The aim of this study was to develop a quinine suppository with adequate release properties that also meets the dual conditions of affordability and ease of administration. Cocoa butter and FattibaseTM were used in the preparation of suppositories containing 200 mg quinine bisulphate. Release profiles of formulations with varying concentrations of polysorbate 80 (0 – 5%) were evaluated by in vitro dissolution in pH 8 buffer medium. Formulations with the two bases released quinine in adequate quantities for the management of malaria. The particle size of quinine is an important factor affecting the physical appearance and drug release from the suppository. The FattibaseTM suppositories were more stable but cost five times the price of the cocoa butter formulations. The cocoa butter formulations, however, still released quinine in sufficient quantities for the management of malaria. Cocoa butter formulations will be more affordable in resource-limited malaria-endemic regions of the world.