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Scientific Articles

Fine scale mapping of malaria infection clusters by using routinely collected health facility data in urban Dar es Salaam, Tanzania

May 25, 2017 - 14:55 -- Open Access
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Author(s): 
Yeromin P. Mlacha, Prosper P. Chaki, Stefan Dongus, et al.
Reference: 
Geospatial Health, Vol 12, No 1 (2017)

This study investigated whether passively collected routine health facility data can be used for mapping spatial heterogeneities in malaria transmission at the level of local government housing cluster administrative units in Dar es Salaam, Tanzania.

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Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

May 25, 2017 - 14:43 -- Open Access
Author(s): 
Raquel Azevedo, Marija Markovic, Marta Machado, Blandine Franke-Fayard, António M. Mendes, and Miguel Prudêncio
Reference: 
Antimicrob. Agents Chemother. June 2017 vol. 61 no. 6 e02699-16

The sporogonic stage of the life cycle of Plasmodium spp., the causative agents of malaria, occurs inside the parasite's mosquito vector, where a process of fertilization, meiosis, and mitotic divisions culminates in the generation of large numbers of mammalian-infective sporozoites.

Microbiota-induced peritrophic matrix regulates midgut homeostasis and prevents systemic infection of malaria vector mosquitoes

May 25, 2017 - 14:42 -- Open Access
Author(s): 
Faye H. Rodgers, Mathilde Gendrin, Claudia A. S. Wyer, George K. Christophides
Reference: 
PLoS Pathog 13(5): e1006391

Manipulation of the mosquito gut microbiota can lay the foundations for novel methods for disease transmission control.

Comparison of artemether-lumefantrine and chloroquine with and without primaquine for the treatment of Plasmodium vivax infection in Ethiopia: A randomized controlled trial

May 25, 2017 - 14:41 -- Open Access
Author(s): 
Tesfay Abreha, Jimee Hwang, Ric N. Price, et al.
Reference: 
PLoS Med 14(5): e1002299

Despite evidence of CQ-resistant P. vivax, the risk of recurrence in this study was greater following treatment with AL unless it was combined with a supervised course of PQ.

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NOT Open Access | Neutrophil alterations in pregnancy-associated malaria and induction of neutrophil chemotaxis by Plasmodium falciparum

May 25, 2017 - 14:39 -- NOT Open Access
Author(s): 
S. Boström, C. Schmiegelow, B. Amulic, et al.
Reference: 
Parasite Immunology, Volume 39, Issue 6, June 2017, e12433

Pregnancy-associated malaria (PAM) is a severe form of the disease caused by sequestration of Plasmodium falciparum-infected red blood cells (iRBCs) in the developing placenta.

Do anti-malarials in Africa meet quality standards? The market penetration of non quality-assured artemisinin combination therapy in eight African countries

May 25, 2017 - 14:38 -- Open Access
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Author(s): 
Paul N. Newton, Kara Hanson and Catherine Goodman
Reference: 
Malaria Journal 2017 16:204, 25 May 2017

Addressing the availability and distribution of non-QAACT will require effective private sector engagement and evidence-based strategies to address provider and consumer demand for these products.

Within-host selection of drug resistance in a mouse model of repeated interrupted treatment of Plasmodium yoelii infection

May 25, 2017 - 14:37 -- Open Access
Author(s): 
Suci Nuralitha, Josephine E. Siregar, Din Syafruddin, Andy I. M. Hoepelman and Sangkot Marzuki
Reference: 
Malaria Journal 2017 16:216, 23 May 2017

RIT of P. yoelii infected mice led to rapid development of resistance to atovaquone and pyrimethamine.

Intermittent preventive treatment for malaria among children in a refugee camp in Northern Uganda: lessons learned

May 25, 2017 - 14:35 -- Open Access
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Author(s): 
Matthew E. Coldiron, Estrella Lasry, Rebecca F. Grais, et al.
Reference: 
Malaria Journal 2017 16:218, 23 May 2017

Northern Uganda hosts a large population of refugees from South Sudan, and malaria is one of the major health problems in the area.

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Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria

May 25, 2017 - 14:32 -- Open Access
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Author(s): 
Rosauro Varo, Valerie M. Crowley, Kevin C. Kain, et al.
Reference: 
Malaria Journal 2017 16:215, 23 May 2017

Adjunctive rosiglitazone was safe and well-tolerated in children with uncomplicated malaria, permitting the extension of its evaluation as adjunctive therapy for severe malaria.

Measuring, manipulating and exploiting behaviours of adult mosquitoes to optimise malaria vector control impact

May 25, 2017 - 09:10 -- Open Access
Author(s): 
Gerry F Killeen, John M Marshall, Samson S Kiware, Andy B South, Lucy S Tusting, Prosper P Chaki, Nicodem J Govella
Reference: 
BMJ Global Healthm April 26, 2017, 2 (2) e000212

Residual malaria transmission can persist despite high coverage with effective long-lasting insecticidal nets (LLINs) and/or indoor residual spraying (IRS), because many vector mosquitoes evade them by feeding on animals, feeding outdoors, resting outdoors or rapidly exiting from houses after entering them.

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