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Scientific Articles

Open Access | Malaria: what can apes teach humans?

August 24, 2010 - 11:38 -- Kabogo Ndegwa
Author(s): 
J Cox-Singh
Reference: 
Future Microbiology August 2010, Vol. 5, No. 8, Pages 1157-1160

Human malaria is caused by four human-host restricted or adapted species of the genus Plasmodium, listed here in their order of risk for causing severe disease Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malariae – or so we thought.

Open Access | Short Report: Malaria among antenatal clients attending primary health care facilities in Kano state, Nigeria

August 24, 2010 - 10:08 -- Kabogo Ndegwa
Author(s): 
AU Gajida, Z Iliyasu, AI Zoakah
Reference: 
Annals of African Medicine, Volume : 9 Issue : 3 2010 Page : 188-193

Intermittent Preventive Treatment (IPT) should be provided especially among primigravid, secondigravid and younger mothers at PHC centres.

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Open Access | Reduction in the proportion of fevers associated with Plasmodium falciparum parasitaemia in Africa: a systematic review

August 24, 2010 - 09:58 -- Kabogo Ndegwa
Author(s): 
D'Acremont V, Lengeler C, Genton B
Reference: 
Malaria Journal 2010, 9:240 (22 August 2010)

There was a considerable reduction of the proportion of malaria among fevers over time in Africa. This decline provides evidence for the policy change from presumptive anti-malarial treatment of all children with fever to laboratory diagnosis and treatment upon result.

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Open Access | Dispatch: Co-infections with Plasmodium knowlesi and Other Malaria Parasites, Myanmar

August 23, 2010 - 14:23 -- Patrick Sampao
Author(s): 
Ning Jiang,1 Qiaocheng Chang,1 Xiaodong Sun,1 Huijun Lu, Jigang Yin, Zaixing Zhang, Mats Wahlgren, and Qijun Chen
Reference: 
Emerging Infectious Diseases, Volume 16, Number 9–September 2010

To determine the frequency of co-infections with Plasmodium species in southern Myanmar, we investigated the prevalence of P. knowlesi.

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Protoporphyrinogen IX oxidase from Plasmodium falciparum is anaerobic and is localized to the mitochondrion

August 23, 2010 - 14:17 -- Patrick Sampao
Author(s): 
Viswanathan Arun Nagaraj, Rajavel Arumugam, Dasari Prasad, Pundi N. Rangarajan, Govindarajan Padmanaban
Reference: 
Molecular and Biochemical Parasitology, Volume 174, Issue 1, November 2010, Pages 44-52

In the present study, PfPPO has been cloned, expressed and shown to be localized to the mitochondrion by immunofluorescence microscopy.

Short Communication: Localization of apical sushi protein in Plasmodium falciparum merozoites

August 23, 2010 - 13:54 -- Patrick Sampao
Author(s): 
Anand Srivastava, Shailja Singh, Shikha Dhawan, M. Mahmood Alam, Asif Mohmmed, Chetan E. Chitnis
Reference: 
Molecular and Biochemical Parasitology, Volume 174, Issue 1, November 2010, Pages 66-69

In the present study, we have used indirect immunofluorescence assays and immunoelectron microscopy to demonstrate that PfASP is localized in the neck of rhoptries and not in micronemes as previously described.

Review: The ABCs of multidrug resistance in malaria

August 23, 2010 - 13:31 -- Patrick Sampao
Author(s): 
Jan B. Koenderink, Reginald A. Kavishe, Sanna R. Rijpma, Frans G.M. Russel
Reference: 
Trends in Parasitology, Volume 26, Issue 9, September 2010, Pages 440-446

Here, we give an overview of the PlasmodiumABC family members with reference to their possible role in multidrug resistance.

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Open Access | Arm-in-cage testing of natural human-derived mosquito repellents

August 23, 2010 - 13:21 -- Kabogo Ndegwa
Tags: 
Author(s): 
Logan JG, Stanczyk NM, Hassanali A, Kemei J, Santana AE, Ribeiro KA, Pickett JA, Mordue (Luntz) A
Reference: 
Malaria Journal 2010, 9:239 (20 August 2010)

The optimum mixture of 6-methyl-5-hepten-2-one and geranylacetone was a 1:1 ratio and this provided the most effective protection against all species of mosquito tested. With further improvements in formulation, selected blends of these compounds have the potential to be exploited and developed as human-derived novel repellents for personal protection.

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Review: Following the path of most resistance: dhps K540E dispersal in African Plasmodium falciparum

August 23, 2010 - 11:56 -- Patrick Sampao
Author(s): 
Inbarani Naidoo, Cally Roper
Reference: 
Trends in Parasitology, Volume 26, Issue 9, September 2010, Pages 447-456

We discuss whether there are common principles governing resistance dispersal in Africa and how these might guide surveillance in future.

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