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Scientific Articles

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants

February 24, 2017 - 09:08 -- Open Access
Author(s): 
Antoine Claessens, Muna Affara, Samuel A. Assefa, Dominic P. Kwiatkowski, and David J. Conway
Reference: 
Sci Rep. 2017; 7: 41303

Cultured human pathogens may differ significantly from source populations. To investigate the genetic basis of laboratory adaptation in malaria parasites, clinical Plasmodium falciparum isolates were sampled from patients and cultured in vitro for up to three months. 

MinorityReport, software for generalized analysis of causal genetic variants

February 23, 2017 - 16:29 -- Open Access
Tags: 
Author(s): 
Jeremy A. Horst, Wesley Wu and Joseph L. DeRisi
Reference: 
Malaria Journal 2017 16:90, 23 February 2017

MinorityReport is readily available (github: JeremyHorst/MinorityReport) to identify the genetic mechanisms of drug resistance in Plasmodium, genotype-phenotype relationships in human diads, or genomic variations between any two related organisms.

Integrating malaria surveillance with climate data for outbreak detection and forecasting: the EPIDEMIA system

February 23, 2017 - 16:26 -- Open Access
Tags: 
Author(s): 
Christopher L. Merkord, Yi Liu, Michael C. Wimberly, et al.
Reference: 
Malaria Journal 2017 16:89, 23 February 2017

Successful implementation and use of EPIDEMIA is an important step forward in the use of epidemiological and environmental informatics systems for malaria surveillance.

Change in Anopheles richness and composition in response to artificial flooding during the creation of the Jirau hydroelectric dam in Porto Velho, Brazil

February 23, 2017 - 16:24 -- Open Access
Author(s): 
Moreno S. Rodrigures, Elis P. Batista, Alexandre A. Silva, Fábio M. Costa, Verissimo A. S. Neto and Luiz Herman S. Gil
Reference: 
Malaria Journal 2017 16:87, 22 February 2017

The continual monitoring of these vectors during the late operational phase may be useful in order to understand how anophelines will behave in this area.

Not Open Access | Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development

February 22, 2017 - 14:56 -- NOT Open Access
Author(s): 
Cláudia Sá e Cunha, Britta Nyboer, Ann-Kristin Mueller, et al.
Reference: 
PNAS February 14, 2017 vol. 114 no. 7 E1138-E1147

The first, obligatory replication phase of malaria parasite infections is characterized by rapid expansion and differentiation of single parasites in liver cells, resulting in the formation and release of thousands of invasive merozoites into the bloodstream.

Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight

February 22, 2017 - 14:55 -- Open Access
Tags: 
Author(s): 
Tania C. d’Almeida, Ibrahim Sadissou, André Garcia, et el.
Reference: 
PLoS ONE 12(2): e0171117

Human leukocyte antigen (HLA) G is a tolerogenic molecule involved in the maternal-fetal immune tolerance phenomenon.

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Optimal control and cost-effective analysis of malaria/visceral leishmaniasis co-infection

February 22, 2017 - 14:54 -- Open Access
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Author(s): 
Folashade B. Agusto, Ibrahim M. ELmojtaba
Reference: 
PLoS ONE 12(2): e0171102

In this paper, a deterministic model involving the transmission dynamics of malaria/visceral leishmaniasis co-infection is presented and studied.

Development and clinical performance of high throughput loop-mediated isothermal amplification for detection of malaria

February 22, 2017 - 14:53 -- Open Access
Tags: 
Author(s): 
Rushini S. Perera, Xavier C. Ding, Frank Tully, James Oliver, Nigel Bright, David Bell, Peter L. Chiodini, Iveth J. Gonzalez, Spencer D. Polley
Reference: 
PLoS ONE 12(2): e0171126

The HTP-LAMP system is a highly sensitive diagnostic test, with the potential to allow large scale population screening in malaria elimination campaigns.

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

February 22, 2017 - 14:51 -- Open Access
Author(s): 
Sanduni V. Hapuarachchi, Simon A. Cobbold, Sarah H. Shafik, Adelaide S. M. Dennis, Malcolm J. McConville, Rowena E. Martin, Kiaran Kirk, Adele M. Lehane
Reference: 
PLoS Pathog 13(2): e1006180

In this study the ‘Malaria Box’ chemical library comprising 400 compounds with antiplasmodial activity was screened for compounds that perturb the internal pH of the malaria parasite, Plasmodium falciparum. Fifteen

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