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Scientific Articles

Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire

January 15, 2019 - 15:32 -- Open Access
Author(s): 
Eveline Hürlimann, Clarisse A. Houngbedji, Richard B. Yapi, Prisca B. N’Dri, Kigbafori D. Silué, Mamadou Ouattara, Jürg Utzinger, Eliézer K. N’Goran, Giovanna Raso
Reference: 
PLoS Negl Trop Dis 13(1): e0007086

No exacerbation from co-infection with Plasmodium and helminths was observed, neither in participants aged 5–18 years nor in adults from the community-based studies.

Molecular monitoring of the diversity of human pathogenic malaria species in blood donations on Bioko Island, Equatorial Guinea

January 15, 2019 - 15:30 -- Open Access
Author(s): 
Tobias Schindler, Tamy Robaina, Claudia Daubenberger, et al.
Reference: 
Malaria Journal 2019 18:9, 15 January 2019

This study confirms that in malaria endemic settings, sub-patent malaria infections among blood donors are prevalent.

Medical Condition: 

Application of the automated haematology analyzer XN-30 for discovery and development of anti-malarial drugs

January 15, 2019 - 15:26 -- Open Access
Author(s): 
Takahiro Tougan, Yuji Toya, Kinya Uchihashi and Toshihiro Horii
Reference: 
Malaria Journal 2019 18:8, 14 January 2019

The current study demonstrates that the XN-30 analyzer objectively, reproducibly, and easily evaluated and characterized the anti-malarial efficacy of various compounds.

Medical Treatment: 

MiRNA-146a polymorphism increases the odds of malaria in pregnancy

January 15, 2019 - 15:24 -- Open Access
Author(s): 
Welmoed van Loon, Prabhanjan P. Gai, Lutz Hamann, George Bedu-Addo and Frank P. Mockenhaupt
Reference: 
Malaria Journal 2019 18:7, 14 January 2019

These results indicate that SNP rs2910164 G > C is associated with increased odds for P. falciparum infection in first-time pregnant women who are considered to lack sufficient acquired immune responses against pregnancy-specific strains of P. falciparum.

Measuring and characterizing night time human behaviour as it relates to residual malaria transmission in sub-Saharan Africa: a review of the published literature

January 15, 2019 - 15:22 -- Open Access
Tags: 
Author(s): 
April Monroe, Sarah Moore, Hannah Koenker, Matthew Lynch and Emily Ricotta
Reference: 
Malaria Journal 2019 18:6, 11 January 2019

While the importance of understanding human-vector interaction is well-established, relatively few studies have included human behaviour when measuring exposure to malaria vectors.

Development of an agent-based model to assess the impact of substandard and falsified anti-malarials: Uganda case study

January 15, 2019 - 15:19 -- Open Access
Tags: 
Author(s): 
Sachiko Ozawa, Daniel R. Evans, Colleen R. Higgins, Sarah K. Laing and Phyllis Awor
Reference: 
Malaria Journal 2019 18:5, 9 January 2019

Improving the quality of treatment is essential to combat the burden of malaria and prevent the development of drug resistance.

Medical Condition: 
Medical Treatment: 

Pyronaridine‐artesunate for treating uncomplicated Plasmodium falciparum malaria

January 11, 2019 - 20:29 -- Open Access
Author(s): 
Joseph Pryce,Paul Hine
Reference: 
Cochrane Systematic Review - Intervention Version published: 08 January 2019

For this update, two review authors independently re‐extracted all data and assessed certainty of evidence. We meta‐analysed data to calculate risk ratios (RRs) for treatment failures between comparisons, and for safety outcomes between and across comparisons.

A saliva-based rapid test to quantify the infectious subclinical malaria parasite reservoir

January 10, 2019 - 15:53 -- Open Access
Author(s): 
Dingyin Tao, Brent McGill, Timothy Hamerly, Tamaki Kobayashi, Prachi Khare, Amanda Dziedzic, Tomasz Leski, Andrew Holtz, Bruce Shull, Anne E. Jedlicka, Andrew Walzer, Paul D. Slowey, Christopher C. Slowey, Sandrine E. Nsango, David A. Stenger, Mike Chaponda, Modest Mulenga, Kathryn H. Jacobsen, David J. Sullivan, Sadie J. Ryan, Rashid Ansumana, William J. Moss, Isabelle Morlais and Rhoel R. Dinglasan
Reference: 
Science Translational Medicine 02 Jan 2019: Vol. 11, Issue 473, eaan4479

The gametocyte sexual form of Plasmodium falciparum, a parasite that causes human malaria, is responsible for mosquito-borne transmission of infection. Some individuals carry low concentrations of the parasite (subclinical infection), which makes detection and eradication difficult. Tao et al. developed a rapid lateral flow assay that detects a female gametocyte-specific protein, PSSP17, in saliva. 


Not Open Access | Epigenetic editing by CRISPR/dCas9 in Plasmodium falciparum

January 8, 2019 - 15:56 -- NOT Open Access
Author(s): 
Bo Xiao, Shigang Yin, Lubin Jiang, et al.
Reference: 
PNAS January 2, 2019 116 (1) 255-260

Genetic manipulation remains a major obstacle for understanding the functional genomics of the deadliest malaria parasite Plasmodium falciparum.

Using Lipoamidase as a Novel Probe To Interrogate the Importance of Lipoylation in Plasmodium falciparum

January 8, 2019 - 15:55 -- Open Access
Author(s): 
Hugo Jhun, Maroya S. Walters and Sean T. Prigge
Reference: 
mBio November/December 2018 9:e01872-18

Lipoate is a redox active cofactor that is covalently bound to key enzymes of oxidative metabolism.

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