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Open Access | Environmental, pharmacological and genetic influences on the spread of drug-resistant malaria

November 25, 2010 - 10:13 -- Patrick Sampao
Tiago Antao and Ian M. Hastings

We describe and apply a flexible new approach to investigate how epistasis, inbreeding, selection heterogeneity and multiple simultaneous drug deployments interact to influence the spread of drug-resistant malaria.

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Field, Genetic, and Modeling Approaches Show Strong Positive Selection Acting upon an Insecticide Resistance Mutation in Anopheles gambiae s.s

April 28, 2010 - 12:13 -- Patrick Sampao
Amy Lynd, David Weetman, Susana Barbosa, Alexander Egyir Yawson, Sara Mitchell, Joao Pinto, Ian Hastings and Martin J. Donnelly
Molecular Biology and Evolution 2010 27(5):1117-1125

In this study, we employ haplotype diversity analysis to examine evidence for selective sweeps around knockdown resistance (kdr) mutations associated with resistance to dichlorodiphenyltrichloroethane and pyrethroid insecticides in the mosquito Anopheles gambiae.

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