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Comparative embryotoxicity of different antimalarial peroxides: In vitro study using the rat whole embryo culture model (WEC)

November 26, 2010 - 13:05 -- Patrick Sampao
Author(s): 
Monica Longo, Sara Zanoncelli, Marco Brughera, Paolo Colombo, Sergio Wittlin, Jonathan L. Vennerstrom, Joerg Moehrle, J. Carl Craft
Reference: 
Reproductive Toxicology, Volume 30, Issue 4, December 2010, Pages 583-590

In an attempt to establish whether and to what extent activity as antimalarials and embryotoxicity can be divorced, IC50s for activity in Plasmodium falciparum strains and the NOELs for RBCs were compared. From this comparison, arterolane showed a better safety margin than artemisinin.

Technology: 
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