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Scientific Articles

Open Access | Commentary: The pharmaceutical death-ride of dihydroartemisinin

July 26, 2010 - 14:23 -- Kabogo Ndegwa
Author(s): 
Jansen F
Reference: 
Malaria Journal 2010, 9:212 (22 July 2010)

In the 2010 second edition of WHO's guidelines for the treatment of malaria, the relatively new fixed dose combination dihydroartemisinin-piperaquine is included as one of the recommended artemisinin combination therapies.

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Open Access | Buffer substitution in malaria rapid diagnostic tests causes false-positive results

July 26, 2010 - 14:16 -- Kabogo Ndegwa
Author(s): 
Gillet P, Mori M, Van den Ende J, Jacobs J
Reference: 
Malaria Journal 2010, 9:215 (22 July 2010)

Replacement of the RDT kit's dedicated buffer by saline, distilled water and tap water can cause false-positive test results.

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Open Access | Pill characterization data streams for reducing exposure to inadequately identified anti-malarial medication in developing countries

July 26, 2010 - 13:53 -- Kabogo Ndegwa
Author(s): 
Pennefather P, Ahmad A, Crandall I, Suhanic W
Reference: 
Malaria Journal 2010, 9:214 (22 July 2010)

A system of this type would allow users to answer several questions. Is this medicine what it is supposed to be? Can it be used to treat locally encountered malaria?

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Filaria-induced IL-10 suppresses murine cerebral malaria

July 26, 2010 - 11:32 -- Patrick Sampao
Author(s): 
Sabine Specht, Daniel Fernández Ruiz, Bettina Dubben, Susanne Deininger, Achim Hoerauf
Reference: 
Microbes and Infection, Volume 12, Issues 8-9, August 2010, Pages 635-642

In the present work a murine model for subsequent has been used to assess this hypothesis. C57BL/6 mice were infected with the rodent filarial parasite Litomosoides sigmodontis and the murine model parasite for CM, Plasmodium berghei ANKA.

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Open Access | Which family members use the best nets? An analysis of the condition of mosquito nets and their distribution within households in Tanzania

July 26, 2010 - 09:27 -- Kabogo Ndegwa
Author(s): 
Tsuang A, Lines J, Hanson K
Reference: 
Malaria Journal 2010, 9:211 (22 July 2010)

Infants and other vulnerable groups were most likely to sleep under the most protective nets. Nevertheless, more communication efforts are needed to increase use of intact ITNs within households for children.

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Open Access | How absolute is zero? An evaluation of historical and current definitions of malaria elimination

July 26, 2010 - 08:48 -- Kabogo Ndegwa
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Author(s): 
Cohen JM, Moonen B, Snow RW, Smith DL
Reference: 
Malaria Journal 2010, 9:213 (22 July 2010)

Decisions to eliminate malaria from all or part of a country involve a complex set of factors, and this complexity is compounded by ambiguity surrounding some of the key terminology, most notably "control" and "elimination."

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Open Access | Successful field trial of attractive toxic sugar bait (ATSB) plant-spraying methods against malaria vectors in the Anopheles gambiae complex in Mali, West Africa

July 26, 2010 - 08:42 -- Kabogo Ndegwa
Author(s): 
Muller GC, Beier JC, Traore SF, Toure MB, Traore MB, Bah S, Doumbia S, Schlein Y
Reference: 
Malaria Journal 2010, 9:210 (21 July 2010)

This study in Mali shows that even a single application of ATSB can substantially decrease malaria vector population densities and longevity.

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Open Access | Knockdown resistance in Anopheles vagus, An. sinensis, An. paraliae and An. peditaeniatus populations of the Mekong region

July 26, 2010 - 08:13 -- Patrick Sampao
Author(s): 
Katrijn Verhaeghen , Wim Van Bortel , Ho Dinh Trung, Tho Sochantha , Kalouna Keokenchanh and Marc Coosemans
Reference: 
Parasites & Vectors 2010, 3:59

In this study, the resistance status of the potential malaria vectors An. vagus, An. sinensis, An. paraliae and An. peditaeniatus was assessed.

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Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum

July 26, 2010 - 08:00 -- Patrick Sampao
Author(s): 
Phurpa Wangchuk, John B. Bremner, Samten, Brian W. Skelton, Allan H. White, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan
Reference: 
Journal of Ethnopharmacology, Volume 130, Issue 3, 9 August 2010, Pages 559-562

Our studies provide the first evidence in support of one of the indicated treatments with Aconitum orochryseum in Bhutanese traditional medicine.

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Review | Of mice and women: rodent models of placental malaria

July 22, 2010 - 09:16 -- Patrick Sampao
Author(s): 
Lars Hviid, Claudio R.F. Marinho, Trine Staalsoe, Carlos Penha-Gonçalves
Reference: 
Trends in Parasitology, Volume 26, Issue 8, August 2010, Pages 412-419

Placental IE sequestration in the intervillous space is mediated by variant surface antigens (VSAs) selectively expressed in placental malaria (PM) and specific for chondroitin sulfate A (CSA). In Plasmodium falciparum, these VSAPM appear largely synonymous with the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family variant VAR2CSA.

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