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Scientific Articles

Review: Vitamin B metabolism in Plasmodium falciparum as a source of drug targets

December 29, 2009 - 14:27 -- Patrick Sampao
Author(s): 
Ingrid B, John E. Hyde and Carsten Wrenger
Reference: 
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 35-43

This review summarizes and updates the current knowledge of vitamin B de novo synthesis and salvage in P. falciparum and focuses on their potential as targets for drug intervention.

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Update: Focusing on complement in the antiparasitic defense of mosquitoes

December 29, 2009 - 14:23 -- Patrick Sampao
Author(s): 
Gloria Volohonskya, Stefanie Steinerta and Elena A. Levashina
Reference: 
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 1-3

Identification of the components of the mosquito complement system now provides new focus for studies on the activation and control of this pathway, whose manipulation is expected to block malaria transmission at the vector level.

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Review: Heroes or villains? T regulatory cells in malaria infection

December 29, 2009 - 14:19 -- Patrick Sampao
Author(s): 
Anja Scholzen, Gabriela Minigo and Magdalena Plebanski
Reference: 
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 16-25

This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection.

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Opinion: Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?

December 29, 2009 - 14:13 -- Patrick Sampao
Author(s): 
Tobias Spielmann and Tim-Wolf Gilberger
Reference: 
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 6-10

We review recent data on the sequences mediating export of PNEPs and compare this process to PEXEL export taking into account novel findings on the function of this motif.

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Opinion: The murine cerebral malaria phenomenon

December 29, 2009 - 14:05 -- Patrick Sampao
Author(s): 
Nicholas J. White, Gareth D.H. Turner, Isabelle M. Medana, Arjen M. Dondorp, and Nicholas P.J. Day
Reference: 
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 11-15

P.berghei ANKA infection in CBA or CB57BL/6 mice is used widely as a murine ‘model’ of human cerebral malaria (HCM), despite markedly different histopathological features.

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Review: Host immunity as a determinant of treatment outcome in Plasmodium falciparum malaria

December 29, 2009 - 13:52 -- Patrick Sampao
Author(s): 
Prof Stephen J Rogerson FRACP, Rushika S Wijesinghe MD, and Steven R Meshnick MD
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 1, January 2010, Pages 51-59

Improved methods for assessing antimalarial immunity will strengthen malaria control efforts.

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Pharmacological evidence favouring the use of Nauclea latifolia in malaria ethnopharmacy: Effects against nociception, inflammation, and pyrexia in rats and mice

December 29, 2009 - 13:28 -- Patrick Sampao
Author(s): 
J. Abbah, S. Amos, B. Chindo, I. Ngazal, H.O. Vongtau, B. Adzu, T. Farida, A.A. Odutola, C. Wambebe and K.S. Gamaniel
Reference: 
Journal of Ethnopharmacology, Volume 127, Issue 1, 8 January 2010, Pages 85-90

The results suggest the presence of biologically active principles in the extract with anti-nociceptive, anti-inflammatory and anti-pyretic activities that justifies its use in malaria ethnopharmacy and subsequent development for clinical application.

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Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

December 29, 2009 - 13:12 -- Patrick Sampao
Author(s): 
Qin Liu, Zongxiang Tang, Lenka Surdenikova, Seungil Kim, Kush N. Patel, Andrew Kim, Fei Ru, Yun Guan, Hao-Jui Weng, Yixun Geng, Bradley J. Undem, Marian Kollarik, Zhou-Feng Chen, David J. Anderson, and Xinzhong Dong
Reference: 
Cell, Volume 139, Issue 7, 24 December 2009, Pages 1353-1365

Itch induced by chloroquine (CQ) is a common side effect of this widely used antimalarial drug. Here, we show that Mrgprs, a family of G protein-coupled receptors expressed exclusively in peripheral sensory neurons, function as itch receptors.

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A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium

December 29, 2009 - 13:08 -- Patrick Sampao
Author(s): 
Luciano A. Moreira, Iñaki Iturbe-Ormaetxe, Jason A. Jeffery, Guangjin Lu, Alyssa T. Pyke, Lauren M. Hedges, Bruno C. Rocha, Sonja Hall-Mendelin, Andrew Day, Markus Riegler, Leon E. Hugo, Karyn N. Johnson, Brian H. Kay, Elizabeth A. McGraw, Andrew F. van den Hurk, Peter A. Ryan and Scott L. O'Neill
Reference: 
Cell, Volume 139, Issue 7, 24 December 2009, Pages 1268-1278

We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases.

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