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Scientific Articles

Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities

May 17, 2010 - 09:34 -- Kabogo Ndegwa
Author(s): 
Ange-Désiré Yapi, Nicolas Desbois, Jean-Michel Chezal, Olivier Chavignon, Jean-Claude Teulade, Alexis Valentin, Yves Blache
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 7, July 2010, Pages 2854-2859

Benzo[c]phenanthridine alkaloids represent interesting lead for the discovery of new potential antiplasmodial and/or anticancer drugs. In this field, a novel library of aza-analogs of benzo[c]phenanthroline framework derivatives was designed and prepared.

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Open Access | Complete mtDNA genomes of Anopheles darlingi and an approach to anopheline divergence time

May 17, 2010 - 09:28 -- Kabogo Ndegwa
Author(s): 
Moreno M, Marinotti O, Krzywinski J, Tadei WP, James AA, Achee NL, Conn JE
Reference: 
Malaria Journal 2010, 9:127 (14 May 2010)

Analyses of mtDNA genomes of Anopheles darlingi do not provide support for speciation in the taxon. The dates estimated for divergence among the anopheline groups tested is in agreement with the geological split of western Gondwana (95 mya), and provides additional support for explaining the absence of Cellia in the New World, and Nyssorhynchus in the Afro-Eurasian continents.

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Open Access | Perspectives of people in Mali toward genetically-modified mosquitoes for malaria control

May 17, 2010 - 09:21 -- Kabogo Ndegwa
Author(s): 
Marshall JM, Toure MB, Traore MM, Famenini S, Taylor CE
Reference: 
Malaria Journal 2010, 9:128 (14 May 2010)

Although there were some dissenters, the majority of participants were pragmatic towards a release of GM mosquitoes. An array of social and cultural issues associated with malaria, mosquitoes and genetic engineering became apparent.

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Open Access | A nuclear targeting system in Plasmodium falciparum

May 17, 2010 - 09:16 -- Kabogo Ndegwa
Author(s): 
Wittayacom K, Uthaipibull C, Kumpornsin K, Tinikul R, Kochakarn T, Songprakhon P, Chookajorn T
Reference: 
Malaria Journal 2010, 9:126 (14 May 2010)

The Gal4 fusion technique enables specific transport of a protein of choice into the P. falciparum nucleus, and thus provides a tool for labeling nuclei without using DNA-staining dyes. The finding also indicates similarities between the nuclear transport mechanisms of yeast and P. falciparum.

Open Access | Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

May 17, 2010 - 09:12 -- Kabogo Ndegwa
Author(s): 
Stephanie G. Valderramos, Juan-Carlos Valderramos, Lise Musset, Lisa A. Purcell, Odile Mercereau-Puijalon, Eric Legrand, David A. Fidock
Reference: 
PLoS Pathog 6(5): e1000887.

Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are ubiquitous to infections that fail CQ treatment.

Open Access | Using the entomological inoculation rate to assess the impact of vector control on malaria parasite transmission and elimination

May 13, 2010 - 14:39 -- Kabogo Ndegwa
Author(s): 
Shaukat AM, Breman JG, McKenzie F
Reference: 
Malaria Journal 2010, 9:122 (12 May 2010)

These studies indicate that current vector control methods alone cannot ultimately eradicate malaria because no intervention sustained an annual EIR less than one. While researchers develop new tools, integrated vector management may make the greatest impact on malaria transmission. There are many gaps in the entomological malaria literature and recommendations for future research are provided.

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Open Access | Understanding caretakers' dilemma in deciding whether or not to adhere with referral advice after pre-referral treatment with rectal artesunate

May 13, 2010 - 14:31 -- Kabogo Ndegwa
Author(s): 
Simba DO, Kakoko DC, Warsame M, Premji Z, Gomes MF, Tomson G, Johansson E
Reference: 
Malaria Journal 2010, 9:123 (12 May 2010)

Successful implementation of the rectal artesunate strategy depends upon effective communication regarding referral to clinic.

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Open Access | In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense

May 13, 2010 - 14:27 -- Kabogo Ndegwa
Author(s): 
Ramazani A, Zakeri S, Sardari S, Khodakarim N, Djadid N
Reference: 
Malaria Journal 2010, 9:124 (12 May 2010)

Anti-plasmodial activities of extracts of B. elegans and S. surattense are reported for the first time.

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Moandaensine, a dimeric indole alkaloid from Strychnos moandaensis (Loganiaceae)

May 13, 2010 - 13:30 -- Patrick Sampao
Author(s): 
Robert V., Michel F., et al.
Reference: 
Phytochemistry Letters, Volume 3, Issue 2, 11 June 2010, Pages 100-103

The chemical investigation of the liana Strychnos moandaensis De Wild. led to the isolation of moandaensine, a novel dimeric indole alkaloid.

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High chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from the island of Car Nicobar, India

May 13, 2010 - 13:17 -- Patrick Sampao
Author(s): 
Manoj K. Das1, Vanshika Lumb, Pooja Mittra, Shiv S. Singh, Aditya P. Dash and Yagya D. Sharma
Reference: 
Journal of Antimicrobial Chemotherapy 2010 65(6):1258-1261

There is a predominance of chloroquine- and antifolate-resistant P. falciparum malaria in Car Nicobar, requiring an alternative antimalarial drug treatment policy, such as implementation of artesunate combination therapy (ACT), for this island.

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