The authors developed a method to count fluorescent malaria parasite oocysts on mosquito midgut. This method should speed up the process of counting malaria parasites and limit data variation due to the observer. They present data highlighting the use of this method to increasing throughput for evaluating the transmission blocking potential of selected anti-malarial drugs.
Conducted in 2004-2006, the results of this study give updated information about anti-malarials efficacy at the time of policy change to ACT treatment (AQ used in combination with artesunate and SP used in IPT for pregnant women.
Preliminary work presenting genetic differentiation for two populations of that species from the same Brazilian locality. It shows promising results as both gene markers and the different analyses used present a consistent trend towards the separation into two taxa.
Having reliable data on malaria prevalence and estimates of clinical malaria incidence, prior to an intensive control effort, is of paramount importance. The authors rightly argue that the efficacy/effectiveness of control efforts might be over-estimated if so were the baseline figures.
The study investigates the effectiveness of an evaporative cooler box prototype developed in Cambodia for the improving storage of malaria rapid diagnostic tests and anti-malarial drugs at the peripheral health facility and community level. This is a very important development, because with the large-scale roll-out of RDTs and ACT in the region.
This hypothesis highlights an important aspect of the application of effective treatment for malaria control: the need of a shift from passive to active case detection, with treatment of asymptomatic cases being critical in the elimination of parasite reservoirs.
This study validates the use of the multiplex assay to measure naturally-acquired IgG antibodies against the merozoite surface protein 1 of P. vivax.
Both RDTs were highly sensitive, met WHO standards for the detection of falciparum malaria monoinfections where parasitaemia was >100 parasites/mul and were easy to use. CareStartTM persistent false positivity decreased quickly after successful anti-malarial treatment, making it a good choice for a RDT for a hyperendemic falciparum malaria area.
Severe malaria causes multiorgan dysfunction, which is the predominant reason for mortality in these children.
Aiming to increase our understanding regarding the interactions between Plasmodium and the Anopheles immune genes, we investigated the patterns of genetic diversity of four anti-Plasmodium genes in the Anopheles gambiae complex of species.