The world's scientific and social network for malaria professionals
8986 malaria professionals are enjoying the free benefits of MalariaWorld today

Scientific Articles

NOT Open Access | Anion inhibition profiles of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum

August 26, 2016 - 18:17 -- NOT Open Access
Author(s): 
Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Pietro di Fonzo, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran, Clemente Capasso
Reference: 
Bioorganic & Medicinal Chemistry, Volume 24, Issue 18, 15 September 2016, Pages 4410–4414

We have cloned, purified and investigated the catalytic activity and anion inhibition profiles of a full catalytic domain (358 amino acid residues) carbonic anhydrase (CA, EC 4.2.1.1) from Plasmodium falciparum, PfCAdom, an enzyme belonging to the η-CA class and identified in the genome of the malaria-producing protozoa.

Average: 
0
No votes yet

NOT Open Access | Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense

August 26, 2016 - 18:16 -- NOT Open Access
Author(s): 
Cigdem Karaaslan, Marcel Kaiser, Reto Brun, Hakan Göker
Reference: 
Bioorganic & Medicinal Chemistry, Volume 24, Issue 18, 15 September 2016, Pages 4038–4044

A series of mono and dicationic new 2-anilinobenzimidazole carboxamidines were prepared in a four step process starting from 4-amino-3-nitrobenzonitrile and corresponding o-phenylenediamines.

Average: 
0
No votes yet

Somatically Hypermutated Plasmodium-Specific IgM+ Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge

August 26, 2016 - 18:15 -- Open Access
Author(s): 
Akshay T. Krishnamurty, Christopher D. Thouvenel, Silvia Portugal, Gladys J. Keitany, Karen S. Kim, Anthony Holder, Peter D. Crompton, David J. Rawlings, Marion Pepper
Reference: 
Immunity, Volume 45, Issue 2, 16 August 2016, Pages 402–414

Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells and rapidly reactive memory B cells (MBC).

Average: 
0
No votes yet

NOT Open Access | PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria

August 26, 2016 - 18:12 -- NOT Open Access
Tags: 
Author(s): 
Peter D. Crompton, Susan K. Pierce
Reference: 
Immunity, Volume 45, Issue 2, 16 August 2016, Pages 231–233

How early interactions between innate and adaptive immune cells influence outcomes of acute infections is incompletely understood.

Average: 
0
No votes yet

Non-falciparum malaria in Dakar: a confirmed case of Plasmodium ovale wallikeri infection

August 26, 2016 - 17:58 -- Open Access
Tags: 
Author(s): 
Mamadou A. Diallo, Aida S. Badiane, Daouda Ndiaye, et al.
Reference: 
Malaria Journal 2016 15:429, 24 August 2016

Malaria due to non-falciparum species is probably underestimated in Senegal. RDTs specific to non-falciparum species and/or pan specific RDTs should be included as tools of diagnosis to fight against malaria in Senegal.

Country: 
Average: 
0
No votes yet

Glucagon-like peptide-1 analogue, liraglutide, in experimental cerebral malaria: implications for the role of oxidative stress in cerebral malaria

August 26, 2016 - 17:57 -- Open Access
Author(s): 
Brian DellaValle, Casper Hempel, Trine Staalsoe, Flemming Fryd Johansen and Jørgen Anders Lindholm Kurtzhals
Reference: 
Malaria Journal 2016 15:427, 24 August 2016

Despite the breadth of models where GLP-1 is neuroprotective, ECM was not affected by liraglutide providing important insight into the pathogenesis of ECM.

Average: 
0
No votes yet

Influence of the agrochemicals used for rice and vegetable cultivation on insecticide resistance in malaria vectors in southern Côte d’Ivoire

August 26, 2016 - 17:50 -- Open Access
Tags: 
Author(s): 
Mouhamadou S. Chouaïbou, Behi K. Fodjo, Gilbert Fokou, Ouattara F. Allassane, Benjamin G. Koudou, Jean-Philippe David, Christophe Antonio-Nkondjio, Hilary Ranson and Bassirou Bonfoh
Reference: 
Malaria Journal 2016 15:426, 24 August 2016

The study describes the use of insecticides and herbicides on crops and highlights the importance of considering agriculture practices when attempting to manage resistance in malaria vectors.

Average: 
0
No votes yet

Behavioural and neurological symptoms accompanied by cellular neuroinflammation in IL-10-deficient mice infected with Plasmodium chabaudi

August 26, 2016 - 17:48 -- Open Access
Author(s): 
Kyle D. Wilson, Sonja J. Stutz, Lorenzo F. Ochoa, Gustavo A. Valbuena, Petra D. Cravens, Kelly T. Dineley, Gracie Vargas and Robin Stephens
Reference: 
Malaria Journal 2016 15:428, 24 August 2016

These studies demonstrate exacerbated neuroinflammation concurrent with development of behavioural symptoms in P. chabaudi infection of IL-10−/− animals.

Person: 
Country: 
Average: 
0
No votes yet

Functional genomic analyses of Enterobacter, Anopheles and Plasmodium reciprocal interactions that impact vector competence

August 26, 2016 - 17:46 -- Open Access
Author(s): 
Nathan J. Dennison, Raúl G. Saraiva, Chris M. Cirimotich, Godfree Mlambo, Emmanuel F. Mongodin and George Dimopoulos
Reference: 
Malaria Journal 2016 15:425, 22 August 2016

Esp_Z is capable of inhibiting sporogonic development of Plasmodium in the presence of the mosquito’s native microbiota without affecting mosquito fitness.

Average: 
0
No votes yet

Pages

Subscribe to Scientific Articles