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immunogenicity

Expression, Immunogenicity, Histopathology, and Potency of a Mosquito-based Malaria Transmission-blocking Recombinant Vaccine

February 8, 2012 - 07:46 -- Patrick Sampao
Author(s): 
D.K. Mathias, J.L. Plieskatt, R.R. Dinglasan, et al.
Reference: 
Infect. Immun. volume 80, issue 2 ,February 2012

MalariaWorldWe have developed a scalable, high-yield E. coli expression and purification platform for the recombinant AnAPN1 TBV antigen and report on its marked vaccine potency and immunogenicity, its capacity for eliciting transmission-blocking antibodies, and its apparent lack of immunization-associated histopathologies in a small animal model.

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Immunogenicity of novel nanoparticle-coated MSP-1 C-terminus malaria DNA vaccine using different routes of administration

October 24, 2011 - 15:10 -- Patrick Sampao
Author(s): 
Mahamoud Sama Cherif, Mohammed Nasir Shuaibu, Tomoaki Kurosaki, Gideon Kofi Helegbe, Mihoko Kikuchi, Tetsuo Yanagi, Takafumi Tsuboi, Hitoshi Sasaki, Kenji Hirayama
Reference: 
Vaccine, Volume 29, Issue 48, 8 November 2011, Pages 9038-9050

MalariaWorldThe immunostimulatory effect of this novel nanoparticle (NP) coated plasmid encoding Plasmodium yoelii MSP1-C-terminus was examined.

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Effect of nanoparticle coating on the immunogenicity of plasmid DNA vaccine encoding P. yoelii MSP-1 C-terminal

April 18, 2011 - 13:52 -- Patrick Sampao
Author(s): 
M.N. Shuaibu, M.S. Cherif, T. Kurosaki, G.K. Helegbe, M. Kikuchi, T. Yanagi, H. Sasaki, K. Hirayama
Reference: 
Vaccine, Volume 29, Issue 17, 12 April 2011, Pages 3239-3247

These results therefore, overall indicate the possibility of selection and optimization of DNA vaccine formulation for intravenous delivery and may be useful in designing a nanoparticle-coated DNA vaccine that could optimally elicit a desired antibody response for various disease conditions.

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