Open Access | High-throughput 454 resequencing for allele discovery and recombination mapping in Plasmodium falciparum
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BMC Genomics 2011, 12:116 (17 February 2011)
We present a scheme to survey recombination in the haploid stage genomes of two sibling parasite clones, using whole genome pyrosequencing that includes a sliding window approach to predict recombination breakpoints.
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Malaria is rampant in Africa and causes untold mortality and morbidity. Vector-borne diseases are climate sensitive and this has raised considerable concern over the implications of climate change on future disease risk.