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Scientific Articles

Open Access | Dispatch: Unusual Transmission of Plasmodium falciparum, Bordeaux, France, 2009

February 4, 2011 - 08:08 -- Patrick Sampao
Author(s): 
Marc-Olivier Vareil., Olivier Tandonnet.,Denis Malvy ., et al.
Reference: 
Emerging Infectious Diseases, Volume 17, Number 2–February 2011

Plasmodium falciparum malaria is usually transmitted by mosquitoes. We report 2 cases in France transmitted by other modes: occupational blood exposure and blood transfusion.

Open Access | Sequence similarity between the erythrocyte binding domain 1 of the Plasmodium vivax Duffy Binding Protein and the V3 loop of HIV-1 strain MN reveals binding residues for the Duffy Antigen Receptor for Chemokines

February 4, 2011 - 08:03 -- Patrick Sampao
Author(s): 
Bolton MJ, Garry RF
Reference: 
Virology Journal 2011, 8:45 (31 January 2011)

Variable loop 3 (V3) of HIV-1 SU and subdomain 1 of the Plasmodium vivax DBP share a sequence similarity. The site of amino acid sequence similarity was necessary, but not sufficient, for DARC binding and contained a consensus heparin binding site essential for DARC binding. Both HIV-1 and P. vivax can be blocked from binding to their chemokine receptors by the chemokine, RANTES and its analog AOP-RANTES.

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Review: Pitfalls in new artemisinin-containing antimalarial drug development

February 4, 2011 - 07:43 -- Patrick Sampao
Author(s): 
Ronan Jambou, Jacques Le Bras, Milijaona Randrianarivelojosia
Reference: 
Trends in Parasitology, Volume 27, Issue 2, February 2011, Pages 82-90

Alongside the deployment of multifocal control programs, the process ranging from artemisia crop production to accreditation of new ACT combinations urgently needs to be strengthened to supply sufficient quantities of high-quality drugs.

Open Access | Intermittent Preventive Treatment of Malaria Provides Substantial Protection against Malaria in Children Already Protected by an Insecticide-Treated Bednet in Mali: A Randomised, Double-Blind, Placebo-Controlled Trial

February 4, 2011 - 07:30 -- Kabogo Ndegwa
Author(s): 
Alassane Dicko, Abdoulbaki I. Diallo, Brian Greenwood, et al.
Reference: 
PLoS Med 8(2): e1000407

IPTc given during the malaria transmission season provided substantial protection against clinical episodes of malaria, malaria infection, and anaemia in children using an LLIN.

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Open Access | Intermittent Preventive Treatment to Reduce the Burden of Malaria in Children: New Evidence on Integration and Delivery

February 4, 2011 - 07:15 -- Kabogo Ndegwa
Author(s): 
James G. Beeson, Stephen J. Rogerson, Ivo Mueller, Jack S. Richards, Freya J. I. Fowkes
Reference: 
PLoS Med 8(2): e1000410

One approach to help reduce the burden of malaria caused by Plasmodium falciparum is intermittent preventive treatment (IPT), which involves periodic therapeutic doses of antimalarials to reduce the incidence of malaria and prevalence of anemia [1],[2].

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Open Access | Detection of an antibody against Plasmodium vivax in residents of Gimpo-si, South Korea, using an indirect fluorescent antibody test

February 4, 2011 - 07:12 -- Kabogo Ndegwa
Author(s): 
Lee W, Kim H, Hwang S, Park M, Kim N, Cho S, In T, Kim J, Sattabongkot J, Sohn Y, Kim H, Lee J, Lee H
Reference: 
Malaria Journal 2011, 10:19 (31 January 2011)

These results indicate that antibody titers obtained using IFAT may provide useful information about the prevalence of P. vivax in low endemic areas and could be used to detect asymptomatic patients. Finding asymptomatic patients is important in eliminating vivax malaria in South Korea.

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The United Nations' Scientific Fraud against DDT

February 3, 2011 - 17:37 -- Ingeborg van Schayk
Author(s): 
Roger Bate, Donald Roberts, Richard Tren
Reference: 
Health Policy Outlook, No. 1, January 2011

Through a mix of environmental fervor, self-interest, and disregard for evidence-based policy, United Nations (UN) agencies are misleading the public about DDT--mistakenly claiming it is not needed and can be eliminated globally by 2020.

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Review: Plasmodium sensitivity to artemisinins: magic bullets hit elusive targets

February 2, 2011 - 13:53 -- Patrick Sampao
Author(s): 
Xavier C. Ding, Hans-Peter Beck, Giovanna Raso
Reference: 
Trends in Parasitology, Volume 27, Issue 2, February 2011, Pages 73-81

In this review different models of artemisinins’ molecular action are briefly presented, focusing on recent advances, and the evidence of potential association between various gene polymorphisms and artemisinin resistance is comprehensively reviewed.

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Opinion: How artemisinin-containing combination therapies slow the spread of antimalarial drug resistance

February 2, 2011 - 13:23 -- Patrick Sampao
Author(s): 
Ian Hastings
Reference: 
Trends in Parasitology, Volume 27, Issue 2, February 2011, Pages 67-72

Recent reports suggest that early stages of resistance to artemisinins and/or its partner drugs could be occurring, thus it is timely to briefly review exactly how ACTs slow the origin and spread of resistance and to interpret the threat of resistance within this context.

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