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Scientific Articles

Explaining variation in adult Anopheles indoor resting abundance: the relative effects of larval habitat proximity and insecticide-treated bed net use

July 18, 2017 - 15:14 -- Open Access
Author(s): 
Robert S. McCann, Joseph P. Messina, David W. MacFarlane, M. Nabie Bayoh, John E. Gimnig, Emanuele Giorgi and Edward D. Walker
Reference: 
Malaria Journal 2017 16:288, 17 July 2017

Variation in the abundance of indoor-resting Anopheles in rural houses of western Kenya varies with clearly identifiable factors.

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An analytical approach to reduce between-plate variation in multiplex assays that measure antibodies to Plasmodium falciparum antigens

July 18, 2017 - 15:12 -- Open Access
Author(s): 
Rui Fang, Andrew Wey, Naveen K. Bobbili, Rose F. G. Leke, Diane Wallace Taylor and John J. Chen
Reference: 
Malaria Journal 2017 16:287, 17 July 2017

For malaria-related research that measure antibodies to multiple antigens with multiplex assays, the natural-log transformation is recommended for data analysis and use of the normalization procedure with multiple pooled controls can improve the precision of antibody measurements.

Demand and willingness-to-pay for bed nets in Tanzania: results from a choice experiment

July 18, 2017 - 15:11 -- Open Access
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Author(s): 
Chris D. Gingrich, Emily Ricotta, Amos Kahwa, Catherine Kahabuka and Hannah Koenker
Reference: 
Malaria Journal 2017 16:285, 14 July 2017

The results suggest that private demand for nets in Tanzania could potentially supplement future coverage campaigns.

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Vector control with driving Y chromosomes: modelling the evolution of resistance

July 18, 2017 - 15:09 -- Open Access
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Author(s): 
Andrea Beaghton, Pantelis John Beaghton and Austin Burt
Reference: 
Malaria Journal 2017 16:286, 14 July 2017

As with any other intervention, there is a risk that resistance will evolve to new genetic approaches to vector control, and steps should be taken to minimize this probability.

Tracking development assistance and government health expenditures for 35 malaria-eliminating countries: 1990–2017

July 18, 2017 - 15:08 -- Open Access
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Author(s): 
Rima Shretta, Brittany Zelman, Maxwell L. Birger, Annie Haakenstad, Lavanya Singh, Yingying Liu and Joseph Dieleman
Reference: 
Malaria Journal 2017 16:251, 14 July 2017

Despite past gains, total financing available for malaria in elimination settings is declining.

Knowledge of prevention, cause, symptom and practices of malaria among women in Burkina Faso

July 12, 2017 - 16:28 -- Open Access
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Author(s): 
Sanni Yaya, Ghose Bishwajit, Michael Ekholuenetale, Vaibhav Shah, Bernard Kadio, Ogochukwu Udenigwe
Reference: 
PLoS ONE 12(7): e0180508

The overall knowledge of malaria prevention practices among a large proportion of women was found to be low, which implies that the knowledge about the prevention of malaria should be improved upon by both urban and rural dwellers.

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The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes

July 12, 2017 - 16:26 -- Open Access
Author(s): 
Christine R. Collins, Fiona Hackett, Jonathan Atid, Michele Ser Ying Tan, Michael J. Blackman
Reference: 
PLoS Pathog 13(7): e1006453

Egress of the malaria parasite Plasmodium falciparum from its host red blood cell is a rapid, highly regulated event that is essential for maintenance and completion of the parasite life cycle.

Developing transmission-blocking strategies for malaria control

July 12, 2017 - 16:25 -- Open Access
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Author(s): 
Robert E. Sinden
Reference: 
PLoS Pathog 13(7): e1006336

Analysis of the varied developmental pathways exploited by malarial parasites as they pass through their differing life stages can be challenging [1–3], the parasites often adopting mechanisms that differ from the conventional norms of their eukaryotic hosts.

NOT Open Access | 1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities

July 12, 2017 - 16:23 -- NOT Open Access
Author(s): 
Sampark S. Thakkar, Parth Thakor, Hiren Doshi, Arabinda Ray
Reference: 
Bioorganic & Medicinal Chemistry, Volume 25, Issue 15, 1 August 2017, Pages 4064-4075

1,2,4-Triazole and 1,3,4-oxadiazole analogues are of interest due to their potential activity against microbial and malarial infections.

NOT Open Access | Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs

July 12, 2017 - 16:22 -- NOT Open Access
Author(s): 
Petr Špaček, Dianne T. Keough, Marina Chavchich, Martin Dračínský, Zlatko Janeba, Lieve Naesens, Michael D. Edstein, Luke W. Guddat, Dana Hocková
Reference: 
Bioorganic & Medicinal Chemistry, Volume 25, Issue 15, 1 August 2017, Pages 4008-4030

Two new series of symmetric acyclic nucleoside bisphosphonates (ANbPs) have been synthesised as potential inhibitors of the Plasmodium falciparum (Pf) and vivax (Pv) 6-oxopurine phosphoribosyltransferases.

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