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The Kennedy phospholipid biosynthesis pathways are refractory to genetic disruption in Plasmodium berghei and therefore appear essential in blood stages

July 19, 2010 - 09:40 -- Patrick Sampao
Sandrine Déchamps, Kai Wengelnik, Laurence Berry-Sterkers, Rachel Cerdan, Henri J. Vial, Laila Gannoun-Zaki
Molecular and Biochemical Parasitology, Volume 173, Issue 2, October 2010, Pages 69-80

Here, we have studied the essential nature of the Kennedy pathways in Plasmodium berghei, a rodent malaria parasite. Sequence analysis of the P. berghei CEPT, CCT, ECT and CK enzymes revealed the presence of all catalytic domains and essential residues and motifs necessary for enzymatic activities.

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