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  • Reply to: Progress with Sanaria’s Plasmodium falciparum sporozoite vaccines   2 days 5 hours ago

    William, while there is no 'loose reference' here, you are correct. Compared to the Yellow Fever vaccine, 2 years is not a long time but a) it is longer than has been observed with any other malaria vaccine, b) it is protection against infection (not just disease), and c) it may well be enough to interrupt transmission for a period of time long enough to make a difference. Indications from the literature are that 2 years of a continued break in transmission is more than sufficient to eliminate Plasmodium falciparum from a focal area. This is not hype but clear reporting of the data. While we are happy with the progress, we are far from complacent. Like you, we recognize that there is much more work needed before we have a vaccine that can prevent malaria in individuals for a period of time that will, with sufficient coverage, be the cornerstone of elimination campaigns.

  • Reply to: Progress with Sanaria’s Plasmodium falciparum sporozoite vaccines   2 days 5 hours ago

    The number of 'vaccines' that are announced in the press reflect not drivel and lies, but the honest and sustained efforts of many malaria researchers across the world. Each vaccine candidate will eventually live or die by the data generated in double blind clinical trials, not against an alternative product but against a placebo or the best licensed vaccine (which for malaria does not yet exist). We all enter these trials in the hope and expectation that our candidate will make a difference, that it will succeed in become a vaccine and the missing new tool needed to combat this disease. Of course, some of these will fail - mainly because malaria is SUCH a difficult parasite to control.

  • Reply to: Progress with Sanaria’s Plasmodium falciparum sporozoite vaccines   2 days 5 hours ago

    Ahsante sana Ogutu. I cannot but agree with you. It is sometimes difficult for people outside a field to understand just how much patience is required, but at the same time we are all impatient to have a good, highly protective vaccine ready for people to use.

  • Reply to: Progress with Sanaria’s Plasmodium falciparum sporozoite vaccines   2 days 5 hours ago

    Thank you. We rely so heavily on the support and commitment of others to make progress. This broad support is exemplified here - with research partners from all over the globe contributing to our continued understanding of how the PfSPZ vaccines work.

  • Reply to: Not Open Access | Platelets activate a pathogenic response to blood-stage Plasmodium infection but not a protective immune response   4 days 14 hours ago
    This is a great article. It would be interesting to know if any of the murine parasite lines used in this study exhibit the platelet-mediated clumping phenotype. This then raises the question of platelet activation, do these parasite lines activate the platelets?