This study sought to identify issues arising in practice during the enrolment of paediatric cases with severe malaria and matched healthy controls into the MalariaGEN study.
The present review explores novel drug targets within the malaria parasite that may be exploited in the search for novel drugs that possess long and UTLs.
We propose to review the current state of development of novel compounds directed against this emerging target of malaria parasites with emphasis on the chemistry.
This review compiles literature concerning the design and study of choline analogues and related cation derivatives as potential anti-malarials.
These findings may explain in part the inadequate development of immunity to blood-stage malaria infection.
Using empirical data, we show that these trials, with small numbers of volunteers, are sufficiently powered to detect protective biological effects induced by preerythrocytic and/or blood-stage candidate vaccines if parasitemia is measured daily by quantitative polymerase chain reaction.
We investigated the utility of plasma concentrations of parasite histidine-rich protein 2 (pHRP2), a Plasmodium-specific protein, as a predictor of intracerebral parasite sequestration at autopsy and of malaria retinopathy on clinical examination in patients with clinically defined CM.
In a series of elegant autopsy-based studies, Taylor and colleagues demonstrated that as many as 23% of children who meet this WHO definition of cerebral malaria actually die from other causes and that the presence of malaria retinopathy has a >90% sensitivity and specificity for predicting “true” cerebral malaria, in which parasite sequestration is documented in cerebral capillaries
We discuss the pitfalls of using microsatellite loci across closely related species and conclude that in addition to the problem of null alleles associated with this practice, many loci may prove to be of very limited use as polymorphic markers even when used in a sibling species.