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Scientific Articles

Price subsidies and the market for mosquito nets in developing countries: A study of Tanzania’s discount voucher scheme

June 28, 2011 - 10:44 -- Patrick Sampao
Author(s): 
Chris D. Gingrich, Kara Hanson, Tanya Marchant, Jo-Ann Mulligan, Hadji Mponda
Reference: 
Social Science & Medicine, Volume 73, Issue 1, July 2011, Pages 160-168

The model describes the ITN market in a typical developing country and is applied to the situation in Tanzania, where the Tanzania National Voucher Scheme (TNVS) provides a targeted subsidy to vulnerable population groups by means of a discount voucher.

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Effects of highly active novel artemisinin–chloroquinoline hybrid compounds on β-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum

June 28, 2011 - 06:57 -- Kabogo Ndegwa
Author(s): 
Tzu-Shean Feng, Eric M. Guantai, Margo Nell, Constance E.J. van Rensburg, Kanyile Ncokazi, Timothy J. Egan, Heinrich C. Hoppe, Kelly Chibale
Reference: 
Biochemical Pharmacology, Volume 82, Issue 3, 1 August 2011, Pages 236-247

4-Aminoquinolines were hybridized with artemisinin and 1,4-naphthoquinone derivatives via the Ugi-four-component condensation reaction, and their biological activities investigated.

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Open Access | Efficacy of PermaNet(R) 2.0 and PermaNet(R) 3.0 against insecticide-resistant Anopheles gambiae in experimental huts in Cote d'Ivoire

June 28, 2011 - 06:52 -- Kabogo Ndegwa
Author(s): 
Koudou BG, Koffi AA, Malone D, Hemingway J
Reference: 
Malaria Journal 2011, 10:172 (23 June 2011)

This study showed that unwashed PermaNet(R) 3.0 caused significantly higher mortality against pyrethroid resistant An. gambiae s.s and Culex spp than PermaNet(R) 2.0 and the CTN.

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Open Access | Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan

June 28, 2011 - 06:43 -- Kabogo Ndegwa
Author(s): 
Howard N, Durrani N, Sanda S, Beshir K, Hallett R, Rowland M
Reference: 
Malaria Journal 2011, 10:171 (23 June 2011)

CQ is not suitable for first-line falciparum treatment in Afghan refugee communities.

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Open Access | Biophysics of Malarial Parasite Exit from Infected Erythrocytes

June 28, 2011 - 06:32 -- Kabogo Ndegwa
Author(s): 
Rajesh Chandramohanadas, YongKeun Park, Lena Lui, Ang Li, David Quinn, Kingsley Liew, Monica Diez-Silva, Yongjin Sung, Ming Dao, Chwee Teck Lim, Peter Rainer Preiser, Subra Suresh
Reference: 
PLoS ONE 6(6): e20869

Upon infection and development within human erythrocytes, P. falciparum induces alterations to the infected RBC morphology and bio-mechanical properties to eventually rupture the host cells through parasitic and host derived proteases of cysteine and serine families.

Short Technical Report: Polysome profiling of the malaria parasite Plasmodium falciparum

June 27, 2011 - 14:54 -- Patrick Sampao
Author(s): 
Joshua R. Lacsina, Gregory LaMonte, Christopher V. Nicchitta, Jen-Tsan Chi
Reference: 
Molecular and Biochemical Parasitology, Volume 179, Issue 1, September 2011, Pages 42-46

We describe here a novel method for polysome profiling in P. falciparum, a powerful approach which allows both a global view of translation and the measurement of ribosomal loading and density for specific mRNAs.

Short Communication: Transcript-level responses of Plasmodium falciparum to thiostrepton

June 27, 2011 - 14:12 -- Patrick Sampao
Author(s): 
Sarah J. Tarr, R. Ellen R. Nisbet, Christopher J. Howe
Reference: 
Molecular and Biochemical Parasitology, Volume 179, Issue 1, September 2011, Pages 37-41

We have analysed global changes in gene expression of the malaria parasite, Plasmodium falciparum, in an attempt to shed light on the responses of the parasite to this drug. Our results indicate a delay in gene expression profiles of thiostrepton-treated parasites.

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Plasmodium falciparum enolase complements yeast enolase functions and associates with the parasite food vacuole

June 27, 2011 - 13:50 -- Patrick Sampao
Author(s): 
Sujaan Das, Saudamini Shevade, Douglas J. LaCount, Gotam K. Jarori
Reference: 
Molecular and Biochemical Parasitology, Volume 179, Issue 1, September 2011, Pages 8-17

To examine the potential functional role of FV-associated Pfeno, we assessed the ability of Pfeno to complement a mutant Saccharomyces cervisiae strain deficient in enolase activity. In this strain (Tetr-Eno2), the enolase 1 gene is deleted and expression of the enolase 2 gene is under the control of a tetracycline repressible promoter.

Open Access | Questionnaire-based approach to assess schoolchildren's physical fitness and its potential role in exploring the putative impact of helminth and Plasmodium spp. infections in Cote d'Ivoire

June 27, 2011 - 13:23 -- Patrick Sampao
Author(s): 
Furst T, Muller I, Coulibaly JT, Yao AK, Utzinger J, N'Goran EK
Reference: 
Parasites & Vectors 2011, 4:116 (24 June 2011)

In early 2010, we administered a questionnaire pertaining to physical fitness to 200 schoolchildren in Cote d'Ivoire. Helminth and Plasmodium spp. infections were determined and schoolchildren's physical fitness objectively measured in a maximal multistage 20 m shuttle run test.

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Open Access | Variations in salinity tolerance of malaria vectors of the Anopheles subpictus complex in Sri Lanka and the implications for malaria transmission

June 27, 2011 - 12:55 -- Patrick Sampao
Author(s): 
Surendran SN, Jude PJ, Ramasamy R
Reference: 
Parasites & Vectors 2011, 4:117 (24 June 2011)

The results suggest that An. subpictus species B/An. sundaicus breed in fresh, brackish and nearly saline water while An. subpictus species C and D do so in fresh and less brackish waters in Sri Lanka as in India.

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