Open Access | Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins
Reference:
Malaria Journal 2012, 11:156 (7 May 2012)
In the present work, it was demonstrated by mass spectrometry analysis that Plasmodium parasites (Plasmodium chabaudi and Plasmodium falciparum) internalize and process plasma kininogen, thereby releasing vasoactive kinins (Lys-BK, BK and des-Arg9-BK) that may mediate haemodynamic alterations during acute malaria.
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