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If insecticide resistance is our problem, what should we look for?

New insecticides
18% (7 votes)
Alternatives, because new insecticides will give resistance problems later on
82% (31 votes)
Total votes: 38

Comments

Submitted by Guest (not verified) on
<P>The host of the malaria parasite is not the mosquito, it is the chronically infected humans. This means that if there weren't any humans infected the mosquito can not transfer malaria.</P> <P>So no matter if we have a vaccine or not we need to treat all malaria cases.</P> <P>As the situation is now, instead of eradicating malaria, the wealthy peoples take malaria profylaksis and this creates a selection pressure on tha parasite to develop resistance. And this is what we are seeing.</P> <P>If we instead started at sysematic eradication the problem could be solved.</P> <P>For all human malaria cases (except knolwesii) the malaria parasite uses humans as host.</P> <P>&nbsp;</P> <P>&nbsp;</P>

Submitted by Guest (not verified) on
<p>Countries should have insecticide resistance management strategies that includes multiple methods to dely insecticide resistance. introduction of new insecticide alone does not solve the problem.</p>

Submitted by Guest (not verified) on
<p>In my opinion Malaria is so complicated disease which demands itself a real integrated fight against it. For this reason, I vote yes for a deep understanding of the mechanisms of insecticide resistance. We due to study every option to stop the spread and disemination of the disease.</p>

Submitted by Guest (not verified) on
<p>Additional insecticides might buy time for novel methods to be developed fully enough to deploy. Resistance-proof insecticides seem like an approach that would buy even more time, but even these will not prevent resistance due to changes in behavior and absorption rates. No magic bullets, so we need all we can get. - Mark Benedict</p>

Mark Birchmore's picture
Submitted by Mark Birchmore on
<P>As an innovation driven company, Syngenta is actively engaged in this hot topic for vector control. I do however struggle with a very open descroption of "alternatives" because its really not clear what they are other than agents that control mosquitoes, i.e. insecticides, and presumably new ones at that, synthetic, "natural", or otherwise. One could argue that alternatives include improved versions of what we have today. We are now supplying Actellic 300CS into countries struggling with pyrethroid resistance. The same countries are also deploying other vector control tactics and parasite control strategies as part of their broader program and educated programs are adopting new tools as soon as they are locally registered to try to stem the tide and protect populations at risk. Sensible, pragmatic, programmatic choices aimed at protecting people.</P> <P>However, we also need new insecticides. History tells us that from every single market where insect control is required whether that be agriculture, public health, or animal health. Evolution and the simple human necessity for insect control means that this will be an ongoing requirement. So the question is to stop talking about it and actually do something concrete - walk the walk, rather than talk the talk (and there's a lot of that these days...)</P> <P>Syngenta an ongoing R&amp;D program with the IVCC to find the next generation insecticide for mosquito control supplementing what we already do when leveraging a huge innovation machine which develops active ingredient for agriculture. We are very excited about the results so far and the project is making great progress.</P> <P>So, we cannot be too fussy in my view!&nbsp; Innovation can and should come be encouraged to come from any source and as long as we can demonstrate real life programmatic impact in the field it deserves a place in the tool kit. As a participant in the IVCC workshop, the output of these recently published on this site, there is a real commitment to try to do innovation better and&nbsp; firmly believe that the private sector has the leading role to play here. We have a broader view on innovation these days and many companies approach us with their ideas to develop partnership models to bring new products to market. So, if you have a new idea, we are all ears (or antennae... )...</P>

Mark Birchmore | Head of Vector Control, Syngenta

William Jobin's picture
Submitted by William Jobin on
<p>Thank you Mark, for explaining the program of Syngenta on biocides,</p><p>I used your products for killing mosquitoes in Africa just a few years ago, and am aware of their value. &nbsp;Actually, I started applying biocides for malaria and also schistosomiasis (bilharzia) control over 50 years ago, and since then have avidly tracked the successes and problems with the use of &nbsp;chemicals to attack malaria.</p><p>But from my experience in helping develop new chemicals to kill the bilharzia snails, I developed the Third Law of Bilharzia Control : &nbsp;When a new chemical is found that is twice as effective as the old one, it will cost three times as much.</p><p>I don't mean this as a criticism of the biocide industry, it is a simple observation on market realities.</p><p>Most important, I think we should all be aware that this Third Law applies to new biocides for mosquitoes, and also applies to new drugs for treating people infected with malaria.</p><p>Thus the widespread optimism about expecting new drugs or biocides to come into the market when resistance develops against malaria drugs and biocides, should be tempered with the fact that each new product carries additional cost. &nbsp;It is not just that we have to find new chemicals or drugs, but we will also have to pay more for the same effect.</p><p>There is reason to believe that the failure of the first Global Malaria Eradication Program in the 1970's was not due to resistance to DDT and chloroquine, but to donor fatigue in trying to pay for the new biocides and drugs which were quite effective, but more costly. &nbsp;</p><p>That is the true Price of Resistance that we will have to pay if we continue to depend solely on biocides and drugs in our suppression of malaria.</p><p>For me the real alternative is to add land reclamation and housing screens to the mix of methods we use in our attack, neither of which cause resistance to develop.</p><p>Bill</p><p>&nbsp;</p>

William Jobin Director of Blue Nile Associates

Submitted by Guest (not verified) on
<p>This is a very weighted question towards the unspecified ‘alternatives.’ We should be exploring all possible avenues.</p>