Reply to: Perspective: End malaria for good: a review of current strategies and future novelties for malaria elimination in Nigeria
Given that the drop in malaria prevalence in Nigeria has been fairly modest in the last 5 years, it would be wise to take another look at the methods being used - which unfortunately are ephemeral and must be repeated every year. The lack of emphasis on permanent measures, such as Larval Source Management, is a key to the problem. The national budget for malaria control can only increase slowly, thus the program will only increase slowly. In contrast, if permanent measures are employed, such as LSM, each year the area under control can be greatly expanded, roughly doubled. Successful control of malaria in the USA was based on this approach, as far back as 1935.
Reply to: Drug use in the management of uncomplicated malaria in public health facilities in the Democratic Republic of the Congo
Many studies like the current from Congo shows that only a part olf the population are exposed to rapid test kit test or qualified microscopic analysis and that even so, non tested and negative tested are still treated with antomlarials. In the case of the negative tgested, if the person then dikes, how iks the death registred ? I asked this question to several people during the MIM conference and the response was always: as malaria caused death, since the patioent was ascribed to anti malarial treatment. so, as malaria get more rare and misdiagnosis and treatment continues, "malaria morbidity and mortality" cannot decline, but that may not be real !
Reply to: Opinion: Fatalism and malaria elimination: A historical perspective from Palestine 100 years ago
The energetic approach to suppressing malaria in Palestine was long before the advent of DDT or chloroquine, but instead utilized permanent environmental improvements, especially drainage, and protected housing. In Panama, Gorgas had used much more labor-intensive methods, but he had a large project to protect.
Reply to: Do we need a more specific test for cerebral malaria?
Notable malaria reality: There has NEVER been a case of cerebral malaria among malaria patients with Southeast Asian Ovalocytosis. If you ever become aware of such a case, you will make medical history. The reason? Cerebral malaria is the result of the abnormal cytoadherence ("stickiness") of red blood cells infected with the falciparum malaria parasite. So, what are the diagnostic implications of this profoundly important clinical reality? This means that if you perform T-REX of red blood cell genetic variants that do not become "sticky" on a patient that actually has cerebral malaria, that patient should improve. These non-sticky, malaria-resistant, malaria-protective red blood cell variants include, Southeast Asian Ovalocytes, sickle-cell-TRAIT red blood cells, and several other genetic "mutant" red blood cells engineered by human evolution to prevent cerebral malaria. If the patient does NOT have cerebral malaria, T-REX will not help.
Reply to: T-REX of RBC Genetic Variants to Prevent or Ameliorate Cerebral Malaria
Regarding time delays for translating new therapies into actual clinical use, these delays can exceed 10-years -- yet another very frustrating "inconvenient truth." If you look at the rate at which children suffer or die from cerebral malaria, the numbers per month are very disturbing.