The mode of action of quinine and chloroquine is almost exclusively based on the inhibition of the crystallization of heme into hemozoin, killing plasmodium in its own digestive rejects. In several papers M Akkawi from the Al Quds University in Palestine has shown that extracts of several medicinal plants : Salvia officinalis, Artemisia sieberi, Artemisia afra, Artemisia annua, Inula viscosa had similar effects, in some cases equivalent or better than chloroquine for the inhibition of beta-hematin (see literature references below). In a previous work they had already noticed that the addition of NaCl to the water used for the extraction enhanced the inhibitory effect. They now have completed another series of experiments using diluted solutions of sodium bicarbonate in lieu of distilled water and they notice a spectacular tenfold increase in inhibitory action of beta-hematin. It needs to be mentioned that Artemisia sieberi doesn’t contain artemisinin. This finding could be a breakthrough in the fight against malaria, using Artemisia sieberi and Artemisia afra growing wild in Africa, with some adjunction of bicarbonate. Freeing these countries from the pharmaceutical colonialism. Data and figures are available on request.
(Akkawi, M., A.K. Sharif, K. Salem, A. Saleh and Q. AbuRemeleh, 2012b. Salvia officinalis as a potential anti-malarial drug. Malaria J., 11, Suppl. 1.
Akkawi M, Jaber S, Abu-Remeleh Q, Engeu OP, Lutgen P (2014)Investigations of Artemisia Annua and Artemisia Sieberi Water Extracts Inhibitory Effects on beta-hematin Formation. Med Aromat Plants 3: 150. doi: 10.4172/2167-0412.1000150)