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Scientific Articles

Not Open Access | EEG markers predictive of epilepsy risk in pediatric cerebral malaria - A feasibility study

November 25, 2020 - 13:29 -- NOT Open Access
Author(s): 
Patel AA, Jannati A, Dhamne SC, Sapuwa M, Kalanga E, Mazumdar M, Birbeck GL, Rotenberg A
Reference: 
Epilepsy Behav. 2020 Nov 21;113:107536

Cerebral malaria (CM) affects 500,000 million children annually, 10% whom develop epilepsy within two years. Acute identification of biomarkers for post-CM epilepsy would allow for follow-up of the highest risk populations in resource-limited regions. We investigated the utility of electroencephalogram (EEG) and clinical metrics obtained during acute CM infection for predicting epilepsy.

Last-come, best served? Mosquito biting order and Plasmodium transmission

November 25, 2020 - 13:21 -- Open Access
Author(s): 
Isaïa J, Rivero A, Glaizot O, Christe P, Pigeault R
Reference: 
Proc Biol Sci. 2020 Nov 25;287(1939):20202615

A pervasive characteristic of parasite infections is their tendency to be overdispersed. Understanding the mechanisms underlying this overdispersed distribution is of key importance as it may impact the transmission dynamics of the pathogen. Although multiple factors ranging from environmental stochasticity to inter-individual heterogeneity may explain parasite overdispersion, parasite infection is also overdispersed in an inbred host population maintained under laboratory conditions, suggesting that other mechanisms are at play.

NOT Open Access | Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection

November 25, 2020 - 13:16 -- NOT Open Access
Author(s): 
Haltalli MLR, Watcham S, Lo Celso C, et al.
Reference: 
Nat Cell Biol. 2020 Nov 23

Severe infections are a major stress on haematopoiesis, where the consequences for haematopoietic stem cells (HSCs) have only recently started to emerge. HSC function critically depends on the integrity of complex bone marrow (BM) niches; however, what role the BM microenvironment plays in mediating the effects of infection on HSCs remains an open question.

NOT Open Access | Citronamine A, an Antiplasmodial Isoquinoline Alkaloid from the Australian Marine Sponge Citronia astra

November 25, 2020 - 13:08 -- NOT Open Access
Author(s): 
Prebble DW, Holland DC, Robertson LP, Avery VM, Carroll AR
Reference: 
Org Lett. 2020 Nov 24

Citronamine A (1), an isoquinoline alkaloid containing an unprecedented pentacyclic ring system, was isolated from the Australian marine sponge Citronia astra.

NOT Open Access | A role for the succinate dehydrogenase in the mode of action of the redox-active antimalarial drug, plasmodione

November 25, 2020 - 13:05 -- NOT Open Access
Author(s): 
Mounkoro P, Michel T, Golinelli-Cohen MP, Blandin S, Davioud-Charvet E, Meunier B
Reference: 
Free Radic Biol Med. 2020 Nov 21:S0891-5849(20)31608-7

Malaria, caused by protozoan parasites, is a major public health issue in subtropical countries. An arsenal of antimalarial treatments is available, however, resistance is spreading, calling for the development of new antimalarial compounds. The new lead antimalarial drug plasmodione is a redox-active compound that impairs the redox balance of parasites leading to cell death.

'The Fever': Questioning Malaria Management as a Colonial Legacy

November 25, 2020 - 13:03 -- Open Access
Author(s): 
Weingartner K
Reference: 
Development (Rome). 2020 Nov 20:1-4

Malaria is the oldest disease of humankind. It is known to have killed more people than all other diseases and wars on Earth combined together and it is probably the one single disease with the most dollars in its belly, when it comes to research and development funding.

Digitalized mass distribution campaign of insecticide-treated nets (ITNs) in the particular context of Covid-19 pandemic in Benin: challenges and lessons learned

November 25, 2020 - 12:47 -- Open Access
Author(s): 
Rock Aïkpon, Cyriaque Affoukou, Aurore Ogouyemi Hounto, et al.
Reference: 
Malaria Journal 2020 19:431, 25 November 2020

In 2020, Benin has implemented a digitalized mass distribution campaign of insecticide-treated nets (ITNs) in the particular context of COVID-19 pandemic. This paper describes the implementation process as well as the challenges and lessons learned from this campaign.

Efficacy and safety of tafenoquine for malaria chemoprophylaxis (1998-2020): A systematic review and meta-analysis

November 25, 2020 - 12:45 -- Open Access
Author(s): 
Maier JD, Siegfried S, Gültekin N, Stanga Z, Baird JK, Grobusch MP, Schlagenhauf P
Reference: 
Travel Med Infect Dis. 2020 Nov 20:101908

In 2018, tafenoquine was approved for malaria chemoprophylaxis. We evaluated all available data on the safety and efficacy of tafenoquine chemoprophylaxis.

Assessing the in vitro sensitivity with associated drug resistance polymorphisms in Plasmodium vivax clinical isolates from Delhi, India

November 25, 2020 - 12:42 -- Open Access
Author(s): 
Matlani M, Kumar A, Singh V
Reference: 
Exp Parasitol. 2020 Nov 19:108047

The drug resistance of Plasmodium vivax in clinical cases remains largely unknown till date because of the difficulty in diagnosing the resistant P. vivax strains. The present study was undertaken to determine the prevalence of mutant alleles in drug resistance genes viz P. vivax multi-drug resistance (pvmdr-1), chloroquine resistance transporter (pvcrt-o), dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps) along with in vitro chloroquine (CQ) sensitivity in P. vivax clinical isolates.

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