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Scientific Articles

A cluster randomized trial comparing deltamethrin and bendiocarb as insecticides for indoor residual spraying to control malaria on Bioko Island, Equatorial Guinea

July 27, 2016 - 07:27 -- Open Access
Author(s): 
John Bradley, Dianna Hergott, Guillermo Garcia, Jo Lines, Jackie Cook, Michel A. Slotman, Wonder Philip Phiri, Christopher Schwabe and Immo Kleinschmidt
Reference: 
Malaria Journal 2016 15:378, 22 July 2016

The results are suggestive of bendiocarb being more effective at preventing malaria on Bioko although evidence for this was weak.

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The application of evolutionary medicine principles for sustainable malaria control: a scoping study

July 27, 2016 - 07:26 -- Open Access
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Author(s): 
Denise Ocampo and Mark Booth
Reference: 
Malaria Journal 2016 15:383, 22 July 2016

This scoping study suggests that it is important to make research, including evolutionary principles, available and easily applicable for programme managers and key decision-makers, including donors and politicians.

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Prenatal exposure to Plasmodium falciparum increases frequency and shortens time from birth to first clinical malaria episodes during the first two years of life: prospective birth cohort study

July 27, 2016 - 07:25 -- Open Access
Author(s): 
Boniphace Sylvester, Dinah B. Gasarasi, Said Aboud, Donath Tarimo, Siriel Massawe, Rose Mpembeni and Gote Swedberg
Reference: 
Malar Journal 2016 15:379, 22 July 2016

Prenatal exposure to P. falciparum shortens time from birth to first clinical malaria episode and increases frequency of clinical malaria episodes in the first 2 years of life.

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Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity

July 27, 2016 - 07:21 -- Open Access
Author(s): 
Bradley W. Hickey, Joanne M. Lumsden, Thomas L. Richie, et al.
Reference: 
Malaria Journal 2016 15:377, 22 July 2016

The protective efficacy of this clinical trial (50 %) was notably less than previously reported (>90 %).

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Malaria vector research and control in Haiti: a systematic review

July 27, 2016 - 07:20 -- Open Access
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Author(s): 
Joseph Frederick, Yvan Saint Jean, Daniel E. Impoinvil, et al.
Reference: 
Malaria Journal 2016 15:376, 22 July 2016

Entomological information generated from past studies in Haiti will contribute to the development of strategies to achieve malaria elimination on Hispaniola.

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In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin

July 27, 2016 - 07:19 -- Open Access
Author(s): 
Muturi J. Njokah, Joseph N. Kang’ethe, Johnson Kinyua, Daniel Kariuki and Francis T. Kimani
Reference: 
Malaria Journal 2016 15:381, 22 July 2016

Artemisinin resistance phenotype as has been shown in this work, is a decrease in parasites susceptibility to artemisinin derivatives together with the parasite’s ability to recover from drug-induced dormancy after exposure to drug dosage above the in vivo clinical concentrations.

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Anti-malarial seroprevalence assessment during an elimination programme in Chabahar District, south-eastern Iran

July 27, 2016 - 07:15 -- Open Access
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Author(s): 
Sedigheh Zakeri, Lotus Leonie van den Hoogen, Akram Abouie Mehrizi, Fatemh Karimi, Ahmad Raeisi and Chris Drakeley
Reference: 
Malaria Journal 2016 15:382, 22 July 2016

Serological analysis identified a decline in P. falciparum transmission in the urban areas of Chabahar, consistent with a previously described decrease in malaria in the early 1990s, demonstrating the utility of this approach to reconstruct exposure history.

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Routine implementation costs of larviciding with Bacillus thuringiensis israelensis against malaria vectors in a district in rural Burkina Faso

July 27, 2016 - 07:02 -- Open Access
Author(s): 
Peter Dambach, Michael Schleicher, Hans-Christian Stahl, Issouf Traoré, Norbert Becker, Achim Kaiser, Ali Sié and Rainer Sauerborn
Reference: 
Malaria Journal 2016 15:380, 22 July 2016

The per capita costs for larval source management interventions with Bti are roughly a third of the annual per capita expenditures for anti-malarial drugs and those for LLINs in Burkina Faso which are US$ 3.80 and 3.00, respectively.

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A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents

July 27, 2016 - 06:59 -- Open Access
Author(s): 
Noemí Bahamontes-Rosa, María G. Gomez-Lorenzo, Joël Lelièvre, Ane Rodriguez Alejandre, María Jesus Almela, Sonia Lozano, Esperanza Herreros and Francisco-Javier Gamo
Reference: 
Malaria Journal 2016 15:385, 22 July 2016

This study describes a novel assay for characterizing the activity of anti-malarial drugs against the later stages of P. falciparum gametocyte development using qPCR in genetically unmodified parasites.

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