.

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Vaccine Potentials of an Intrinsically Unstructured Fragment Derived from the Blood Stage-Associated Plasmodium falciparum Protein PFF0165c

December 7, 2009 - 11:20 -- Ingeborg van Schayk
Author(s): 
S. Olugbile, C. Kulangara, G. Bang, S. Bertholet, E. Suzarte, V. Villard, G. Frank, R. Audran, A. Razaname, I. Nebie, O. Awobusuyi, F. Spertini, A. V. Kajava, I. Felger, P. Druilhe, and G. Corradin
Reference: 
Infect. Immun. 2009;77 5701-5709

We have identified new malaria vaccine candidates through the combination of bioinformatics prediction of stable protein domains in the Plasmodium falciparum genome, chemical synthesis of polypeptides, in vitro biological functional assays, and association of an antigen-specific antibody response with protection against clinical malaria.

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Malaria Ookinete Surface Protein-Based Vaccination via the Intranasal Route Completely Blocks Parasite Transmission in both Passive and Active Vaccination Regimens in a Rodent Model of Malaria Infection

December 7, 2009 - 11:12 -- Ingeborg van Schayk
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Author(s): 
Takeshi Arakawa, Mayumi Tachibana, Takeshi Miyata, Tetsuya Harakuni, Hideyasu Kohama, Yasunobu Matsumoto, Naotoshi Tsuji, Hajime Hisaeda, Anthony Stowers, Motomi Torii, and Takafumi Tsuboi
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Infect. Immun. 2009;77 5496-5500

To our knowledge, this is the first time that mucosal vaccination has been demonstrated to be efficacious for directly preventing parasite transmission from vaccinated animals to mosquitoes, and the results may provide important insight into rational design of nonparenteral vaccines for use against human malaria.

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Open Access | Commentary: Knowlesi malaria in Vietnam

December 5, 2009 - 16:58 -- Ingeborg van Schayk
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Author(s): 
Janet Cox-Singh
Reference: 
Malaria Journal 2009, 8:269 (26 November 2009)

However, there are many settings where knowlesi transmission to humans would be expected but is not found. A recent report on the Ra-glai population of southern central Vietnam is taken as an example to help explain why this may be so.

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Characterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34)

December 5, 2009 - 16:25 -- Kabogo Ndegwa
Author(s): 
Alvaro Mongui, Diana I. Angel, Gina Gallego, Claudia Reyes, Paola Martinez, Felipe Guhl, Manuel A. Patarroyo
Reference: 
Vaccine, Volume 28, Issue 2, 11 December 2009, Pages 415-421, doi:10.1016/j.vaccine.2009.10.034

This study describes the identification of the Plasmodium vivax rhoptry antigen Pv34 whose sequence was obtained based on homology comparison with the Plasmodium falciparum Pf34.

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Correspondence: Diagnostic importance of headache as a key symptom in suspecting malaria in adult returning travelers

December 5, 2009 - 16:21 -- Patrick Sampao
Author(s): 
Francisco M. Pherez, Burke A. Cunha
Reference: 
Travel Medicine and Infectious Disease, Volume 7, Issue 6, November 2009, Pages 383-384. doi:10.1016/j.tmaid.2009.09.004

No abstract available.

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