These results indicate that SO are a new class of immunomodulatory drugs and support further studies investigating this class of agents as potential adjunctive therapy for severe malaria.
In P. berghei, P51 was expressed in both asexual erythrocytic and sexual stages and localized on the surface of these stages with the exception of the ring stage.
Ensuring adequate and timely supplies of RDTs and ACT to PPM sites is critical.
Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM).
Cerebral malaria is one of the most severe complications of human infection by the Plasmodium falciparum parasite.
Malaria parasite ookinetes must traverse the vector mosquito midgut epithelium to transform into sporozoite-producing oocysts.
Drug development efforts have focused mostly on the asexual blood stages of the malaria parasite Plasmodium falciparum.
Mitigating key drivers that favour poor utilization of public-sector services among highly mobile migrant workers in less stable work-settings should be given priority in a malaria-elimination setting.
During the clinically silent liver phase of malaria, an increase of peripheral total leukocyte count and differential lymphocytes and monocytes occurs.
Rapamycin exerts pleotropic effects on host immunity, vascular activation and parasite sequestration that rescue mice from ECM, and thus support the potential clinical use of rapamycin as an adjunctive therapy in CM.