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Scientific Articles

Prevalence of Plasmodium parasites in non-human primates and mosquitoes in areas with different degrees of fragmentation in Colombia

August 19, 2019 - 18:04 -- Open Access
Author(s): 
Silvia Rondón, Cielo León, Andrés Link and Camila González
Reference: 
Malaria Journal 2019 18:276, 19 August 2019

Parasites from the genus Plasmodium, the aetiological agent of malaria in humans, can also infect non-human primates (NHP), increasing the potential risk of zoonotic transmission with its associated global public health concerns. In Colombia, there are no recent studies on Plasmodium spp. infecting free-ranging NHP. Thus, this study aimed to determine the diversity of Plasmodium species circulating in fragmented forests in central Colombia, both in Anopheles mosquitoes and in the four sympatric NHP in the region (Ateles hybridus, Cebus versicolor, Alouatta seniculus and Aotus griseimembra), in order to evaluate the risk of infection to humans associated with the presence of sylvatic hosts and vectors infected with Plasmodium spp.

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Molecular detection of drug resistant malaria in Southern Thailand

August 19, 2019 - 17:40 -- Open Access
Author(s): 
Chaturong Noisang, Christiane Prosser, Wieland Meyer, Waenurama Chemoh, John Ellis, Nongyao Sawangjaroen and Rogan Lee
Reference: 
Malaria Journal 2019 18:275, 15 August 2019

Drug resistance within the major malaria parasites Plasmodium vivax and Plasmodium falciparum threatens malaria control and elimination in Southeast Asia. Plasmodium vivax first-line treatment drug is chloroquine together with primaquine, and the first-line treatment for P. falciparum malaria is artemisinin in combination with a partner drug. Plasmodium vivax and P. falciparum parasites resistant to their respective first-line therapies are now found within Southeast Asia. The resistance perimeters may include high transmission regions of Southern Thailand which are underrepresented in surveillance efforts.

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Bed net care practices and associated factors in western Kenya

August 19, 2019 - 17:33 -- Open Access
Author(s): 
Ellen M. Santos, Jenna E. Coalson, Elizabeth T. Jacobs, Yann C. Klimentidis, Stephen Munga, Maurice Agawo, Elizabeth Anderson, Nancy Stroupe and Kacey C. Ernst
Reference: 
Malaria Journal 2019 18:274, 14 August 2019

Insecticide-treated nets (ITNs) and long-lasting insecticidal nets (LLINs) are effective for malaria prevention and are designed to provide nearly 5 years of mosquito protection. However, many ITNs and LLINs become damaged and ineffective for mosquito bite prevention within 1 to 2 years in field conditions. Non-adherence to recommended bed net care and repair practices may partially explain this shortened net longevity.

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Larviciding to prevent malaria transmission

August 19, 2019 - 13:51 -- Open Access
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Author(s): 
Leslie Choi, Silas Majambere, Anne L Wilson
Reference: 
Cochrane Systematic Review - Intervention Version published: 14 August 2019

Larviciding refers to the regular application of chemical or microbial insecticides to water bodies or water containers to kill the aquatic immature forms of the mosquito (the larvae and pupae).

Knowledge, attitude and practice towards malaria among symptomatic patients attending Tumbi Referral Hospital: A cross-sectional study

August 13, 2019 - 15:53 -- Open Access
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Author(s): 
David Zadock Munisi, Azan A. Nyundo, Bonaventura C. Mpondo
Reference: 
PLoS ONE 14(8): e0220501

Despite significant improvement in prevention and control over the past decades malaria remains a significant public health concern in Tanzania with 93% of the population being at risk. To prevent malaria infection and promote malaria free zones, understanding the community’s knowledge, attitudes, and practices toward malaria control are essential. This study therefore aimed at determining the levels of understanding, and attitudes, as well as socio-cultural aspects of malaria prevention and treatment-seeking behaviours among suspected malaria patients.

Serologic responses to the PfEMP1 DBL-CIDR head structure may be a better indicator of malaria exposure than those to the DBL-α tag

August 13, 2019 - 15:52 -- Open Access
Author(s): 
Emily M. Stucke, Amadou Niangaly, Mark A. Travassos, et al.
Reference: 
Malaria Journal 2019 18:273, 13 August 2019

Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-terminal constitutive domain in a PfEMP1 is the Duffy binding-like alpha (DBL-α) domain, which contains a 300 to 400 base pair region unique to each particular protein (the DBL-α “tag”). This DBL-α tag has been used as a marker of PfEMP1 diversity and serologic responses in malaria-exposed populations. In this study, using sera from a malaria-endemic region, responses to DBL-α tags were compared to responses to the corresponding entire DBL-α domain (or “parent” domain) coupled with the succeeding cysteine-rich interdomain region (CIDR).

A comparison of two PCR protocols for the differentiation of Plasmodium ovale species and implications for clinical management in travellers returning to Germany: a 10-year cross-sectional study

August 13, 2019 - 15:44 -- Open Access
Author(s): 
Hagen Frickmann, Christine Wegner, Stefanie Ruben, Ulrike Loderstädt and Egbert Tannich
Reference: 
Malaria Journal 2019 18:272, 9 August 2019

To assess the occurrence of Plasmodium ovale wallikeri and Plasmodium ovale curtisi species in travellers returning to Germany, two real-time PCR protocols for the detection and differentiation of the two P. ovale species were compared. Results of parasite differentiation were correlated with patient data.

Implementing population-based mass drug administration for malaria: experience from a high transmission setting in North Eastern Uganda

August 13, 2019 - 15:41 -- Open Access
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Author(s): 
Ronald Mulebeke, Humphrey Wanzira, Fred Bukenya, Thomas Eganyu, Kathryn Collborn, Richard Elliot, Jean-Pierre Van Geertruyden, Dorothy Echodu and Adoke Yeka
Reference: 
Malaria Journal 2019 18:271, 9 August 2019

Mass drug administration (MDA) is a suggested mean to accelerate efforts towards elimination and attainment of malaria-free status. There is limited evidence of suitable methods of implementing MDA programme to achieve a high coverage and compliance in low-income countries. The objective of this paper is to assess the impact of this MDA delivery strategy while using coverage measured as effective population in the community and population available.

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Genome annotation improvements from cross-phyla proteogenomics and time-of-day differences in malaria mosquito proteins using untargeted quantitative proteomics

August 9, 2019 - 15:17 -- Open Access
Author(s): 
Lisa Imrie, Thierry Le Bihan, Áine O'Toole, Paul V. Hickner, W. Augustine Dunn, Benjamin Weise, Samuel S. C. Rund
Reference: 
PLoS ONE 14(7): e0220225

The malaria mosquito, Anopheles stephensi, and other mosquitoes modulate their biology to match the time-of-day.

Essential role of GEXP15, a specific protein Phosphatase type 1 partner, in Plasmodium berghei in asexual erythrocytic proliferation and transmission

August 9, 2019 - 14:53 -- Open Access
Author(s): 
Thomas Hollin, Caroline De Witte, Aline Fréville, Ida Chiara Guerrera, Cerina Chhuon, Jean-Michel Saliou, Fabien Herbert, Christine Pierrot, Jamal Khalife
Reference: 
PLoS Pathog 15(7): e1007973

The essential and distinct functions of Protein Phosphatase type 1 (PP1) catalytic subunit in eukaryotes are exclusively achieved through its interaction with a myriad of regulatory partners.

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