Using this methodology a range of bridged tetraoxanes which display good in vitro antimalarial activity were synthesized.
The frequently observed mild outcomes of falciparum malaria in many places of the Amazon area prompted us to ask whether a globally restricted variant (var) gene repertoire is present in currently circulating and older isolates of this area.
These findings are highly relevant for our understanding of chromosome end biology and variegated expression in P. falciparum and other eukaryotes, and for the future analysis of the role of ApiAP2-DNA interactions in parasite biology.
To improve the current annotation and gene identification status of the draft genomes of P. berghei, P. chabaudi and P. yoelii, we performed genome-wide comparisons between these three species.
The perspective of the community is of high importance for a new treatment policy to be effective. The paper shows that implementation of ACT-based treatment guidelines must be complemented with educational campaigns to insure that mothers seek prompt help for their children after onset of fever.
Despite the obviously important role that gametocytes play in the transmission of malaria and spread of anti-malarial resistance, it is common to estimate gametocyte carriage indirectly based on asexual parasite measurements. The objective of this research was to directly model observed gametocyte densities over time, during the primary infection.
An important and well written paper with very important public health messages in Laos.
An important finding and conclusion from this study is that although there have been massive gains in intervention coverage in Ethiopia, there is still some work required to make sure that the interventions are used.
MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting.
Indoor residual spraying (IRS) and insecticide-treated nets (ITNs), two principal malaria control strategies, are similar in cost and efficacy. We aimed to describe recent policy development regarding their use in Mozambique, South Africa and Zimbabwe.