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GCE Special: Malaria β-Haematin in blood results in synergistic attenuation enhancement: Studies with a conventional multimode reader and a custom LED device

May 27, 2013 - 19:50 -- Bart G.J. Knols
Eugene Y. Chan, Kristyn Maiorca, Candice Bae, Nathaniel Sharpe, Vinay Tripuraneni, Julia Z. Sharpe
MWJ 2013, 4, 7

The aim of this GCE project was to develop a non-invasive method for diagnosing malaria. In order to do this, we sought to identify a novel optical property of β-haematin that gives it a robust optical signature. The optical signature needs to be readily detected with light-emitting diodes (LEDs) and photodiodes, which are compatible with low-cost operation in the developing world. The product is envisioned to be similar to a commercial fingertip pulse oximeter, which can be purchased for $20 and can be utilised for thousands of tests with a single battery.

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Open Access | Field evaluation of a rapid diagnostic test (ParascreenTM) for malaria diagnosis in the Peruvian Amazon

June 8, 2010 - 09:54 -- Kabogo Ndegwa
Bendezu J, Rosas A, Grande T, Rodriguez H, Llanos-Cuentas A, Escobedo J, Gamboa D
Malaria Journal 2010, 9:154 (7 June 2010)

The study results indicate that ParascreenTM is not a valid and acceptable test for malaria diagnosis under the field conditions found in the Peruvian Amazon.

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Short Communication: Performance of a prototype malaria rapid diagnostic test versus thick film microscopy among HIV-positive subjects in rural Rakai, Uganda

March 5, 2010 - 11:27 -- Kabogo Ndegwa
Lisa A. Mills, Joseph Kagaayi, Joseph P. Shott, Kevin Newell, John Baptist Bwanika, Victor Ssempijja, Simon Aluma, Thomas C. Quinn, Steven J. Reynolds, Ronald H. Gray
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 3, March 2010, Pages 237-239

In this study, we report the performance of a prototype malaria rapid diagnostic test, Malaria F-test (MFT), compared with thick blood films from HIV-positive Ugandans undergoing malaria testing.

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Identification of Malaria Retinopathy Improves the Specificity of the Clinical Diagnosis of Cerebral Malaria: Findings from a Prospective Cohort Study

February 11, 2010 - 13:31 -- Ingeborg van Schayk
Gretchen L. Birbeck, Nicholas Beare, Susan Lewallen, Simon J. Glover, Malcolm E. Molyneux, Peter W. Kaplan, AND Terrie E. Taylor
Am J Trop Med Hyg 2010;82 231-234

The diagnosis of cerebral malaria (CM) is difficult to confirm in endemic regions with limited neurodiagnostics. Accurate diagnoses are critical for trials and outcomes studies.


Cost-effectiveness analysis of rapid diagnostic test, microscopy and syndromic approach in the diagnosis of malaria in Nigeria: implications for scaling-up deployment of ACT

November 26, 2009 - 12:49 -- Ingeborg van Schayk
Benjamin SC Uzochukwu, Eric N Obikeze, Obinna E Onwujekwe, Chima A Onoka, Ulla K Griffiths
Malaria Journal 2009, 8:265 (23 November 2009)

Paper comparing different diagnostic methods used in Nigeria, from a cost-effectiveness view point .

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