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Scientific Articles

Open Access | Gestational malaria associated to Plasmodium vivax and Plasmodium falciparum placental mixed-infection followed by foetal loss: a case report from an unstable transmission area in Brazil

June 30, 2011 - 06:45 -- Kabogo Ndegwa
Author(s): 
Carvalho BO, Matsuda JS, Luz SL, Martinez-Espinosa FE, Leite JA, Franzin F, Orlandi PP, Gregoracci GB, Lacerda MV, Nogueira PA, Costa FT
Reference: 
Malaria Journal 2011, 10:178 (27 June 2011)

Gestational malaria is a multi-factorial syndrome leading to poor outcomes for both the mother and foetus.

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Open Access | Short Report: Improvement of the observational method for Plasmodium berghei oocysts in the midgut of mosquitoes

June 29, 2011 - 13:21 -- Patrick Sampao
Author(s): 
Miho Usui, Shinya Fukumoto, Noboru Inoue and Shin-ichiro Kawazu
Reference: 
Parasites & Vectors 2011, 4:11, 27 June 2011

To evaluate the accuracy in the oocyst counting with the improved technique, mosquitoes were infected with the green fluorescent protein (GFP)-expressing parasite.

Open Access | Spatial and temporal distribution patterns of Anopheles arabiensis breeding sites in La Reunion Island - multi-year trend analysis of historical records from 1996-2009

June 29, 2011 - 12:39 -- Patrick Sampao
Author(s): 
Louis C Gouagna, Jean-Sebastien Dehecq, Romain Girod , Sebastien Boyer, Guy Lemperiere and Didier Fontenille
Reference: 
Parasites & Vectors 2011, 4:12, 27 June 2011

A retrospective examination was made from archival data which provided the complete enumeration of An. arabiensis breeding habitats in three distinct geographic zones - extending North-east, West and South of the island over 14 years, from January 1996 to December 2009.

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Open Access | Spatial patterns of malaria in a land reform colonization project, Juruena municipality, Mato Grosso, Brazil

June 29, 2011 - 07:00 -- Kabogo Ndegwa
Author(s): 
Oliveira EC, Santos ES, Zeilhofer P, Souza-Santos R, Atanaka-Santos M
Reference: 
Malaria Journal 2011, 10:177 (26 June 2011)

Environmental factors and their alteration are associated with the occurrence and spatial distribution of malaria cases in rural settlements.

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Open Access | Accuracy of malaria rapid diagnostic tests in community studies and their impact on treatment of malaria in an area with declining malaria burden in north-eastern Tanzania

June 29, 2011 - 06:54 -- Kabogo Ndegwa
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Author(s): 
Ishengoma DS, Francis F, Mmbando BP, Lusingu JP, Magistrado P, Alifrangis M, Theander TG, Bygbjerg IC, Lemnge MM
Reference: 
Malaria Journal 2011, 10:176 (26 June 2011)

Although RDTs had low sensitivity and specificity, which varied widely depending on fever and parasite density, using RDTs reduced over-treatment with anti-malarials significantly.

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Open Access | Real-time PCR assay and rapid diagnostic tests for the diagnosis of clinically suspected malaria patients in Bangladesh

June 29, 2011 - 06:47 -- Kabogo Ndegwa
Author(s): 
Alam MS, Mohon AN, Mustafa S, Khan WA, Islam N, Karim MJ, Khanum H, Sullivan Jr. DJ, Haque R
Reference: 
Malaria Journal 2011, 10:175 (26 June 2011)

The results of this study suggest that the SYBR Green-based real-time PCR assay could be used as an alternative gold standard method in a reference setting.

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Identification and characterization of a novel chitinase-like gene cluster (AgCht5) possibly derived from tandem duplications in the African malaria mosquito, Anopheles gambiae

June 29, 2011 - 06:34 -- Kabogo Ndegwa
Author(s): 
Jianzhen Zhang, Xin Zhang, Yasuyuki Arakane, Subbaratnam Muthukrishnan, Karl J. Kramer, Enbo Ma, Kun Yan Zhu
Reference: 
Insect Biochemistry and Molecular Biology, Volume 41, Issue 8, August 2011, Pages 521-528

Insect chitinase 5 (Cht5), a well-characterized enzyme found in the molting fluid and/or integument, is classified as a group I chitinase and is usually encoded by a single gene.

Open Access | Population dynamics, structure and behaviour of Anopheles darlingi in a rural settlement in the Amazon rainforest of Acre, Brazil

June 28, 2011 - 14:12 -- Kabogo Ndegwa
Author(s): 
Moutinho PR, Gil LH, Cruz RB, Ribolla PE
Reference: 
Malaria Journal 2011, 10:174 (24 June 2011)

Anopheles darlingi depends on forested regions for their larval and adult survival.

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Pharmaceutical Nanotechnology: Absorption of the novel artemisinin derivatives artemisone and artemiside: Potential application of Pheroid™ technology

June 28, 2011 - 12:41 -- Patrick Sampao
Author(s): 
J. Dewald Steyn, Lubbe Wiesner, Lissinda H. du Plessis, Anne F. Grobler, Peter J. Smith, Wing-Chi Chan, Richard K. Haynes, Awie F. Kotzé
Reference: 
International Journal of Pharmaceutics, Volume 414, Issues 1-2, 29 July 2011, Pages 260-266

Pharmacokinetic models were constructed for artemisone and artemiside in Pheroid™ vesicle formulations. The compounds were administered at a dose of 50.0 mg/kg bodyweight to C57 BL/6 mice via an oral gavage tube and blood samples were collected by means of tail-bleeding.

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