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Scientific Articles

The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate

November 11, 2019 - 16:13 -- Open Access
Author(s): 
Shwu-Maan Lee, Yimin Wu, John M. Hickey, Kazutoyo Miura, Neal Whitaker, Sangeeta B. Joshi, David B. Volkin, C. Richter King and Jordan Plieskatt
Reference: 
Malaria Journal 2019 18:356, 8 November 2019

Control and elimination of malaria can be accelerated by transmission-blocking interventions such as vaccines. A surface antigen of Plasmodium falciparum gametocytes, Pfs230, is a leading vaccine target antigen, and has recently progressed to experimental clinical trials. To support vaccine product development, an N-terminal Pfs230 antigen was designed to increase yield, as well as to improve antigen quality, integrity, and homogeneity.

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Systematic review of the status of pfhrp2 and pfhrp3 gene deletion, approaches and methods used for its estimation and reporting in Plasmodium falciparum populations in Africa: review of published studies 2010–2019

November 11, 2019 - 16:08 -- Open Access
Author(s): 
Bosco B. Agaba, Adoke Yeka, Sam Nsobya, Emmanuel Arinaitwe, Joaniter Nankabirwa, Jimmy Opigo, Paul Mbaka, Chae Seung Lim, Joan N. Kalyango, Charles Karamagi and Moses R. Kamya
Reference: 
Malaria Journal 2019 18:355, 6 November 2019

Malaria rapid diagnostic tests based on histidine-rich protein-2 have played a vital role in improving malaria case management and surveillance particularly in Africa, where Plasmodium falciparum is predominant. However, their usefulness has been threatened by the emergence of gene deletion on P. falciparum histidine rich protein 2 (pfhrp2) and P. falciparum histidine rich protein 3 (pfhrp3). 

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Diagnostic performance of CareStart™ malaria HRP2/pLDH test in comparison with standard microscopy for detection of uncomplicated malaria infection among symptomatic patients, Eastern Coast of Tanzania

November 11, 2019 - 16:02 -- Open Access
Author(s): 
George M. Bwire, Billy Ngasala, Manase Kilonzi, Wigilya P. Mikomangwa, Fatuma F. Felician and Appolinary A. R. Kamuhabwa
Reference: 
Malaria Journal 2019 18:354, 5 November 2019

CareStart™ malaria HRP2/pLDH (Pf/pan) combo test is one of the several rapid diagnostic tests (RDT) approved for diagnosis of malaria at the point of care in Tanzania. However, there are limited studies on the diagnostic performance of RDT after wide scale use in primary health care facilities in Tanzania. 

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TRIBE Uncovers the Role of Dis3 in Shaping the Dynamic Transcriptome in Malaria Parasites

November 8, 2019 - 17:07 -- Open Access
Author(s): 
Meng Liu, Binbin Lu, Yanting Fan, Xiaohui He, Shijun Shen, Cizhong Jiang and Qingfeng Zhang
Reference: 
Front. Cell Dev. Biol., 01 November 2019

Identification of RNA targets of RNA-binding proteins (RBPs) is essential for complete understanding of their biological functions. However, it is still a challenge to identify the biologically relevant targets of RBPs through in vitro strategies of RIP-seq, HITS-CLIP, or GoldCLIP due to the potentially high background and complicated manipulation. 

Current scenario of ferrocene-containing hybrids for antimalarial activity

November 8, 2019 - 17:02 -- Open Access
Author(s): 
Xiao J, Sun Z, Kong F, Gao F.
Reference: 
Eur J Med Chem. 2019 Oct 17; 185:111791

Hybrid molecules have the potential to enhance the efficacy against both drug-sensitive and drug-resistant organisms, and Ferroquine, a ferrocene hybrid, has demonstrated great potency in clinical trials against both drug-sensitive and drug-resistant malaria. Accordingly, hybridization of ferrocene with other antimalarial pharmacophores represents a promising strategy to develop novel antimalarial candidates.

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NOT Open Access | Malaria Hybrids: A Chronological Evolution

November 8, 2019 - 17:00 -- NOT Open Access
Author(s): 
Marella A, Verma G, Shaquiquzzaman M, Khan MF, Akhtar W, Alam MM.
Reference: 
Mini Rev Med Chem. 2019;19(14):1144-1177

Malaria, an upsetting malaise caused by a diverse class of Plasmodium species affects about 40% of the world's population. The distress associated with it has reached colossal scales owing to the development of resistance to most of the clinically available agents. 

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Utilization of key preventive measures for pregnancy complications and malaria among women in Jimma Zone, Ethiopia

November 8, 2019 - 16:57 -- Open Access
Author(s): 
Mariame Ouedraogo, Jaameeta Kurji, Lakew Abebe, Ronald Labonté, Sudhakar Morankar, Kunuz Haji Bedru, Gebeyehu Bulcha, Muluemebet Abera, Beth K. Potter, Marie-Hélène Roy-Gagnon & Manisha A. Kulkarni
Reference: 
BMC Public Health volume 19, Article number: 1443 (2019)

In Ethiopia, malaria infections and other complications during pregnancy contribute to the high burden of maternal morbidity and mortality. Preventive measures are available, however little is known about the factors influencing the uptake of maternal health services and interventions by pregnant women in Ethiopia.

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Farmers’ pesticide usage practices in the malaria endemic region of North-Western Tanzania: implications to the control of malaria vectors

November 8, 2019 - 16:53 -- Open Access
Author(s): 
Anitha Philbert, Sylvester Leonard Lyantagaye & Gamba Nkwengulila
Reference: 
BMC Public Health volume 19, Article number: 1456 (2019)

Pesticides remain the mainstay for the control of agricultural pests and disease vectors. However, their indiscriminate use in agriculture has led to development of resistance to both crop pests and disease vectors. 

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Occurrence and seasonal variation of human Plasmodium infection in Punjab Province, Pakistan

November 8, 2019 - 16:47 -- Open Access
Author(s): 
Naveeda Akhtar Qureshi, Huma Fatima, Muhammad Afzal, Aamir Ali Khattak & Muhammad Ali Nawaz
Reference: 
BMC Infectious Diseases 19, Article number: 935 (2019)

Malaria is the fifth leading cause of death worldwide. Pakistan is considered as a moderate malaria-endemic country but still, 177 million individuals are at risk of malaria. Roughly 60% of Pakistan’s population, live in malaria-endemic regions. The present study is based upon the survey of various health care centers in 10 major cities of Northern and Southern Punjab to find out the malarial infection patterns in 2015. The diagnosis, seasonal variations, age and gender-wise distribution of Plasmodium spp. circulating in the study area were also included in the objectives.

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A single dose combination study with the experimental antimalarials artefenomel and DSM265 to determine safety and antimalarial activity against blood-stage Plasmodium falciparum in healthy volunteers

November 8, 2019 - 16:44 -- Open Access
Author(s): 
McCarthy J, Rückle T, Elliott SL, Ballard E, Collins KA, Marquart L, Griffin P, Chalon S, Möhrle JJ
Reference: 
Antimicrob Agents Chemother. 2019 Nov 4

Artefenomel and DSM265 are two new compounds that have been shown to be well tolerated and effective when administered as monotherapy malaria treatment. This study aimed to determine the safety, pharmacokinetics and pharmacodynamics of artefenomel and DSM265 administered in combination to healthy subjects in a volunteer infection study using the Plasmodium falciparum induced blood stage malaria model. 

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