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Scientific Articles

In Vivo and In Vitro Antimalarial Properties of Azithromycin-Chloroquine Combinations That Include the Resistance Reversal Agent Amlodipine

June 21, 2011 - 06:51 -- Kabogo Ndegwa
Author(s): 
Marcus R. Pereira, Philipp P. Henrich, Amar bir Singh Sidhu, David Johnson, Joel Hardink, Jeffrey Van Deusen, Jian Lin, Katrina Gore, Connor O'Brien, Mamadou Wele, Abdoulaye Djimde, Richa Chandra, David A. Fidock
Reference: 
Antimicrobial Agents and Chemotherapy, July 2011,p. 3115-3124, Vol. 55, No. 7

Evidence of emerging Plasmodium falciparum resistance to artemisinin-based combination therapies, documented in western Cambodia, underscores the continuing need to identify new antimalarial combinations.

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Molecular Mechanism of Renal Tubular Secretion of the Antimalarial Drug Chloroquine

June 21, 2011 - 06:47 -- Kabogo Ndegwa
Author(s): 
Fabian Müller, Jörg König, Hartmut Glaeser, Ingrid Schmidt, Oliver Zolk, Martin F. Fromm, and Renke Maas
Reference: 
Antimicrobial Agents and Chemotherapy, July 2011,p. 3091-3098, Vol. 55, No. 7

The antimalarial drug chloroquine is eliminated to a significant extent by renal tubular secretion.

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Open Access | Insecticide-treated net (ITN) ownership, usage, and malaria transmission in the highlands of western Kenya

June 20, 2011 - 14:16 -- Patrick Sampao
Author(s): 
Harrysone E Atieli, Guofa Zhou, Yaw A Afrane, Ming-Chieh Lee, Isaac Mwanzo, Andrew K Githeko and Guiyun Yan
Reference: 
Parasites & Vectors 2011, 4:11 , 18 June 2011

This study examined ITN ownership and underlying factors for among-household variation in use, and malaria transmission in two highland regions of western Kenya.

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Superior Antimalarial Immunity after Vaccination with Late Liver Stage-Arresting Genetically Attenuated Parasites

June 18, 2011 - 15:05 -- Kabogo Ndegwa
Author(s): 
Noah S. Butler, Nathan W. Schmidt, Ashley M. Vaughan, Ahmed S. Aly, Stefan H.I. Kappe, John T. Harty
Reference: 
Cell Host & Microbe, Volume 9, Issue 6, 16 June 2011, Pages 451-462

While subunit vaccines have shown partial efficacy in clinical trials, radiation-attenuated sporozoites (RAS) remain the “gold standard” for sterilizing protection against Plasmodium infection in human vaccinees.

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Open Access | Insecticide resistance in malaria vector mosquitoes at four localities in Ghana, West Africa

June 18, 2011 - 14:09 -- Patrick Sampao
Author(s): 
Richard H Hunt, Godwin Fuseini, Steve Knowles, Joseph Stiles-Ocran, Rolf Verster, Maria L Kaiser, Kwang Shik Choi, Lizette L Koekemoer and Maureen Coetzee
Reference: 
Parasites & Vectors 2011, 4:107, June 2011

The data highlight the complexity of the situation prevailing in southern Ghana and the challenges facing the malaria vector control programmes in this region.

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Open Access | Field evaluation of the intermittent preventive treatment of malaria during pregnancy (IPTp) in Benin: evolution of the coverage rate since its implementation

June 18, 2011 - 13:54 -- Patrick Sampao
Author(s): 
Tania CDA d'Almeida, Marie-Agnes Agboton-Zoumenou, Andre Garcia, Achille Massougbodji, Valerie Briand, Yacoubou Imorou and Gilles Cottrell
Reference: 
Parasites & Vectors 2011, 4:108, 16 June 2011

The study investigated 2420 women who gave birth from 2005 to 2009. The antenatal cards of those women were randomly selected over 5 years with the aim of analyzing the IPT coverage in the study's maternity hospitals.

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Open Access | Pattern of malaria transmission along the Rahad River basin, Eastern Sudan

June 18, 2011 - 13:32 -- Patrick Sampao
Author(s): 
Yousif E Himeidan, Mervet M Elzaki, Eliningaya J Kweka, Muntaser Ibrahim and Ibrahim M Elhassan
Reference: 
Parasites & Vectors 2011, 4:109,16 June 2011

A longitudinal study for mosquito sampling using pyrethrum spray catch (PSC) was conducted in two villages (Koka & Um Salala) along the Rahad River basin from December 2005 to October 2006.

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Open Access | Phylogenomic analyses of malaria parasites and evolution of their exported proteins

June 16, 2011 - 08:33 -- Patrick Sampao
Author(s): 
Christian Pick, Ingo Ebersberger, Tobias Spielmann , Iris Bruchhaus and Thorsten Burmester
Reference: 
BMC Evolutionary Biology 2011, 11:167

Our phylogenomic analyses strongly support the hypotheses that the Laverania have been founded by a single Plasmodium species switching from birds to African great apes or vice versa.

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