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Scientific Articles

Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase

June 14, 2011 - 14:21 -- Kabogo Ndegwa
Author(s): 
Eliseo Recio, Alexander Musso-Buendía, Antonio E. Vidal, Gian Filippo Ruda, Ganasan Kasinathan, Corinne Nguyen, Luis Miguel Ruiz-Pérez, Ian H. Gilbert, Dolores González-Pacanowska
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 8, August 2011, Pages 3309-3314

We have previously identified a series of triphenylmethane derivatives of deoxyuridine with antimalarial activity in vitro which selectively inhibit Plasmodium falciparum deoxyuridine triphosphate nucleotidohydrolase (PfdUTPase) compared to the human enzyme.

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Open Access | Producing A Successful Malaria Vaccine: Innovation In The Lab And Beyond

June 14, 2011 - 14:20 -- Patrick Sampao
Author(s): 
Christian Loucq, Ashley Birkett, David Poland, Carla Botting, Julia Nunes and Sally Ethelston
Reference: 
Health Aff June 2011 vol. 30 no. 6 1065-1072

This article recounts the pivotal roles in that achievement played by collaborations of nonprofit organizations, pharmaceutical companies, private and public donors, and countries whose citizens would benefit most directly from a vaccine.

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Open Access | Plasmodium falciparum Genetic Diversity Maintained and Amplified Over 5 Years of a Low Transmission Endemic in the Peruvian Amazon

June 14, 2011 - 14:12 -- Patrick Sampao
Author(s): 
OraLee H. Branch, Patrick L. Sutton, Carmen Barnes, Juan Carlos Castro, Julie Hussin, Philip Awadalla and Gisely Hijar
Reference: 
Mol Biol Evol (2011) 28 (7): 1973-1986.

We examined parasite population structure and traced the parasite genetic diversity temporally and spatially. We genotyped infections over 5 years (2003–2007) using 14 microsatellite (MS) markers scattered across ten different chromosomes. Despite low transmission, there was considerable genetic diversity, which we compared with other geographic regions.

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Open Access | Use of remote sensing to identify spatial risk factors for malaria in a region of declining transmission: a cross-sectional and longitudinal community survey

June 14, 2011 - 14:10 -- Kabogo Ndegwa
Author(s): 
Moss WJ, Hamapumbu H, Kobayashi T, Shields T, Kamanga A, Clennon J, Mharakurwa S, Thuma PE, Glass G
Reference: 
Malaria Journal 2011, 10:163 (10 June 2011)

Remote sensing technologies can be used to target malaria control interventions in a region of declining malaria transmission in southern Zambia, enabling a more efficient use of resources for malaria elimination.

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Open Access | To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia: study protocol for a two-armed cluster-randomised tria

June 14, 2011 - 13:54 -- Patrick Sampao
Author(s): 
Margaret Pinder, Musa Jawara, Lamin BS Jarju, Balla Kandeh, David Jeffries, Manuel F Lluberas, Kalifa Bojang, David J Conway and Steve W Lindsay
Reference: 
Trials 2011, 12:147, 10 June 2011

Exposure to malaria parasites will be assessed using light and exit traps followed by detection of Anopheles gambiae species and sporozoite infection. Study children will be surveyed at the end of each transmission season to estimate the prevalence of Plasmodium falciparum infection and the prevalence of anaemia.

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Falcipains and other cysteine proteases of malaria parasites.

June 14, 2011 - 13:33 -- Patrick Sampao
Author(s): 
Rosenthal PJ
Reference: 
Adv Exp Med Biol. 2011;712:30-48.

Gene disruption studies suggested that SERA-5 and SERA-6 are essential. activation of SERA-5 by a serine protease seems to be required for merozoite egress from the erythrocyte. New drugs for malaria are greatly needed and cysteine proteases represent potential drug targets.

Open Access | Validation of oral fluid samples to monitor serological changes to Plasmodium falciparum: an observational study in southern Zambia

June 14, 2011 - 12:05 -- Kabogo Ndegwa
Author(s): 
Chidi AP, Chishimba S, Kobayashi T, Hamapumbu H, Mharakurwa S, Thuma PE, Moss WJ
Reference: 
Malaria Journal 2011, 10:162 (10 June 2011)

Oral fluid is a valid alternative specimen for monitoring changes in antibodies to P. falciparum antigens.

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Open Access | Knowledge Attitudes and Practices of grade three primary schoolchildren in relation to schistosomiasis, soil transmitted helminthiasis and malaria in Zimbabwe

June 13, 2011 - 14:54 -- Patrick Sampao
Author(s): 
Nicholas Midzi, Sekesai Mtapuri-Zinyowera, Takafira Mduluza, et al.
Reference: 
BMC Infectious Diseases 2011, 11:169, 13 June 2011

This study sought to assess KAP of grade 3 children in relation to schistosomiasis, STHs and malaria in order to establish an effective school based health education for disease transmission control.

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Overexpression, purification and assessment of cyclosporin binding of a family of cyclophilins and cyclophilin-like proteins of the human malarial parasite Plasmodium falciparum

June 13, 2011 - 14:14 -- Patrick Sampao
Author(s): 
Alejandro Marín-Menéndez, Angus Bell
Reference: 
Protein Expression and Purification, Volume 78, Issue 2, August 2011, Pages 225-234

Previously a pET vector conferring a C-terminal His6 tag was used for recombinant expression and purification of one member of the P. falciparum cyclophilin family in Escherichia coli. The approach here was to use an identical method to produce all of the other members of this family and thereby allow the most consistent functional comparisons.

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Plasmodium vivax malaria: Is it actually benign?

June 13, 2011 - 13:38 -- Patrick Sampao
Author(s): 
Harpal Singh, Ankit Parakh, Srikanta Basu, Bimbadarh Rath
Reference: 
Journal of Infection and Public Health, Volume 4, Issue 2, June 2011, Pages 91-95

Twenty-three patients of Pv malaria were retrospectively analyzed. Thrombocytopenia was present in 22 (96%) patients with counts less than 50,000/μL in 9 patients. Severe anemia (hgb < 5 mg/dl) was present in 8 (34%) patients. Cerebral malaria was present in 3 patients.

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