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Scientific Articles

Synthesis and biological evaluation of arylidene analogues of Meldrum’s acid as a new class of antimalarial and antioxidant agents

July 21, 2010 - 12:28 -- Kabogo Ndegwa
Author(s): 
Harmeet S. Sandhu, Sameer Sapra, Mukesh Gupta, Kunal Nepali, Raju Gautam, Sunil Yadav, Raj Kumar, Sanjay M. Jachak, Manoj Chugh, Manish K. Gupta, Om P. Suri, K.L. Dhar
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 15, 1 August 2010, Pages 5626-5633

A series of arylidene analogues of Meldrum’s acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time.

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Open Access | Comparative field performance and adherence to test results of four malaria rapid diagnostic tests among febrile patients more than five years of age in Blantyre, Malawi

July 21, 2010 - 12:24 -- Kabogo Ndegwa
Author(s): 
Chinkhumba J, Skarbinski J, Chilima B, Campbell C, Ewing V, San Joaquin M, Sande J, Ali D, Mathanga D
Reference: 
Malaria Journal 2010, 9:209 (20 July 2010)

The results of this evaluation, combined with other published data and global recommendations, have been used to select RDTs for national scale-up. In addition, the study identified some key issues that need to be further delineated: the low field specificity of RDTs, variable RDT performance by different cadres of health workers and the need for a robust quality assurance system.

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Open Access | The Major Yolk Protein Vitellogenin Interferes with the Anti-Plasmodium Response in the Malaria Mosquito Anopheles gambiae

July 21, 2010 - 11:59 -- Kabogo Ndegwa
Author(s): 
Martin K. Rono, Miranda M. A. Whitten, Mustapha Oulad-Abdelghani, Elena A. Levashina, Eric Marois
Reference: 
PLoS Biol 8(7): e1000434

When taking a blood meal on a person infected with malaria, female Anopheles gambiae mosquitoes, the major vector of human malaria, acquire nutrients that will activate egg development (oogenesis) in their ovaries.

Open Access | Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria

July 21, 2010 - 10:14 -- Kabogo Ndegwa
Author(s): 
Dell'Agli M, Galli GV, Bulgari M, Basilico N, Romeo S, Bhattacharya D, Taramelli D, Bosisio E
Reference: 
Malaria Journal 2010, 9:208 (19 July 2010)

The beneficial effect of the fruit rind of Punica granatum for the treatment of malarial disease may be attributed to the anti-parasitic activity and the inhibition of the pro-inflammatory mechanisms involved in the onset of cerebral malaria.

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Antimalarial compounds from the aerial parts of Flacourtia indica (Flacourtiaceae)

July 21, 2010 - 09:03 -- Patrick Sampao
Author(s): 
Ali M., Valérie M., et al.
Reference: 
Journal of Ethnopharmacology, Volume 130, Issue 2, 20 July 2010, Pages 272-274

This study reports for the first time antiplasmodial activity for Flacourtia indica, for its AcOEt extract and the three major constituents and confirms its traditional use.

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Open Access | Laboratory evaluation on the sensitivity and specificity of a novel and rapid detection method for malaria diagnosis based on magneto-optical technology (MOT)

July 21, 2010 - 08:38 -- Kabogo Ndegwa
Author(s): 
Mens PF, Matelon RJ, Nour BY, Newman DM, Schallig HD
Reference: 
Malaria Journal 2010, 9:207 (19 July 2010)

Although MOT sensitivity and specificity are currently not yet at a competing level compared to other diagnostic test, such as PCR and RDTs, it has a potential to rapidly screen patients for malaria in endemic as well as non-endemic countries.

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Immunogenicity of the Plasmodium falciparum Pf332-DBL domain in combination with different adjuvants

July 21, 2010 - 08:24 -- Patrick Sampao
Author(s): 
Cheng Du, Sandra Nilsson, Huijun Lu, Jigang Yin, Ning Jiang, Mats Wahlgren, Qijun Chen
Reference: 
Vaccine, Volume 28, Issue 31, 12 July 2010, Pages 4977-4983

In the present study, we have investigated the immunogenicity of the Duffy-binding like (DBL)-domain of the Pf332 molecule in combination with different adjuvants in four animal species.

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3D structure determination of STARP peptides implicated in P. falciparum invasion of hepatic cells

July 21, 2010 - 07:22 -- Patrick Sampao
Author(s): 
Adriana Bermúdez, Martha Patricia Alba, Magnolia Vanegas, Manuel Elkin Patarroyo
Reference: 
Vaccine, Volume 28, Issue 31, 12 July 2010, Pages 4989-4996

This study shows the results of immunization trials in Aotus monkeys with native STARP peptides and analogues modified in critical hepatic-cell binding residues.

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Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-γ/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection

July 21, 2010 - 07:09 -- Patrick Sampao
Author(s): 
James F., Michele D., et al.
Reference: 
Vaccine, Volume 28, Issue 31, 12 July 2010, Pages 5135-5144

Although the optimal antigen dose of LSA-NRC may not have been selected for the challenge portion of the protocol, further vaccine development based upon LSA-1 should not be excluded and should include alternative vaccine platforms able to elicit additional effector mechanisms such as CD8+ T cells.

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Review: The RTS, S malaria vaccine

July 21, 2010 - 06:47 -- Patrick Sampao
Author(s): 
Sofia Casares, Teodor-Doru Brumeanu, Thomas L. Richie
Reference: 
Vaccine, Volume 28, Issue 31, 12 July 2010, Pages 4880-4894

This review will focus on current knowledge about the protective efficacy of RTS,S and what we have learned regarding its impact on the human immune system.

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