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Scientific Articles

Open Access | A Large Proportion of P. falciparum Isolates in the Amazon Region of Peru Lack pfhrp2 and pfhrp3: Implications for Malaria Rapid Diagnostic Tests

January 29, 2010 - 14:01 -- Ingeborg van Schayk
Author(s): 
Gamboa D, Ho M-F, Bendezu J, Torres K, Chiodini PL, et al.
Reference: 
PLoS ONE 5(1): e8091

RDTs detecting parasite LDH or aldolase and quality microscopy should be use for malaria diagnosis in this region. There is an urgent need for investigation of the abundance and geographic distribution of these parasites in Peru and neighbouring countries.

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Open Access | Plasma Levels of Apoliporptoein A1 in Malaria-Exposed Primigravidae Are Associated with Severe Anemia

January 29, 2010 - 13:55 -- Ingeborg van Schayk
Author(s): 
David C. Simpson, Edward Kabyemela, Atis Muehlenbachs, Yuko Ogata, Theonest K. Mutabingwa, Patrick E. Duffy, Michal Fried
Reference: 
PLoS ONE 5(1): e8822

Here we aimed to identify additional changes in the plasma proteome associated with pregnancy malaria that may contribute to the development of malaria-related maternal anemia.

Open Access | Phase 1 Trial of the Plasmodium falciparum Blood Stage Vaccine MSP142-C1/Alhydrogel with and without CPG 7909 in Malaria Naïve Adults

January 29, 2010 - 13:48 -- Ingeborg van Schayk
Author(s): 
Ellis RD, Martin LB, Shaffer D, Long CA, Miura K, et al.
Reference: 
PLoS ONE 5(1): e8787

A Phase 1 clinical trial was conducted in healthy malaria-naïve adults at the Center for Immunization Research in Washington, D.C., to evaluate the safety and immunogenicity of MSP142-C1/Alhydrogel +/− CPG 7909.

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Open Access | Health in Action: Microscopy Quality Control in Médecins Sans Frontières Programs in Resource-Limited Settings

January 29, 2010 - 11:54 -- Ingeborg van Schayk
Author(s): 
Derryck B. Klarkowski, Juan Daniel Orozco
Reference: 
PLoS Med 7(1): e1000206

Derryck Klarkowski and Daniel Orozco describe the Médecins Sans Frontières program for monitoring the quality of microscopy for malaria, pulmonary tuberculosis, and leishmaniasis.

Open Access | Cost Implications of Improving Malaria Diagnosis: Findings from North-Eastern Tanzania

January 29, 2010 - 10:55 -- Ingeborg van Schayk
Author(s): 
Jacklin F. Mosha, Lesong Conteh, Fabrizio Tediosi, Samwel Gesase, Jane Bruce, Daniel Chandramohan, Roly Gosling
Reference: 
PLoS ONE 5(1): e8707

This paper attempts to estimate the rates of over diagnosis of malaria among children attending dispensaries in rural Tanzania and examines the potential cost implications of improving the quality of diagnosis.

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Update: Only the good die young: a novel paradigm for mosquito control

January 28, 2010 - 12:52 -- Kabogo Ndegwa
Author(s): 
Peter F. Billingsley
Reference: 
Trends in Parasitology, Volume 26, Issue 2, February 2010, Pages 53-55

Andrew Read and colleagues have proposed that insecticides acting late in the vector lifetime are less susceptible to evolutionary pressures, thereby avoiding insecticide resistance.

Heat shock proteins contribute to mosquito dehydration tolerance

January 28, 2010 - 12:50 -- Kabogo Ndegwa
Author(s): 
Joshua B. Benoit, Giancarlo Lopez-Martinez, Zachary P. Phillips, Kevin R. Patrick and David L. Denlinger
Reference: 
Journal of Insect Physiology, Volume 56, Issue 2, February 2010, Pages 151-156

This study examines the responses of heat shock protein transcripts, Hsp70 and Hsp90, to dehydration stress in three mosquito species, Aedes aegypti, Anopheles gambiae and Culex pipiens. 

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Review: Do paediatric drug formulations of artemisinin combination therapies improve the treatment of children with A systematic review and meta-analysis

January 28, 2010 - 12:47 -- Kabogo Ndegwa
Author(s): 
Florian Kurth, Sabine Bélard, Ayola A Adegnika, Prof Oumar Gaye, Prof Peter G Kremsner, and Dr Michael Ramharter
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 2, February 2010, Pages 125-132

These data provide, for the first time, evidence for improved management of children by use of paediatric formulations, and support the further development and use of paediatric ACTs.

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The role of platelets in the pathogenesis of cerebral malaria

January 28, 2010 - 12:40 -- Kabogo Ndegwa
Author(s): 
Dermot Cox and Sam McConkey
Reference: 
Cellular and Molecular Life Sciences, Volume 67, Number 4 / February, 2010, Pages 557-568

There is a strong association between thrombocytopenia and outcome in malaria, suggesting a role for platelets in the pathogenesis of malaria.

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