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Scientific Articles

Molecular surveillance of Plasmodium falciparum drug resistance in the Republic of Congo: four and nine years after the introduction of artemisinin-based combination therapy

April 25, 2017 - 15:54 -- Open Access
Author(s): 
Felix Koukouikila-Koussounda, Sankarganesh Jeyaraj, Christian N. Nguetse, Charles Nchotebah Nkonganyi, Kossiwa Clarisse Kokou, Mandingha K. Etoka-Beka, Francine Ntoumi and Thirumalaisamy P. Velavan
Reference: 
Malaria Journal 2017 16:155, 19 April 2017

The implementation of ACT has led to the decline in prevalence of chloroquine-resistant parasites in the Republic of Congo.

Distinct parasite populations infect individuals identified through passive and active case detection in a region of declining malaria transmission in southern Zambia

April 25, 2017 - 15:53 -- Open Access
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Author(s): 
Kelly M. Searle, Ben Katowa, William J. Moss, et al.
Reference: 
Malaria Journal 2017 16:154, 19 April 2017

Distinct parasite populations were identified among infected individuals identified through active and passive surveillance, suggesting that infected individuals detected through active surveillance may not have contributed substantially to ongoing transmission.

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Assessment of copy number variation in genes related to drug resistance in Plasmodium vivax and Plasmodium falciparum isolates from the Brazilian Amazon and a systematic review of the literature

April 25, 2017 - 15:51 -- Open Access
Author(s): 
Gabriel Luíz Costa, Lara Cotta Amaral, Cor Jesus Fernandes Fontes, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito and Taís Nóbrega de Sousa
Reference: 
Malaria Journal 2017 16:152, 19 April 2017

The present study was the first to evaluate gch1 CNV in P. falciparum isolates from Brazil, showing an absence of amplification of this gene more than 20 years after the withdrawal of the Brazilian antifolates therapeutic scheme.

High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations

April 25, 2017 - 15:50 -- Open Access
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Author(s): 
Yaye Dié Ndiaye, Cyrille K. Diédhiou, Daouda Ndiaye, et al.
Reference: 
Malaria Journal 2017 16:153, 19 April 2017

Here the results demonstrate that HRM is a rapid, sensitive, and field-deployable alternative technique to PCR–RFLP genotyping that is useful in populations harbouring more than one parasite genome (polygenomic infections).

Travel and the emergence of high-level drug resistance in Plasmodium falciparum in southwest Uganda: results from a population-based study

April 18, 2017 - 15:33 -- Open Access
Author(s): 
Caroline A. Lynch, Richard Pearce, Hirva Pota, Connie Egwang, Thomas Egwang, Amit Bhasin, Jonathan Cox, Tarekegn A. Abeku and Cally Roper
Reference: 
Malaria Journal 2017 16:150, 17 April 2017

There is sustained local transmission of parasites with the dhfr I164L mutation in Rukungiri and no evidence to indicate its occurrence is associated with recent travel to highly resistant neighbouring areas.

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An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia

April 18, 2017 - 15:31 -- Open Access
Author(s): 
Raffaele Dell’Acqua, Claudia Fabrizio, Gioacchino Angarano, et al.
Reference: 
Malaria Journal 2017 16:149, 14 April 2017

This experience highlights the importance of a careful management that should be based not only on the most up-to-date guidelines, but also on the awareness of a rapidly evolving scenario.

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The end of a dogma: the safety of doxycycline use in young children for malaria treatment

April 18, 2017 - 15:30 -- Open Access
Author(s): 
Tiphaine Gaillard, Sébastien Briolant, Marylin Madamet and Bruno Pradines
Reference: 
Malaria Journal 2017 16:148, 13 April 2017

Anti-malarial drug resistance to chloroquine and sulfadoxine–pyrimethamine has spread from Southeast Asia to Africa.

Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

April 18, 2017 - 15:29 -- Open Access
Author(s): 
Wei Sun, Xiuli Huang, Wei Zheng, et al.
Reference: 
Malaria Journal 2017 16:147, 13 April 2017

This study revealed important new structural scaffolds that can be used as starting points for dual activity anti-malarial drug development.

Spatial clustering and risk factors of malaria infections in Bata district, Equatorial Guinea

April 18, 2017 - 15:27 -- Open Access
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Author(s): 
Diana Gómez-Barroso, Emely García-Carrasco, Agustín Benito, et al.
Reference: 
Malaria Journal 2017 16:146, 12 April 2017

This study reveals a high prevalence of RDT-based malaria among children in Bata district.

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Not Open Access | Platelets activate a pathogenic response to blood-stage Plasmodium infection but not a protective immune response

April 18, 2017 - 15:26 -- NOT Open Access
Author(s): 
Irene Gramaglia, Joyce Velez, Valery Combes, Georges E. R. Grau, Melanie Wree, and Henri C. van der Heyde
Reference: 
Blood 129, Volume: 129, Issue: 12, Pages: 1669-1679

Clinical studies indicate that thrombocytopenia correlates with the development of severe falciparum malaria, suggesting that platelets either contribute to control of parasite replication, possibly as innate parasite killer cells or function in eliciting pathogenesis.

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