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Scientific Articles

Report: “Singing on the Wing” as a Mechanism for Species Recognition in the Malarial Mosquito Anopheles gambiae

January 28, 2010 - 12:38 -- Kabogo Ndegwa
Author(s): 
Cédric Pennetier, Ben Warren, K. Roch Dabiré, Ian J. Russell, and Gabriella Gibson
Reference: 
Current Biology, Volume 20, Issue 2, 26 January 2010, Pages 131-136

This is the first description of close-range mating interactions in incipient An. gambiae species.

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Dispatch: Speciation: Mosquitoes Singing in Harmony

January 28, 2010 - 12:37 -- Kabogo Ndegwa
Author(s): 
Michael G. Ritchiea, and Elina Immonen
Reference: 
Current Biology, Volume 20, Issue 2, 26 January 2010, Pages R58-R60

Anopheles gambiae, a major vector of malaria, is a complex of cryptic species and subspecies. A new study describes a remarkable behaviour that might contribute to sexual isolation in this species complex: males and females are much more likely to show harmonic convergence of wing beat sounds when courting individuals of the same type.

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Genetics and Evolution: Chronic malaria infections increase family inequalities and reduce parental fitness: experimental evidence from a wild bird population

January 28, 2010 - 12:35 -- Kabogo Ndegwa
Author(s): 
S. Knowles, V. Palinauskas, B. Sheldon
Reference: 
Journal of Evolutionary Biology, Volume 23 Issue 3, Pages 557 – 569

Overall, these results demonstrate that chronic avian malaria infections, far from being benign, can have significant effects on host fitness and may thus constitute an important selection pressure in wild bird populations.

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Computational characterization of Plasmodium falciparum proteomic data for screening of potential vaccine candidates

January 28, 2010 - 12:34 -- Kabogo Ndegwa
Author(s): 
Satarudra P. Singh, Feroz Khan and Bhartendu N. Mishra
Reference: 
Human Immunology, Volume 71, Issue 2, February 2010, Pages 136-143

In this study, we have characterized 25 antigens as a vaccine candidate and screened the potential T-lymphocyte epitopes presented by human leukocyte antigen (HLA)-A, -B, and -DR molecules based on the proteomic data of Plasmodium falciparum.

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Plasmodium falciparum circumsporozoite protein (CSP)

January 28, 2010 - 12:31 -- Kabogo Ndegwa
Author(s): 
Published online
Reference: 
SciBX: Science-Business eXchange, Volume 3 / Issue 3, January 21 2010

A study in mice suggests that CSP-based protein-peptide conjugates could be useful vaccines against malaria infection. Further details on the research, next steps and licensing status are discussed in the article.

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The carbon and energy sources of the non-photosynthetic plastid in the malaria parasite

January 28, 2010 - 12:18 -- Kabogo Ndegwa
Author(s): 
Liting Lim, Marc Linka, Kylie A. Mullin, Andreas P.M. Weber and Geoffrey I. McFadden
Reference: 
FEBS Letters, Volume 584, Issue 3, 5 February 2010, Pages 549-554

The malaria parasite harbours an indispensable plastid known as the ‘apicoplast’. The apicoplast’s exact role remains uncertain, but it houses components involved in fatty acid, isoprenoid and haem biosyntheses.

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Letter: Atorvastatin as a Potential Antimalarial Drug: In Vitro Synergy in Combinational Therapy with Dihydroartemisinin

January 28, 2010 - 12:17 -- Kabogo Ndegwa
Author(s): 
Hélène Savini, Jean Baptiste Souraud, Sébastien Briolant, Eric Baret, Rémy Amalvict, Christophe Rogier, and Bruno Pradines
Reference: 
Antimicrobial Agents and Chemotherapy, February 2010, p. 966-967, Vol. 54, No. 2

No abstract available

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Clinical Therapeutics: Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune Subjects{triangledown}

January 28, 2010 - 12:14 -- Kabogo Ndegwa
Author(s): 
Peter E. Nasveld, Michael D. Edstein, Mark Reid, Leonard Brennan, Ivor E. Harris, Scott J. Kitchener, Peter A. Leggat, Philip Pickford, Caron Kerr, Colin Ohrt, William Prescott, and the Tafenoquine Study Team
Reference: 
Antimicrobial Agents and Chemotherapy, February 2010, p. 792-798, Vol. 54, No. 2

This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis.

Synthesis, antimalarial and antitubercular activity of acetylenic chalcones

January 28, 2010 - 12:12 -- Kabogo Ndegwa
Author(s): 
Renate H. Hans, Eric M. Guantai, Carmen Lategan, Peter J. Smith, Baojie Wan, Scott G. Franzblau, Jiri Gut, Philip J. Rosenthal and Kelly Chibal
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 3, 1 February 2010, Pages 942-944

A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity.

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Gomphostenins: Two new antimalarial compounds from the leaves of Gomphostemma niveum

January 28, 2010 - 12:09 -- Kabogo Ndegwa
Author(s): 
Manisha Sathe and M.P. Kaushik
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 3, 1 February 2010, Pages 1312-1314

Phytochemical investigation of CHCl3 extract of the Gomphostemma niveum leaves led to the isolation of two new diterpene, compound 1 and 2. Their structures were elucidated by spectroscopic procedures and single crystal XRD.

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