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dissolution

Fabrication of drug nanoparticles by evaporative precipitation of nanosuspension

November 26, 2009 - 07:15 -- Patrick Sampao
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Author(s): 
M. Kakran, N.G. Sahoo, L. Li, Z. Judeh, Y. Wang, K. Chong, L. Loh.
Reference: 
International Journal of Pharmaceutics, Volume 383, Issues 1-2, 4 January 2010, Pages 285-292, doi:10.1016/j.ijpharm.2009.09.030

Evaporative precipitation of nanosuspension (EPN) was used to fabricate nanoparticles of a poorly water-soluble antimalarial drug, artemisinin (ART), with the aim of enhancing its dissolution rate. We investigated the nanoparticle fabrication of ART via a full factorial experimental design considering the effects of drug concentration and solvent to antisolvent ratio on the physical, morphological and dissolution properties of ART.

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