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Scientific Articles

LLIN Evaluation in Uganda Project (LLINEUP): factors associated with ownership and use of long-lasting insecticidal nets in Uganda: a cross-sectional survey of 48 districts

November 15, 2018 - 21:00 -- Open Access
Samuel Gonahasa, Catherine Maiteki-Sebuguzi, Sarah G. Staedke, et al.
Malaria Journal 2018 17:421

Long-lasting insecticidal net ownership and coverage have reduced markedly in Uganda since the last net distribution campaign in 2013/14. Houses with many residents, poorer households, and school-aged children should be targeted to improve LLIN coverage and use.

Spatial–temporal distribution of Anopheles larval habitats in Uganda using GIS/remote sensing technologies

November 15, 2018 - 20:43 -- Open Access
Ryan Tokarz and Robert J. Novak
Malaria Journal 2018 17:420

The findings show that the spatial outcomes of productive habitats can be made starkly apparent through initial habitat modelling and resulting time-series output. However, mosquito control resources are often limited and it is at this point that the Local Moran’s I statistics demonstrates its value. 

Malaria epidemiology in Suriname from 2000 to 2016: trends, opportunities and challenges for elimination

November 15, 2018 - 20:23 -- Open Access
Hélène Hiwat, Beatriz Martínez-López, Hedley Cairo, Loretta Hardjopawiro, Agatha Boerleider, Elisabeth Carmen Duarte and Zaida E. Yadon
Malaria Journal 2018 17:418

Suriname has successfully reduced malaria to near-elimination level in the last 17 years. However, the high malaria import rate resulting from cross-border moving migrants is a major challenge for reaching elimination. This requires continued investment in the national health system, with a focus on border screening and migrant health. A regional approach to malaria elimination within the Guianas and Brazil is urgently needed.


Correlation of malaria parasitaemia with peripheral blood monocyte to lymphocyte ratio as indicator of susceptibility to severe malaria in Ghanaian children

November 15, 2018 - 15:10 -- Open Access
Samuel Antwi-Baffour, Ransford Kyeremeh, Dorcas Buabeng, Jonathan Kofi Adjei, Claudia Aryeh, George Kpentey and Mahmood Abdulai Seidu
Malaria Journal 2018 17:419

The study comprised of 1629 (m = 896; f = 733) children up to 5 years presenting with clinical malaria as cases and 445 (m = 257; f = 188) apparently healthy children as controls. The results indicated that there was a significant positive correlation between the monocytes to lymphocytes ratio and the presence of parasites (p = 0.04) and the level of parasitaemia within the age group of 0–3 years (p = 0.02) and 4–5 years (p = 0.03).

Specificity of the IgG antibody response to Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium ovale MSP119 subunit proteins in multiplexed serologic assays

November 15, 2018 - 15:07 -- Open Access
Jeffrey W. Priest, Mateusz M. Plucinski, Curtis S. Huber, Eric Rogier, Bunsoth Mao, Christopher J. Gregory, Baltazar Candrinho, James Colborn and John W. Barnwell
Malaria Journal 2018 17:417

A pan-malaria MSP119 cross-reactive antibody response was observed in elutions of blood spots from two 20–30 years old Mozambique donors. The antibody response from one of these two donors had low avidity and skewed almost entirely to the IgG3 subclass.

G6PD deficiency, primaquine treatment, and risk of haemolysis in malaria-infected patients

November 15, 2018 - 15:00 -- Open Access
Sara Avalos, Rosa E. Mejia, Gustavo Fontecha, et al.
Malaria Journal 2018 17:415

The findings support that the intake of PQ during 14 days of treatment against vivax malaria is safe in patients with a class III variant of G6PDd. In view of the new national regulations in the shortened treatment of vivax malaria for 7 days, it is advisable to be alert of potential cases of severe haemolysis that could occur among G6PD deficient hemizygous males with a class II mutation such as the Santamaria variant, previously reported in the country.

Characterization and monitoring of deltamethrin-resistance in Anopheles culicifacies in the presence of a long-lasting insecticide-treated net intervention

November 15, 2018 - 14:55 -- Open Access
Madhavinadha Prasad Kona, Raghavendra Kamaraju, Veena Pandey, et al.
Malaria Journal 2018 17:414

This field study, in a tribal district of India, after distribution of deltamethrin-impregnated LLINs showed decrease in deltamethrin susceptibility in An. culicifacies, a major vector of malaria in this study area and in India. Results indicated development of resistance as imminent with the increase in insecticide selection pressure. 


Elevated atmospheric CO2 promoted speciation in mosquitoes (Diptera, Culicidae)

November 8, 2018 - 14:51 -- Open Access
Chufei Tang, Katie E. Davis, Cyrille Delmer, Ding Yang & Matthew A. Wills
Communications Biology, volume 1, Article number: 182 (2018)

Mosquitoes are of great medical significance as vectors of deadly diseases. Despite this, little is known about their evolutionary history or how their present day diversity has been shaped. Within a phylogenetic framework, here we show a strong correlation between climate change and mosquito speciation rates: the first time to our knowledge such an effect has been demonstrated for insects.

Towards a re-emergence of chloroquine sensitivity in Côte d’Ivoire?

November 7, 2018 - 15:12 -- Open Access
Oléfongo Dagnogo, Aristide Berenger Ako, Lacinan Ouattara, Noel Dougba Dago, David N’golo Coulibaly, André Offianan Touré and Joseph Allico Djaman
Malaria Journal 2018 17:413, 7 November 2018

More than a decade after the discontinuation of the use of chloroquine in Côte d’Ivoire, the proportion of parasites sensitive to this anti-malarial seems to increase in Anonkoua-kouté, Port-bouët and Ayamé.

Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines

November 7, 2018 - 15:10 -- Open Access
Jonathan Berman, Tracey Brown, Geoffrey Dow and Stephen Toovey
Malaria Journal 2018 17:407, 6 November 2018

Extrapolation of data from Rhesus monkeys to humans, and the available clinical data, suggest that tafenoquine also does not exhibit pamaquine, pentaquine or plasmocid-like clinical neurologic signs in humans.

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