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Scientific Articles

Open Access | Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human Equilibrative Nucleoside Transporter and the human Facilitative Nucleobase Transporter

February 1, 2010 - 11:06 -- Ingeborg van Schayk
Author(s): 
Neils B Quashie, Lisa C Ranford-Cartwright, Harry P De Koning
Reference: 
Malaria Journal 2010, 9:36 (29 January 2010)

Paper that provides conclusive novel information on purine transport in Plasmodium-infected RBC. The information is important as the purine salvage pathway is a target for new chemotherapy.

Open Access | A cell-based high-throughput screen validates the plasmodial surface anion channel as an antimalarial target

February 1, 2010 - 10:48 -- Ingeborg van Schayk
Author(s): 
Ajay D. Pillai, Margaret Pain, Tsione Solomon, Abdullah A.B. Bokhari, and Sanjay A Desai
Reference: 
Mol. Pharmacol. published 25 January 2010

A statistically significant correlation between channel inhibition and in vitro parasite killing by a family of compounds provided chemical validation of PSAC as a drug target. 

Open Access | A global view of the nonprotein-coding transcriptome in Plasmodium falciparum

February 1, 2010 - 10:36 -- Ingeborg van Schayk
Author(s): 
Carsten A. Raabe, Cecilia P. Sanchez, Timofey S. Rozhdestvensky et al.
Reference: 
Nucleic Acids Res. 2010; 38:608-617

Our findings have important implications for a better understanding of gene regulatory mechanisms in P. falciparum, revealing an extended and sophisticated npcRNA network that may control the expression of housekeeping genes and virulence factors.

Assessment of DDT levels in selected environmental media and biological samples from Mexico and Central America

February 1, 2010 - 10:28 -- Ingeborg van Schayk
Author(s): 
ván N. Pérez-Maldonado, Antonio Trejo, Fernando Díaz-Barriga et al.
Reference: 
Chemosphere Article in Press, Corrected Proof

Taking into account the environmental persistence and the toxicity of DDT, the Pan American Health Organization (PAHO) organized a surveillance program in Mesoamerica which included the detection of residual DDT in environmental (soil) and biological samples (fish tissue and children’s blood).

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Characterization of Two Linear Cationic Antimalarial Peptides in the Scorpion Mesobuthus eupeus

February 1, 2010 - 10:17 -- Ingeborg van Schayk
Author(s): 
Bin Gao, Jia Xu, Maria del Carmen Rodriguez, Humberto Lanz-Mendoza, Rosaura Hernández-Rivas, Weihong Du and Shunyi Zhu
Reference: 
Biochimie, Article in Press, Uncorrected Proof

In this work, we report two cDNA clones from the scorpion Mesobuthus eupeus venom gland, which encode peptides inhibiting the development of Plasmodium berghei, killing intraerythrocytic P. falciparum, and toxic to the Drosophila S2 cell at micromolar concentrations.

African great apes are natural hosts of multiple related malaria species, including Plasmodium falciparum

February 1, 2010 - 09:56 -- Ingeborg van Schayk
Author(s): 
Franck Prugnolle, Patrick Durand, François Renaud et al.
Reference: 
PNAS, Published online before print January 19, 2010

The continuously increasing contacts between humans and primate populations raise concerns about further reciprocal host transfers of these pathogens.

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Open Access | A novel method for standardized application of fungal spore coatings for mosquito exposure bioassays

January 31, 2010 - 17:30 -- Ingeborg van Schayk
Author(s): 
Marit Farenhorst, Bart G J Knols
Reference: 
Malaria Journal 2010, 9:27 (20 January 2010)

Two novel fungus application methods using equipment developed in the paint industry are presented and compared.

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Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants

January 31, 2010 - 13:55 -- Ingeborg van Schayk
Author(s): 
H.M Malebo, W Tanja, S.A.M Swaleh, M Cal, M.O Omolo, A Hassanali, U Séquin, M Hamburger, R Brun, I.O Ndiege
Reference: 
Tanzania Journal of Health Research > Vol 11, No 4 (2009)

The antiplasmodial, anti-trypanosomal and anti-leishmanial activity of 25 plant extracts obtained from seven Tanzanian medicinal plants: Annickia (Enantia) kummeriae (Annonaceae), Artemisia annua (Asteraceae), Pseudospondias microcarpa (Anacardiaceae), Drypetes natalensis (Euphorbiaceae), Acridocarpus chloropterus (Malpighiaceae), Maytenus senegalensis (Celastraceae) and Neurautanenia mitis (Papilonaceae), were evaluated in vitro against Plasmodium falciparum K1, Trypanosoma brucei rhodesiense STIB 900 and axenic Leishmania donovani MHOM-ET-67/82.

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Knowledge and practices on malaria and its control among pastoralists in Simanjiro District, northern Tanzania

January 31, 2010 - 13:53 -- Ingeborg van Schayk
Author(s): 
A.L Malisa, M Ndukai
Reference: 
Tanzania Journal of Health Research > Vol 11, No 4 (2009)

This study was carried out to assess knowledge and practices on malaria and identify factors contributing to the low mosquito net coverage in Simanjiro District in northern Tanzania.

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Patterns of malaria related mortality based on verbal autopsy in Muleba District, north-western Tanzania

January 31, 2010 - 13:50 -- Ingeborg van Schayk
Author(s): 
G.M Kaatano, F.M Mashauri, S.M Kinung’hi, I.R Mwanga, R.C Malima, C Kishamawe, S.E Nnko, S.M Magesa, L.E.G Mboera
Reference: 
Tanzania Journal of Health Research > Vol 11, No 4 (2009

This study was carried out to determine malaria related mortality and establish its trend change over time in both epidemic and non-epidemic areas of Muleba District of north-western Tanzania.

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