Reply to: Vitamin C and malaria: beware!
Really, that's some verification right there. I just got an ACT together with vitamin c, the later to assist with my catarrh. However, as I googled on Artemeter and lumefantrine to check for the dosage and interactions, I came across this suggestion with vitamin c. Ok, now I know I've got to keep my vit c tabs for later.
Reply to: Cognitive performance of children living in endemic areas for Plasmodium vivax
Is there reverse causality? Lower verbal scores could be associated with poverty (e.g. because of reduced capacity to pay school fees?), and poverty is a risk factor for malaria. Let's not blame the children.
Reply to: Artequick: programmed for failure
Irene i fully disagree with your article. atrequick is a combination of artemisinin and not dihyroartemisinin. duo cortexin has that combination of dihydro. so maybe you referring to that. am a medical representative of artequick and i have also been a patient of the same. artequick is 98% compliant with less than 3% side effects.
Reply to: Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic
In P.ovale, as well as in P.vivax infections, blood is quite often free from parasites, whereas they are present in the liver, in the form of hypnozoites. In the case described, I guess, blood did not contain P.ovale on the day 1 altogether. Parasites emerged from the liver by the fourth week, but it could have happened even later, within a year or so.
Reply to: Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: A hospital-based cohort study
In case of PQ, the duration of uninterrupted treatment is essential, besides the total dose. Varieties of vivax malaria that are prevalent in the Western Pacific (so-called Chesson strains) are more refractory to PQ than elsewhere. The first campaign of mass prophylactic treatment with PQ conducted by Lysenko et al. in Azerbaijan in 1971-73 (in which I took part) demonstrated that the adult dose of no less than 15 mg PQ base for 14 days without interruptions was efficacious in complete clearing of hypnozoites. This course should be expanded to 28 days in case of Chesson strains (Lysenko and Kondrashin (2003) "Malariologija". WHO EURO Copenhagen p.126 (in Russian)) In the above experiment by Douglas et al. (2017) the dose was, obviously, much less, and no special attention to the uninterrupted treatment was paid.