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Scientific Articles

Review : Pyrethroid resistance in African anopheline mosquitoes: what are the implications for malaria control?

February 2, 2011 - 12:47 -- Patrick Sampao
Author(s): 
Hilary Ranson, Raphael N’Guessan, Jonathan Lines, Nicolas Moiroux, Zinga Nkuni, Vincent Corbel
Reference: 
Trends in Parasitology, Volume 27, Issue 2, February 2011, Pages 91-98

As we move into the malaria eradication era, it is vital that the implications of insecticide resistance are understood and strategies to mitigate these effects are implemented.

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In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

February 2, 2011 - 12:26 -- Patrick Sampao
Author(s): 
Jean Bernard Lekana-Douki., Jean Bernard Bongui., Maryvonne Kombila., et al.
Reference: 
Journal of Ethnopharmacology, Volume 133, Issue 3, 16 February 2011, Pages 1103-1108

As part of a project to identify new compounds active on malarial parasites, we tested the in vitro antiplasmodial activity of nine plants traditionally used to treat malaria symptoms in Haut-Ogooué Province, South-East Gabon.

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Open Access | Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan

February 2, 2011 - 08:23 -- Kabogo Ndegwa
Author(s): 
Ghanchi NK, Ursing J, Beg MA, Veiga MI, Jafri S, Martensson A
Reference: 
Malaria Journal 2011, 10:18 (28 January 2011)

The results indicate high prevalence of in vivo resistance to chloroquine, whereas high grade resistance to sulphadoxine-pyrimethamine does not appear to be widespread among P. falciparum in southern Pakistan.

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Open Access | Allelic Diversity of the Plasmodium falciparum Erythrocyte Membrane Protein 1 Entails Variant-Specific Red Cell Surface Epitopes

February 2, 2011 - 07:41 -- Kabogo Ndegwa
Author(s): 
Inès Vigan-Womas, Micheline Guillotte, Alexandre Juillerat, Cindy Vallieres, Anita Lewit-Bentley, Adama Tall, Laurence Baril, Graham A. Bentley, Odile Mercereau-Puijalon
Reference: 
PLoS ONE 6(1): e16544

The clonally variant Plasmodium falciparum PfEMP1 adhesin is a virulence factor and a prime target of humoral immunity.

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Open Access | Plasmodium vivax Sub-Patent Infections after Radical Treatment Are Common in Peruvian Patients: Results of a 1-Year Prospective Cohort Study

February 2, 2011 - 07:10 -- Kabogo Ndegwa
Author(s): 
Peter Van den Eede, Veronica E. Soto-Calle, Christopher Delgado, Dionicia Gamboa, Tanilu Grande, Hugo Rodriguez, Alejandro Llanos-Cuentas, Jozef Anné, Umberto D'Alessandro, Annette Erhart
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PLoS ONE 6(1): e16257

In Peru, the P. vivax recurrent infections were common and displayed a high turnover of parasite genotypes compared to day 0.

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Open Access | Erratum: The Th1 Immune Response to Plasmodium falciparum Circumsporozoite Protein Is Boosted by Adenovirus Vectors 35 and 26 with a Homologous Insert

February 2, 2011 - 07:06 -- Kabogo Ndegwa
Author(s): 
Katarina Radosevic, Ariane Rodriguez, Angelique A. C. Lemckert, Marjolein van der Meer, Gert Gillissen, Carolien Warnar, Rie von Eyben, Maria Grazia Pau, and Jaap Goudsmit
Reference: 
Clinical and Vaccine Immunology, February 2011, p. 353, Vol. 18, No. 2

The most advanced malaria vaccine, RTS,S, is comprised of a portion of the Plasmodium falciparum circumsporozoite (CS) protein

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Open Access | Evolutionary Dynamics of the Ty3/Gypsy LTR Retrotransposons in the Genome of Anopheles gambiae

February 2, 2011 - 06:41 -- Kabogo Ndegwa
Author(s): 
Jose Manuel C. Tubio, Marta Tojo, Laia Bassaganyas, Georgia Escaramis, Igor V. Sharakhov, Maria V. Sharakhova, Cristian Tornador, Maria F. Unger, Horacio Naveira, Javier Costas, Nora J. Besansky
Reference: 
PLoS ONE 6(1): e16328

Ty3/gypsy elements represent one of the most abundant and diverse LTR-retrotransposon (LTRr) groups in the Anopheles gambiae genome, but their evolutionary dynamics have not been explored in detail.

Open Access | Plasmodium vivax Tryptophan-Rich Antigen PvTRAg33.5 Contains Alpha Helical Structure and Multidomain Architecture

February 2, 2011 - 06:35 -- Kabogo Ndegwa
Author(s): 
Hema Bora, Sheena Garg, Priyankar Sen, Deepak Kumar, Punit Kaur, Rizwan Hasan Khan, Yagya D. Sharma
Reference: 
PLoS ONE 6(1): e16294

Tryptophan-rich proteins from several malarial parasites have been identified where they play an important role in host-parasite interaction.

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