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Scientific Articles

Open Access | Prozone in malaria rapid diagnostics tests: how many cases are missed?

June 16, 2011 - 07:51 -- Kabogo Ndegwa
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Author(s): 
Gillet P, Scheirlinck A, Stokx J, De Weggheleire A, Chauque HS, Canhanga ODJV, Tadeu BT, Mosse CDD, Tiago A, Mabunda S, Bruggeman C, Bottieau E, Jacobs J
Reference: 
Malaria Journal 2011, 10:166 (15 June 2011)

Prozone occurs at different frequency and intensity in HRP-2 RDTs and may decrease diagnostic accuracy in the most affected RDTs.

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Open Access | Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa

June 16, 2011 - 07:48 -- Kabogo Ndegwa
Author(s): 
Slavic K, Krishna S, Derbyshire ET, Staines HM
Reference: 
Malaria Journal 2011, 10:165 (15 June 2011)

Glucose is the primary source of energy and a key substrate for most cells.

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Antibodies directed against merozoite surface protein-6 are induced by natural exposure to Plasmodium falciparum in a low transmission environment

June 16, 2011 - 07:46 -- Kabogo Ndegwa
Author(s): 
S. J. Jordan, A. L. Oliveira, A. T. Neal, J. N. Hernandez, O. H. Branch, J. C. Rayner
Reference: 
Parasite Immunology, Volume 33, Issue 7, pages 401–410, July 2011

Malaria caused by Plasmodium falciparum is a major cause of global infant mortality, and there is currently no licensed vaccine that provides protection against infection or disease.

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Open Access | Safety, pharmacokinetics and efficacy of artemisinins in pregnancy

June 15, 2011 - 14:42 -- Kabogo Ndegwa
Author(s): 
Veronica Ades
Reference: 
Infectious Disease Reports, Vol 3, No 1 (2011)

Malaria in pregnancy can lead to serious maternal and fetal morbidity and mortality. Access to the most effective antimalarials in pregnancy is essential.

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Open Access | Polymorphism of Plasmodium falciparum Na+/H+ exchanger is indicative of a low in vitro quinine susceptibility in isolates from Viet Nam

June 15, 2011 - 14:40 -- Kabogo Ndegwa
Author(s): 
Sinou V, Quang L, Pelleau S, Huong V, Huong N, Tai L, Bertaux L, Desbordes M, Latour C, Long L, Thanh N, Parzy D
Reference: 
Malaria Journal 2011, 10:164 (14 June 2011)

The haplotype 7 which is the typical Asian profile is likely well-adapted to high drug pressure in this area and may constitute a good genetic marker to evaluate the dissemination of QNR in this part of the world.

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Open Access | Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1

June 15, 2011 - 13:54 -- Kabogo Ndegwa
Author(s): 
Wilson Wong, Colleen T. Skau, Danushka S. Marapana, Eric Hanssen, Nicole L. Taylor, David T. Riglar, Elizabeth S. Zuccala, Fiona Angrisano, Heather Lewis, Bruno Catimel, Oliver B. Clarke, Nadia J. Kershaw, Matthew A. Perugini, David R. Kovar, Jacqueline M. Gulbis, and Jake Baum
Reference: 
PNAS June 14, 2011 vol. 108 no. 24 9869-9874

Malaria parasite cell motility is a process that is dependent on the dynamic turnover of parasite-derived actin filaments.

Open Access | Genotyping of polymorphic marker (MSP3α and MSP3β) genes of Plasmodium vivax field isolates from malaria endemic of Thailand

June 15, 2011 - 09:40 -- Kabogo Ndegwa
Author(s): 
Kanchana Rungsihirunrat, Wanna Chaijaroenkul, Napapoon Siripoon, Aree Seugorn and Kesara Na-Bangchang
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 7, pages 794–801, July 2011

Two polymorphic marker genes, merozoite surface protein 3α (PvMSP3α) and merozoite surface protein 3β (PvMSP3β), from 100 Plasmodium vivax field isolates, were investigated using polymerase chain reaction and restriction fragment length polymorphism (PCR/RFLP). Genotyping of PvMSP3α and PvMSP3β revealed marked polymorphisms in length and sequence.

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Malaria prevalence defined by microscopy, antigen detection, DNA amplification and total nucleic acid amplification in a malaria-endemic region during the peak malaria transmission season

June 15, 2011 - 06:48 -- Kabogo Ndegwa
Author(s): 
John N. Waitumbi, Jay Gerlach, Irina Afonina, Samuel B. Anyona, Joseph N. Koros, Joram Siangla, Irina Ankoudinova, Mitra Singhal, Kate Watts, Mark E. Polhemus, Nicolaas M. Vermeulen, Walt Mahoney, Matt Steele and Gonzalo J. Domingo
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 7, pages 786–793, July 2011

The prevalence of submicroscopic malaria infection was significantly higher when detecting total nucleic acid than just DNA in this outpatient population during the high transmission season.

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Open Access | Detection of malarial byproduct hemozoin utilizing its unique scattering properties

June 14, 2011 - 14:48 -- Patrick Sampao
Author(s): 
Benjamin K. Wilson, Matthew R. Behrend, Matthew P. Horning, and Michael C. Hegg
Reference: 
Optics Express, Vol. 19, Issue 13, pp. 12190-12196 (2011)

A new detection method is proposed and demonstrated using dark-field in conjunction with cross-polarization imaging and spectroscopy. SNRs greater than 50:1 are achieved for hemozoin in fresh blood without the addition of stains or reagents. The potential of such a detection system is discussed.

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Intermittent preventive treatment of malaria in pregnancy: at the crossroads of public health policy

June 14, 2011 - 14:26 -- Kabogo Ndegwa
Author(s): 
R. Matthew Chico and Daniel Chandramohan
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 7, pages 774–785, July 2011

The intermittent preventive treatment of malaria in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) has been a key component of the focused antenatal care package for nearly a decade, reducing the burden of low birthweight attributable to malaria in sub-Saharan Africa.

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