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Scientific Articles

Characterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34)

May 28, 2010 - 15:04 -- Patrick Sampao
Author(s): 
Alvaro Mongui, Diana I. Angel, Gina Gallego, Claudia Reyes, Paola Martinez, Felipe Guhl, Manuel A. Patarroyo
Reference: 
Vaccine, Volume 28, Issue 2, 11 December 2009, Pages 415-421

This study describes the identification of the Plasmodium vivax rhoptry antigen Pv34 whose sequence was obtained based on homology comparison with the Plasmodium falciparum Pf34.

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Evaluation of the safety and immunogenicity of Plasmodium falciparum apical membrane antigen 1, merozoite surface protein 1 or RTS,S vaccines with adjuvant system AS02A administered alone or concurrently in rhesus monkeys

May 28, 2010 - 14:56 -- Patrick Sampao
Author(s): 
Pichyangkul S., Kum-Arb U., et al.
Reference: 
Vaccine, Volume 28, Issue 2, 11 December 2009, Pages 452-462

The objectives of this study were (i) to determine whether MSP142 and AMA1 vaccines formulated with the AS02A Adjuvant System were safe and immunogenic in the rhesus monkey model; (ii) to investigate whether MSP142 or AMA1 induced immune interference to each other, or to RTS,S, when added singly or in combinations at a single injection site; (iii) in the event of immune interference, to determine if this could be reduced when antigens were administered at separate sites.

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Open Access | Using an Improved Phagocytosis Assay to Evaluate the Effect of HIV on Specific Antibodies to Pregnancy-Associated Malaria

May 28, 2010 - 10:09 -- Kabogo Ndegwa
Author(s): 
Ricardo Ataíde, Wina Hasang, Danny W. Wilson, James G. Beeson, Victor Mwapasa, Malcolm E. Molyneux, Steven R. Meshnick, Stephen J. Rogerson
Reference: 
PLoS ONE 5(5): e10807.

This flow cytometry-based phagocytosis assay proved to be efficient and accurate for the measurement of Fc-receptor mediated phagocytosis-inducing antibodies in large cohorts. HIV was found to affect mainly the acquisition of antibodies to pregnancy-specific malaria in primigravidae. Further studies of the relationship between opsonising antibodies to malaria in pregnancy and HIV are indicated.

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Open Access | Malaria and Under-Nutrition: A Community Based Study Among Under-Five Children at Risk of Malaria, South-West Ethiopia

May 28, 2010 - 10:06 -- Kabogo Ndegwa
Author(s): 
Amare Deribew, Fessehaye Alemseged, Fasil Tessema, Lelisa Sena, Zewdie Birhanu, Ahmed Zeynudin, Morankar Sudhakar, Nasir Abdo, Kebede Deribe, Sibhatu Biadgilign
Reference: 
PLoS ONE 5(5): e10775.

In this study, there is no association between malaria and under-nutrition. Children who have malaria are more likely to be anaemic. Malaria prevention and control program should consider nutrition interventions particularly anemia.

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Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β-carbolines as a new class of antimalarial agents

May 28, 2010 - 10:02 -- Kabogo Ndegwa
Author(s): 
Leena Gupta, Kumkum Srivastava, Shubhra Singh, S.K. Puri, Prem M.S. Chauhan
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 11, 1 June 2008, Pages 3306-3309

A series of hybrid molecules 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β-carbolines have been synthesized and screened for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum.

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Synthetic glycosylphosphatidylinositol microarray reveals differential antibody levels and fine specificities in children with mild and severe malaria

May 28, 2010 - 09:47 -- Kabogo Ndegwa
Author(s): 
Marco Tamborrini, Xinyu Liu, Joseph Paschal Mugasa, Yong-Uk Kwon, Faustin Kamena, Peter H. Seeberger, Gerd Pluschke
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 11, 1 June 2010, Pages 3747-3752

Glycosylphosphatidylinositol (GPI) glycolipids abound on the cell surface at the merozoite stage of Plasmodium falciparum life cycle are a central toxin in malaria.

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Genetic association of Toll-like-receptor 4 and tumor necrosis factor-α polymorphisms with Plasmodium falciparum blood infection levels

May 27, 2010 - 15:05 -- Patrick Sampao
Author(s): 
Madhumita B., Ardhendu K. M., et al.
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 686-696

Association of parasite load with genotypes was examined using model based and model free approaches.

Evidence for negative selection on the gene encoding rhoptry-associated protein 1 (RAP-1) in Plasmodium spp.

May 27, 2010 - 14:51 -- Patrick Sampao
Author(s): 
Elizabeth M. R., Amanda C. P., et al.
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 655-661

We investigated the genetic diversity of orthologous genes encoding the rhoptry-associated protein 1 (RAP-1), a low polymorphic protein of malarial parasites that is involved in erythrocyte invasion.

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Sequence variation of ookinete surface proteins Pvs25 and Pvs28 of Plasmodium vivax isolates from Southern Mexico and their association to local anophelines infectivity

May 27, 2010 - 11:50 -- Patrick Sampao
Author(s): 
Lilia C., Alejandro D., et al.
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 645-654

The polymorphism of Pvs25 and Pvs28 ookinete surface proteins, their association to circumsporozoite protein repeat (CSPr) genotypes (Vk210 and Vk247) and their infectivity to local Anopheles albimanus and Anopheles pseudopunctipennis were investigated in Plasmodium vivax-infected blood samples obtained from patients in Southern Mexico.

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Evolutionary insights into insecticide resistance gene families of Anopheles gambiae

May 27, 2010 - 11:42 -- Patrick Sampao
Author(s): 
Hemlata Srivastava, Meenu Sharma, Jyotsana Dixit, Aparup Das
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 620-628

We herein utilized the whole genome sequence information of the malaria vector Anopheles gambiae and inferred evolutionary pattern of the three known IR gene families (CYP, GST and COE).

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