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Scientific Articles

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria

November 15, 2017 - 16:08 -- Open Access
Valerie M. Crowley, Kodjo Ayi, Ziyue Lu, Karen T. Liby, Michael Sporn and Kevin C. Kain
Malaria Journal 2017 16:463, 14 November 2017

These results indicate that SO are a new class of immunomodulatory drugs and support further studies investigating this class of agents as potential adjunctive therapy for severe malaria.

Characterization of Pb51 in Plasmodium berghei as a malaria vaccine candidate targeting both asexual erythrocytic proliferation and transmission

November 15, 2017 - 16:07 -- Open Access
Jian Wang, Wenqi Zheng, Fei Liu, Yaru Wang, Yiwen He, Li Zheng, Qi Fan, Enjie Luo, Yaming Cao and Liwang Cui
Malaria Journal 2017 16:458, 13 November 2017

In P. berghei, P51 was expressed in both asexual erythrocytic and sexual stages and localized on the surface of these stages with the exception of the ring stage.

Expanding malaria diagnosis and treatment in Lao PDR: lessons learned from a public–private mix initiative

November 15, 2017 - 16:03 -- Open Access
Nouannipha Simmalavong, Sengkham Phommixay, Phoudaliphone Kongmanivong, Odai Sichanthongthip, Bouasy Hongvangthong, Deyer Gopinath and David M. Sintasath
Malaria Journal 2017 16:460, 13 November 2017

Ensuring adequate and timely supplies of RDTs and ACT to PPM sites is critical.

Immune Regulation of Plasmodium Is Anopheles Species Specific and Infection Intensity Dependent

November 15, 2017 - 16:00 -- Open Access
Maria L. Simões, Godfree Mlambo, Abhai Tripathi, Yuemei Dong and George Dimopoulos
mBio vol. 8 no. 5 e01631-17

Malaria parasite ookinetes must traverse the vector mosquito midgut epithelium to transform into sporozoite-producing oocysts.

Plasmodium falciparum Calcium-Dependent Protein Kinase 2 Is Critical for Male Gametocyte Exflagellation but Not Essential for Asexual Proliferation

November 15, 2017 - 15:59 -- Open Access
Abhisheka Bansal, Alvaro Molina-Cruz, Joseph Brzostowski, Jianbing Mu and Louis H. Miller
mBio vol. 8 no. 5 e01656-17

Drug development efforts have focused mostly on the asexual blood stages of the malaria parasite Plasmodium falciparum.

Understanding malaria treatment-seeking preferences within the public sector amongst mobile/migrant workers in a malaria elimination scenario: a mixed-methods study

November 14, 2017 - 15:56 -- Open Access
Aung Ye Naung Win, Thae Maung Maung, Khin Thet Wai, Tin Oo, Aung Thi, Rungrawee Tipmontree, Ngamphol Soonthornworasiri, Mondha Kengganpanich and Jaranit Kaewkungwal
Malaria Journal 2017 16:462, 13 November 2017

Mitigating key drivers that favour poor utilization of public-sector services among highly mobile migrant workers in less stable work-settings should be given priority in a malaria-elimination setting.


Changes in total and differential leukocyte counts during the clinically silent liver phase in a controlled human malaria infection in malaria-naïve Dutch volunteers

November 14, 2017 - 15:54 -- Open Access
Marlies E. van Wolfswinkel, Marijke C. C. Langenberg, Linda J. Wammes, Robert W. Sauerwein, Rob Koelewijn, Cornelus C. Hermsen, Jaap J. van Hellemond and Perry J. van Genderen
Malaria Journal 2017 16:457, 10 November 2017

During the clinically silent liver phase of malaria, an increase of peripheral total leukocyte count and differential lymphocytes and monocytes occurs.

A single rapamycin dose protects against late-stage experimental cerebral malaria via modulation of host immunity, endothelial activation and parasite sequestration

November 14, 2017 - 15:53 -- Open Access
Pedro Mejia, J. Humberto Treviño-Villarreal, Justin S. Reynolds, Mariana De Niz, Andrew Thompson, Matthias Marti and James R. Mitchell
Malaria Journal 2017 16:455, 9 November 2017

Rapamycin exerts pleotropic effects on host immunity, vascular activation and parasite sequestration that rescue mice from ECM, and thus support the potential clinical use of rapamycin as an adjunctive therapy in CM.


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