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model

Modeling of hemodynamics arising from malaria infection

February 27, 2010 - 09:52 -- Ingeborg van Schayk
Author(s): 
Yohsuke Imai, Hitoshi Kondo, Takuji Ishikawa, Chwee Teck Lim, Takami Yamaguchi
Reference: 
Journal of Biomechanics, In Press, Corrected Proof, Available online 21 February 2010

We propose a numerical model of hemodynamics arising from malaria infection. This model is based on a particle method, where all the components of blood are represented by the finite number of particles.

The dynamics of mutations associated with anti-malarial drug resistance in Plasmodium falciparum.

November 18, 2009 - 12:38 -- Kabogo Ndegwa
Author(s): 
Ananias A. Escalante, David L. Smith, Yuseob Kim.
Reference: 
Trends in Parasitology, Volume 25, Issue 12, December 2009, Pages 557-563, doi:10.1016/j.pt.2009.09.008

The evolution of resistance in Plasmodium falciparum against safe and affordable drugs such as chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) is a major global health threat. Investigating the dynamics of resistance against these antimalarial drugs will lead to approaches for addressing the problem of resistance in malarial parasites that are solidly based in evolutionary genetics and population biology. In this article, we discuss current developments in population biology modeling and evolutionary genetics.

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Case report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors

November 10, 2009 - 20:48 -- Ingeborg van Schayk
Author(s): 
Sócrates Herrera, Olga Fernández, María R. Manzano, Bermans Murrain, Juana Vergara, Pedro Blanco, Ricardo Palacios, Juan D. Vélez, Judith E. Epstein, Mario Chen-Mok, Zarifah H. Reed, AND Myriam Arévalo-Herrera
Reference: 
Am J Trop Med Hyg 2009;81 740-746

In conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2–10 An. albimanus mosquitoes carrying P. vivax sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.

 

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