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Scientific Articles

Open Access | Methodology: A semi-automated method for counting fluorescent malaria oocysts increases the throughput of transmission blocking studies

January 29, 2010 - 15:14 -- Ingeborg van Schayk
Author(s): 
Michael J Delves, Robert E Sinden
Reference: 
Malaria Journal 2010, 9:35 (29 January 2010)

The authors developed a method to count fluorescent malaria parasite oocysts on mosquito midgut. This method should speed up the process of counting malaria parasites and limit data variation due to the observer. They present data highlighting the use of this method to increasing throughput for evaluating the transmission blocking potential of selected anti-malarial drugs.

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Open Access | Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy

January 29, 2010 - 15:07 -- Ingeborg van Schayk
Author(s): 
Wilfred F Mbacham, Marie-Solange B Evehe, Palmer M Netongo, Isabel A Ateh, Patrice N Mimche, Anthony Ajua, Akindeh M Nji, Justin B Echouffo-Tcheugui, Bantar Tawe, Rachel Hallett, Cally Roper, Geoffrey Targett, Brian Greenwood
Reference: 
Malaria Journal 2010, 9:34 (27 January 2010)

Conducted in 2004-2006, the results of this study give updated information about anti-malarials efficacy at the time of policy change to ACT treatment (AQ used in combination with artesunate and SP used in IPT for pregnant women.

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Open Access | Molecular evidence for the occurrence of a new sibling species within the Anopheles (Kerteszia) cruzii complex in south-east Brazil

January 29, 2010 - 15:00 -- Ingeborg van Schayk
Author(s): 
Luisa DP Rona, Carlos J Carvalho-Pinto, Alexandre A Peixoto
Reference: 
Malaria Journal 2010, 9:33 (26 January 2010)

Preliminary work presenting genetic differentiation for two populations of that species from the same Brazilian locality. It shows promising results as both gene markers and the different analyses used present a consistent trend towards the separation into two taxa.

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Open Access | Malaria incidence and prevalence on Pemba Island before the onset of the successful control intervention on the Zanzibar Archipelago

January 29, 2010 - 14:53 -- Ingeborg van Schayk
Author(s): 
Thomas Jaenisch, David J Sullivan, Arup Dutta, Saikat Deb, Mahdi Ramsan, Mashavu K Othman, Roger Gaczkowski, James Tielsch, Sunil Sazawal
Reference: 
Malaria Journal 2010, 9:32 (25 January 2010)

Having reliable data on malaria prevalence and estimates of clinical malaria incidence, prior to an intensive control effort, is of paramount importance. The authors rightly argue that the efficacy/effectiveness of control efforts might be over-estimated if so were the baseline figures.

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Open Access | Low-technology cooling box for storage of malaria RDTs and other medical supplies in remote areas

January 29, 2010 - 14:45 -- Ingeborg van Schayk
Author(s): 
Lon Chanthap, Frederic Ariey, Duong Socheat, Reiko Tsuyuoka, David Bell
Reference: 
Malaria Journal 2010, 9:31 (23 January 2010)

The study investigates the effectiveness of an evaporative cooler box prototype developed in Cambodia for the improving storage of malaria rapid diagnostic tests and anti-malarial drugs at the peripheral health facility and community level. This is a very important development, because with the large-scale roll-out of RDTs and ACT in the region.

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Open Access | Treatment of asymptomatic carriers with artemether-lumefantrine: an opportunity to reduce the burden of malaria?

January 29, 2010 - 14:33 -- Ingeborg van Schayk
Author(s): 
Bernhards Ogutu, Alfred B Tiono, Michael Makanga, Zulfiqarali Premji, Adama Dodji Gbadoe, David Ubben, Anne Claire Marrast, Oumar Gaye
Reference: 
Malaria Journal 2010, 9:30 (22 January 2010)

This hypothesis highlights an important aspect of the application of effective treatment for malaria control: the need of a shift from passive to active case detection, with treatment of asymptomatic cases being critical in the elimination of parasite reservoirs.

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Open Access | Naturally-acquired humoral immune responses against the N- and C-termini of the Plasmodium vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assay

January 29, 2010 - 14:27 -- Ingeborg van Schayk
Author(s): 
Carmen Fernandez-Becerra, Sergi Sanz, Marina Brucet, Danielle I Stanisic, Fabiana P Alves, Erney P Camargo, Pedro L Alonso, Ivo Mueller, Hernando A del Portillo
Reference: 
Malaria Journal 2010, 9:29 (21 January 2010)

This study validates the use of the multiplex assay to measure naturally-acquired IgG antibodies against the merozoite surface protein 1 of P. vivax.

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Open Access | Assessment of two malaria rapid diagnostic tests in children under five years of age, with follow-up of false-positive pLDH test results, in a hyperendemic falciparum malaria area, Sierra Leone

January 29, 2010 - 14:23 -- Ingeborg van Schayk
Author(s): 
Sibylle Gerstl, Sophie Dunkley, Ahmed Mukhtar, Martin De Smet, Samuel Baker, Jacob Maikere
Reference: 
Malaria Journal 2010, 9:28 (21 January 2010)

Both RDTs were highly sensitive, met WHO standards for the detection of falciparum malaria monoinfections where parasitaemia was >100 parasites/mul and were easy to use. CareStartTM persistent false positivity decreased quickly after successful anti-malarial treatment, making it a good choice for a RDT for a hyperendemic falciparum malaria area.

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Case report: Myocardial Dysfunction in Severe Falciparum Malaria

January 29, 2010 - 14:14 -- Ingeborg van Schayk
Author(s): 
Poddutoor Preetham Kumar, Chirla Dinesh Kumar, Farhan A. R. Shaik, and Satish Babu Ghanta
Reference: 
J Trop Pediatr 2010 56: 67-68; doi:10.1093/tropej/fmp050

Severe malaria causes multiorgan dysfunction, which is the predominant reason for mortality in these children.

Open Access | Anopheles Immune Genes and Amino Acid Sites Evolving Under the Effect of Positive Selection

January 29, 2010 - 14:09 -- Ingeborg van Schayk
Author(s): 
Parmakelis A, Moustaka M, Poulakakis N, Louis C, Slotman MA, et al.
Reference: 
PLoS ONE 5(1): e8885

Aiming to increase our understanding regarding the interactions between Plasmodium and the Anopheles immune genes, we investigated the patterns of genetic diversity of four anti-Plasmodium genes in the Anopheles gambiae complex of species.

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