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Scientific Articles

Introduction: Malaria management - progress made and challenges still to face

October 25, 2009 - 14:45 -- Bart G.J. Knols
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Author(s): 
Bernhards R Ogutu
Reference: 
Malaria Journal 2009, 8(Suppl 1):S1 (12 October 2009)

This supplement reviews the contribution made by AL as an ACT to the tremendous progress made in the control of malaria and establishes effective treatment as a cornerstone in the foundation of effective, quality patient care for infants, children and adults with malaria.

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Review: The use of schools for malaria surveillance and programme evaluation in Africa

October 25, 2009 - 14:06 -- Bart G.J. Knols
Author(s): 
Simon Brooker, Jan H Kolaczinski, Carol W Gitonga, Abdisalan M Noor, Robert W Snow
Reference: 
Malaria Journal 2009, 8:231 (19 October 2009)

This paper reviews the historical experience and current rationale for the use of schools and school children as a complementary, inexpensive framework for planning, monitoring and evaluating malaria control in Africa.

 

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Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria

October 25, 2009 - 13:57 -- Bart G.J. Knols
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Author(s): 
Izumi Naka et al.
Reference: 
Malaria Journal 2009, 8:232 (19 October 2009)

A haplotype block in which a primary polymorphism associated with severe malaria is likely to be encoded was identified in Thai malaria patients.

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Special Focus Review: Genetically engineered, attenuated whole-cell vaccine approaches for malaria

October 25, 2009 - 13:53 -- Bart G.J. Knols
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Author(s): 
Ashley Vaughan, Ruobing Wang and Stefan H.I. Kappe
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

The discovery of genetically engineered parasite strains that are fully attenuated during the early asymptomatic liver infection and confer complete sterile protection in animal malaria models support the development of a live attenuated sporozoite vaccine for Plasmodium falciparum and its accelerated safety and efficacy testing in malaria challenge models and in malaria endemic areas.

 

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Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting

October 25, 2009 - 13:48 -- Bart G.J. Knols
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Author(s): 
Noranate N et al.
Reference: 
BMC Microbiology 2009, 9:219 (15 October 2009)

The Pfmsp1 block2 locus presents a very large population sequence diversity. The lack of stable acquisition of novel antibody specificities despite exposure to novel allelic forms is reminiscent of clonal imprinting. The locus appears under antibody-mediated diversifying selection in a variable environment that maintains a balance between the various family types without selecting for sequence variant allelic forms. There is no evidence of positive selection for intra-family sequence diversity, consistent with the observed characteristics of the antibody response.

 

Cochrane Library

October 21, 2009 - 09:29 -- Bart G.J. Knols
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Author(s): 
Paul Garner
Reference: 
Submitted by author to MW editor

Basing policies on the best available evidence will help ensure maximum impact in terms of reducing death and illness globally, and, with such a high disease burden globally, this has to be a priority in international health.

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