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Scientific Articles

Open Access | Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections

August 20, 2010 - 13:59 -- Kabogo Ndegwa
Author(s): 
Daneshvar C, Davis TM, Cox-Singh J, Rafa'ee MZ, Zakaria SK, Divis PC, Singh B
Reference: 
Malaria Journal 2010, 9:238 (19 August 2010)

Chloroquine plus primaqine is an inexpensive and highly effective treatment for uncomplicated knowlesi malaria infections in humans and there is no evidence of drug resistance.

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Open Access | Application of mobile-technology for disease and treatment monitoring of malaria in the "Better Border Healthcare Programme"

August 20, 2010 - 13:55 -- Kabogo Ndegwa
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Author(s): 
Meankaew P, Kaewkungwal J, Khamsiriwatchara A, Khunthong P, Singhasivanon P, Satimai W
Reference: 
Malaria Journal 2010, 9:237 (19 August 2010)

The module was successfully integrated and functioned as part of the malaria prevention and control programme.

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Open Access | Chaperone expression profiles correlate with distinct physiological states of Plasmodium falciparum in malaria patients

August 20, 2010 - 13:50 -- Kabogo Ndegwa
Author(s): 
Pallavi R, Acharya P, Chandran S, Daily JP, Tatu U
Reference: 
Malaria Journal 2010, 9:236 (19 August 2010)

In all, this study demonstrates an intimate involvement of parasite-encoded chaperones, PfHsp90 in particular, in defining pathogenesis of malaria.

Open Access | Poverty and fever vulnerability in Nigeria: a multilevel analysis

August 20, 2010 - 13:19 -- Kabogo Ndegwa
Author(s): 
Yusuf OB, Adeoye BW, Oladepo OO, Peters DH, Bishai D
Reference: 
Malaria Journal 2010, 9:235 (19 August 2010)

While, overall bednet possession was low, less fever was reported in households that possessed bednets. Malaria control strategies and interventions should be designed that will target the poor and make an impact on poverty.

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Open Access | Cost Effectiveness of Seasonal Intermittent Preventive Treatment Using Amodiaquine & Artesunate or Sulphadoxine-Pyrimethamine in Ghanaian Children

August 20, 2010 - 12:07 -- Kabogo Ndegwa
Author(s): 
Lesong Conteh, Edith Patouillard, Margaret Kweku, Rosa Legood, Brian Greenwood, Daniel Chandramohan
Reference: 
PLoS ONE 5(8): e12223

We demonstrate how cost-effective IPTc is using three different drug regimens and the possibilities for reducing costs further if the intervention was to be scaled up to the district level. The need for effective training, drug delivery channels and supervision to support a strong network of community based volunteers is emphasised.

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Open Access | Continued Decline of Malaria in The Gambia with Implications for Elimination

August 20, 2010 - 12:03 -- Kabogo Ndegwa
Author(s): 
Serign J. Ceesay, Climent Casals-Pascual, David J. Conway, et al
Reference: 
PLoS ONE 5(8): e12242

Malaria has continued to decline in The Gambia, as indicated by a downward trend in slide positivity at health facilities, and unprecedented low incidence and seroprevalence in community surveys.

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Open Access | Detectability of Plasmodium falciparum clones

August 20, 2010 - 11:58 -- Kabogo Ndegwa
Author(s): 
Bretscher MT, Valsangiacomo F, Owusu-Agyei S, Penny MA, Felger I, Smith T
Reference: 
Malaria Journal 2010, 9:234 (18 August 2010)

A simple algorithm based on analysing blood samples collected 7 days apart is justified for generating robust estimates of detectability.

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Open Access | Review: Major effect genes or loose confederations? The development of insecticide resistance in the malaria vector Anopheles gambiae

August 19, 2010 - 14:53 -- Patrick Sampao
Author(s): 
Brooke BD, Koekemoer LL
Reference: 
Parasites & Vectors 2010, 3:74 (17 August 2010)

Insecticide resistance is a common occurrence and has been intensively studied in the major malaria vector Anopheles gambiae, providing a useful model for examining how insecticide resistance develops and what pleiotropic effects are likely to emerge as a consequence of resistance.

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Open Access | The dominant Anopheles vectors of human malaria in the Americas: occurrence data, distribution maps and bionomic precis

August 18, 2010 - 15:21 -- Patrick Sampao
Author(s): 
Sinka ME, Rubio-Palis Y, Manguin S, Patil AP, Temperley WH, Gething PW, Van Boeckel T, Kabaria CW, Harbach RE, Hay SI
Reference: 
Parasites & Vectors 2010, 3:72 (16 August 2010)

The results for the nine DVS of the Americas are described in detail here. Nearly 6000 occurrence records were gathered from 25 countries in the region and were complemented by a synthesis of published expert opinion range maps, refined further by a technical advisory group of medical entomologists.

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Host Response and Inflammation: Accumulation of Plasmodium berghei-Infected Red Blood Cells in the Brain Is Crucial for the Development of Cerebral Malaria in Mice

August 18, 2010 - 15:02 -- Patrick Sampao
Author(s): 
Fernanda G. Baptista, Ana Pamplona, Ana C. Pena, Maria M. Mota, Sylviane Pied, and Ana M. Vigário
Reference: 
Infect. Immun., Sep 2010; 78: 4033 - 4039.

Importantly, these results also demonstrated that the experimental cerebral malaria model shares many features with human pathology and might be a relevant model to study its pathogenesis.

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