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Scientific Articles

The effect of declining exposure on T cell-mediated immunity to Plasmodium falciparum – an epidemiological “natural experiment”

September 23, 2016 - 14:30 -- Open Access
Author(s): 
Bediako Y, Ngoi J, Nyangweso G, Wambua J, Opiyo M, Nduati E, Bejon P, Marsh K, Ndungu F
Reference: 
BMC Medicine 2016, 14:143 (22 September 2016)

Notably, we found a significant positive association between duration since last febrile episode and P. falciparum-specific CD4+ T cell proliferation, with more recent febrile episodes associated with lower proliferation.

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Undernutrition and malaria in pregnancy – a dangerous dyad?

September 23, 2016 - 14:28 -- Open Access
Author(s): 
Unger H, Ashorn P, Cates J, Dewey K, Rogerson S
Reference: 
BMC Medicine 2016, 14:142 (19 September 2016)

Affected pregnancies may result in stillbirth and neonatal death, and surviving children are at risk of poor growth and infection in infancy, and of non-communicable diseases in adulthood.

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Failure of dihydroartemisinin plus piperaquine treatment of falciparum malaria by under-dosing in an overweight patient

September 21, 2016 - 17:39 -- Open Access
Author(s): 
Jean Baptiste Roseau, Bruno Pradines, Nicolas Paleiron, Serge Vedy, Marylin Madamet, Fabrice Simon and Emilie Javelle
Reference: 
Malaria Journal 2016 15:479, 20 September 2016

This case confirms the risk of therapeutic failure with dihydroartemisinin–piperaquine by under-dosing in patients weighing more than 100 kg.

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Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite

September 21, 2016 - 17:36 -- Open Access
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Author(s): 
Christopher Dean Goodman, Ingvild Austarheim, Vanessa Mollard, Bertin Mikolo, Karl Egil Malterud, Geoffrey I. McFadden and Helle Wangensteen
Reference: 
Malaria Journal 2016 15:481, 20 September 2016

Three compounds with anti-parasitic activity were identified in Z. heitzii bark extract.

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Impact of the Mass Drug Administration for malaria in response to the Ebola outbreak in Sierra Leone

September 21, 2016 - 17:35 -- Open Access
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Author(s): 
Maru Aregawi, Samuel J. Smith, Musa Sillah-Kanu, John Seppeh, Anitta R. Y. Kamara, Ryan O. Williams, John J. Aponte, Andrea Bosman and Pedro Alonso
Reference: 
Malaria Journal 2016 15:480, 20 September 2016

The MDA achieved its goals of reducing malaria morbidity and febrile cases that would have been potentially diagnosed as suspected Ebola cases with increased risk of nosocomial infections.

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Cedrol, a malaria mosquito oviposition attractant is produced by fungi isolated from rhizomes of the grass Cyperus rotundus

September 21, 2016 - 17:32 -- Open Access
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Author(s): 
Lynda K. Eneh, Hiromi Saijo, Anna-Karin Borg-Karlson, Jenny M. Lindh and Gunaratna Kuttuva Rajarao
Reference: 
Malaria Journal 2016 15:478, 17 September 2016

Cedrol an oviposition attractant for African malaria vectors is produced by two fungi species isolated from grass rhizomes collected from a natural mosquito breeding site.

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The association between household bed net ownership and all-cause child mortality in Madagascar

September 21, 2016 - 17:30 -- Open Access
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Author(s): 
Dominique Meekers and Joshua O. Yukich
Reference: 
Malaria Journal 2016 15:475, 17 September 2016

Mass bed net distributions contributed strongly to the overall decline in child mortality in Madagascar during the period 2008–2013.

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Safety, efficacy and pharmacokinetic evaluations of a new coated chloroquine tablet in a single-arm open-label non-comparative trial in Brazil: a step towards a user-friendly malaria vivax treatment

September 21, 2016 - 17:28 -- Open Access
Author(s): 
Dhelio Pereira, André Daher, Graziela Zanini, Ivan Maia, Lais Fonseca, Luciana Pitta, Rosilene Ruffato, Paola Marchesini and Cor Jesus Fontes
Reference: 
Malaria Journal 2016 15:477, 17 September 2016

This study reports an appropriate safety and efficacy profile of a new formulation of coated chloroquine tablets for vivax malaria treatment in the Brazilian Amazon.

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Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report

September 21, 2016 - 17:17 -- Open Access
Author(s): 
Arnaud Chêne, Sophie Houard, Nicola K. Viebig, et al.
Reference: 
Malaria Journal 2016 15:476, 17 September 2016

Placental malaria caused by Plasmodium falciparum infection constitutes a major health problem manifesting as severe disease and anaemia in the mother, impaired fetal development, low birth weight or spontaneous abortion.

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Probucol dramatically enhances dihydroartemisinin effect in murine malaria

September 21, 2016 - 17:15 -- Open Access
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Author(s): 
Aiko Kume, Dang Trinh Minh Anh, Mototada Shichiri, Noriko Ishida and Hiroshi Suzuki
Reference: 
Malaria Journal 2016 15:472, 15 September 2016

This study demonstrated that probucol has some impact on malaria by oxidative stress through the induction of host plasma vitamin E deficiency.

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