Reply to: Does diabetes have antimalarial properties
The concentration of caffeoylquinic (chlorogenic) acids is on the average 5-10 times higher than flavonoids in all Artemisia species. A Russian paper shows a strong inhibitory effect of the caffeoylquinic acids on α-glucosidase and α-amylase. These are digestive enzymes responsible for starch and carbohydrate cleaving them into smaller fragments, producing glucose in the final product. Plasmodium falciparum is feeding on glucose. If indeed the chlorogenic acids inhibit the glucose production in the human body they may have an influence on malaria. They will starve Plasmodium.
Boudelial A, Siracusa L, Henchiri C, Antidiabetic effects of aqueous infusions of Artemisia herba-alba. Planta Med. 2015 81, 696-704.
Along the same lines it was found that 2-deoxy glucose (2DG) prevented the development of cerebral malaria.
Wang A, Huen SC2. Glucose metabolism mediates disease tolerance in cerebral malaria. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11042-11047. doi: 10.1073/pnas.1806376115..
Reply to: Not Open Access | Biological concepts in recurrent Plasmodium vivax malaria
There is a subsequent analysis (in "Trends in Parasitology") that can be read in conjunction with this paper. The title is "New Evidence for Hypnozoite-Independent Plasmodium vivax Malarial Recurrences". View at: https://doi.org/10.1016/j.pt.2018.08.010
Reply to: Significance of time to clinical recurrence in vivax malaria
In addition to directly providing miscellaneous information relevant to the temporal matter (but one should also read between the lines), the two publications include non-drug-resistance comments in relation to recurrences. It is unlikely that resistance is the only drug factor involved in treatment-compliant patients. Alternative possible causes of drug failure (leaving aside host genetic factors and drug dosage) need to be considered by researchers. For instance, the drug-associated implications of whereabouts in the body parasites occur.
Reply to: Do we need a more specific test for cerebral malaria?
So far, T-REX articles have been submitted to peer-review, PubMed-recognized journals (some open-access: 4 published, 5 accepted for publication, 4 under review). Of note, the genetic engineering of "Mother Nature" warrants both respect and awe: Human evolution has prevented human extinction via malaria using ultra, ultra high-tech mechanisms involving special microRNAs, membrane alterations, and more. Scientists are, of course, humbled by mechanisms they couldn't even dream of previously. It's a fascinating story! At the same time, T-REX is a special variation of RBC exchange transfusion which has been used safely and effectively for more than 70-years. So, T-REX can be viewed as either "old" or "new." Regardless, malaria is considered the greatest driver of human evolution and we can learn a lot from many thousands of years of Mother Nature's magnificent genetic engineering. Enjoy !!
Reply to: Malaria eradication
Good day to you.I am Awosolu, Oluwaseun, an assistant lecturer from Federal University of Technology, Akure, Nigeria. I will appreciate we collaborate together on malaria research.
Federal University of Technology, Akure