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Scientific Articles

Open Access | Artemisone effective against murine cerebral malaria

August 11, 2010 - 12:34 -- Kabogo Ndegwa
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Author(s): 
Waknine-Grinberg JH, Hunt N, Bentura-Marciano A, McQuillan JA, Chan H, Chan W, Barenholz Y, Haynes RK, Golenser J
Reference: 
Malaria Journal 2010, 9:227 (9 August 2010)

Altogether, the results support the use of artemisone for combined therapy of CM.

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Open Access | Book review: Review of "A realistic strategy for fighting malaria in Africa" by William Jobin

August 10, 2010 - 14:18 -- Patrick Sampao
Author(s): 
Bart GJ Knols
Reference: 
Parasites & Vectors 2010, 3:68

"Jobin’s book, however, serves as a contrasting wake-up call, and tries to shed light on what he claims to be ‘the mess we are currently making in Africa’. "

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Quantitative Imaging of Human Red Blood Cells Infected with Plasmodium falciparum

August 10, 2010 - 09:48 -- Kabogo Ndegwa
Author(s): 
A Esposito, JB Choimet, JN Skepper, JM Mauritz, VL Lew, CF Kaminski, T Tiffert
Reference: 
Biophysical Journal, Volume 99, Issue 3, 953-960, 4 August 2010

During its 48 h asexual reproduction cycle, the malaria parasite Plasmodium falciparum ingests and digests hemoglobin in excess of its metabolic requirements and causes major changes in the homeostasis of the host red blood cell (RBC).

Arterolane, a New Synthetic Trioxolane for Treatment of Uncomplicated Plasmodium falciparum Malaria: A Phase II, Multicenter, Randomized, Dose-Finding Clinical Trial

August 10, 2010 - 09:38 -- Kabogo Ndegwa
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Author(s): 
N Valecha, S Looareesuwan, A Martensson, SM Abdulla, S Krudsood, N Tangpukdee, S Mohanty, SK Mishra, PK Tyagi, SK Sharma, J Moehrle, A Gautam, A Roy, JK Paliwal, M Kothari, N Saha, AP Dash, A örkman
Reference: 
Clinical Infectious Diseases 2010;51:000–000

Arterolane at daily doses of 100 and 200 mg is a rapidly acting, effective, and safe synthetic antimalarial drug, which may potentially represent an alternative to artemisinin derivatives in antimalarial combination therapy.

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Fetal Immune Activation to Malaria Antigens Enhances Susceptibility to In Vitro HIV Infection in Cord Blood Mononuclear Cells

August 10, 2010 - 09:21 -- Kabogo Ndegwa
Author(s): 
K Steiner, L Myrie, I Malhotra, P Mungai, E Muchiri, A Dent, CL King
Reference: 
The Journal of Infectious Diseases 2010;202:000–000

Mother-to-child-transmission (MTCT) of human immunodeficiency virus (HIV) remains a significant cause of new HIV infections in many countries.

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Open Access | Mosquito fauna and perspectives for integrated control of urban vector-mosquito populations in Southern Benin (West Africa)

August 10, 2010 - 09:09 -- Kabogo Ndegwa
Author(s): 
A Lingenfelser, K Rydzanicz, A Kaiser, N Becker
Reference: 
Ann Agric Environ Med 2010, 17, 49–57.

This study aims at an integrated vector management (IVM) concept of implementing biological control agents against vector mosquito larvae as a cost-effective and scalable control strategy.

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Comparative Analysis of Stage Specific Gene Regulation of Apicomplexan Parasites: Plasmodium falciparum and Toxoplasma gondii

August 10, 2010 - 08:56 -- Kabogo Ndegwa
Author(s): 
M. Gopalakrishnan, Anusha; Lopez-Estrano, Carlos
Reference: 
Infectious Disorders - Drug Targets, Volume 10, Number 4, August 2010, pp. 303-311(9)

Apicomplexans comprise some of the most life threatening parasites infecting human and livestock and includes Plasmodium and Toxoplasma, the causative agents of malaria and toxoplasmosis respectively, in humans as well as Neospora caninum (abortion in livestock, neosporosis in dogs), Cryptosporidium (Diarrheal cryptosporidiosis and opportunistic infections in AIDS patients) and Eimeria (poultry coccidiosis).

Synthesis, Structure-Activity Relationship, and Mode-of-Action Studies of Antimalarial Reversed Chloroquine Compounds

August 10, 2010 - 08:20 -- Kabogo Ndegwa
Author(s): 
SJ Burgess, JX Kelly, S Shomloo, S Wittlin, R Brun, K Liebmann, DH Peyton
Reference: 
J. Med. Chem. August 4, 2010

We have previously shown that a "reversed chloroquine (RCQ)" molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum

Open Access | Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia

August 10, 2010 - 08:10 -- Kabogo Ndegwa
Author(s): 
Eshetu T, Berens-Riha N, Fekadu S, Tadesse Z, Gurkov R, Holscher M, Loscher T, Barreto Miranda I
Reference: 
Malaria Journal 2010, 9:226 (7 August 2010)

The prevalence of mutations was in accordance with the expected patterns considering recent drug regiments. The broad introduction of AL and the cessation of former drug regimens might probably change the current distribution of polymorphisms, possibly leading to decreased sensitivity to AL in future.

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Open Access | Effects of larval growth condition and water availability on desiccation resistance and its physiological basis in adult Anopheles gambiae sensu stricto

August 10, 2010 - 08:01 -- Kabogo Ndegwa
Author(s): 
Aboagye-Antwi F, Tripet F
Reference: 
Malaria Journal 2010, 9:225 (7 August 2010)

These results demonstrate the importance of growth conditions and water availability on adult physiological status and subsequent.

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