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Scientific Articles

NOT Open Access | Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase-Deficient Malaria Patient in Southeastern Bangladesh

November 12, 2019 - 16:16 -- NOT Open Access
Author(s): 
Phru CS, Kibria MG, Thriemer K, Chowdhury MU, Jahan N, Aktaruzzaman MM, Rahmat H, Satyagraha AW, Prue AS, Khan WA, Ley B, Alam MS.
Reference: 
Am J Trop Med Hyg. 2019 Nov 4

We herein report the first case of Mediterranean glucose-6-phosphate dehydrogenase (G6PD) variant from Bangladesh. A boy had been admitted to hospital and was diagnosed with uncomplicated Plasmodium vivax infection and treated with 30 mg/kg body weight (BW) chloroquine for 3 days and 4.8 mg/kg BW primaquine (PQ) to be taken over 14 days.

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NOT Open Access | Estimation of Malaria-Attributable Fever in Malaria Test-Positive Febrile Outpatients in Three Provinces of Mozambique, 2018

November 12, 2019 - 16:13 -- NOT Open Access
Author(s): 
Plucinski MM, Candrinho B, Dimene M, Smith T, Thwing J, Colborn J, Rogier E, Zulliger R.
Reference: 
Am J Trop Med Hyg. 2019 Nov 4

Like most malaria-endemic countries, Mozambique relies on tabulation of confirmed malaria test–positive febrile patients to track incidence of malaria. However, this approach is potentially biased by incidental malaria parasitemia in patients with fever of another etiology.

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Trypanosoma brucei infection protects mice against malaria

November 12, 2019 - 16:10 -- Open Access
Author(s): 
Sanches-Vaz M, Temporão A, Luis R, Nunes-Cabaço H, Mendes AM, Goellner S, Carvalho T, Figueiredo LM, Prudêncio M.
Reference: 
PLoS Pathog. 2019 Nov 8;15(11):e1008145

Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness, would inhibit a subsequent infection by Plasmodium, the malaria parasite, decreasing the severity of its associated pathology.

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Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathy in South Western Region Nepal: a boon or burden

November 12, 2019 - 16:05 -- Open Access
Author(s): 
Narayan Gautam, Bhagwati Gaire, Trishna Manandhar, Bishnu P. Marasini, Niranjan Parajuli, Sunil P. Lekhak and Monica Nepal
Reference: 
BMC Research Notes volume 12, Article number: 734 (2019)

The study was carried out to optimize the phenotypic method to characterize the sickle cell trait (SCT), sickle cell anemia (SCA), and β-thalassemia (β-TT) suspected sample from tharu community of South Western province-5, Nepal. SCT and SCA were further evaluated by genotypic method employing amplification refractory mutation system (ARMS PCR). 

Non-adherence to malaria prophylaxis: The influence of travel-related and psychosocial factors

November 12, 2019 - 15:59 -- Open Access
Author(s): 
Jolanda G.M. Hoefnagel, Karlijn Massar, Jeannine L.A. Hautvast
Reference: 
Journal of Infection and Public Health, 6 November 2019

The effectiveness of malaria chemoprophylaxis is limited by a lack of compliance in travellers. This study assesses the demographic, travel-related, and psychosocial determinants of non-compliance with chemoprophylaxis.

NOT Open Access | Polymorphism and natural selection in the merozoite surface protein 3F2 (PVX_97710) locus of Plasmodium vivax among field isolates

November 12, 2019 - 15:56 -- NOT Open Access
Author(s): 
Napaporn Kuamsab, Chaturong Putaporntip, Somchai Jongwutiwes
Reference: 
Infection, Genetics and Evolution, November 2019, 104058

Plasmodium vivax, the chronic relapsing human malaria parasite with the most widespread distribution, possesses proteins associated with the merozoite surface that could be targets for host immune responses and potential vaccine candidates. Of these, the merozoite surface protein 3 of P. vivax (PvMSP3) is an attractive vaccine target as well as a genetic marker for epidemiological surveillance.

NOT Open Access | Relationship between land cover and Anophelinae species abundance, composition and diversity in NW Colombia

November 12, 2019 - 15:50 -- NOT Open Access
Author(s): 
Naranjo-Díaz N, Hernandez-Valencia JC, Marín A, Correa MM
Reference: 
Infection, Genetics and Evolution, 9 November 2019, 104114

Anthropic activities, mainly deforestation, have produced rapid transformation of land cover types in the Urabá region at northwest Colombia. Land cover alterations impact the abundance and composition of the Anophelinae community, affecting malaria transmission dynamics.

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Modelled and observed mean and seasonal relationships between climate, population density and malaria indicators in Cameroon

November 11, 2019 - 16:24 -- Open Access
Author(s): 
Amelie D. Mbouna, Adrian M. Tompkins, Andre Lenouo, Ernest O. Asare, Edmund I. Yamba and Clement Tchawoua
Reference: 
Malaria Journal 2019 18:359, 10 November 2019

A major health burden in Cameroon is malaria, a disease that is sensitive to climate, environment and socio-economic conditions, but whose precise relationship with these drivers is still uncertain. An improved understanding of the relationship between the disease and its drivers, and the ability to represent these relationships in dynamic disease models, would allow such models to contribute to health mitigation and adaptation planning. 

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Determinants of malaria treatment delay in northwestern zone of Tigray region, Northern Ethiopia, 2018

November 11, 2019 - 16:20 -- Open Access
Author(s): 
Afewerki Tesfahunegn, Dawit Zenebe and Alefech Addisu
Reference: 
Malaria Journal 2019 18:358, 9 November 2019

Globally malaria affects 212 million people and causes 438,000 deaths each year. Ensuring early and timely treatment of malaria is important for preventing and controlling of life-threatening complications and further transmission. 

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The effect of ivermectin® on fertility, fecundity and mortality of Anopheles arabiensis fed on treated men in Ethiopia

November 11, 2019 - 16:16 -- Open Access
Author(s): 
Wondemeneh Mekuriaw, Meshesha Balkew, Louisa A. Messenger, Delenasaw Yewhalaw, Adugna Woyessa and Fekadu Massebo
Reference: 
Malaria Journal 2019 18:357, 8 November 2019

Insecticide resistance is a growing threat to malaria vector control. Ivermectin, either administered to humans or animals, may represent an alternate strategy to reduce resistant mosquito populations. The aim of this study was to assess the residual or delayed effect of administering a single oral dose of ivermectin to humans on the survival, fecundity and fertility of Anopheles arabiensis in Ethiopia.

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