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Scientific Articles

Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination

April 12, 2011 - 14:15 -- Patrick Sampao
Author(s): 
Teun Bousema and Chris Drakeley
Reference: 
Clin. Microbiol. Rev., Apr 2011; 24: 377 - 410.

We discuss how the application of molecular techniques has led to the identification of submicroscopic gametocyte carriage and to a reassessment of the human infectious reservoir.

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Highly conserved gene arrangement of the mitochondrial genomes of 23 Plasmodium species

April 12, 2011 - 14:05 -- Patrick Sampao
Author(s): 
Kenji Hikosaka, Yoh-ichi Watanabe, Fumie Kobayashi, Seiji Waki, Kiyoshi Kita, Kazuyuki Tanabe
Reference: 
Parasitology International, Volume 60, Issue 2, June 2011, Pages 175-180

In this study, we determined the arrangement of mt rRNA gene fragments in 23 Plasmodium species, including two newly determined mt genome sequences from P. gallinaceum and P. vinckei vinckei, as well as Leucocytozoon caulleryi, an outgroup of Plasmodium.

Open Access | Plasmodium knowlesi: Reservoir Hosts and Tracking the Emergence in Humans and Macaques

April 12, 2011 - 08:11 -- Kabogo Ndegwa
Author(s): 
Kim-Sung Lee, Paul C. S. Divis, Siti Khatijah Zakaria, Asmad Matusop, Roynston A. Julin, David J. Conway, Janet Cox-Singh, Balbir Singh
Reference: 
PLoS Pathog 7(4): e1002015

Plasmodium knowlesi, a malaria parasite originally thought to be restricted to macaques in Southeast Asia, has recently been recognized as a significant cause of human malaria.

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Open Access | Interethnic Differences in Antigen-Presenting Cell Activation and TLR Responses in Malian Children during Plasmodium falciparum Malaria

April 12, 2011 - 08:03 -- Kabogo Ndegwa
Author(s): 
Charles Arama, Pablo Giusti, Stéphanie Boström, Victor Dara, Boubacar Traore, Amagana Dolo, Ogobara Doumbo, Stefania Varani, Marita Troye-Blomberg
Reference: 
PLoS ONE 6(3): e18319

The Fulani ethnic group from West Africa is relatively better protected against Plasmodium falciparum malaria as compared to other sympatric ethnic groups, such as the Dogon.

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In vitro activity of new artemisinin derivatives against Plasmodium falciparum clinical isolates from Gabon

April 12, 2011 - 07:46 -- Kabogo Ndegwa
Author(s): 
Jana Held, Shahid A. Soomro, Peter G. Kremsner, F. Herwig Jansen, Benjamin Mordmüller
Reference: 
International Journal of Antimicrobial Agents Volume 37, Issue 5, May 2011, Pages 485-488

Nowadays, artemisinins are the mainstay of malaria treatment, but initial indications of resistance against clinically used derivatives are present.

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Short Technical Report: Small-scale in vitro culture and purification of Plasmodium berghei for transfection experiment

April 11, 2011 - 15:03 -- Patrick Sampao
Author(s): 
Voravuth Somsak, Somdet Srichairatanakool, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong, Chairat Uthaipibull
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 2, June 2011, Pages 156-159

This small-scale protocol provides significant advantages, namely reduction of parasite sample, laboratory consumables and mice for transfection experiments.

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Review: Update on genetic markers of quinine resistance in Plasmodium falciparum

April 11, 2011 - 14:56 -- Patrick Sampao
Author(s): 
John Okombo, Eric Ohuma, Stephane Picot, Alexis Nzila
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 2, June 2011, Pages 77-82

In this report, we have reviewed work on the in vivo efficacy and in vitro activity of quinine, and discussed recent data on genetic markers of resistance to this drug.

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Short Technical Report: A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue

April 11, 2011 - 14:44 -- Patrick Sampao
Author(s): 
Takeshi Q Tanaka, Kim C. Williamson
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 2, June 2011, Pages 160-163

This new assay provides an important tool to efficiently screen compounds for gametocytocidal activity.

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Short Communication: Malaria drug resistance is associated with defective DNA mismatch repair

April 11, 2011 - 14:04 -- Patrick Sampao
Author(s): 
Meryl A. Castellini, Jeffrey S. Buguliskis, Louis J. Casta, Charles E. Butz, Alan B. Clark, Thomas A. Kunkel, Theodore F. Taraschi
Reference: 
Molecular and Biochemical Parasitology, Volume 177, Issue 2, June 2011, Pages 143-147

These data imply that antimalarial drug resistance can result from defective MMR.

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Open Access | Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients

April 7, 2011 - 07:43 -- Kabogo Ndegwa
Author(s): 
Zakeri S, Pirahmadi S, Mehrizi AA, Djadid ND
Reference: 
Malaria Journal 2011, 10:77 (4 April 2011)

These data point towards the need for addressing the exact role of TLRs in contributing to human genetic factors in malaria susceptibility/resistance/severity within different malaria settings in the world.

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