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Scientific Articles

Immunology: Boosting antibody responses to Plasmodium falciparum merozoite antigens in children with highly seasonal exposure to infection

March 11, 2010 - 13:14 -- Patrick Sampao
Author(s): 
O. J. Akpogheneta, S. Dunyo, M. Pinder, D. J. Conway
Reference: 
Parasite Immunology,Volume 32, Issue 4, April 2010, Pages: 296-304

Longitudinal cohort studies are important to describe the dynamics of naturally acquired antibody response profiles to defined Plasmodium falciparum malaria antigens relative to clinical malaria episodes.

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Clinical Microbiology: Long-lasting insecticide–treated net usage in eastern Sierra Leone – the success of free distribution

March 11, 2010 - 13:08 -- Patrick Sampao
Author(s): 
Sibylle Gerstl, Sophie Dunkley, Ahmed Mukhtar, Peter Maes, Martin De Smet, Samuel Baker, Jacob Maikere
Reference: 
Tropical Medicine & International Health,Volume 15, Issue 4,April 2010, Pages: 480-488

Our results show that MSF achieved good usage with freely distributed LLINs. It is one of the few areas where results almost achieve the new targets set in 2005 by Roll Back Malaria to have at least 80% of pregnant women and children under 5 years using LLINs by 2010.

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Clinical Microbiology: The effect of food consumption on lumefantrine bioavailability in African children receiving artemether–lumefantrine crushed or dispersible tablets (Coartem®) for acute uncomplicated Plasmodium falciparum malaria

March 11, 2010 - 13:02 -- Patrick Sampao
Author(s): 
Steffen Borrmann, William M. Sallas, Steven E. Kern et al.
Reference: 
Tropical Medicine & International Health,Volume 15, Issue 4, April 2010

Concomitant food consumption may affect absorption of lumefantrine but data in the most important target population, i.e. children, are lacking. Therefore, we evaluated the effect of food intake on oral lumefantrine bioavailability in African children with malaria.

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Short Communication: Comparative fitness assessment of Anopheles stephensi transgenic lines receptive to site-specific integration

March 11, 2010 - 12:34 -- Patrick Sampao
Author(s): 
D. A. Amenya, M. Bonizzoni, A. T. Isaacs, N. Jasinskiene, H. Chen, O. Marinotti, G. Yan, A. A. James
Reference: 
Insect Molecular Biology, Volume 19, Issue 2,April 2010, Pages: 263-269

Genetically modified mosquitoes that are unable to transmit pathogens offer opportunities for controlling vector-borne diseases such as malaria and dengue.

Genetics and Evolution: Chronic malaria infections increase family inequalities and reduce parental fitness: experimental evidence from a wild bird population

March 11, 2010 - 12:10 -- Patrick Sampao
Author(s): 
S. C. L. Knowles, V. Palinauskas, B. C. Sheldon
Reference: 
Journal of Evolutionary Biology, Volume 30, Issue 2, March 2010, Pages: 258-269

Overall, these results demonstrate that chronic avian malaria infections, far from being benign, can have significant effects on host fitness and may thus constitute an important selection pressure in wild bird populations.

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Open Access | Catestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum

March 11, 2010 - 11:32 -- Patrick Sampao
Author(s): 
Aziza Akaddar, Cécile Doderer-Lang, Ermanno Candolfi et al.
Reference: 
Cellular and Molecular Life Sciences, Volume 67, Number 6, March, 2010

We have tested the activities of catestatin and other related peptides on the growth of Plasmodium falciparum in vitro.

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Microbiology and Virology: An α-amylase is a novel receptor for Bacillus thuringiensis ssp. israelensis Cry4Ba and Cry11Aa toxins in the malaria vector mosquito Anopheles albimanus (Diptera: Culicidae)

March 11, 2010 - 10:15 -- Kabogo Ndegwa
Author(s): 
Maria Teresa Fernandez-Luna, Humberto Lanz-Mendoza, Sarjeet S. Gill, Alejandra Bravo, Mario Soberon, Juan Miranda-Rios
Reference: 
Environmental Microbiology, Volume 12, Issue 3, Date: March 2010, Pages: 746-757

Previous work showed that Bti is highly toxic to Anopheles albimanus, the main vector for transmission of malaria in Mexico. In this work, we analysed the toxicity of isolated Cry proteins of Bti and identified an An. albimanus midgut protein as a putative Cry4Ba and Cry11Aa receptor molecule.

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Predictive Factors of Imported Malaria in 272 Febrile Returning Travelers Seen as Outpatients

March 10, 2010 - 15:39 -- Ingeborg van Schayk
Author(s): 
Séverine Ansart, Lucia Perez, Marc Thellier, Martin Danis, François Bricaire, Eric Caumes
Reference: 
Journal of Travel Medicine Volume 17 Issue 2, Pages 124 - 129

We conducted a prospective study to evaluate the aetiologies of fever in returning travelers and to identify the clinical and laboratory factors predictive of malaria in travelers returning from tropical areas with fever.

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Quartan malaria-associated childhood nephrotic syndrome: now a rare clinical entity in malaria endemic Nigeria

March 10, 2010 - 15:28 -- Ingeborg van Schayk
Author(s): 
Wasiu A. Olowu, Kayode A. Adelusola, Olufemi Adefehinti, and Tajudeen G. Oyetunji
Reference: 
Nephrol. Dial. Transplant. 2010; 25:794-801

The study determined (i) whether or not quartan malaria nephropathy (QMN) is still a major cause of childhood nephrotic syndrome (CNS) in Nigeria, (ii) secondary causes other than QMN and their associated glomerular pathology and (iii) renal and patient outcome.

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High prevalence of sulfadoxine/pyrimethamine-resistant alleles of Plasmodium falciparum isolates in pregnant women at the time of introduction of intermittent preventive treatment with sulfadoxine/pyrimethamine in Gabon

March 10, 2010 - 13:58 -- Ingeborg van Schayk
Author(s): 
Marielle Karine Bouyou-Akotet, Denise Patricia Mawili-Mboumba, Tanguy de Dieu Tchantchou, and Maryvonne Kombila
Reference: 
J. Antimicrob. Chemother. 2010 65: 438-441

These findings underline the need for a regular assessment of the relationship between the presence of resistant isolates and in vitro/in vivo IPTp/SP efficacy, and evaluation of an alternative drug.

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