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Scientific Articles

Biophotonic techniques for the study of malaria-infected red blood cells

August 2, 2010 - 08:01 -- Patrick Sampao
Author(s): 
Jakob M., Alessandro E., et al.
Reference: 
Medical and Biological Engineering and Computing

In this article, we review a wide range of optical techniques for quantitative measurements of critical homeostatic parameters in malaria-infected red blood cells.

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Open Access | Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer

July 30, 2010 - 15:17 -- Kabogo Ndegwa
Author(s): 
Jorge F.S. Ferreira, Devanand L. Luthria, Tomikazu Sasaki, Arne Heyerick
Reference: 
Molecules 2010, Vol 15 Issue 5, P 3135-3170

Artemisia annua is currently the only commercial source of the sesquiterpene lactone artemisinin.Since artemisinin was discovered as the active component of A. annua in early 1970s, hundreds of papers have focused on the anti-parasitic effects of artemisinin and its semi-synthetic analogs dihydroartemisinin, artemether, arteether, and artesunate.

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Parasitology: Mitochondrial DNA Targets Increase Sensitivity of Malaria Detection Using Loop-Mediated Isothermal Amplification

July 30, 2010 - 12:31 -- Patrick Sampao
Author(s): 
Spencer D. Polley, Yasuyoshi Mori, Julie Watson, Mark D. Perkins, Iveth J. González, Tsugunori Notomi, Peter L. Chiodini, and Colin J. Sutherland
Reference: 
J. Clin. Microbiol., Aug 2010; 48: 2866 - 2871.

Here we describe the use of mitochondrial targets for LAMP-based detection of any Plasmodium genus parasite and of P. falciparum specifically.

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Parasitology: Comparison of the Novel Partec Rapid Malaria Test to the Conventional Giemsa Stain and the Gold Standard Real-Time PCR

July 30, 2010 - 12:18 -- Patrick Sampao
Author(s): 
Bernard N., Alex A., et al.
Reference: 
J. Clin. Microbiol., Aug 2010; 48: 2925 - 2928.

In this study, we evaluated the recently developed Partec rapid malaria test (PM) for the detection of Plasmodium spp. in human blood from patients in an area where malaria is endemic and compared the results with those of thick blood film Giemsa stain (GS) in terms of its performance and operational characteristics, using real-time (RT) PCR as the gold standard.

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Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum

July 29, 2010 - 18:05 -- Kabogo Ndegwa
Author(s): 
Amit K. Gupta, Shruti Saxena, Mridula Saxena
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 16, 15 August 2010, Pages 4779-4781

A common feature pharmacophore with two hydrogen-bond acceptor and one aromatic hydrophobic feature has been generated using seven active flavonoids.

Open Access | Plasmodium falciparum FIKK Kinase Members Target Distinct Components of the Erythrocyte Membrane

July 29, 2010 - 11:46 -- Kabogo Ndegwa
Author(s): 
Marta C. Nunes, Mami Okada, Christine Scheidig-Benatar, Brian M. Cooke, Artur Scherf
Reference: 
PLoS ONE 5(7): e11747

Our results suggest that FIKK members phosphorylate different membrane skeleton proteins of the infected erythrocyte in a stage-specific manner, inducing alterations in the mechanical properties of the parasite-infected red blood cell.

Open Access | Case Report: First case of detection of Plasmodium knowlesi in Spain by Real Time PCR in a traveller from Southeast Asia

July 29, 2010 - 11:16 -- Kabogo Ndegwa
Author(s): 
Ta Tang T, Salas A, Ali-Tammam M, Martinez M, Lanza M, Arroyo E, Rubio J
Reference: 
Malaria Journal 2010, 9:219 (27 July 2010)

Previously, Plasmodium knowlesi was not considered as a species of Plasmodium that could cause malaria in human beings, as it is parasite of long-tailed (Macaca fascicularis) and pig-tailed (Macaca nemestrina) macaques found in Southeast Asia.

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Review: Changes in the burden of malaria in sub-Saharan Africa

July 29, 2010 - 10:38 -- Patrick Sampao
Author(s): 
Wendy Prudhomme O'Meara, Judith Nekesa Mangeni, Rick Steketee, Brian Greenwood
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 8, August 2010, Pages 545-555

To assess the contribution of specific malaria interventions and other general factors in bringing about these changes, we reviewed studies that have reported recent changes in the incidence or prevalence of malaria in sub-Saharan Africa.

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Open Access | Plasmodium falciparum parasites causing cerebral malaria share variant surface antigens, but are they specific?

July 29, 2010 - 10:32 -- Kabogo Ndegwa
Author(s): 
Kheliouen N, Viwami F, Lalya F, Tuikue-Ndam N, Eboumbou Moukoko EC, Rogier C, Deloron P, Aubouy A
Reference: 
Malaria Journal 2010, 9:220 (27 July 2010)

In conclusion, this study suggests the existence of serologically distinct VSACM and VSAUM. CM isolates were shown to share common epitopes. Specific antibody response to VSAUM was predominant, suggesting a relative low diversity of VSAUM in the study area.

Report: Plasmodium falciparum Accompanied the Human Expansion out of Africa

July 29, 2010 - 10:27 -- Kabogo Ndegwa
Author(s): 
Kazuyuki Tanabe, Toshihiro Mita, Hirohisa Kishino, et al.
Reference: 
Current Biology, Volume 20, Issue 14, 27 July 2010, Pages 1283-1289

Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 million cases of malaria every year, with a further 1.4 billion people at risk of infection [[1], [2] and [3]].

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