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rapid diagnostic test

Open Access | Research: How can malaria rapid diagnostic tests achieve their potential? A qualitative study of a trial at health facilities in Ghana

April 16, 2010 - 08:03 -- Kabogo Ndegwa
Author(s): 
Chandler CI, Whitty CJ, Ansah EK
Reference: 
Malaria Journal 2010, 9:95 (14 April 2010)

Rapid diagnostic tests (RDTs) for malaria are at the early stages of introduction across malaria endemic countries. This is central to efforts to decrease malaria overdiagnosis and the consequent overuse of valuable anti-malarials and underdiagnosis of alternative causes of fever.

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Short Communication: Performance of a prototype malaria rapid diagnostic test versus thick film microscopy among HIV-positive subjects in rural Rakai, Uganda

March 5, 2010 - 11:27 -- Kabogo Ndegwa
Author(s): 
Lisa A. Mills, Joseph Kagaayi, Joseph P. Shott, Kevin Newell, John Baptist Bwanika, Victor Ssempijja, Simon Aluma, Thomas C. Quinn, Steven J. Reynolds, Ronald H. Gray
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 3, March 2010, Pages 237-239

In this study, we report the performance of a prototype malaria rapid diagnostic test, Malaria F-test (MFT), compared with thick blood films from HIV-positive Ugandans undergoing malaria testing.

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Open Access | Low-technology cooling box for storage of malaria RDTs and other medical supplies in remote areas

January 29, 2010 - 14:45 -- Ingeborg van Schayk
Author(s): 
Lon Chanthap, Frederic Ariey, Duong Socheat, Reiko Tsuyuoka, David Bell
Reference: 
Malaria Journal 2010, 9:31 (23 January 2010)

The study investigates the effectiveness of an evaporative cooler box prototype developed in Cambodia for the improving storage of malaria rapid diagnostic tests and anti-malarial drugs at the peripheral health facility and community level. This is a very important development, because with the large-scale roll-out of RDTs and ACT in the region.

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Open Access | A Large Proportion of P. falciparum Isolates in the Amazon Region of Peru Lack pfhrp2 and pfhrp3: Implications for Malaria Rapid Diagnostic Tests

January 29, 2010 - 14:01 -- Ingeborg van Schayk
Author(s): 
Gamboa D, Ho M-F, Bendezu J, Torres K, Chiodini PL, et al.
Reference: 
PLoS ONE 5(1): e8091

RDTs detecting parasite LDH or aldolase and quality microscopy should be use for malaria diagnosis in this region. There is an urgent need for investigation of the abundance and geographic distribution of these parasites in Peru and neighbouring countries.

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Quality Assurance of Rapid Diagnostic Tests for Malaria in Routine Patient Care in Rural Tanzania

January 14, 2010 - 11:09 -- Ingeborg van Schayk
Author(s): 
Meredith L. McMorrow, M. Irene Masanja, Elizeus Kahigwa, Salim M. K. Abdulla, AND S. Patrick Kachur
Reference: 
Am J Trop Med Hyg 2010;82 151-155

We evaluated sensitivity and specificity of RDTs during routine use for malaria case management in peripheral health facilities.

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Brief report: Utility of a Point-of-Care Malaria Rapid Diagnostic Test for Excluding Malaria as the Cause of Fever among HIV-Positive Adults in Rural Rakai, Uganda

January 14, 2010 - 11:01 -- Ingeborg van Schayk
Author(s): 
Lisa A. Mills, Joseph Kagaayi, Gertrude Nakigozi, Ronald M. Galiwango, Joseph Ouma, Joseph P. Shott, Victor Ssempijja, Ronald H. Gray, Maria J. Wawer, David Serwadda, Thomas C. Quinn, AND Steven J. Reynolds
Reference: 
Am J Trop Med Hyg 2010;82 145-147

We compared results of a malaria rapid diagnostic test (Binax Now® Malaria, Binax-M, Inverness Medical Innovations, Inc., Waltham, MA) performed at rural mobile clinics in Uganda by clinicians evaluating febrile adult HIV patients to thick smear evaluated at a central laboratory by trained microscopists.

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Open Access | Use and limitations of malaria rapid diagnostic testing by community health workers in war-torn Democratic Republic of Congo

January 7, 2010 - 12:58 -- Ingeborg van Schayk
Author(s): 
Michael Hawkes, Jean Paul Katsuva, Claude K Masumbuko
Reference: 
Malaria Journal 2009, 8:308 (23 December 2009)

CHWs can safely and effectively use RDTs in their management of febrile children; however, cost-effectiveness of RDTs is limited in zones of high malaria prevalence.

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Open Access | Evaluation of the Palutop+4 malaria rapid diagnostic test in a non-endemic setting

December 23, 2009 - 10:46 -- Ingeborg van Schayk
Author(s): 
David PJ van Dijk, Philippe Gillet, Erika Vlieghe, Lieselotte Cnops, Marjan Van Esbroeck, Jan Jacobs
Reference: 
Malaria Journal 2009, 8:293 (12 December 2009)

Palutop+4 performed moderately for the detection of P. falciparum and P. vivax, but sensitivities were lower than those of three-band malaria RDTs.

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Open Access | Multiplex real-time quantitative PCR, microscopy and rapid diagnostic immuno-chromatographic tests for the detection of Plasmodium spp: performance, limit of detection analysis and quality assurance

December 14, 2009 - 11:40 -- Ingeborg van Schayk
Author(s): 
Krishna Khairnar, Donald Martin, Rachel Lau, Filip Ralevski, Dylan R Pillai
Reference: 
Malaria Journal 2009, 8:284 (9 December 2009)

Multiplex QPCR but not ICTs are an essential adjunct to microscopy in the reference laboratory detection of malaria species specifically due to the superior LOD.

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Open access | Assessment of the prozone effect in malaria rapid diagnostic tests

December 8, 2009 - 11:49 -- Ingeborg van Schayk
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Author(s): 
Philippe Gillet, Marcella Mori, Marjan Van Esbroeck, Jef Van den Ende, Jan Jacobs
Reference: 
Malaria Journal 2009, 8:271 (30 November 2009)

This study confirms the prozone effect as a cause of false-negative HRP-2 RDTs in samples with hyperparasitaemia.

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