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Scientific Articles

PfHRP2 detection using plasmonic optrodes: performance analysis

August 4, 2021 - 15:55 -- Open Access
Loyez M, Wells M, Hambÿe S, Hubinon F, Blankert B, Wattiez R, Caucheteur C
Malar J. 2021 Jul 28;20(1):332

Early malaria diagnosis and its profiling require the development of new sensing platforms enabling rapid and early analysis of parasites in blood or saliva, aside the widespread rapid diagnostic tests (RDTs).

Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes

August 4, 2021 - 15:47 -- Open Access
Thomson-Luque R, Votborg-Novél L, Portugal S, et al.
Nat Commun. 2021 Jul 30;12(1):4711

Following Plasmodium falciparum infection, individuals can remain asymptomatic, present with mild fever in uncomplicated malaria cases, or show one or more severe malaria symptoms. Several studies have investigated associations between parasite transcription and clinical severity, but no broad conclusions have yet been drawn. Here, we apply a series of bioinformatic approaches based on P. falciparum's tightly regulated transcriptional pattern during its ~48-hour intraerythrocytic developmental cycle (IDC) to publicly available transcriptomes of parasites obtained from malaria cases of differing clinical severity across multiple studies.

Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria

August 4, 2021 - 15:44 -- Open Access
Conroy AL, Opoka RO, Bangirana P, Namazzi R, Okullo AE, Georgieff MK, Cusick S, Idro R, Ssenkusu JM, John CC
BMC Med. 2021 Jul 28;19(1):168

In 2011, the World Health Organization recommended injectable artesunate as the first-line therapy for severe malaria (SM) due to its superiority in reducing mortality compared to quinine. There are limited data on long-term clinical and neurobehavioral outcomes after artemisinin use for treatment of SM.

NOT Open Access | Epidemiology of Plasmodium falciparum Infections in a Semi-Arid Rural African Setting: Evidence of Reactive Case Detection in Northwestern Kenya

August 4, 2021 - 15:43 -- NOT Open Access
Meredith HR, Wesolowski A, Obala AA, et al.
Am J Trop Med Hyg. 2021 Aug 2:tpmd210256

In northwestern Kenya, Turkana County has been historically considered unsuitable for stable malaria transmission because of its unfavorable climate and predominantly semi-nomadic population; consequently, it is overlooked during malaria control planning. However, the area is changing, with substantial development, an upsurge in travel associated with resource extraction, and more populated settlements forming. Recently, numerous malaria outbreaks have highlighted the need to characterize malaria transmission and its associated risk factors in the region to inform control strategies.

Expression Patterns of Plasmodium falciparum Clonally Variant Genes at the Onset of a Blood Infection in Malaria-Naive Humans

August 4, 2021 - 15:40 -- Open Access
Pickford AK, Michel-Todó L, Dupuy F, Mayor A, Alonso PL, Lavazec C, Cortés A
mBio. 2021 Aug 3:e0163621

Clonally variant genes (CVGs) play fundamental roles in the adaptation of Plasmodium falciparum to fluctuating conditions of the human host. However, their expression patterns under the natural conditions of the blood circulation have been characterized in detail for only a few specific gene families. Here, we provide a detailed characterization of the complete P. falciparum transcriptome across the full intraerythrocytic development cycle (IDC) at the onset of a blood infection in malaria-naive human volunteers.

Plasmodium falciparum PhIL1-associated complex plays an essential role in merozoite reorientation and invasion of host erythrocytes

August 4, 2021 - 15:33 -- Open Access
Saini E, Sheokand PK, Sharma V, Agrawal P, Kaur I, Singh S, Mohmmed A, Malhotra P
PLoS Pathog. 2021 Jul 29;17(7):e1009750

The human malaria parasite, Plasmodium falciparum possesses unique gliding machinery referred to as the glideosome that powers its entry into the insect and vertebrate hosts. Several parasite proteins including Photosensitized INA-labelled protein 1 (PhIL1) have been shown to associate with glideosome machinery. Here we describe a novel PhIL1 associated protein complex that co-exists with the glideosome motor complex in the inner membrane complex of the merozoite.

Characterization of the Plasmodium and Haemoproteus parasite community in temperate-tropical birds during spring migration

August 4, 2021 - 15:31 -- Open Access
DeBrock S, Cohen E, Balasubramanian S, Marra PP, Hamer SA
Int J Parasitol Parasites Wildl. 2021 Apr 1;15:12-21

Animal movements, especially avian migration, can be a mechanism for the large-scale dispersal and geographic range expansion of parasites. The host-parasite relationships among birds during migration have yet to be fully explored. We characterized the haemosporidian parasite lineages in passerines during spring migration on the Texas coast of the Gulf of Mexico, and identified associations among wintering origin (US, Central America, South America) and foraging height (canopy, understory, ground) and infection status.

Simplified binomial estimation of human malaria transmission exposure distributions based on hard classification of where and when mosquitoes are caught: statistical applications with off-the-shelf tools

August 4, 2021 - 15:29 -- Open Access
Killeen GF, Monroe A, Govella NJ
Parasit Vectors. 2021 Aug 3;14(1):384

The impacts and limitations of personal protection measures against exposure to vectors of malaria and other mosquito-borne pathogens depend on behavioural interactions between humans and mosquitoes. Therefore, understanding where and when they overlap in time and space is critical. Commonly used approaches for calculating behaviour-adjusted estimates of human exposure distribution deliberately use soft classification of where and when people spend their time, to yield nuanced and representative distributions of mean exposure to mosquito bites across entire human populations or population groups.

Structures of the Plasmodium falciparum heat-shock protein 70-x ATPase domain in complex with chemical fragments identify conserved and unique binding sites

August 4, 2021 - 12:30 -- Open Access
Mohamad N, O'Donoghue A, Kantsadi AL, Vakonakis I
Acta Crystallogr F Struct Biol Commun. 2021 Aug 1;77(Pt 8):262-268

Plasmodium falciparum invades erythrocytes and extensively modifies them in a manner that increases the virulence of this malaria parasite. A single heat-shock 70 kDa-type chaperone, PfHsp70-x, is among the parasite proteins exported to the host cell. PfHsp70-x assists in the formation of a key protein complex that underpins parasite virulence and supports parasite growth during febrile episodes.


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