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attenuated sporozoites

Special Focus Review: Genetically engineered, attenuated whole-cell vaccine approaches for malaria

October 25, 2009 - 13:53 -- Bart G.J. Knols
Ashley Vaughan, Ruobing Wang and Stefan H.I. Kappe
Human Vaccines, Volume 6, Issue 1, January 2010

The discovery of genetically engineered parasite strains that are fully attenuated during the early asymptomatic liver infection and confer complete sterile protection in animal malaria models support the development of a live attenuated sporozoite vaccine for Plasmodium falciparum and its accelerated safety and efficacy testing in malaria challenge models and in malaria endemic areas.


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