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Scientific Articles

Short Communication: Characterization of Plasmodium berghei glutathione synthetase

June 27, 2011 - 12:48 -- Patrick Sampao
Author(s): 
S.K. Sharma, H.S. Banyal
Reference: 
Parasitology International, Volume 60, Issue 3, September 2011, Pages 321-323

Plasmodium berghei contained 0.454 ± 0.031 U/mg of glutathione synthetyase (GS). GS was purified using solid ammonium sulfate and Sephadex G-200 from P. berghei infected mouse erythrocytes.

Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol

June 27, 2011 - 12:43 -- Patrick Sampao
Author(s): 
Akira Sato, Akiko Hiramoto, Hye-Sook Kim, et al.
Reference: 
Parasitology International, Volume 60, Issue 3, September 2011, Pages 270-273

Here, we report the in vitro and in vivo antimalarial activities of 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against P. falciparum and Plasmodium berghei parasites.

PEXEL-independent trafficking of Plasmodium falciparum SURFIN4.2 to the parasite-infected red blood cell and Maurer's clefts

June 27, 2011 - 12:33 -- Patrick Sampao
Author(s): 
Jean Semé Fils Alexandre, Kazuhide Yahata, Satoru Kawai, Motomi Torii, Osamu Kaneko
Reference: 
Parasitology International, Volume 60, Issue 3, September 2011, Pages 313-320

To analyze the region responsible for the intracellular trafficking of SURFIN4.2 to the iRBC and Maurer's clefts, a panel of transgenic parasite lines expressing recombinant SURFIN4.2 fused with green fluorescent protein was generated and evaluated for their localization.

Open Access | A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs

June 24, 2011 - 13:45 -- Patrick Sampao
Author(s): 
Kate Broadbent, Daniel Park, Ashley R Wolf, Daria Van Tyne, Jennifer S Sims, Ulf Ribacke, Sarah Volkman, Manoj Duraisingh, Dyann Wirth, Pardis C Sabeti and John L Rinn
Reference: 
Genome Biology , 12: gb-2011-12-6-r56 , June 2011

We used a high-resolution DNA tiling microarray to survey transcriptional activity across 22.6% of the P. falciparum strain 3D7 genome. We identified 872 protein-coding genes and 60 putative P. falciparum lncRNAs under developmental regulation during the parasite's pathogenic human blood stage.

Prevalence of malaria parasitemia amongst asymptomatic pregnant women attending a Nigerian teaching hospital.

June 24, 2011 - 13:30 -- Patrick Sampao
Author(s): 
Isah AY, Amanabo MA, Ekele BA.
Reference: 
Ann Afr Med. 2011 Apr-Jun;10(2):171-4.

This was a cross-sectional, descriptive study of only well pregnant women recruited consecutively at the time of booking for antenatal care.

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Open Access | Efficacy of integrated school based de-worming and prompt malaria treatment on helminths-Plasmodium falciparum co-infections: A 33 months follow up study

June 24, 2011 - 13:08 -- Patrick Sampao
Author(s): 
Nicholas Midzi, Sekesai Mtapuri-Zinyowera, Takafira Mduluza, et al.
Reference: 
BMC International Health and Human Rights 2011, 22 June 2011

Longitudinal data showed that two rounds of combined praziquantel and albendazole treatment for schistosomiasis and STHs at 6 monthly intervals and sustained prompt malaria treatment significantly reduced the overall prevalence of S. haematobium, S. mansoni, hookworms and P. falciparum infection in primary schoolchildren by 73.5%, 70.8%, 67.3% and 58.8%, respectively (p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively).

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Consequences of HIV infection on malaria and therapeutic implications: a systematic review

June 23, 2011 - 14:53 -- Patrick Sampao
Author(s): 
Clara Flateau, Guillaume Le Loup, Gilles Pialoux
Reference: 
The Lancet Infectious Diseases, Volume 11, Issue 7, July 2011, Pages 541-556

In this systematic review, we collate data on the effects of HIV on malaria and discuss their therapeutic consequences.

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Open Access | Relationship between care-givers' misconceptions and non-use of ITNs by under-five Nigerian children

June 23, 2011 - 14:14 -- Kabogo Ndegwa
Author(s): 
Arogundade ED, Adebayo SB, Anyanti J, Nwokolo E, Ladipo O, Ankomah A, Meremikwu MM
Reference: 
Malaria Journal 2011, 10:170 (22 June 2011)

Misconceptions about causes and prevention of malaria by caregivers adversely influence the use ITN by under-five children. Appropriate communication strategies should correct these misconceptions.

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Open Access | Field trial of three different Plasmodium vivax-detecting rapid diagnostic tests with and without evaporative cool box storage in Afghanistan

June 23, 2011 - 14:08 -- Kabogo Ndegwa
Author(s): 
Mikhail AF, Leslie TJ, Mayan MI, Zekria R, Mohammad N, Hasanzai MA, Safi N, Whitty CJ, Rowland M
Reference: 
Malaria Journal 2011, 10:169 (22 June 2011)

Of the three RDTs, the CSPfPan test was the most consistent and reliable, rendering it appropriate for this P. vivax predominant region.

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Plasmodium berghei proteome changes in response to SSJ-183 treatment

June 23, 2011 - 07:25 -- Kabogo Ndegwa
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Author(s): 
Jun Lu, Chika Arai, Abu Bakar Md, Masataka Ihara
Reference: 
Bioorganic & Medicinal Chemistry, Volume 19, Issue 13, 1 July 2011, Pages 4144-4147

The benzo[a]phenoxazine derivative, SSJ-183 has shown excellent anti-malarial efficacy and safety.

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