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Scientific Articles

A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle

January 17, 2017 - 15:43 -- Open Access
Author(s): 
Katarzyna Modrzynska, Claudia Pfander, Oliver Billker, et al.
Reference: 
Cell Host & Microbe, Volume 21, Issue 1, 11 January 2017, Pages 11–22

A family of apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s) was identified in malaria parasites. This family includes sequence-specific transcription factors that are key regulators of development. However, functions for the majority of ApiAP2 genes remain unknown. Here, a systematic knockout screen in Plasmodium berghei identified ten ApiAP2 genes that were essential for mosquito transmission: four were critical for the formation of infectious ookinetes, and three were required for sporogony.

Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts

January 17, 2017 - 15:42 -- Open Access
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Author(s): 
Thomas S. Churcher, Robert E. Sinden, Andrew M. Blagborough, et al.
Reference: 
PLoS Pathog 13(1): e1006108

Over a century since Ronald Ross discovered that malaria is caused by the bite of an infectious mosquito it is still unclear how the number of parasites injected influences disease transmission.

Rationale for Further Development of a Vaccine Based on the Circumsporozoite Protein of Plasmodium vivax

January 17, 2017 - 15:41 -- Open Access
Author(s): 
Anjali Yadava, Norman C. Waters
Reference: 
PLoS Negl Trop Dis 11(1): e0005164

Plasmodium vivax and its mosquito vectors have several distinctive characteristics that allow the transmission of this parasite in both temperate and tropical climates.

The Power of Malaria Vaccine Trials Using Controlled Human Malaria Infection

January 17, 2017 - 15:40 -- Open Access
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Author(s): 
Luc E. Coffeng, Cornelus C. Hermsen, Robert W. Sauerwein, Sake J. de Vlas
Reference: 
PLoS Comput Biol 13(1): e1005255

Controlled human malaria infection (CHMI) in healthy human volunteers is an important and powerful tool in clinical malaria vaccine development.

Detection of Plasmodium knowlesi, Plasmodium falciparum and Plasmodium vivax using loop-mediated isothermal amplification (LAMP) in a co-endemic area in Malaysia

January 17, 2017 - 15:38 -- Open Access
Author(s): 
Kim A. Piera, Ammar Aziz, Timothy William, David Bell, Iveth J. González, Bridget E. Barber, Nicholas M. Anstey and Matthew J. Grigg
Reference: 
Malaria Journal 2017 16:29, 13 January 2017

The Eiken Loopamp™ MALARIA Pan Detection kit is sensitive for detection of P. knowlesi in low parasitaemia clinical infections, as well as P. falciparum and P. vivax.

Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin–piperaquine in the south of Vietnam

January 17, 2017 - 15:36 -- Open Access
Author(s): 
Ngo Viet Thanh, Nguyen Thuy-Nhien, Tran Tinh Hien, et al.
Reference: 
Malaria Journal 2017 16:27, 13 January 2017

Alternative treatments are urgently needed.

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Profile of molecular mutations in pfdhfr, pfdhps, pfmdr1, and pfcrt genes of Plasmodium falciparum related to resistance to different anti-malarial drugs in the Bata District (Equatorial Guinea)

January 17, 2017 - 15:34 -- Open Access
Author(s): 
Pedro Berzosa, Andrés Esteban-Cantos, Agustín Benito, et al.
Reference: 
Malaria Journal 2017 16:28, 13 January 2017

The high level of mutations detected in P. falciparum genes related to SP resistance could be linked to the unsuccessful withdrawal of SP treatment in this area.

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New developments in anti-malarial target candidate and product profiles

January 17, 2017 - 15:33 -- Open Access
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Author(s): 
Jeremy N. Burrows, Stephan Duparc, Winston E. Gutteridge, Rob Hooft van Huijsduijnen, Wiweka Kaszubska, Fiona Macintyre, Sébastien Mazzuri, Jörg J. Möhrle and Timothy N. C. Wells
Reference: 
Malaria Journal 2017 16:26, 13 January 2017

A decade of discovery and development of new anti-malarial medicines has led to a renewed focus on malaria elimination and eradication.

In vivo antiplasmodial activity and toxicological assessment of hydroethanolic crude extract of Ajuga remota

January 17, 2017 - 15:32 -- Open Access
Author(s): 
Aschalew Nardos and Eyasu Makonnen
Reference: 
Malaria Journal 2017 16:25, 13 January 2017

The investigation results suggest that the leave extract of Ajuga remota possesses antimalarial activity.

Comparison of two adult mosquito sampling methods with human landing catches in south-central Ethiopia

January 17, 2017 - 15:30 -- Open Access
Tags: 
Author(s): 
Oljira Kenea, Meshesha Balkew, Habte Tekie, Teshome Gebre-Michael, Wakgari Deressa, Eskindir Loha, Bernt Lindtjørn and Hans J. Overgaard
Reference: 
Malaria Journal 2017 16:30, 13 January 2017

Results showed that HLC was the most efficient method for sampling An. arabiensis.

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