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Scientific Articles

Seeking consent to genetic and genomic research in a rural Ghanaian setting: A qualitative study of the MalariaGEN experience

July 12, 2012 - 08:58 -- Patrick Sampao
Author(s): 
Paulina Tindana, Susan Bull, Lucas Amenga-Etego, Jantina de Vries, Raymond Aborigo, Kwadwo Koram, Dominic Kwiatkowski and Michael Parker
Reference: 
BMC Medical Ethics 2012, 13:15

MalariaWorldThis study sought to identify issues arising in practice during the enrolment of paediatric cases with severe malaria and matched healthy controls into the MalariaGEN study.

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Not Open Access | Novel Drug Targets in Malaria Parasite with Potential to Yield Antimalarial Drugs with Long Useful Therapeutic Lives

July 12, 2012 - 08:37 -- Patrick Sampao
Author(s): 
W. Muregi, Francis; Nyakio Wamakima, Hannah; T. Kimani, Francis
Reference: 
Current Pharmaceutical Design, Volume 18, Number 24, August 2012 , pp. 3505-3521(17)

MalariaWorldThe present review explores novel drug targets within the malaria parasite that may be exploited in the search for novel drugs that possess long and UTLs.

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Not Open Access | The Apicoplast: A Key Target to Cure Malaria

July 12, 2012 - 08:32 -- Patrick Sampao
Author(s): 
MacRae, James; Marechal, Eric; Biot, Christophe; Y. Botte, Cyrille
Reference: 
Current Pharmaceutical Design, Volume 18, Number 24, August 2012 , pp. 3490-3504(15)

MalariaWorldWe propose to review the current state of development of novel compounds directed against this emerging target of malaria parasites with emphasis on the chemistry.

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Not Open Access | Choline Analogues in Malaria Chemotherapy

July 12, 2012 - 08:13 -- Patrick Sampao
Author(s): 
Peyrottes, Suzanne; Caldarelli, Sergio; Wein, Sharon; Perigaud, Christian; Pellet, Alain; Vial, Henri
Reference: 
Current Pharmaceutical Design, Volume 18, Number 24, August 2012 , pp. 3454-3466(13)

MalariaWorldThis review compiles literature concerning the design and study of choline analogues and related cation derivatives as potential anti-malarials.

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Not Open Access | Low-Level Plasmodium falciparum Blood-Stage Infection Causes Dendritic Cell Apoptosis and Dysfunction in Healthy Volunteers

July 12, 2012 - 07:45 -- Patrick Sampao
Author(s): 
Tonia Woodberry, Gabriela Minigo, Kim A. Piera, Fiona H. Amante, Alberto Pinzon-Charry, Michael F. Good, J. Alejandro Lopez, Christian R. Engwerda, James S. McCarthy and Nicholas M. Anstey
Reference: 
J Infect Dis. (2012) 206 (3): 333-340

MalariaWorldThese findings may explain in part the inadequate development of immunity to blood-stage malaria infection.

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Not Open Access | Efficacy of Preerythrocytic and Blood-Stage Malaria Vaccines Can Be Assessed in Small Sporozoite Challenge Trials in Human Volunteers

July 11, 2012 - 14:59 -- Patrick Sampao
Author(s): 
Meta Roestenberg, Sake J. de Vlas, An-Emmie Nieman, Robert W. Sauerwein and Cornelus C. Hermsen
Reference: 
J Infect Dis. (2012) 206 (3): 319-323.

MalariaWorldUsing empirical data, we show that these trials, with small numbers of volunteers, are sufficiently powered to detect protective biological effects induced by preerythrocytic and/or blood-stage candidate vaccines if parasitemia is measured daily by quantitative polymerase chain reaction.

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Not Open Access | Plasma Concentrations of Parasite Histidine-Rich Protein 2 Distinguish Between Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria in Malawian Children

July 11, 2012 - 14:51 -- Patrick Sampao
Author(s): 
Karl B. Seydel, Lindsay L. Fox, Simon J. Glover, Mathew J. Reeves, Paul Pensulo, Alice Muiruri, Ashley Mpakiza, Malcolm E. Molyneux and Terrie E. Taylor
Reference: 
J Infect Dis. (2012) 206 (3): 309-318.

MalariaWorldWe investigated the utility of plasma concentrations of parasite histidine-rich protein 2 (pHRP2), a Plasmodium-specific protein, as a predictor of intracerebral parasite sequestration at autopsy and of malaria retinopathy on clinical examination in patients with clinically defined CM.

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Not Open Access | Accurate Diagnosis of Cerebral Malaria: A Role for Parasite Histidine-Rich Protein 2?

July 11, 2012 - 14:37 -- Patrick Sampao
Author(s): 
Chandy C. John
Reference: 
J Infect Dis. (2012) 206 (3): 307-308.

MalariaWorldIn a series of elegant autopsy-based studies, Taylor and colleagues demonstrated that as many as 23% of children who meet this WHO definition of cerebral malaria actually die from other causes and that the presence of malaria retinopathy has a >90% sensitivity and specificity for predicting “true” cerebral malaria, in which parasite sequestration is documented in cerebral capillaries

Not Open Access | Limited Usefulness of Microsatellite Markers from the Malaria Vector Anophelesgambiae When Applied to the Closely Related Species Anopheles melas

July 11, 2012 - 14:30 -- Patrick Sampao
Author(s): 
Kevin C. Deitz, Vamsi P. Reddy, Michael R. Reddy, Neha Satyanarayanah, Michael W. Lindsey, Hans J. Overgaard, Musa Jawara, Adalgisa Caccone and Michel A. Slotman
Reference: 
J Hered (2012) 103 (4): 585-593.

MalariaWorldWe discuss the pitfalls of using microsatellite loci across closely related species and conclude that in addition to the problem of null alleles associated with this practice, many loci may prove to be of very limited use as polymorphic markers even when used in a sibling species.

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Not Open Access | Impact of Environmental Changes and Human-Related Factors on the Potential Malaria Vector, Anopheles labranchiae (Diptera: Culicidae), in Maremma, Central Italy

July 11, 2012 - 14:10 -- Patrick Sampao
Author(s): 
D. Boccolini, L. Toma, R. Romi, et al.
Reference: 
Journal of Medical Entomology 49(4):833-842. 2012

MalariaWorldOur findings suggest the need for the continuous monitoring of An. labranchiae in the study area.

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