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Scientific Articles

Energy metabolism affects susceptibility of Anopheles gambiae mosquitoes to Plasmodium infection

April 14, 2011 - 13:01 -- Kabogo Ndegwa
Author(s): 
Jose Henrique M. Oliveira, Renata L.S. Gonçalves, Giselle A. Oliveira, Pedro L. Oliveira, Marcus F. Oliveira and Carolina Barillas-Mury
Reference: 
Insect Biochemistry and Molecular Biology, Volume 41, Issue 6, June 2011, Pages 349-355

Previous studies showed that Anopheles gambiae L3-5 females, which are refractory (R) to Plasmodium infection, express higher levels of genes involved in redox-metabolism and mitochondrial respiration than susceptible (S) G3 females.

Plasmodium vivax: Collaborative roles for plasmepsin 4 and vivapains in hemoglobin hydrolysis

April 14, 2011 - 12:53 -- Kabogo Ndegwa
Author(s): 
Sung-Ung Moon, Jung-Mi Kang, Tong-Soo Kim, Yoon Kong, Woon-Mok Sohn, Byoung-Kuk Na
Reference: 
Experimental Parasitology, Volume 128, Issue 2, June 2011, Pages 127-132

Plasmepsins, a family of aspartic proteases of Plasmodium species, are known to participate in a wide variety of cellular processes essential for parasite survival.

Calcium signal regulates temperature-dependent transformation of sporozoites in malaria parasite development

April 14, 2011 - 12:39 -- Kabogo Ndegwa
Author(s): 
Yuko Doi, Naoaki Shinzawa, Shinya Fukumoto, Hideyuki Okano, Hirotaka Kanuka
Reference: 
Experimental Parasitology, Volume 128, Issue 2, June 2011, Pages 176-180

The infection by the malaria parasite of its mammalian host is initiated by the asexual reproduction of the parasite within the host hepatocyte.

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Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication

April 14, 2011 - 12:35 -- Kabogo Ndegwa
Author(s): 
Michael J. Brumlik, Standwell Nkhoma, Mark J. Kious, George R. Thompson III, Thomas F. Patterson, John J. Siekierka, Tim J.C. Anderson, Tyler J. Curiel
Reference: 
Experimental Parasitology, Volume 128, Issue 2, June 2011, Pages 170-175

We recently demonstrated that human p38 mitogen-activated protein kinase (MAPK) inhibitors reduced in vitro and in vivo replication of the protozoan parasites Toxoplasma gondii and Encephalitozoon cuniculi.

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Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure–activity relationships

April 14, 2011 - 12:14 -- Kabogo Ndegwa
Author(s): 
Adela Mendoza, Silvia Pérez-Silanes, Miguel Quiliano, Adriana Pabón, Silvia Galiano, Germán González, Giovanny Garavito, Mirko Zimic, Abraham Vaisberg, Ignacio Aldana, Antonio Monge, Eric Deharo
Reference: 
Experimental Parasitology, Volume 128, Issue 2, June 2011, Pages 97-103

Piperazine and pyrrolidine derivatives were synthesised and evaluated for their capacity to inhibit the growth of Plasmodium falciparum chloroquine-resistant (FCR-3) strain in culture.

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Open Access | Claims about the Misuse of Insecticide-Treated Mosquito Nets: Are These Evidence-Based?

April 14, 2011 - 12:03 -- Kabogo Ndegwa
Author(s): 
Thomas P. Eisele, Julie Thwing, Joseph Keating
Reference: 
PLoS Med 8(4): e1001019

Nearly all experts agree that insecticide-treated mosquito nets (ITNs) are a lifesaving intervention, supported by strong evidence from carefully conducted trials that show ITNs to be efficacious at preventing all-cause child mortality and malaria morbidity in children and pregnant women.

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Open Access | Aquaporin water channel AgAQP1 in the malaria vector mosquito Anopheles gambiae during blood feeding and humidity adaptation

April 14, 2011 - 11:44 -- Kabogo Ndegwa
Author(s): 
Kun Liu, Hitoshi Tsujimoto, Sung-Jae Cha, Peter Agre and Jason L. Rasgon
Reference: 
PNAS April 12, 2011 vol. 108 no. 15 6062-6066

Altered patterns of malaria endemicity reflect, in part, changes in feeding behavior and climate adaptation of mosquito vectors.

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A multi-bioreactor system for optimal production of malaria vaccines with Pichia pastoris

April 14, 2011 - 11:35 -- Kabogo Ndegwa
Author(s): 
J Fricke, K Pohlmann, F Tatge, R Lang, B Faber, R Luttmann
Reference: 
Biochemical Engineering Science, Volume 6, Issue 4, pages 437–451, April 2011

The successful development of optimal multistage production processes for recombinant products with Pichia pastoris needs to meet three pre-conditions.

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Tracking Glideosome-Associated Protein 50 Reveals the Development and Organization of the Inner Membrane Complex of Plasmodium falciparum

April 14, 2011 - 08:31 -- Patrick Sampao
Author(s): 
Jeffrey A. Yeoman, Eric Hanssen, Leann Tilley, et al.
Reference: 
Eukaryot. Cell, Apr 2011; 10: 556 - 564.

Using immunoprecipitation and fluorescence photobleaching, we show that C-terminally tagged PfGAP50-GFP can form a complex with endogenous copies of the linker protein PfGAP45 and the myosin A tail domain-interacting protein (MTIP).

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Review: Mitosis in the Human Malaria Parasite Plasmodium falciparum

April 14, 2011 - 08:01 -- Patrick Sampao
Author(s): 
Noel Gerald, Babita Mahajan, and Sanjai Kumar
Reference: 
Eukaryot. Cell, Apr 2011; 10: 474 - 482.

In this review, we will discuss the current understanding of the architecture and key events of mitosis in Plasmodium falciparum and related parasites and compare them with the traditional mitotic events described for other eukaryotes.

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