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Scientific Articles

Accuracy of malaria rapid diagnosis test Optimal-IT® in Kinshasa, the Democratic Republic of Congo

July 13, 2012 - 09:48 -- Patrick Sampao
Author(s): 
Muhindo H, Ilombe G, Meya R, Mitashi PM, Kutekemeni A, Gasigwa D, Lutumba P, Van geertruyden J
Reference: 
Malaria Journal 2012, 11:224 (6 July 2012)

MalariaWorldThis was a two-stage cluster randomized survey, conducted in one health centre in 12 health zones in Kinshasa city.

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Not Open Access | Estimation of human body concentrations of DDT from indoor residual spraying for malaria control

July 13, 2012 - 09:32 -- Patrick Sampao
Author(s): 
Tenzing Gyalpo, Lukas Fritsche, Henk Bouwman, Riana Bornman, Martin Scheringer, Konrad Hungerbühler
Reference: 
Environmental Pollution, Volume 169, October 2012, Pages 235-241

MalariaWorldFocusing on DDT use in South Africa, we employ a pharmacokinetic model to estimate DDT levels in human lipid tissue over the lifetime of an individual to determine the amount of DDT transferred to children during breastfeeding, and to identify the dominant DDT uptake routes. In particular, the effects of breastfeeding duration, parity, and mother's age on DDT concentrations of mother and infant are investigated.

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Not Open Access | Spermatozoa and Plasmodium zoites: the same way to invade oocyte and host cells?

July 13, 2012 - 09:18 -- Patrick Sampao
Author(s): 
Aminata Touré, Gordon Langsley, Stéphane Egée
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 874-879

MalariaWorldThis short review aims at highlighting these common features by comparing knowledge on motile forms of Plasmodium falciparum and one of the best known motile cell namely the spermatozoa.

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Not Open Access | Insights into the Plasmodium falciparum schizont phospho-proteome

July 13, 2012 - 09:15 -- Patrick Sampao
Author(s): 
Edwin Lasonder, Moritz Treeck, Mahmood Alam, Andrew B. Tobin
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 811-819

MalariaWorldA major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.

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Not Open Access | Generation of second messengers in Plasmodium

July 13, 2012 - 09:09 -- Patrick Sampao
Author(s): 
Alexandre Budu, Célia R.S. Garcia
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 787-795

MalariaWorldThe scope of this review is to discuss external stimuli in the parasite life cycle and the upstream machinery responsible for translating them into intracellular responses, focussing particularly on the calcium signalling pathway.

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Not Open Access | Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target

July 13, 2012 - 08:51 -- Patrick Sampao
Author(s): 
Nina M. Haste, Hana Talabani, Alex Doo, Anais Merckx, Gordon Langsley, Susan S. Taylor
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 838-850

MalariaWorldThe important differences between Plasmodium and mammalian PKA isoforms that indicate the parasite kinase is a valid anti-malaria therapeutic target.

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Not Open Access | The role of cGMP signalling in regulating life cycle progression of Plasmodium

July 13, 2012 - 08:38 -- Patrick Sampao
Author(s): 
Christine S. Hopp, Paul W. Bowyer, David A. Baker
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 831-837

MalariaWorldThis article reviews the role of PKG in Plasmodium falciparum during gametogenesis and blood stage schizont rupture, as well as the role of the Plasmodium berghei orthologue in ookinete differentiation and motility, and liver stage schizont development.

Not Open Access | Calcium dependent protein kinase 1 and calcium fluxes in the malaria parasite

July 13, 2012 - 08:15 -- Patrick Sampao
Author(s): 
Anthony A. Holder, Mohd A. Mohd Ridzuan, Judith L. Green
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 825-830

MalariaWorldApicomplexan parasites also contain CDPK families and this review is focused on CDPK1 in Plasmodium spp.

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Not Open Access | Purinoceptor signaling in malaria-infected erythrocytes

July 13, 2012 - 08:08 -- Patrick Sampao
Author(s): 
Stephan M. Huber
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 779-786

MalariaWorldThis review summarizes the pivotal function of purinergic signaling in erythrocyte control of vascular tone, in hemolytic septicemia, and in malaria.

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Not Open Access | Abnormal PfEMP1/knob display on Plasmodium falciparum-infected erythrocytes containing hemoglobin variants: fresh insights into malaria pathogenesis and protection

July 13, 2012 - 08:04 -- Patrick Sampao
Author(s): 
Rick M. Fairhurst, Cameron D. Bess, Michael A. Krause
Reference: 
Microbes and Infection, Volume 14, Issue 10, August 2012, Pages 851-862

MalariaWorldWe propose a model in which Hb variants allow parasites to display relatively low levels of PfEMP1, sufficient for sequestering PfRBCs in microvessels and avoiding their clearance from the bloodstream by the spleen.

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