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Scientific Articles

An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity

March 5, 2010 - 09:01 -- Kabogo Ndegwa
Author(s): 
Gemma L. Ellis, Richard Amewu, Charlotte Hall, Karen Rimmer, Steven A. Ward, Paul M. O’Neill
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 5, 1 March 2008, Pages 1720-1724

Using this methodology a range of bridged tetraoxanes which display good in vitro antimalarial activity were synthesized.

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The South American Plasmodium falciparum var gene repertoire is limited, highly shared and possibly lacks several antigenic types

March 5, 2010 - 08:59 -- Kabogo Ndegwa
Author(s): 
Letusa Albrecht, Catarina Castiñeiras, Bruna O. Carvalho, Simone Ladeia-Andrade, Natal Santos da Silva, Erika H.E. Hoffmann, Rosimeire C. dalla Martha, Fabio T.M. Costa, Gerhard Wunderlich
Reference: 
Gene, Volume 453, Issues 1-2, 15 March 2010, Pages 37-44

The frequently observed mild outcomes of falciparum malaria in many places of the Amazon area prompted us to ask whether a globally restricted variant (var) gene repertoire is present in currently circulating and older isolates of this area.

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Open Access | A Major Role for the Plasmodium falciparum ApiAP2 Protein PfSIP2 in Chromosome End Biology

March 3, 2010 - 13:51 -- Ingeborg van Schayk
Author(s): 
Christian Flueck, Richard Bartfai, Igor Niederwieser, Kathrin Witmer, Blaise T. F. Alako, Suzette Moes, Zbynek Bozdech, Paul Jenoe, Hendrik G. Stunnenberg, Till S. Voss
Reference: 
PLoS Pathog 6(2): e1000784

These findings are highly relevant for our understanding of chromosome end biology and variegated expression in P. falciparum and other eukaryotes, and for the future analysis of the role of ApiAP2-DNA interactions in parasite biology.

Open Access | Defining species specific genome differences in malaria parasites

March 3, 2010 - 12:35 -- Ingeborg van Schayk
Author(s): 
Liew KJ, Hu G, Bozdech Z, Preiser PR
Reference: 
BMC Genomics 2010, 11:128 (23 February 2010)

To improve the current annotation and gene identification status of the draft genomes of P. berghei, P. chabaudi and P. yoelii, we performed genome-wide comparisons between these three species.

Open Access | Community response to artemisinin-based combination therapy for childhood malaria: a case study from Dar es Salaam, Tanzania

March 2, 2010 - 10:38 -- Ingeborg van Schayk
Author(s): 
Vinay R Kamat, Daniel J Nyato
Reference: 
Malaria Journal 2010, 9:61 (26 February 2010)

The perspective of the community is of high importance for a new treatment policy to be effective. The paper shows that implementation of ACT-based treatment guidelines must be complemented with educational campaigns to insure that mothers seek prompt help for their children after onset of fever.

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Open Access | Nonlinear mixed effects modeling of gametocyte carriage in patients with uncomplicated malaria

March 2, 2010 - 10:33 -- Ingeborg van Schayk
Author(s): 
Greg B Distiller, Francesca Little, Karen I Barnes
Reference: 
Malaria Journal 2010, 9:60 (26 February 2010)

Despite the obviously important role that gametocytes play in the transmission of malaria and spread of anti-malarial resistance, it is common to estimate gametocyte carriage indirectly based on asexual parasite measurements. The objective of this research was to directly model observed gametocyte densities over time, during the primary infection.

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Open Access | High heterogeneity in Plasmodium falciparum risk illustrates the need for detailed mapping to guide resource allocation: a new malaria risk map of the Lao People's Democratic Republic

March 2, 2010 - 10:28 -- Ingeborg van Schayk
Author(s): 
Pernille Jorgensen, Simone Nambanya, Deyer Gopinath, Bouasy Hongvanthong, Kongxay Luangphengsouk, David Bell, Samlane Phompida, Rattanaxay Phetsouvanh
Reference: 
Malaria Journal 2010, 9:59 (24 February 2010)

An important and well written paper with very important public health messages in Laos.

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Open Access | Malaria indicator survey 2007, Ethiopia: coverage and use of major malaria prevention and control interventions

March 2, 2010 - 10:24 -- Ingeborg van Schayk
Author(s): 
Daddi Jima, Asefaw Getachew, Hana Bilak, Richard W Steketee, Paul M Emerson, Patricia M Graves, Teshome Gebre, Richard Reithinger, Jimee Hwang, Ethiopia Malaria Indicator Survey Working Group
Reference: 
Malaria Journal 2010, 9:58 (24 February 2010)

An important finding and conclusion from this study is that although there have been massive gains in intervention coverage in Ethiopia, there is still some work required to make sure that the interventions are used.

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Open Access | MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease

February 27, 2010 - 10:15 -- Ingeborg van Schayk
Author(s): 
Foley DH, Wilkerson RC, Birney I, Harrison S, Christensen J, Rueda LM
Reference: 
International Journal of Health Geographics 2010, 9:11 (18 February 2010)

MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting.

Open Access | Policy development in malaria vector management in Mozambique, South Africa and Zimbabwe

February 27, 2010 - 10:03 -- Ingeborg van Schayk
Author(s): 
Julie Cliff, Simon Lewin, Godfrey Woelk, Benedita Fernandes, Alda Mariano, Esperança Sevene, Karen Daniels, Sheillah Matinhure, Andrew Oxman, and John Lavis
Reference: 
Health Policy Plan. published 21 February 2010, 10.1093/heapol/czq008

Indoor residual spraying (IRS) and insecticide-treated nets (ITNs), two principal malaria control strategies, are similar in cost and efficacy. We aimed to describe recent policy development regarding their use in Mozambique, South Africa and Zimbabwe.

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