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Scientific Articles

Open Access | Measuring the efficacy of anti-malarial drugs in vivo: quantitative PCR measurement of parasite clearance

November 16, 2010 - 11:58 -- Kabogo Ndegwa
Author(s): 
Khalid B Beshir, Rachel L Hallett, Alice C Eziefula, Robin Bailey, Julie Watson, Stephen G Wright, Peter L Chiodini, Spencer D Polley, Colin J Sutherland
Reference: 
Malaria Journal 2010, 9:312 (5 November 2010)

Large studies, particularly in Africa where children represent a major proportion of treated cases, will require a simpler blood sample collection regime, and a method capable of high throughput.

Open Access | Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions

November 16, 2010 - 11:53 -- Kabogo Ndegwa
Author(s): 
Thomas S Churcher, Emma J Dawes, Robert E Sinden, George K Christophides, Jacob C Koella, Maria-Gloria Basanez
Reference: 
Malaria Journal 2010, 9:311 (4 November 2010)

A greater understanding of the development of the malaria parasite within the mosquito is required to fully evaluate the impact of TBIs.

Open Access | Survey of artemisinin production by diverse Artemisia species in Northern Pakistan

November 16, 2010 - 11:45 -- Kabogo Ndegwa
Author(s): 
Abdul Mannan, Ibrar Ahmed, Waheed Arshad, Muhammad F Asim, Rizwana A Qureshi, Izhar Hussain, Bushra Mirza
Reference: 
Malaria Journal 2010, 9:310 (4 November 2010)

This study identifies twelve novel plant sources of artemisinin, which may be helpful for pharmaceutical production of artemisinin.

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Synthesis and bio-evaluation of alkylaminoaryl phenyl cyclopropyl methanones as antitubercular and antimalarial agents

November 16, 2010 - 11:38 -- Kabogo Ndegwa
Author(s): 
Arya Ajay, Vandana Singh, Shubhra Singh, Swaroop Pandey, Sarika Gunjan, Divya Dubey, Sudhir Kumar Sinha, Bhupendra N. Singh, Vinita Chaturvedi, Renu Tripathi, Ravishankar Ramchandran, Rama P. Tripathi
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 23, 1 December 2010, Pages 8289-8301

A series of 4-alkylaminoaryl phenyl cyclopropyl methanones (6a–6u and 8a–8c) were synthesized from 4-fluorochalcones (3a and 3b) by cyclopropanation of double bond followed by nucleophilic substitution of F with different amines.

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Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds

November 16, 2010 - 11:33 -- Kabogo Ndegwa
Author(s): 
Eric M. Guantai, Kanyile Ncokazi, Timothy J. Egan, Jiri Gut, Philip J. Rosenthal, Peter J. Smith, Kelly Chibale
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 23, 1 December 2010, Pages 8243-8256

A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity. The Cu(I)-catalyzed cycloaddition of azides and terminal alkynes was applied as the hybridization strategy.

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Open Access | Impact of Schistosome Infection on Plasmodium falciparum Malariometric Indices and Immune Correlates in School Age Children in Burma Valley, Zimbabwe

November 16, 2010 - 10:13 -- Kabogo Ndegwa
Author(s): 
Davison T. Sangweme, Nicholas Midzi, Sekesai Zinyowera-Mutapuri, Takafira Mduluza, Marie Diener-West, Nirbhay Kumar
Reference: 
PLoS Negl Trop Dis 4(11): e882

A group of children aged 6–17 years was recruited and followed up for 12 months to study the impact of schistosome infection on malaria parasite prevalence, density, distribution and anemia.

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Microbial Immunity and Vaccines: Elevated Levels of the Plasmodium yoelii Homologue of Macrophage Migration Inhibitory Factor Attenuate Blood-Stage Malaria

November 16, 2010 - 10:02 -- Patrick Sampao
Author(s): 
Swati Thorat, Thomas M. Daly, Lawrence W. Bergman, and James M. Burns, Jr.
Reference: 
Infect. Immun., Dec 2010; 78: 5151 - 5162.

Combined, the data indicate that parasite-derived MIF does not contribute significantly to immunopathology but, through its chemotactic ability toward macrophages, may attenuate disease and prolong infection of highly virulent parasite isolates.

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Comparative responses of ovipositing Anopheles gambiae and Culex quinquefasciatus females to the presence of Culex egg rafts and larvae

November 16, 2010 - 09:18 -- Kabogo Ndegwa
Author(s): 
S. W. Wachira, M. Ndunb’u, P. G. N. Njagi, A. Hassanali
Reference: 
Medical and Veterinary Entomology, Volume 24, Issue 4, pages 369–374, December 2010

Field observations have demonstrated that gravid Anopheles gambiae Giles s.s. (Diptera: Culicidae) are selective in their choice of oviposition sites. For example, immature stages of An. gambiae s.s. are rarely found in water that contains Culex quinquefasciatus Say immatures.

An experimental hut evaluation of PermaNet® 3.0, a deltamethrin–piperonyl butoxide combination net, against pyrethroid-resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes in southern Benin

November 15, 2010 - 14:22 -- Patrick Sampao
Author(s): 
Raphael N’Guessan, Alex Asidi, Pelagie Boko, Abibatou Odjo, Martin Akogbeto, Olivier Pigeon, Mark Rowland
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 12, December 2010, Pages 758-765

An experimental hut trial comparing unwashed and 20 times washed PermaNet 3.0 and PermaNet 2.0, Olyset Net and a conventional deltamethrin-treated net washed three times was conducted in southern Benin.

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Towards eradication: three years after the tsunami of 2004, has malaria transmission been eliminated from the island of Simeulue?

November 15, 2010 - 14:07 -- Patrick Sampao
Author(s): 
Mohammad Sudomo, Yusniar Arianti, Isra Wahid, Din Safruddin, Erling M. Pedersen, J. Derek Charlwood
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 12, December 2010, Pages 777-781

The results indicate that despite the continuing presence of potential vectors in some places the anti-malaria measures introduced following the tsunami have controlled, and may be close to eliminating, malaria from the island.

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